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Protein

E3 ubiquitin-protein ligase UBR4

Gene

Ubr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1655 – 1728UBR-typePROSITE-ProRule annotationAdd BLAST74

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Transferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR4 (EC:2.3.2.27)
Alternative name(s):
N-recognin-4
RING-type E3 ubiquitin transferase UBR4
Zinc finger UBR1-type protein 1
p600
Gene namesi
Name:Ubr4
Synonyms:Kiaa0462, Zubr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916366 Ubr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868621 – 5180E3 ubiquitin-protein ligase UBR4Add BLAST5180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei370PhosphotyrosineCombined sources1
Modified residuei905PhosphothreonineBy similarity1
Modified residuei1083N6-acetyllysineBy similarity1
Modified residuei1401PhosphoserineBy similarity1
Modified residuei1646PhosphoserineBy similarity1
Modified residuei1651PhosphoserineBy similarity1
Modified residuei1746PhosphoserineBy similarity1
Modified residuei1753PhosphoserineBy similarity1
Modified residuei1876PhosphoserineBy similarity1
Modified residuei1902PhosphoserineBy similarity1
Modified residuei2712PhosphothreonineBy similarity1
Modified residuei2716PhosphoserineBy similarity1
Modified residuei2719PhosphoserineCombined sources1
Modified residuei2721PhosphothreonineCombined sources1
Modified residuei2941PhosphothreonineBy similarity1
Modified residuei2949PhosphoserineBy similarity1
Isoform 5 (identifier: A2AN08-5)
Modified residuei2603PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiA2AN08
PaxDbiA2AN08
PeptideAtlasiA2AN08
PRIDEiA2AN08

PTM databases

iPTMnetiA2AN08
PhosphoSitePlusiA2AN08
SwissPalmiA2AN08

Expressioni

Tissue specificityi

Widely expressed in adult and embryonic stages with highest levels in testis and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000066036 Expressed in 306 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiA2AN08 baseline and differential
GenevisibleiA2AN08 MM

Interactioni

Subunit structurei

Interacts with RB1 and calmodulin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
E7P069332EBI-4285947,EBI-7730971From Bovine papillomavirus type 1.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213238, 10 interactors
DIPiDIP-61499N
IntActiA2AN08, 10 interactors
MINTiA2AN08
STRINGi10090.ENSMUSP00000095433

Structurei

3D structure databases

ProteinModelPortaliA2AN08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 15Poly-Ala7
Compositional biasi608 – 626Pro-richAdd BLAST19
Compositional biasi811 – 816Poly-Leu6
Compositional biasi2725 – 2735Poly-AspAdd BLAST11

Sequence similaritiesi

Belongs to the UBR4 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1655 – 1728UBR-typePROSITE-ProRule annotationAdd BLAST74

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1776 Eukaryota
ENOG410XPP8 LUCA
GeneTreeiENSGT00600000084471
HOVERGENiHBG058328
InParanoidiA2AN08
KOiK10691
OMAiDEPHEYL
OrthoDBiEOG091G000I
PhylomeDBiA2AN08
TreeFamiTF314406

