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Protein
Submitted name:

Alpha-1D adrenergic receptor

Gene

Adra1d

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390696 Adrenoceptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-1D adrenergic receptorImported
Gene namesi
Name:Adra1dImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:106673 Adra1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 115HelicalSequence analysisAdd BLAST23
Transmembranei127 – 146HelicalSequence analysisAdd BLAST20
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei207 – 228HelicalSequence analysisAdd BLAST22
Transmembranei248 – 273HelicalSequence analysisAdd BLAST26
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Transmembranei380 – 399HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Proteomic databases

PaxDbiA2ANQ2
PRIDEiA2ANQ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000027335 Expressed in 16 organ(s), highest expression level in Ammon's horn

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099473

Structurei

3D structure databases

ProteinModelPortaliA2ANQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 396G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239244
HOVERGENiHBG106962
KOiK04137
OMAiGATCQAY
OrthoDBiEOG091G06VI
PhylomeDBiA2ANQ2
TreeFamiTF331895

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000363 ADRA1D_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF14 PTHR24248:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00240 ADRENRGCA1DR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2ANQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFRDILSVT FEGPRASSST GGSGAGGGAG TVGPEGPAVG GVPGATGGSA
60 70 80 90 100
VVGTGSGEDN QSSTAEAGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF
110 120 130 140 150
ILTAVAGNLL VILSVACNRH LQTVTNYFIV NLAVADLLLS AAVLPFSATM
160 170 180 190 200
EVLGFWAFGR TFCDVWAAVD VLCCTASILS LCTISVDRYV GVRHSLKYPA
210 220 230 240 250
IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC GITEEVGYAI
260 270 280 290 300
FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI
310 320 330 340 350
HCRGAATSAK GNPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV
360 370 380 390 400
FVLCWFPFFF VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS
410 420 430 440 450
REFKRAFLRL LRCQCRRRRR RLWRVYGHHW RASTGDPRSD CAPSPRIAPP
460 470 480 490 500
GAPLALTAHP GPGSVDTPEA QASVSGRRKP ASALREWRLL GPLQRPTTQL
510 520 530 540 550
RAKVSSLSHK FRSGGARRAE TACALRSEVE AVSLNVPQDG AEAVICQAYE
560
PGDLSNLRET DI
Length:562
Mass (Da):59,519
Last modified:February 20, 2007 - v1
Checksum:i643F965FC626B7F6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P97714ADA1D_MOUSE
Alpha-1D adrenergic receptor
Adra1d Adra1a, Gpcr8
562Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831731 Genomic DNA No translation available.
RefSeqiNP_038488.4, NM_013460.4
UniGeneiMm.389380

Genome annotation databases

EnsembliENSMUST00000103184; ENSMUSP00000099473; ENSMUSG00000027335
GeneIDi11550
KEGGimmu:11550
UCSCiuc008mlu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831731 Genomic DNA No translation available.
RefSeqiNP_038488.4, NM_013460.4
UniGeneiMm.389380

3D structure databases

ProteinModelPortaliA2ANQ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099473

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiA2ANQ2
PRIDEiA2ANQ2

Protocols and materials databases

DNASUi11550
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103184; ENSMUSP00000099473; ENSMUSG00000027335
GeneIDi11550
KEGGimmu:11550
UCSCiuc008mlu.1 mouse

Organism-specific databases

CTDi146
MGIiMGI:106673 Adra1d

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239244
HOVERGENiHBG106962
KOiK04137
OMAiGATCQAY
OrthoDBiEOG091G06VI
PhylomeDBiA2ANQ2
TreeFamiTF331895

Enzyme and pathway databases

ReactomeiR-MMU-390696 Adrenoceptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027335 Expressed in 16 organ(s), highest expression level in Ammon's horn

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000363 ADRA1D_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF14 PTHR24248:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00240 ADRENRGCA1DR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2ANQ2_MOUSE
AccessioniPrimary (citable) accession number: A2ANQ2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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