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Entry version 108 (08 May 2019)
Sequence version 1 (20 Feb 2007)
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Protein

E3 ubiquitin-protein ligase UBR4

Gene

Ubr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1655 – 1728UBR-typePROSITE-ProRule annotationAdd BLAST74

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Transferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6798695 Neutrophil degranulation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR4 (EC:2.3.2.27)
Alternative name(s):
N-recognin-4
RING-type E3 ubiquitin transferase UBR4
Zinc finger UBR1-type protein 1
p600
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ubr4
Synonyms:Kiaa0462, Zubr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916366 Ubr4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002868621 – 5180E3 ubiquitin-protein ligase UBR4Add BLAST5180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei178PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei370PhosphotyrosineCombined sources1
Modified residuei905PhosphothreonineBy similarity1
Modified residuei1083N6-acetyllysineBy similarity1
Modified residuei1401PhosphoserineBy similarity1
Modified residuei1646PhosphoserineBy similarity1
Modified residuei1651PhosphoserineBy similarity1
Modified residuei1746PhosphoserineBy similarity1
Modified residuei1753PhosphoserineBy similarity1
Modified residuei1876PhosphoserineBy similarity1
Modified residuei1902PhosphoserineBy similarity1
Modified residuei2712PhosphothreonineBy similarity1
Modified residuei2716PhosphoserineBy similarity1
Modified residuei2719PhosphoserineCombined sources1
Modified residuei2721PhosphothreonineCombined sources1
Modified residuei2941PhosphothreonineBy similarity1
Modified residuei2949PhosphoserineBy similarity1
Isoform 5 (identifier: A2AN08-5)
Modified residuei2603PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AN08

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AN08

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AN08

PeptideAtlas

More...
PeptideAtlasi
A2AN08

PRoteomics IDEntifications database

More...
PRIDEi
A2AN08

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AN08

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AN08

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A2AN08

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in adult and embryonic stages with highest levels in testis and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000066036 Expressed in 306 organ(s), highest expression level in cerebral cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AN08 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AN08 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RB1 and calmodulin.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
E7P069332EBI-4285947,EBI-7730971From Bovine papillomavirus type 1.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
213238, 11 interactors

Database of interacting proteins

More...
DIPi
DIP-61499N

Protein interaction database and analysis system

More...
IntActi
A2AN08, 11 interactors

Molecular INTeraction database

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MINTi
A2AN08

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000095433

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 15Poly-Ala7
Compositional biasi608 – 626Pro-richAdd BLAST19
Compositional biasi811 – 816Poly-Leu6
Compositional biasi2725 – 2735Poly-AspAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UBR4 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1655 – 1728UBR-typePROSITE-ProRule annotationAdd BLAST74

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1776 Eukaryota
ENOG410XPP8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00600000084471

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AN08

KEGG Orthology (KO)