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR025704 E3_Ub_ligase_UBR4
IPR036322 WD40_repeat_dom_sf
IPR003126 Znf_UBR
PfamiView protein in Pfam
PF13764 E3_UbLigase_R4, 1 hit
PF02207 zf-UBR, 1 hit
SMARTiView protein in SMART
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51157 ZF_UBR, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AN08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATSGGEEAA AAAPAPGAPA TGQDTTPGWE VAVRPLLSAS YSAFEMKELP
60 70 80 90 100
QLVASVIESE SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV
110 120 130 140 150
AAACKVLIEF SLLRLENPDE ACAVSQKHLI LLIKGLCTGC SRLDRTEIIT
160 170 180 190 200
FTAMMKSAKL PQTVKTLSDV EDQKELASPV SPELRQKEVQ MNFLNQLTSV
210 220 230 240 250
FNPRTVPSPP ISPQALVEGE NDEQSSPDQV SAAKTKSVFI AQNVASLQEL
260 270 280 290 300
GGSEKLLRVC LNLPYFLRYI NRFQDAVVAN SFFIMPATVA DATAVRNGFH
310 320 330 340 350
SLVIDVTMAL DTLSLPVLEP LNPSRLQDVT VLSLSCLYAG VSVATCMAIL
360 370 380 390 400
HVGSAQQVRT GSTSSKEDDY ESDAATIVQK CLEIYDMIGQ AISSSRRAGG
410 420 430 440 450
EHFQNFQLLG AWCLLNSLFL ILNLSPTALA DKGKEKDPLA ALRVRDILSR
460 470 480 490 500
TKEGVGSPKL GPGKGHQGFG VLSVILANHA IKLLASLFQD LQVEALHKGW
510 520 530 540 550
ETDGPPAVLS IMAQSTSTQR IQRLIDSVPL TNLLLTLLST SYRKACVLQR
560 570 580 590 600
QRKGSMSSDA SASTDSNTYY EDDFSSTEED SSQDDDSEPI LGQWFEETIS
610 620 630 640 650
PSKEKAAPPP PPPPPPLESS PRVKSPNKQA SGEKGNILAS RKDPELFSGL
660 670 680 690 700
ASNILNFITT SMLNSRNSFI RSYLSASLSE HHMATLASII KEVDKDGLKG
710 720 730 740 750
SSDEDFAAAL YHFNHSLVTS DLQSPNLQNT LLQQLGVAPF SEGPWPLYIH
760 770 780 790 800
PQGLSVLSRL LLIWQHKAGA QGDPDVPECL KVWDRFLTTM KQNALQGVVP
810 820 830 840 850
SETEDLNVEH LQLLLLIFHS FSEKGRRAIL TMLVQSIQEL SVNMEVQMRT
860 870 880 890 900
APLILARLLL IFDYLLHQYS KAPVYLFEQV QHNLLSPPFG WASGSQDSSS
910 920 930 940 950
RRANTPLYHG FKEVEENWSK HFSSDAAPQP RFYCVLSTEA SEEDLNRLDS
960 970 980 990 1000
EACEVLFSKP VKYDELYSSL TTLLAAGSQL DTTRRKEKKN VTALEACALQ
1010 1020 1030 1040 1050
YYFLILWRIL GILPPSKTYM NQLAMNSPEM SECDILHTLR WSSRLRISSY
1060 1070 1080 1090 1100
VSWIKDHLIK QGMKPEHAGS LIELAASKCS SVKYDVEIVE EYFARQISSF
1110 1120 1130 1140 1150
CSIDCTAVLQ LHEIPSLQSI YTLDAAVSKV QVSLDEHFSK MAAETDPHKS
1160 1170 1180 1190 1200
SEITKNLLPA TLQLIDTYAS FTRAYLLQNL NEEGSTEKPS QEKLHGFAAV
