Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein shortage in chiasmata 1 ortholog

Gene

Shoc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity).By similarity1 Publication

Caution

Although related to the XPF family, the nuclease active site is not conserved.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • resolution of meiotic recombination intermediates Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Hydrolase
Biological processMeiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein shortage in chiasmata 1 orthologCurated (EC:3.6.-.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shoc11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2140313 AI481877

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality due to defects in meiosis (PubMed:29742103). The use of a hypomorphic allele showed that spermatogenesis progresses normally until the end of prophase I when spermatocytes arrest at metaphase I: homologous chromosomes pair in spermatocytes but show defective synapsis (PubMed:29742103).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004448811 – 1481Protein shortage in chiasmata 1 orthologAdd BLAST1481

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2ALV5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2ALV5

PRoteomics IDEntifications database

More...
PRIDEi
A2ALV5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2ALV5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2ALV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in adult testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038598 Expressed in 11 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TEX11.By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2ALV5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPF family. Highly divergent.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHV8 Eukaryota
ENOG41122IN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013037

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230895

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059265

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2ALV5

Identification of Orthologs from Complete Genome Data

More...
OMAi
QIADHNL

Database of Orthologous Groups

More...
OrthoDBi
60413at2759

TreeFam database of animal gene trees

More...
TreeFami
TF338326

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039991 SHOC1

The PANTHER Classification System

More...
PANTHERi
PTHR35668 PTHR35668, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2ALV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALNGRTMFP AFKYYAIDYL QEDIIKERLY RDALLLQIPS CLNQDKNIID
60 70 80 90 100
DKYRTPWTRA IPVQEMEDNS VLEQWRTRFC VEGVPEKKTV TGVMINGTFE
110 120 130 140 150
EIVPSSNPNS PPGIENDKLF PSKDYVDDFI PVKCSLYYPG VKAEHQGLLI
160 170 180 190 200
DEEMIFMNKA MDNHLPTVNG LLSRLKLYLV KDPFLDFKEE LSGKDNFTEY
210 220 230 240 250
FSVQECSEPF VRDFHMAEET FCKKKLPSVF PSGFKSLIST NPKQEILILP
260 270 280 290 300
PSKLKKPLNS IPKIMDSVDE SECFKGDITS KHEFDTEDIK CNSTENLTFA
310 320 330 340 350
SLCEPECSEP GDLEMPPTHL ILPRQHSAVS SLHMGFQTFP FSATCKINLL
360 370 380 390 400
SAGESANKYC MLWQLGGCRN SWVSFLLTVP RFQEPSSQYS LADMRNIFSV
410 420 430 440 450
KGDSLVINPA KAKGWRQARL HPIMAETLAH LKAYLCHNGL SSQETKLEIF
460 470 480 490 500
LPTKVFQLES WLELKSRPLP IVPISEKSTD VHQLHPQKRP IPSSEKEVPH
510 520 530 540 550
LCLSGESISV KKSKVEANPK NDQEPEARIM QKPENSCVGL GCSSQVPSAE
560 570 580 590 600
SASSSQIQAS YDKKQDDLDL LSEFIILRSK HQTFPSEADV DVKSHDHDQN
610 620 630 640 650
NEFQDKEKYS LTLQEESLVA SNSKAPEERC EERTDGVIEI PASDTQCQAY
660 670 680 690 700
CLLEATANPI LKELVCLCTY PAANWKFATV NFDQTRFFLK EQEKKINDAT
710 720 730 740 750
HPDKNDDRKM TFRHAALLHL LITIRDVLLT CNLDTALGYL SNAKDIYKSV
760 770 780 790 800
LDSRLDNIWR QLKILQFIKE KRPKSNYKIQ ELQCQILSRL QNQQQMKVLI
810 820 830 840 850
IIRMDSDGEK HLLIKTLKKI EGLTMTVLRS NDRKKILETT SILKGTNACV
860 870 880 890 900
VVHNHSIGAD FPWSSFSLVV EYNHVGHSCW AEHCQLLDIP FLAFKVAVPD
910 920 930 940 950
TALQRDALLD GFGGFLLKIP IPYVFFASEG LLNTPEILRL LESNYNITLV
960 970 980 990 1000
ERCCCGSLKL FGSTECYVVV TVDEHTAIVV QDLEELHHEK ASDNIIMRLM
1010 1020 1030 1040 1050
ALSFQYSCCW IILYSKETLN SQYHLTEETL RHLAQVYAAL VSSGLKSEEL
1060 1070 1080 1090 1100
DVKLIIAPGV EETALIIRQI ADHNLMTSTR DPHEWLDKSW VEVSPSKEEM
1110 1120 1130 1140 1150
SLLDFPCINP LVAQLMLHRA PSLHWLLIAT PAELQELLPQ VPGKVLKHFC
1160 1170 1180 1190 1200
SITSLFKISS PSMTKSSQIS SLQEDMNQTD LFISQSSAPI IQEQEEYYPY
1210 1220 1230 1240 1250
EDSEGTSSSP VELRATPCML PSAAPHSQRG CWEDPSCGPD PVQNNPSLMN
1260 1270 1280 1290 1300
AESKKVTWPS VPSWSDSESD VFSLARTQVS CEPIMTLTDS QRRGTNGFVN
1310 1320 1330 1340 1350
CPEAKGPRNM QVSTPVFLPE NSQSHLHWDF KKNSCRKQIY SFNPSCGTEQ
1360 1370 1380 1390 1400
TTYNKWYSWK DDFSSNQPEC LWDEMEDVTY RNANAGTRET FWRELPAVPS
1410 1420 1430 1440 1450
WDSPCASDSN ANQRGFKGLD FCQRAGNYLG QRSLPVSSSN WGDYKTPTDL
1460 1470 1480
MYSQVPQPKK RRLMYEKVPG RVDGQTRLKF L
Length:1,481
Mass (Da):168,065
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00C1AFDA987A7AD2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL805972 Genomic DNA No translation available.
AL808112 Genomic DNA No translation available.
BX001048 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_017175979.1, XM_017320490.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.331636

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000107547; ENSMUSP00000103171; ENSMUSG00000038598

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100155

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805972 Genomic DNA No translation available.
AL808112 Genomic DNA No translation available.
BX001048 Genomic DNA No translation available.
RefSeqiXP_017175979.1, XM_017320490.1
UniGeneiMm.331636

3D structure databases

SMRiA2ALV5
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA2ALV5
PhosphoSitePlusiA2ALV5

Proteomic databases

MaxQBiA2ALV5
PaxDbiA2ALV5
PRIDEiA2ALV5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107547; ENSMUSP00000103171; ENSMUSG00000038598
GeneIDi100155
KEGGimmu:100155

Organism-specific databases

MGIiMGI:2140313 AI481877

Phylogenomic databases

eggNOGiENOG410IHV8 Eukaryota
ENOG41122IN LUCA
GeneTreeiENSGT00390000013037
HOGENOMiHOG000230895
HOVERGENiHBG059265
InParanoidiA2ALV5
OMAiQIADHNL
OrthoDBi60413at2759
TreeFamiTF338326

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038598 Expressed in 11 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR039991 SHOC1
PANTHERiPTHR35668 PTHR35668, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHOC1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ALV5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 18, 2018
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again