More...
KOi
K10691

Identification of Orthologs from Complete Genome Data

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OMAi
DEPHEYL

Database of Orthologous Groups

More...
OrthoDBi
717at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AN08

TreeFam database of animal gene trees

More...
TreeFami
TF314406

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR025704 E3_Ub_ligase_UBR4
IPR036322 WD40_repeat_dom_sf
IPR003126 Znf_UBR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13764 E3_UbLigase_R4, 1 hit
PF02207 zf-UBR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00396 ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51157 ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AN08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATSGGEEAA AAAPAPGAPA TGQDTTPGWE VAVRPLLSAS YSAFEMKELP
60 70 80 90 100
QLVASVIESE SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV
110 120 130 140 150
AAACKVLIEF SLLRLENPDE ACAVSQKHLI LLIKGLCTGC SRLDRTEIIT
160 170 180 190 200
FTAMMKSAKL PQTVKTLSDV EDQKELASPV SPELRQKEVQ MNFLNQLTSV
210 220 230 240 250
FNPRTVPSPP ISPQALVEGE NDEQSSPDQV SAAKTKSVFI AQNVASLQEL
260 270 280 290 300
GGSEKLLRVC LNLPYFLRYI NRFQDAVVAN SFFIMPATVA DATAVRNGFH
310 320 330 340 350
SLVIDVTMAL DTLSLPVLEP LNPSRLQDVT VLSLSCLYAG VSVATCMAIL
360 370 380 390 400
HVGSAQQVRT GSTSSKEDDY ESDAATIVQK CLEIYDMIGQ AISSSRRAGG
410 420 430 440 450
EHFQNFQLLG AWCLLNSLFL ILNLSPTALA DKGKEKDPLA ALRVRDILSR
460 470 480 490 500
TKEGVGSPKL GPGKGHQGFG VLSVILANHA IKLLASLFQD LQVEALHKGW
510 520 530 540 550
ETDGPPAVLS IMAQSTSTQR IQRLIDSVPL TNLLLTLLST SYRKACVLQR
560 570 580 590 600
QRKGSMSSDA SASTDSNTYY EDDFSSTEED SSQDDDSEPI LGQWFEETIS
610 620 630 640 650
PSKEKAAPPP PPPPPPLESS PRVKSPNKQA SGEKGNILAS RKDPELFSGL
660 670 680 690 700
ASNILNFITT SMLNSRNSFI RSYLSASLSE HHMATLASII KEVDKDGLKG
710 720 730 740 750
SSDEDFAAAL YHFNHSLVTS DLQSPNLQNT LLQQLGVAPF SEGPWPLYIH
760 770 780 790 800
PQGLSVLSRL LLIWQHKAGA QGDPDVPECL KVWDRFLTTM KQNALQGVVP
810 820 830 840 850
SETEDLNVEH LQLLLLIFHS FSEKGRRAIL TMLVQSIQEL SVNMEVQMRT
860 870 880 890 900
APLILARLLL IFDYLLHQYS KAPVYLFEQV QHNLLSPPFG WASGSQDSSS
910 920 930 940 950
RRANTPLYHG FKEVEENWSK HFSSDAAPQP RFYCVLSTEA SEEDLNRLDS
960 970 980 990 1000
EACEVLFSKP VKYDELYSSL TTLLAAGSQL DTTRRKEKKN VTALEACALQ
1010 1020 1030 1040 1050