1210 1220 1230 1240 1250
LAIGSSRCKA NTLGPTLVQN LPSSVQSVCE SWNNINTNEF PNIGSWRNAF
1260 1270 1280 1290 1300
ANDTIPSESY ISAVQAAHLG TLCGQSLPLA ASLKHTLLSL VRLTGDLIVW
1310 1320 1330 1340 1350
SDEMNPAQVI RTLLPLLLES STESAAEISS NSLERILGPA ESDEFLARVY
1360 1370 1380 1390 1400
EKLITGCYNI LANHADPNSG LDESILEECL QYLEKQLESS QARKAMEEFF
1410 1420 1430 1440 1450
SDGGELVQIM MATANEDLSA KFCNRVLKFF TKLFQLTEKS PNPSLLHLCG
1460 1470 1480 1490 1500
SLAQLACVEP VRLQAWLTRM TTSPPKDSDQ LEVIQENRQL LQLLTTYIVR
1510 1520 1530 1540 1550
ENSQVGEGVC AVLLGTLTPM ATDMLANGDG TGFPELMVVM ATLASAGQGA
1560 1570 1580 1590 1600
GHLQLHNAAV DWLGRCKKYL SQKNVVEKLN ANVMHGKHVM VLECTCHIMS
1610 1620 1630 1640 1650
YLADVTNALS QSNGQGPSHL SVDGEERAIE VDSDWVEELA VEEEDSQAED
1660 1670 1680 1690 1700
SDEDSLCNKL CTFTITQKEF MNQHWYHCHT CKMVDGVGVC TVCAKVCHKD
1710 1720 1730 1740 1750
HEISYAKYGS FFCDCGAKED GSCLALVKRT PSSGMSSTMK ESAFQSEPRV
1760 1770 1780 1790 1800
SESLVRHAST SPADKAKVTI SDGKVTDEEK PKKSSLCRTV EGCREELQNQ
1810 1820 1830 1840 1850
ANFSFAPLVL DMLSFLMDAI QTNFQQASAV GSSSRAQQAL SELHTVDKGV
1860 1870 1880 1890 1900
EMTDQLMVPT LGSQEGAFEN VRMNYSGDQG QTIRQLISAH VLRRVAMCVL
1910 1920 1930 1940 1950
SSPHGRRQHL AVSHEKGKIT VLQLSALLKQ ADSSKRKLTL TRLASAPVPF
1960 1970 1980 1990 2000
TVLSLTGNPC KEDYLAVCGL KDCHVLTFSS SGSVSDHLVL HPQLATGNFI
2010 2020 2030 2040 2050
IKAVWLPGSQ TELAIVTADF VKIYDLSIDA LSPTFYFLLP SSKIRDVTFL
2060 2070 2080 2090 2100
FNEEGKNIIV IMSSAGYMYT QLMEEASSAQ QGPFYVTNVL EINHEDLKDS
2110 2120 2130 2140 2150
NSQVAGGGVS VYYSHVLQML FFSYSQGRSF AATVSRSTLE VLQLFPINIK
2160 2170 2180 2190 2200
SSNGGSKTSP ALCQWSEVMN HPGLVCCVQQ TTGVPLVVMV KPGTFLIQEI
2210 2220 2230 2240 2250
KTLPAKAKIQ DMVAIRHTAC NEQQRTTMIL LCEDGSLRIY MANVENTSYW
2260 2270 2280 2290 2300
LQPSLQPSSV ISIMKPVRKR KTATITARTS SQVTFPIDFF EHNQQLTDVE
2310 2320 2330 2340 2350
FGGNDLLQVY NAQQIKHRLN STGMYVANTK PGGFTIEISN NSSTMVMTGM
2360 2370 2380 2390 2400
RIQIGTQAIE RAPSYIEIFG RTMQLNLSRS RWFDFPFTRE EALQADRKLS
2410 2420 2430 2440 2450
LFIGASVDPA GVTMIDAVKI YGKTKEQFGW PDEPPEDFPS ASVSNICPPN
2460 2470 2480 2490 2500
LNQSNGTGES DSAAPATTSG TVLERLVVSS LEALESCFAV GPIIEKERNK
2510 2520 2530 2540 2550
HAAQELATLL LSLPAPASVQ QQSKSLLASL HSSRSAYHSH KDQALLSKAV
2560 2570 2580 2590 2600
