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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

Gene

Ndufaf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8By similarity
Gene namesi
Name:Ndufaf8By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913676 Ndufaf8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994811 – 74NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 61PROSITE-ProRule annotation
Disulfide bondi35 ↔ 51PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiA2AMZ4
PaxDbiA2AMZ4
PeptideAtlasiA2AMZ4
PRIDEiA2AMZ4

PTM databases

PhosphoSitePlusiA2AMZ4

Expressioni

Gene expression databases

BgeeiENSMUSG00000078572
ExpressionAtlasiA2AMZ4 baseline and differential
GenevisibleiA2AMZ4 MM

Interactioni

Subunit structurei

Interacts with NDUFAF5.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 69CHCHPROSITE-ProRule annotationAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi25 – 35Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi51 – 61Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Phylogenomic databases

eggNOGiENOG410J7SE Eukaryota
ENOG410Y78Q LUCA
GeneTreeiENSGT00520000061927
HOGENOMiHOG000060278
HOVERGENiHBG089736
InParanoidiA2AMZ4
PhylomeDBiA2AMZ4

Family and domain databases

InterProiView protein in InterPro
IPR034595 NDUFAF8
PANTHERiPTHR34561 PTHR34561, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

A2AMZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVNGAVWGR VRSRFRAFPE HLAACGAEAS AYGKCVQAST APGGRLSKDL
60 70
CVREFEALRS CFAAAAKKTM MGGS
Length:74
Mass (Da):7,785
Last modified:February 20, 2007 - v1
Checksum:iC802666F70B4889C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807824 Genomic DNA No translation available.
BC147711 mRNA Translation: AAI47712.1
BC147720 mRNA Translation: AAI47721.1
CCDSiCCDS36388.1
RefSeqiNP_001103712.1, NM_001110242.1
UniGeneiMm.46699

Genome annotation databases

EnsembliENSMUST00000106223; ENSMUSP00000101830; ENSMUSG00000078572
GeneIDi208501
KEGGimmu:208501
UCSCiuc007mru.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUF8_MOUSE
AccessioniPrimary (citable) accession number: A2AMZ4
Secondary accession number(s): B2RWC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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