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Protein

Protein shortage in chiasmata 1 ortholog

Gene

Shoc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity).By similarity1 Publication

Caution

Although related to the XPF family, the nuclease active site is not conserved.1 Publication

GO - Molecular functioni

GO - Biological processi

  • resolution of meiotic recombination intermediates Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, Hydrolase
Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shortage in chiasmata 1 orthologCurated (EC:3.6.-.-By similarity)
Gene namesi
Name:Shoc11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140313 AI481877

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality due to defects in meiosis (PubMed:29742103). The use of a hypomorphic allele showed that spermatogenesis progresses normally until the end of prophase I when spermatocytes arrest at metaphase I: homologous chromosomes pair in spermatocytes but show defective synapsis (PubMed:29742103).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004448811 – 1481Protein shortage in chiasmata 1 orthologAdd BLAST1481

Proteomic databases

MaxQBiA2ALV5
PaxDbiA2ALV5
PRIDEiA2ALV5

PTM databases

iPTMnetiA2ALV5
PhosphoSitePlusiA2ALV5

Expressioni

Tissue specificityi

Mainly expressed in adult testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000038598 Expressed in 11 organ(s), highest expression level in testis

Interactioni

Subunit structurei

Interacts with TEX11.By similarity

Structurei

3D structure databases

SMRiA2ALV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XPF family. Highly divergent.Curated

Phylogenomic databases

eggNOGiENOG410IHV8 Eukaryota
ENOG41122IN LUCA
GeneTreeiENSGT00390000013037
HOGENOMiHOG000230895
HOVERGENiHBG059265
InParanoidiA2ALV5
OMAiQIADHNL
OrthoDBiEOG091G00S3
TreeFamiTF338326

Family and domain databases

InterProiView protein in InterPro
IPR039991 SHOC1
PANTHERiPTHR35668 PTHR35668, 1 hit

Sequencei

Sequence statusi: Complete.