QCLNTSSKEG KDLDPEVFQR LVITARSIAV TRPNNLVHFT ESKLPQMETE
2610 2620 2630 2640 2650
GADEGKEPQK QEGDGCSFIT QLVNHFWKLH ASKPKNAFLA PACLPGLTHI
2660 2670 2680 2690 2700
EATVNALVDI IHGYCTCELD CINTASKIYM QMLLCPDPAV SFSCKQALIR
2710 2720 2730 2740 2750
VLRPRNKRRH VTLPSSPRSN TPMGDKDDDD DDDADEKMQS SGIPDGGHIR
2760 2770 2780 2790 2800
QESQEQSEVD HGDFEMVSES MVLETAENVN NGNPSPLEAL LAGAEGFPPM
2810 2820 2830 2840 2850
LDIPPDADDE TMVELAIALS LQQDQQGSSS SALGLQSLGL SGQAPSSSSL
2860 2870 2880 2890 2900
DAGTLSDTTA SAPASDDEGS TAATDGSTLR TSPADHGGSV GSESGGSAVD
2910 2920 2930 2940 2950
SVAGEHSVSG RSSAYGDATA EGHPAGPGSV SSSTGAISTA TGHQEGDGSE
2960 2970 2980 2990 3000
GEGEGEAEGD VHTSNRLHMV RLMLLERLLQ TLPQLRNVGG VRAIPYMQVI
3010 3020 3030 3040 3050
LMLTTDLDGE DEKDKGALDN LLAQLIAELG MDKKDVSKKN ERSALNEVHL
3060 3070 3080 3090 3100
VVMRLLSVFM SRTKSGSKSS ICESSSLISS ATAAALLSSG AVDYCLHVLK
3110 3120 3130 3140 3150
SLLEYWKSQQ SDEEPVAASQ LLKPHTTSSP PDMSPFFLRQ YVKGHAADVF
3160 3170 3180 3190 3200
EAYTQLLTEM VLRLPYQIKK IADTSSRIPP PVFDHSWFYF LSEYLMIQQT
3210 3220 3230 3240 3250
PFVRRQVRKL LLFICGSKEK YRQLRDLHTL DSHVRGIKKL LEEQGIFLRA
3260 3270 3280 3290 3300
SVVTASSGSA LQYDTLISLM EHLKACAEIA AQRTINWQKF CIKDDSVLYF
3310 3320 3330 3340 3350
LLQVSFLVDE GVSPVLLQLL SCALCGSKVL AALAASTGSS SVASSSAPPA
3360 3370 3380 3390 3400
ASSGQATTQS KSSTKKSKKE EKEKEKEGES SGSQEDQLCT ALVNQLNRFA
3410 3420 3430 3440 3450
DKETLIQFLR CFLLESNSSS VRWQAHCLTL HIYRNSNKAQ QELLLDLMWS
3460 3470 3480 3490 3500
IWPELPAYGR KAAQFVDLLG YFSLKTAQTE KKLKEYSQKA VEILRTQNHI
3510 3520 3530 3540 3550
LTNHPNSNIY NTLSGLVEFD GYYLESDPCL VCNNPEVPFC YIKLSSIKVD
3560 3570 3580 3590 3600
TRYTTTQQVV KLIGSHTISK VTVKIGDLKR TKMVRTINLY YNNRTVQAIV
3610 3620 3630 3640 3650
ELKNKPARWH KAKKVQLTPG QTEVKIDLPL PIVASNLMIE FADFYENYQA
3660 3670 3680 3690 3700
STETLQCPRC SASVPANPGV CGNCGENVYQ CHKCRSINYD EKDPFLCNAC
3710 3720 3730 3740 3750
GFCKYARFDF MLYAKPCCAV DPIENEEDRK KAVSNINTLL DKADRVYHQL
3760 3770 3780 3790 3800
MGHRPQLENL LCKVNEAAPE KPQEDSGTAG GISSTSASVN RYILQLAQEY
3810 3820 3830 3840 3850
CGDCKNSFDE LSKIIQKVFA SRKELLEYDL QQREAATKSS RTSVQPTFTA
3860 3870 3880 3890 3900
SQYRALSVLG CGHTSSTKCY GCASAVTEHC ITLLRALATN PALRHILVSQ
3910 3920 3930 3940 3950