YYFLILWRIL GILPPSKTYM NQLAMNSPEM SECDILHTLR WSSRLRISSY
1060 1070 1080 1090 1100
VSWIKDHLIK QGMKPEHAGS LIELAASKCS SVKYDVEIVE EYFARQISSF
1110 1120 1130 1140 1150
CSIDCTAVLQ LHEIPSLQSI YTLDAAVSKV QVSLDEHFSK MAAETDPHKS
1160 1170 1180 1190 1200
SEITKNLLPA TLQLIDTYAS FTRAYLLQNL NEEGSTEKPS QEKLHGFAAV
1210 1220 1230 1240 1250
LAIGSSRCKA NTLGPTLVQN LPSSVQSVCE SWNNINTNEF PNIGSWRNAF
1260 1270 1280 1290 1300
ANDTIPSESY ISAVQAAHLG TLCGQSLPLA ASLKHTLLSL VRLTGDLIVW
1310 1320 1330 1340 1350
SDEMNPAQVI RTLLPLLLES STESAAEISS NSLERILGPA ESDEFLARVY
1360 1370 1380 1390 1400
EKLITGCYNI LANHADPNSG LDESILEECL QYLEKQLESS QARKAMEEFF
1410 1420 1430 1440 1450
SDGGELVQIM MATANEDLSA KFCNRVLKFF TKLFQLTEKS PNPSLLHLCG
1460 1470 1480 1490 1500
SLAQLACVEP VRLQAWLTRM TTSPPKDSDQ LEVIQENRQL LQLLTTYIVR
1510 1520 1530 1540 1550
ENSQVGEGVC AVLLGTLTPM ATDMLANGDG TGFPELMVVM ATLASAGQGA
1560 1570 1580 1590 1600
GHLQLHNAAV DWLGRCKKYL SQKNVVEKLN ANVMHGKHVM VLECTCHIMS
1610 1620 1630 1640 1650
YLADVTNALS QSNGQGPSHL SVDGEERAIE VDSDWVEELA VEEEDSQAED
1660 1670 1680 1690 1700
SDEDSLCNKL CTFTITQKEF MNQHWYHCHT CKMVDGVGVC TVCAKVCHKD
1710 1720 1730 1740 1750
HEISYAKYGS FFCDCGAKED GSCLALVKRT PSSGMSSTMK ESAFQSEPRV
1760 1770 1780 1790 1800
SESLVRHAST SPADKAKVTI SDGKVTDEEK PKKSSLCRTV EGCREELQNQ
1810 1820 1830 1840 1850
ANFSFAPLVL DMLSFLMDAI QTNFQQASAV GSSSRAQQAL SELHTVDKGV
1860 1870 1880 1890 1900
EMTDQLMVPT LGSQEGAFEN VRMNYSGDQG QTIRQLISAH VLRRVAMCVL
1910 1920 1930 1940 1950
SSPHGRRQHL AVSHEKGKIT VLQLSALLKQ ADSSKRKLTL TRLASAPVPF
1960 1970 1980 1990 2000
TVLSLTGNPC KEDYLAVCGL KDCHVLTFSS SGSVSDHLVL HPQLATGNFI
2010 2020 2030 2040 2050
IKAVWLPGSQ TELAIVTADF VKIYDLSIDA LSPTFYFLLP SSKIRDVTFL
2060 2070 2080 2090 2100
FNEEGKNIIV IMSSAGYMYT QLMEEASSAQ QGPFYVTNVL EINHEDLKDS
2110 2120 2130 2140 2150
NSQVAGGGVS VYYSHVLQML FFSYSQGRSF AATVSRSTLE VLQLFPINIK
2160 2170 2180 2190 2200
SSNGGSKTSP ALCQWSEVMN HPGLVCCVQQ TTGVPLVVMV KPGTFLIQEI
2210 2220 2230 2240 2250
KTLPAKAKIQ DMVAIRHTAC NEQQRTTMIL LCEDGSLRIY MANVENTSYW
2260 2270 2280 2290 2300
LQPSLQPSSV ISIMKPVRKR KTATITARTS SQVTFPIDFF EHNQQLTDVE
2310 2320 2330 2340 2350
FGGNDLLQVY NAQQIKHRLN STGMYVANTK PGGFTIEISN NSSTMVMTGM
2360 2370 2380 2390 2400
RIQIGTQAIE RAPSYIEIFG RTMQLNLSRS RWFDFPFTRE EALQADRKLS
2410 2420 2430 2440 2450
LFIGASVDPA GVTMIDAVKI YGKTKEQFGW PDEPPEDFPS ASVSNICPPN
