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UniProtKB - A2AM57 (A2AM57_MOUSE)

Entry version 128 (19 Jan 2022)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
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Protein
Submitted name:

Inversin

Gene

Invs

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
InversinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:InvsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1335082, Invs

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000028344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		339259

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000028344, Expressed in saccule of membranous labyrinth and 272 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2AM57, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A2AM57, 76 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2AM57

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati47 – 79ANKPROSITE-ProRule annotationAdd BLAST33
Repeati80 – 112ANKPROSITE-ProRule annotationAdd BLAST33
Repeati148 – 180ANKPROSITE-ProRule annotationAdd BLAST33
Repeati220 – 240ANKPROSITE-ProRule annotationAdd BLAST21
Repeati254 – 286ANKPROSITE-ProRule annotationAdd BLAST33
Repeati288 – 320ANKPROSITE-ProRule annotationAdd BLAST33
Repeati356 – 388ANKPROSITE-ProRule annotationAdd BLAST33
Repeati389 – 421ANKPROSITE-ProRule annotationAdd BLAST33
Repeati422 – 454ANKPROSITE-ProRule annotationAdd BLAST33
Repeati455 – 487ANKPROSITE-ProRule annotationAdd BLAST33
Repeati488 – 520ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni589 – 849DisorderedSequence analysisAdd BLAST261
Regioni1042 – 1062DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi589 – 614Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi635 – 660Polar residuesSequence analysisAdd BLAST26
Compositional biasi677 – 691Polar residuesSequence analysisAdd BLAST15
Compositional biasi724 – 743Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi776 – 804Basic and acidic residuesSequence analysisAdd BLAST29

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157688

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010082_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		GKVHHPT

Database of Orthologous Groups

More...OrthoDBi		316949at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2AM57

TreeFam database of animal gene trees

More...TreeFami		TF312824

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR000048, IQ_motif_EF-hand-BS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 3 hits
PF12796, Ank_2, 4 hits
PF00612, IQ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 15 hits
SM00015, IQ, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50088, ANK_REPEAT, 11 hits
PS50096, IQ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2AM57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNISEDVLST GSSLASQVHA AAVNGDKGAL QRLIVGNSAL RDKEDRFGRT 
        60         70         80         90        100
PLMYCVLADR VDCADALLKA GADVNKTDHS RRTALHLAAQ KGNYRFMKLL 
       110        120        130        140        150
LTRRANWMQK DLEEMTPLHL STRHRSPKCL ALLLKFMAPG EVDTQDKNKQ 
       160        170        180        190        200
TALHWSAYYN NPEHAKLLIK HDSNIGIPDV EGKIPLHWAA NHKDPSAVHT 
       210        220        230        240        250
VRCILDAAPT ESLLNWQDYE GRTPLHFAVA DGNLTVVDVL TSYESCNITS 
       260        270        280        290        300
YDNLFRTPLH WAALLGHAQI VHLLLERNKS GTIPSDSQGA TPLHYAAQSN 
       310        320        330        340        350
FAETVKVFLQ HPSVKDDSDL EGRTSFMWAA GKGNDDVLRT MLSLKSDIDI 
       360        370        380        390        400
NMSDKYGGTA LHAAALSGHV STVKLLLDND AQVDATDVMK HTPLFRACEM 
       410        420        430        440        450
GHRDVIQTLI KGGARVDLVD QDGHSLLHWA ALGGNADVCQ ILIENKINPN 
       460        470        480        490        500
VQDYAGRTPL QCAAYGGYIN CMAVLMENNA DPNIQDKEGR TALHWSCNNG 
       510        520        530        540        550
YLDAIKLLLD FAAFPNQMEN NEERYTPLDY ALLGERHEVI QFMLEHGALS 
       560        570        580        590        600
IAAIQDIAAF KIQAVYKGYK VRKAFRDRKN LLMKHEQLRK DAAAKKREEE 
       610        620        630        640        650
NKRKEAEQQK GQLDTDPPRS HCSSSAPVLP CPPSPQNEAS KQDATPSKQP 
       660        670        680        690        700
PASHTVQSPD PEHSRPPGRC PGRASQGDSS IDLQGTASRK PSETPIEHCR 
       710        720        730        740        750
GPSACVHPRS WEGGNSSKNQ GTSSVEKRRG ETNGKHRRCE EGPSSARQPL 
       760        770        780        790        800
CTGSGRPAEK GEDSSPAVAS ASQQDHPRKP NKRQDRAARP RGASQKRRTH 
       810        820        830        840        850
QLRDRCSPAG SSRPGSAKGE VACADQSSLH RHTPRSKVTQ DKLIGGVSSG 
       860        870        880        890        900
LPLSTEASRS GCKQLYEDIC ASPETGVAHG PPPGQCMNIH LLPVEQRLLI 
       910        920        930        940        950
IQRERSRKEL FRRKNKAAAV IQRAWRSYQL RKHLSRLLHL KQLGAREVLR 
       960        970        980        990       1000
CTQVCTALLL QVWRKELELK FPKSISVSRT SKSPSKGSSA TKYARHSVLR 
      1010       1020       1030       1040       1050
QIYGCSQEGK GHHPIKSSKA PAVLHLSSVN SLQSIHLDNS GRSKKFSYNL 
      1060 
QPSSQSKNKP KL
Length:1,062
Mass (Da):117,127
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC8C6CDAD236AFC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O89019INVS_MOUSE
Inversin
Invs Inv, Nphp2
1,062Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2B7S4R2B7_MOUSE
Inversin
Invs
436Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		NP_034699.3, NM_010569.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000030029; ENSMUSP00000030029; ENSMUSG00000028344

Database of genes from NCBI RefSeq genomes

More...GeneIDi		16348

UCSC genome browser

More...UCSCi		uc008sva.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_034699.3, NM_010569.4

3D structure databases

SMRiA2AM57
ModBaseiSearch...

Protein-protein interaction databases

IntActiA2AM57, 76 interactors

Proteomic databases

ProteomicsDBi339259

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29080, 113 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		16348

Genome annotation databases

EnsembliENSMUST00000030029; ENSMUSP00000030029; ENSMUSG00000028344
GeneIDi16348
UCSCiuc008sva.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27130
MGIiMGI:1335082, Invs
VEuPathDBiHostDB:ENSMUSG00000028344

Phylogenomic databases

GeneTreeiENSGT00940000157688
HOGENOMiCLU_010082_0_0_1
OMAiGKVHHPT
OrthoDBi316949at2759
PhylomeDBiA2AM57
TreeFamiTF312824

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		16348, 0 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Invs, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000028344, Expressed in saccule of membranous labyrinth and 272 other tissues
ExpressionAtlasiA2AM57, baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 4 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR000048, IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF00023, Ank, 3 hits
PF12796, Ank_2, 4 hits
PF00612, IQ, 2 hits
SMARTiView protein in SMART
SM00248, ANK, 15 hits
SM00015, IQ, 2 hits
SUPFAMiSSF48403, SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 11 hits
PS50096, IQ, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AM57_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AM57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: January 19, 2022
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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