GLIRELFDYN LRRGAAAIRE EVRQLMCLLT RDNPEATQQM NDLIIGKVST
3960 3970 3980 3990 4000
ALKGHWANPD LASSLQYEML LLTDSISKED SCWELRLRCA LSLFLMAVNI
4010 4020 4030 4040 4050
KTPVVVENIT LMCLRILQKL IKPPAPTSKK NKDVPVEALT TVKPYCNEIH
4060 4070 4080 4090 4100
AQAQLWLKRD PKASYEAWKK CLPIRGVDGN GKSPSKSELH RLYLTEKYVW
4110 4120 4130 4140 4150
RWKQFLSRRG KRTTPLDLKL GHNNWLRQVL FTPATQAARQ AACTIVEALA
4160 4170 4180 4190 4200
TVPSRKQQVL DLLTSYLDEL SVAGECAAEY LALYQKLIAS CHWKVYLAAR
4210 4220 4230 4240 4250
GVLPYVGNLI TKEIARLLAL EEATLSTDLQ QGYALKSLTG LLSSFVEVES
4260 4270 4280 4290 4300
IKRHFKSRLV GTVLNGYLCL RKLVLQRTKL IDETQDMLLE MLEDMTTGTE
4310 4320 4330 4340 4350
SETKAFMAVC IETAKRYNLD DYRTPVFIFE RLCSIIYPEE NEVTEFFVTL
4360 4370 4380 4390 4400
EKDPQQEDFL QGRMPGNPYS SNEPGIGPLM RDIKNKICQD CDLVALLEDD
4410 4420 4430 4440 4450
SGMELLVNNK IISLDLPVAE VYKKVWCATN EGEPMRIVYR MRGLLGDATE
4460 4470 4480 4490 4500
EFIESLDSTT DEEEDEEEVY RMAGVMAQCG GLQCMLNRLA GVKDFKQGRH
4510 4520 4530 4540 4550
LLTVLLKLFS YCVKVKVNRQ QLVKLETNTL NVMLGTLNLA LVAEQESKDS
4560 4570 4580 4590 4600
GGAAVAEQVL SIMEIILDES NAEPLSEDKG NLLLTGDKDQ LVMLLDQINS
4610 4620 4630 4640 4650
TFVRSNPSVL QGLLRIIPYL SFGEVEKMQI LVERFKPYCS FEKYDEDHSG
4660 4670 4680 4690 4700
DDKVFLDCFC KIAAGIKNNS NGHQLKDLIL QKGITQNALD YMKKHIPSAK
4710 4720 4730 4740 4750
NLDADIWKKF LSRPALPFIL RLLRGLAMQH PATQVLIGTD SITSLHKLEQ
4760 4770 4780 4790 4800
VSSDEGIGTL AENLLEALRE HPDVNKKIDA ARRETRAEKK RMAMAMRQKA
4810 4820 4830 4840 4850
LGTLGMTTNE KGQVVTKTAL LKQMEELIEE PGLTCCICRE GYKFQPTKVL
4860 4870 4880 4890 4900
GIYTFTKRVA LEEMENKPRK QQGYSTVSHF NIVHYDCHLA AVRLARGREE
4910 4920 4930 4940 4950
WESAALQNAN TKCNGLLPVW GPHVPESAFA TCLARHNTYL QECTGQREPT
4960 4970 4980 4990 5000
YQLNIHDIKL LFLRFAMEQS FSADTGGGGR ESNIHLIPYI IHTVLYVLNT
5010 5020 5030 5040 5050
TRATSREEKN LQGFLEQPKE KWTESAFDVD GPHYFTILAL HVLPPEQWKA
5060 5070 5080 5090 5100
IRVEILRRLL VASHARAVAP GGATRLTDKA VKDYSAYRSS LLFWALVDLI
5110 5120 5130 5140 5150
YNMFKKVPTS NTEGGWSCSL AEYIRHNDMP IYEAADKALK TFQEEFMPVE
5160 5170 5180
TFSEFLDAAG LLSEITDPES FLKDLLNSVP
Length:5,180
Mass (Da):572,290
Last modified:February 20, 2007 - v1
Checksum:i5F4238194DF88EE0
GO
Isoform 2 (identifier: A2AN08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3159: Missing.

