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UniProtKB - A2AM57 (A2AM57_MOUSE)
Protein
Submitted name:
Inversin
Gene
Invs
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: InversinImported |
Gene namesi | Name:InvsImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1335082, Invs |
VEuPathDBi | HostDB:ENSMUSG00000028344 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028344, Expressed in saccule of membranous labyrinth and 272 other tissues |
ExpressionAtlasi | A2AM57, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 47 – 79 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 80 – 112 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 148 – 180 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 220 – 240 | ANKPROSITE-ProRule annotationAdd BLAST | 21 | |
Repeati | 254 – 286 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 288 – 320 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 356 – 388 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 389 – 421 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 422 – 454 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 455 – 487 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 488 – 520 | ANKPROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 589 – 849 | DisorderedSequence analysisAdd BLAST | 261 | |
Regioni | 1042 – 1062 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 589 – 614 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 635 – 660 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 677 – 691 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 724 – 743 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 776 – 804 | Basic and acidic residuesSequence analysisAdd BLAST | 29 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotation, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157688 |
HOGENOMi | CLU_010082_0_0_1 |
OMAi | GKVHHPT |
OrthoDBi | 316949at2759 |
PhylomeDBi | A2AM57 |
TreeFami | TF312824 |
Family and domain databases
Gene3Di | 1.25.40.20, 4 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR000048, IQ_motif_EF-hand-BS |
Pfami | View protein in Pfam PF00023, Ank, 3 hits PF12796, Ank_2, 4 hits PF00612, IQ, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 15 hits SM00015, IQ, 2 hits |
SUPFAMi | SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 11 hits PS50096, IQ, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A2AM57-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNISEDVLST GSSLASQVHA AAVNGDKGAL QRLIVGNSAL RDKEDRFGRT
60 70 80 90 100
PLMYCVLADR VDCADALLKA GADVNKTDHS RRTALHLAAQ KGNYRFMKLL
110 120 130 140 150
LTRRANWMQK DLEEMTPLHL STRHRSPKCL ALLLKFMAPG EVDTQDKNKQ
160 170 180 190 200
TALHWSAYYN NPEHAKLLIK HDSNIGIPDV EGKIPLHWAA NHKDPSAVHT
210 220 230 240 250
VRCILDAAPT ESLLNWQDYE GRTPLHFAVA DGNLTVVDVL TSYESCNITS
260 270 280 290 300
YDNLFRTPLH WAALLGHAQI VHLLLERNKS GTIPSDSQGA TPLHYAAQSN
310 320 330 340 350
FAETVKVFLQ HPSVKDDSDL EGRTSFMWAA GKGNDDVLRT MLSLKSDIDI
360 370 380 390 400
NMSDKYGGTA LHAAALSGHV STVKLLLDND AQVDATDVMK HTPLFRACEM
410 420 430 440 450
GHRDVIQTLI KGGARVDLVD QDGHSLLHWA ALGGNADVCQ ILIENKINPN
460 470 480 490 500
VQDYAGRTPL QCAAYGGYIN CMAVLMENNA DPNIQDKEGR TALHWSCNNG
510 520 530 540 550
YLDAIKLLLD FAAFPNQMEN NEERYTPLDY ALLGERHEVI QFMLEHGALS
560 570 580 590 600
IAAIQDIAAF KIQAVYKGYK VRKAFRDRKN LLMKHEQLRK DAAAKKREEE
610 620 630 640 650
NKRKEAEQQK GQLDTDPPRS HCSSSAPVLP CPPSPQNEAS KQDATPSKQP
660 670 680 690 700
PASHTVQSPD PEHSRPPGRC PGRASQGDSS IDLQGTASRK PSETPIEHCR
710 720 730 740 750
GPSACVHPRS WEGGNSSKNQ GTSSVEKRRG ETNGKHRRCE EGPSSARQPL
760 770 780 790 800
CTGSGRPAEK GEDSSPAVAS ASQQDHPRKP NKRQDRAARP RGASQKRRTH
810 820 830 840 850
QLRDRCSPAG SSRPGSAKGE VACADQSSLH RHTPRSKVTQ DKLIGGVSSG
860 870 880 890 900
LPLSTEASRS GCKQLYEDIC ASPETGVAHG PPPGQCMNIH LLPVEQRLLI
910 920 930 940 950
IQRERSRKEL FRRKNKAAAV IQRAWRSYQL RKHLSRLLHL KQLGAREVLR
960 970 980 990 1000
CTQVCTALLL QVWRKELELK FPKSISVSRT SKSPSKGSSA TKYARHSVLR
1010 1020 1030 1040 1050
QIYGCSQEGK GHHPIKSSKA PAVLHLSSVN SLQSIHLDNS GRSKKFSYNL
1060
QPSSQSKNKP KL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO89019 | INVS_MOUSE | Inversin | Invs Inv, Nphp2 | 1,062 | Annotation score: | ||
S4R2B7 | S4R2B7_MOUSE | Inversin | Invs | 436 | Annotation score: |
Sequence databases
RefSeqi | NP_034699.3, NM_010569.4 |
Genome annotation databases
Ensembli | ENSMUST00000030029; ENSMUSP00000030029; ENSMUSG00000028344 |
GeneIDi | 16348 |
UCSCi | uc008sva.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_034699.3, NM_010569.4 |
3D structure databases
SMRi | A2AM57 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A2AM57, 76 interactors |
Proteomic databases
ProteomicsDBi | 339259 |
Protocols and materials databases
Antibodypediai | 29080, 113 antibodies from 19 providers |
DNASUi | 16348 |
Genome annotation databases
Ensembli | ENSMUST00000030029; ENSMUSP00000030029; ENSMUSG00000028344 |
GeneIDi | 16348 |
UCSCi | uc008sva.2, mouse |
Organism-specific databases
CTDi | 27130 |
MGIi | MGI:1335082, Invs |
VEuPathDBi | HostDB:ENSMUSG00000028344 |
Phylogenomic databases
GeneTreei | ENSGT00940000157688 |
HOGENOMi | CLU_010082_0_0_1 |
OMAi | GKVHHPT |
OrthoDBi | 316949at2759 |
PhylomeDBi | A2AM57 |
TreeFami | TF312824 |
Miscellaneous databases
BioGRID-ORCSi | 16348, 0 hits in 63 CRISPR screens |
ChiTaRSi | Invs, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028344, Expressed in saccule of membranous labyrinth and 272 other tissues |
ExpressionAtlasi | A2AM57, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.20, 4 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR000048, IQ_motif_EF-hand-BS |
Pfami | View protein in Pfam PF00023, Ank, 3 hits PF12796, Ank_2, 4 hits PF00612, IQ, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 15 hits SM00015, IQ, 2 hits |
SUPFAMi | SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 11 hits PS50096, IQ, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A2AM57_MOUSE | |
Accessioni | A2AM57Primary (citable) accession number: A2AM57 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | January 19, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |