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Entry version 116 (02 Dec 2020)
Sequence version 1 (20 Feb 2007)
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Protein

Galactose-1-phosphate uridylyltransferase

Gene

Galt

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.UniRule annotationARBA annotation
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei62UDP-alpha-D-glucose; via amide nitrogenUniRule annotation1
Binding sitei154UDP-alpha-D-glucoseUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi165ZincPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei167Tele-UMP-histidine intermediateUniRule annotation1
Binding sitei169UDP-alpha-D-glucoseUniRule annotation1
Metal bindingi183IronUniRule annotation1
Metal bindingi282IronUniRule annotation1
Metal bindingi300IronUniRule annotation1
Metal bindingi302IronUniRule annotation1
Binding sitei327UDP-alpha-D-glucoseUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationARBA annotation, Transferase
Biological processCarbohydrate metabolism, Galactose metabolismUniRule annotationARBA annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotationARBA annotation, ZincARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00214

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferaseUniRule annotation (EC:2.7.7.12UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GaltImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95638, Galt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AMS3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AMS3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AMS3

PeptideAtlas

More...
PeptideAtlasi
A2AMS3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036073, Expressed in epithelium of small intestine and 303 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AMS3, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AMS3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 32UDP-alpha-D-glucose binding; shared with dimeric partnerUniRule annotation4
Regioni78 – 79UDP-alpha-D-glucose bindingUniRule annotation2
Regioni160 – 162UDP-alpha-D-glucose bindingUniRule annotation3
Regioni315 – 316UDP-alpha-D-glucose binding; shared with dimeric partnerUniRule annotation2
Regioni320 – 321UDP-alpha-D-glucose binding; shared with dimeric partnerUniRule annotation2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.UniRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016188

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029960_0_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HAIYYPP

Database of Orthologous Groups

More...
OrthoDBi
1135699at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300018

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00608, GalT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.428.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001937, GalP_UDPtransf1
IPR019779, GalP_UDPtransf1_His-AS
IPR005850, GalP_Utransf_C
IPR005849, GalP_Utransf_N
IPR036265, HIT-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11943, PTHR11943, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02744, GalP_UDP_tr_C, 1 hit
PF01087, GalP_UDP_transf, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000808, GalT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54197, SSF54197, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00209, galT_1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00117, GAL_P_UDP_TRANSF_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2AMS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATFRASEH QHIRYNPLQD EWVLVSAHRM KRPWQGQVEP QLLKTVPRHD
60 70 80 90 100
PLNPLCPGAT RANGEVNPHY DGTFLFDNDF PALQPDAPDP GPSDHPLFRA
110 120 130 140 150
EAARGVCKVM CFHPWSDVTL PLMSVPEIRA VIDAWASVTE ELGAQYPWVQ
160 170 180 190 200
IFENKGAMMG CSNPHPHCQV WASSFLPDIA QREERSQQTY HSQHGKPLLL
210 220 230 240 250
EYGHQELLRK ERLVLTSEHW IVLVPFWAVW PFQTLLLPRR HVRRLPELNP
260 270 280 290 300
AERDDLASIM KKLLTKYDNL FETSFPYSMG WHGAPTGLKT GATCDHWQLH
310 320 330 340 350
AHYYPPLLRS ATVRKFMVGY EMLAQAQRDL TPEQAAERLR ALPEVHYCLA
360
QKDKETAAIA
Length:360
Mass (Da):41,235
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i405BA48C7A5D33E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q03249GALT_MOUSE
Galactose-1-phosphate uridylyltrans...
Galt
379Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AMS2A2AMS2_MOUSE
Galactose-1-phosphate uridylyltrans...
Galt
356Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL807796 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_057867.2, NM_016658.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000084695; ENSMUSP00000081745; ENSMUSG00000036073

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14430

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:14430

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807796 Genomic DNA No translation available.
RefSeqiNP_057867.2, NM_016658.3

3D structure databases

SMRiA2AMS3
ModBaseiSearch...

Proteomic databases

EPDiA2AMS3
jPOSTiA2AMS3
MaxQBiA2AMS3
PeptideAtlasiA2AMS3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1384, 313 antibodies

Genome annotation databases

EnsembliENSMUST00000084695; ENSMUSP00000081745; ENSMUSG00000036073
GeneIDi14430
KEGGimmu:14430

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2592
MGIiMGI:95638, Galt

Phylogenomic databases

GeneTreeiENSGT00390000016188
HOGENOMiCLU_029960_0_1_1
OMAiHAIYYPP
OrthoDBi1135699at2759
TreeFamiTF300018

Enzyme and pathway databases

UniPathwayiUPA00214

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
14430, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Galt, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036073, Expressed in epithelium of small intestine and 303 other tissues
ExpressionAtlasiA2AMS3, baseline and differential

Family and domain databases

CDDicd00608, GalT, 1 hit
Gene3Di3.30.428.10, 2 hits
InterProiView protein in InterPro
IPR001937, GalP_UDPtransf1
IPR019779, GalP_UDPtransf1_His-AS
IPR005850, GalP_Utransf_C
IPR005849, GalP_Utransf_N
IPR036265, HIT-like_sf
PANTHERiPTHR11943, PTHR11943, 1 hit
PfamiView protein in Pfam
PF02744, GalP_UDP_tr_C, 1 hit
PF01087, GalP_UDP_transf, 1 hit
PIRSFiPIRSF000808, GalT, 1 hit
SUPFAMiSSF54197, SSF54197, 2 hits
TIGRFAMsiTIGR00209, galT_1, 1 hit
PROSITEiView protein in PROSITE
PS00117, GAL_P_UDP_TRANSF_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AMS3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AMS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: December 2, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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