Show »
Length:2,021
Mass (Da):227,773
Checksum:iF6AD243037D80A83
GO
Isoform 3 (identifier: A2AN08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2474-2474: E → ESSETESLTKLD
     2827-2861: Missing.

Show »
Length:5,156
Mass (Da):570,301
Checksum:i2D7221BA3112D680
GO
Isoform 4 (identifier: A2AN08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-474: HQGFGVLSV → CVSACKLHF
     475-5180: Missing.

Show »
Length:474
Mass (Da):51,162
Checksum:i9C77086D2F5886E0
GO
Isoform 5 (identifier: A2AN08-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2599-2599: T → TDCFSPRCACWNLGIVGILIGAPLETPSA

Show »
Length:5,208
Mass (Da):575,176
Checksum:iDE8A38E5894270F6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SSP6F6SSP6_MOUSE
E3 ubiquitin-protein ligase UBR4
Ubr4
2,065Annotation score:
Z4YMA7Z4YMA7_MOUSE
E3 ubiquitin-protein ligase UBR4
Ubr4
1,301Annotation score:
Z4YLP1Z4YLP1_MOUSE
E3 ubiquitin-protein ligase UBR4
Ubr4
204Annotation score:

Sequence cautioni

The sequence BAC39609 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti445R → K in BAC39609 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0252101 – 3159Missing in isoform 2. 1 PublicationAdd BLAST3159
Alternative sequenceiVSP_025211466 – 474HQGFGVLSV → CVSACKLHF in isoform 4. 1 Publication9
Alternative sequenceiVSP_025212475 – 5180Missing in isoform 4. 1 PublicationAdd BLAST4706
Alternative sequenceiVSP_0252132474E → ESSETESLTKLD in isoform 3. 1 Publication1
Alternative sequenceiVSP_0252142599T → TDCFSPRCACWNLGIVGILI GAPLETPSA in isoform 5. Curated1
Alternative sequenceiVSP_0252152827 – 2861Missing in isoform 3. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044277 mRNA Translation: BAC31850.1
AK080556 mRNA Translation: BAC37944.1
AK082231 mRNA Translation: BAC38442.2 Sequence problems.
AK083644 mRNA Translation: BAC38980.2 Sequence problems.
AK086097 mRNA Translation: BAC39609.1 Different initiation.
AL807833 Genomic DNA No translation available.
AB093242 mRNA Translation: BAC41426.2
BC040468 mRNA Translation: AAH40468.1
BC051096 mRNA Translation: AAH51096.1
BC057625 mRNA Translation: AAH57625.1
BC059890 mRNA Translation: AAH59890.1
BC094329 mRNA Translation: AAH94329.1
CCDSiCCDS51340.1 [A2AN08-1]
RefSeqiNP_001153791.1, NM_001160319.1 [A2AN08-1]
UniGeneiMm.271956

Genome annotation databases

EnsembliENSMUST00000097822; ENSMUSP00000095433; ENSMUSG00000066036 [A2AN08-1]
ENSMUST00000165860; ENSMUSP00000125800; ENSMUSG00000066036 [A2AN08-3]
GeneIDi69116
KEGGimmu:69116
UCSCiuc008vmj.2 mouse [A2AN08-4]
uc008vmm.2 mouse [A2AN08-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044277 mRNA Translation: BAC31850.1
AK080556 mRNA Translation: BAC37944.1
AK082231 mRNA Translation: BAC38442.2 Sequence problems.
AK083644 mRNA Translation: BAC38980.2 Sequence problems.
AK086097 mRNA Translation: BAC39609.1 Different initiation.
AL807833 Genomic DNA No translation available.
AB093242 mRNA Translation: BAC41426.2
BC040468 mRNA Translation: AAH40468.1
BC051096 mRNA Translation: AAH51096.1
BC057625 mRNA Translation: AAH57625.1
BC059890 mRNA Translation: AAH59890.1
BC094329 mRNA Translation: AAH94329.1
CCDSiCCDS51340.1 [A2AN08-1]
RefSeqiNP_001153791.1, NM_001160319.1 [A2AN08-1]
UniGeneiMm.271956

3D structure databases

ProteinModelPortaliA2AN08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213238, 10 interactors
DIPiDIP-61499N
IntActiA2AN08, 10 interactors
MINTiA2AN08
STRINGi10090.ENSMUSP00000095433

PTM databases

iPTMnetiA2AN08
PhosphoSitePlusiA2AN08
SwissPalmiA2AN08

Proteomic databases

MaxQBiA2AN08
PaxDbiA2AN08
PeptideAtlasiA2AN08
PRIDEiA2AN08

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097822; ENSMUSP00000095433; ENSMUSG00000066036 [A2AN08-1]
ENSMUST00000165860; ENSMUSP00000125800; ENSMUSG00000066036 [A2AN08-3]
GeneIDi69116
KEGGimmu:69116
UCSCiuc008vmj.2 mouse [A2AN08-4]
uc008vmm.2 mouse [A2AN08-1]

Organism-specific databases

CTDi23352
MGIiMGI:1916366 Ubr4
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1776 Eukaryota
ENOG410XPP8 LUCA
GeneTreeiENSGT00600000084471
HOVERGENiHBG058328
InParanoidiA2AN08
KOiK10691
OMAiDEPHEYL
OrthoDBiEOG091G000I
PhylomeDBiA2AN08
TreeFamiTF314406

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiUbr4 mouse
PROiPR:A2AN08
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066036 Expressed in 306 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiA2AN08 baseline and differential
GenevisibleiA2AN08 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR025704 E3_Ub_ligase_UBR4
IPR036322 WD40_repeat_dom_sf
IPR003126 Znf_UBR
PfamiView protein in Pfam
PF13764 E3_UbLigase_R4, 1 hit
PF02207 zf-UBR, 1 hit
SMARTiView protein in SMART
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51157 ZF_UBR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBR4_MOUSE
AccessioniPrimary (citable) accession number: A2AN08
Secondary accession number(s): A2AN07
, A2AN09, A2AN10, A2AN11, Q52KI4, Q6PB49, Q6PFC7, Q80Y11, Q8BGB9, Q8C3E8, Q8C4W5, Q8C8X7, Q8CGE0, Q8CHF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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