2460 2470 2480 2490 2500
LNQSNGTGES DSAAPATTSG TVLERLVVSS LEALESCFAV GPIIEKERNK
2510 2520 2530 2540 2550
HAAQELATLL LSLPAPASVQ QQSKSLLASL HSSRSAYHSH KDQALLSKAV
2560 2570 2580 2590 2600
QCLNTSSKEG KDLDPEVFQR LVITARSIAV TRPNNLVHFT ESKLPQMETE
2610 2620 2630 2640 2650
GADEGKEPQK QEGDGCSFIT QLVNHFWKLH ASKPKNAFLA PACLPGLTHI
2660 2670 2680 2690 2700
EATVNALVDI IHGYCTCELD CINTASKIYM QMLLCPDPAV SFSCKQALIR
2710 2720 2730 2740 2750
VLRPRNKRRH VTLPSSPRSN TPMGDKDDDD DDDADEKMQS SGIPDGGHIR
2760 2770 2780 2790 2800
QESQEQSEVD HGDFEMVSES MVLETAENVN NGNPSPLEAL LAGAEGFPPM
2810 2820 2830 2840 2850
LDIPPDADDE TMVELAIALS LQQDQQGSSS SALGLQSLGL SGQAPSSSSL
2860 2870 2880 2890 2900
DAGTLSDTTA SAPASDDEGS TAATDGSTLR TSPADHGGSV GSESGGSAVD
2910 2920 2930 2940 2950
SVAGEHSVSG RSSAYGDATA EGHPAGPGSV SSSTGAISTA TGHQEGDGSE
2960 2970 2980 2990 3000
GEGEGEAEGD VHTSNRLHMV RLMLLERLLQ TLPQLRNVGG VRAIPYMQVI
3010 3020 3030 3040 3050
LMLTTDLDGE DEKDKGALDN LLAQLIAELG MDKKDVSKKN ERSALNEVHL
3060 3070 3080 3090 3100
VVMRLLSVFM SRTKSGSKSS ICESSSLISS ATAAALLSSG AVDYCLHVLK
3110 3120 3130 3140 3150
SLLEYWKSQQ SDEEPVAASQ LLKPHTTSSP PDMSPFFLRQ YVKGHAADVF
3160 3170 3180 3190 3200
EAYTQLLTEM VLRLPYQIKK IADTSSRIPP PVFDHSWFYF LSEYLMIQQT
3210 3220 3230 3240 3250
PFVRRQVRKL LLFICGSKEK YRQLRDLHTL DSHVRGIKKL LEEQGIFLRA
3260 3270 3280 3290 3300
SVVTASSGSA LQYDTLISLM EHLKACAEIA AQRTINWQKF CIKDDSVLYF
3310 3320 3330 3340 3350
LLQVSFLVDE GVSPVLLQLL SCALCGSKVL AALAASTGSS SVASSSAPPA
3360 3370 3380 3390 3400
ASSGQATTQS KSSTKKSKKE EKEKEKEGES SGSQEDQLCT ALVNQLNRFA
3410 3420 3430 3440 3450
DKETLIQFLR CFLLESNSSS VRWQAHCLTL HIYRNSNKAQ QELLLDLMWS
3460 3470 3480 3490 3500
IWPELPAYGR KAAQFVDLLG YFSLKTAQTE KKLKEYSQKA VEILRTQNHI
3510 3520 3530 3540 3550
LTNHPNSNIY NTLSGLVEFD GYYLESDPCL VCNNPEVPFC YIKLSSIKVD
3560 3570 3580 3590 3600
TRYTTTQQVV KLIGSHTISK VTVKIGDLKR TKMVRTINLY YNNRTVQAIV
3610 3620 3630 3640 3650
ELKNKPARWH KAKKVQLTPG QTEVKIDLPL PIVASNLMIE FADFYENYQA
3660 3670 3680 3690 3700
STETLQCPRC SASVPANPGV CGNCGENVYQ CHKCRSINYD EKDPFLCNAC
3710 3720 3730 3740 3750
GFCKYARFDF MLYAKPCCAV DPIENEEDRK KAVSNINTLL DKADRVYHQL
3760 3770 3780 3790 3800
MGHRPQLENL LCKVNEAAPE KPQEDSGTAG GISSTSASVN RYILQLAQEY
3810 3820 3830 3840 3850
CGDCKNSFDE LSKIIQKVFA SRKELLEYDL QQREAATKSS RTSVQPTFTA
3860 3870 3880 3890 3900