A2ALV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALNGRTMFP AFKYYAIDYL QEDIIKERLY RDALLLQIPS CLNQDKNIID
60 70 80 90 100
DKYRTPWTRA IPVQEMEDNS VLEQWRTRFC VEGVPEKKTV TGVMINGTFE
110 120 130 140 150
EIVPSSNPNS PPGIENDKLF PSKDYVDDFI PVKCSLYYPG VKAEHQGLLI
160 170 180 190 200
DEEMIFMNKA MDNHLPTVNG LLSRLKLYLV KDPFLDFKEE LSGKDNFTEY
210 220 230 240 250
FSVQECSEPF VRDFHMAEET FCKKKLPSVF PSGFKSLIST NPKQEILILP
260 270 280 290 300
PSKLKKPLNS IPKIMDSVDE SECFKGDITS KHEFDTEDIK CNSTENLTFA
310 320 330 340 350
SLCEPECSEP GDLEMPPTHL ILPRQHSAVS SLHMGFQTFP FSATCKINLL
360 370 380 390 400
SAGESANKYC MLWQLGGCRN SWVSFLLTVP RFQEPSSQYS LADMRNIFSV
410 420 430 440 450
KGDSLVINPA KAKGWRQARL HPIMAETLAH LKAYLCHNGL SSQETKLEIF
460 470 480 490 500
LPTKVFQLES WLELKSRPLP IVPISEKSTD VHQLHPQKRP IPSSEKEVPH
510 520 530 540 550
LCLSGESISV KKSKVEANPK NDQEPEARIM QKPENSCVGL GCSSQVPSAE
560 570 580 590 600
SASSSQIQAS YDKKQDDLDL LSEFIILRSK HQTFPSEADV DVKSHDHDQN
610 620 630 640 650
NEFQDKEKYS LTLQEESLVA SNSKAPEERC EERTDGVIEI PASDTQCQAY
660 670 680 690 700
CLLEATANPI LKELVCLCTY PAANWKFATV NFDQTRFFLK EQEKKINDAT
710 720 730 740 750
HPDKNDDRKM TFRHAALLHL LITIRDVLLT CNLDTALGYL SNAKDIYKSV
760 770 780 790 800
LDSRLDNIWR QLKILQFIKE KRPKSNYKIQ ELQCQILSRL QNQQQMKVLI
810 820 830 840 850
IIRMDSDGEK HLLIKTLKKI EGLTMTVLRS NDRKKILETT SILKGTNACV
860 870 880 890 900
VVHNHSIGAD FPWSSFSLVV EYNHVGHSCW AEHCQLLDIP FLAFKVAVPD
910 920 930 940 950
TALQRDALLD GFGGFLLKIP IPYVFFASEG LLNTPEILRL LESNYNITLV
960 970 980 990 1000
ERCCCGSLKL FGSTECYVVV TVDEHTAIVV QDLEELHHEK ASDNIIMRLM
1010 1020 1030 1040 1050
ALSFQYSCCW IILYSKETLN SQYHLTEETL RHLAQVYAAL VSSGLKSEEL
1060 1070 1080 1090 1100
DVKLIIAPGV EETALIIRQI ADHNLMTSTR DPHEWLDKSW VEVSPSKEEM
1110 1120 1130 1140 1150
SLLDFPCINP LVAQLMLHRA PSLHWLLIAT PAELQELLPQ VPGKVLKHFC
1160 1170 1180 1190 1200
SITSLFKISS PSMTKSSQIS SLQEDMNQTD LFISQSSAPI IQEQEEYYPY
1210 1220 1230 1240 1250
EDSEGTSSSP VELRATPCML PSAAPHSQRG CWEDPSCGPD PVQNNPSLMN
1260 1270 1280 1290 1300
AESKKVTWPS VPSWSDSESD VFSLARTQVS CEPIMTLTDS QRRGTNGFVN
1310 1320 1330 1340 1350
CPEAKGPRNM QVSTPVFLPE NSQSHLHWDF KKNSCRKQIY SFNPSCGTEQ
1360 1370 1380 1390 1400
TTYNKWYSWK DDFSSNQPEC LWDEMEDVTY RNANAGTRET FWRELPAVPS
1410 1420 1430 1440 1450
WDSPCASDSN ANQRGFKGLD FCQRAGNYLG QRSLPVSSSN WGDYKTPTDL
1460 1470 1480
MYSQVPQPKK RRLMYEKVPG RVDGQTRLKF L
Length:1,481
Mass (Da):168,065
Last modified:February 20, 2007 - v1
Checksum:i00C1AFDA987A7AD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805972 Genomic DNA No translation available.
AL808112 Genomic DNA No translation available.
BX001048 Genomic DNA No translation available.
RefSeqiXP_017175979.1, XM_017320490.1
UniGeneiMm.331636

Genome annotation databases

EnsembliENSMUST00000107547; ENSMUSP00000103171; ENSMUSG00000038598
GeneIDi100155
KEGGimmu:100155

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805972 Genomic DNA No translation available.
AL808112 Genomic DNA No translation available.
BX001048 Genomic DNA No translation available.
RefSeqiXP_017175979.1, XM_017320490.1
UniGeneiMm.331636

3D structure databases

SMRiA2ALV5
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA2ALV5
PhosphoSitePlusiA2ALV5

Proteomic databases

MaxQBiA2ALV5
PaxDbiA2ALV5
PRIDEiA2ALV5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107547; ENSMUSP00000103171; ENSMUSG00000038598
GeneIDi100155
KEGGimmu:100155

Organism-specific databases

MGIiMGI:2140313 AI481877

Phylogenomic databases

eggNOGiENOG410IHV8 Eukaryota
ENOG41122IN LUCA
GeneTreeiENSGT00390000013037
HOGENOMiHOG000230895
HOVERGENiHBG059265
InParanoidiA2ALV5
OMAiQIADHNL
OrthoDBiEOG091G00S3
TreeFamiTF338326

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038598 Expressed in 11 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR039991 SHOC1
PANTHERiPTHR35668 PTHR35668, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHOC1_MOUSE
AccessioniPrimary (citable) accession number: A2ALV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 18, 2018
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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