SQYRALSVLG CGHTSSTKCY GCASAVTEHC ITLLRALATN PALRHILVSQ
3910 3920 3930 3940 3950
GLIRELFDYN LRRGAAAIRE EVRQLMCLLT RDNPEATQQM NDLIIGKVST
3960 3970 3980 3990 4000
ALKGHWANPD LASSLQYEML LLTDSISKED SCWELRLRCA LSLFLMAVNI
4010 4020 4030 4040 4050
KTPVVVENIT LMCLRILQKL IKPPAPTSKK NKDVPVEALT TVKPYCNEIH
4060 4070 4080 4090 4100
AQAQLWLKRD PKASYEAWKK CLPIRGVDGN GKSPSKSELH RLYLTEKYVW
4110 4120 4130 4140 4150
RWKQFLSRRG KRTTPLDLKL GHNNWLRQVL FTPATQAARQ AACTIVEALA
4160 4170 4180 4190 4200
TVPSRKQQVL DLLTSYLDEL SVAGECAAEY LALYQKLIAS CHWKVYLAAR
4210 4220 4230 4240 4250
GVLPYVGNLI TKEIARLLAL EEATLSTDLQ QGYALKSLTG LLSSFVEVES
4260 4270 4280 4290 4300
IKRHFKSRLV GTVLNGYLCL RKLVLQRTKL IDETQDMLLE MLEDMTTGTE
4310 4320 4330 4340 4350
SETKAFMAVC IETAKRYNLD DYRTPVFIFE RLCSIIYPEE NEVTEFFVTL
4360 4370 4380 4390 4400
EKDPQQEDFL QGRMPGNPYS SNEPGIGPLM RDIKNKICQD CDLVALLEDD
4410 4420 4430 4440 4450
SGMELLVNNK IISLDLPVAE VYKKVWCATN EGEPMRIVYR MRGLLGDATE
4460 4470 4480 4490 4500
EFIESLDSTT DEEEDEEEVY RMAGVMAQCG GLQCMLNRLA GVKDFKQGRH
4510 4520 4530 4540 4550
LLTVLLKLFS YCVKVKVNRQ QLVKLETNTL NVMLGTLNLA LVAEQESKDS
4560 4570 4580 4590 4600
GGAAVAEQVL SIMEIILDES NAEPLSEDKG NLLLTGDKDQ LVMLLDQINS
4610 4620 4630 4640 4650
TFVRSNPSVL QGLLRIIPYL SFGEVEKMQI LVERFKPYCS FEKYDEDHSG
4660 4670 4680 4690 4700
DDKVFLDCFC KIAAGIKNNS NGHQLKDLIL QKGITQNALD YMKKHIPSAK
4710 4720 4730 4740 4750
NLDADIWKKF LSRPALPFIL RLLRGLAMQH PATQVLIGTD SITSLHKLEQ
4760 4770 4780 4790 4800
VSSDEGIGTL AENLLEALRE HPDVNKKIDA ARRETRAEKK RMAMAMRQKA
4810 4820 4830 4840 4850
LGTLGMTTNE KGQVVTKTAL LKQMEELIEE PGLTCCICRE GYKFQPTKVL
4860 4870 4880 4890 4900
GIYTFTKRVA LEEMENKPRK QQGYSTVSHF NIVHYDCHLA AVRLARGREE
4910 4920 4930 4940 4950
WESAALQNAN TKCNGLLPVW GPHVPESAFA TCLARHNTYL QECTGQREPT
4960 4970 4980 4990 5000
YQLNIHDIKL LFLRFAMEQS FSADTGGGGR ESNIHLIPYI IHTVLYVLNT
5010 5020 5030 5040 5050
TRATSREEKN LQGFLEQPKE KWTESAFDVD GPHYFTILAL HVLPPEQWKA
5060 5070 5080 5090 5100
IRVEILRRLL VASHARAVAP GGATRLTDKA VKDYSAYRSS LLFWALVDLI
5110 5120 5130 5140 5150
YNMFKKVPTS NTEGGWSCSL AEYIRHNDMP IYEAADKALK TFQEEFMPVE
5160 5170 5180
TFSEFLDAAG LLSEITDPES FLKDLLNSVP
Length:5,180
Mass (Da):572,290
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F4238194DF88EE0
GO
Isoform 2 (identifier: A2AN08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3159: Missing.

Show »
Length:2,021
Mass (Da):227,773
Checksum:iF6AD243037D80A83
GO
Isoform 3 (identifier: A2AN08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2474-2474: E → ESSETESLTKLD
     2827-2861: Missing.

Show »
Length:5,156
Mass (Da):570,301
Checksum:i2D7221BA3112D680
GO
Isoform 4 (identifier: A2AN08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-474: HQGFGVLSV → CVSACKLHF
     475-5180: Missing.

Show »
Length:474
Mass (Da):51,162
Checksum:i9C77086D2F5886E0
GO
Isoform 5 (identifier: A2AN08-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2599-2599: T → TDCFSPRCACWNLGIVGILIGAPLETPSA

Show »
Length:5,208
Mass (Da):575,176
Checksum:iDE8A38E5894270F6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SSP6F6SSP6_MOUSE
E3 ubiquitin-protein ligase UBR4
Ubr4
2,065Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YMA7Z4YMA7_MOUSE
E3 ubiquitin-protein ligase UBR4
Ubr4
1,301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YLP1Z4YLP1_MOUSE
E3 ubiquitin-protein ligase UBR4
Ubr4
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC39609 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti445R → K in BAC39609 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0252101 – 3159Missing in isoform 2. 1 PublicationAdd BLAST3159
Alternative sequenceiVSP_025211466 – 474HQGFGVLSV → CVSACKLHF in isoform 4. 1 Publication9
Alternative sequenceiVSP_025212475 – 5180Missing in isoform 4. 1 PublicationAdd BLAST4706
Alternative sequenceiVSP_0252132474E → ESSETESLTKLD in isoform 3. 1 Publication1
Alternative sequenceiVSP_0252142599T → TDCFSPRCACWNLGIVGILI GAPLETPSA in isoform 5. Curated1
Alternative sequenceiVSP_0252152827 – 2861Missing in isoform 3. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK044277 mRNA Translation: BAC31850.1
AK080556 mRNA Translation: BAC37944.1
AK082231 mRNA Translation: BAC38442.2 Sequence problems.
AK083644 mRNA Translation: BAC38980.2 Sequence problems.
AK086097 mRNA Translation: BAC39609.1 Different initiation.
AL807833 Genomic DNA No translation available.
AB093242 mRNA Translation: BAC41426.2
BC040468 mRNA Translation: AAH40468.1
BC051096 mRNA Translation: AAH51096.1
BC057625 mRNA Translation: AAH57625.1
BC059890 mRNA Translation: AAH59890.1
BC094329 mRNA Translation: AAH94329.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51340.1 [A2AN08-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001153791.1, NM_001160319.1 [A2AN08-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000097822; ENSMUSP00000095433; ENSMUSG00000066036 [A2AN08-1]
ENSMUST00000165860; ENSMUSP00000125800; ENSMUSG00000066036 [A2AN08-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
69116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:69116

UCSC genome browser

More...
UCSCi
uc008vmj.2 mouse [A2AN08-4]
uc008vmm.2 mouse [A2AN08-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044277 mRNA Translation: BAC31850.1
AK080556 mRNA Translation: BAC37944.1
AK082231 mRNA Translation: BAC38442.2 Sequence problems.
AK083644 mRNA Translation: BAC38980.2 Sequence problems.
AK086097 mRNA Translation: BAC39609.1 Different initiation.
AL807833 Genomic DNA No translation available.
AB093242 mRNA Translation: BAC41426.2
BC040468 mRNA Translation: AAH40468.1
BC051096 mRNA Translation: AAH51096.1
BC057625 mRNA Translation: AAH57625.1
BC059890 mRNA Translation: AAH59890.1
BC094329 mRNA Translation: AAH94329.1
CCDSiCCDS51340.1 [A2AN08-1]
RefSeqiNP_001153791.1, NM_001160319.1 [A2AN08-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi213238, 11 interactors
DIPiDIP-61499N
IntActiA2AN08, 11 interactors
MINTiA2AN08
STRINGi10090.ENSMUSP00000095433

PTM databases

iPTMnetiA2AN08
PhosphoSitePlusiA2AN08
SwissPalmiA2AN08

Proteomic databases

jPOSTiA2AN08
MaxQBiA2AN08
PaxDbiA2AN08
PeptideAtlasiA2AN08
PRIDEiA2AN08

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097822; ENSMUSP00000095433; ENSMUSG00000066036 [A2AN08-1]
ENSMUST00000165860; ENSMUSP00000125800; ENSMUSG00000066036 [A2AN08-3]
GeneIDi69116
KEGGimmu:69116
UCSCiuc008vmj.2 mouse [A2AN08-4]
uc008vmm.2 mouse [A2AN08-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23352
MGIiMGI:1916366 Ubr4

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1776 Eukaryota
ENOG410XPP8 LUCA
GeneTreeiENSGT00600000084471
InParanoidiA2AN08
KOiK10691
OMAiDEPHEYL
OrthoDBi717at2759
PhylomeDBiA2AN08
TreeFamiTF314406

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ubr4 mouse

Protein Ontology

More...
PROi
PR:A2AN08

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000066036 Expressed in 306 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiA2AN08 baseline and differential
GenevisibleiA2AN08 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR025704 E3_Ub_ligase_UBR4
IPR036322 WD40_repeat_dom_sf
IPR003126 Znf_UBR
PfamiView protein in Pfam
PF13764 E3_UbLigase_R4, 1 hit
PF02207 zf-UBR, 1 hit
SMARTiView protein in SMART
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51157 ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBR4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AN08
Secondary accession number(s): A2AN07
, A2AN09, A2AN10, A2AN11, Q52KI4, Q6PB49, Q6PFC7, Q80Y11, Q8BGB9, Q8C3E8, Q8C4W5, Q8C8X7, Q8CGE0, Q8CHF3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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