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UniProtKB - A2ALU4 (SHRM2_MOUSE)

Entry version 106 (25 May 2022)
Sequence version 1 (20 Feb 2007)
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Protein

Protein Shroom2

Gene

Shroom2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Shroom2
Alternative name(s):
Protein Apxl
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shroom2
Synonyms:Apxl
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107194, Shroom2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000045180

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860631 – 1481Protein Shroom2Add BLAST1481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei236PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1
Modified residuei959PhosphoserineCombined sources1
Modified residuei960PhosphoserineCombined sources1
Modified residuei962PhosphoserineCombined sources1
Modified residuei963PhosphothreonineCombined sources1
Modified residuei1041PhosphoserineBy similarity1
Modified residuei1043PhosphoserineBy similarity1
Modified residuei1165PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		A2ALU4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2ALU4

PeptideAtlas

More...PeptideAtlasi		A2ALU4

PRoteomics IDEntifications database

More...PRIDEi		A2ALU4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		257162 [A2ALU4-1]
257163 [A2ALU4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A2ALU4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2ALU4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in kidney tubules and in the vasculature of many tissues (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present in the vasculature and in multiple epithelial populations at 10.5 dpc. Present in the cell junctions of the retinal pigmented epithelium at 15.5 dpc (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000045180, Expressed in central nervous system and 253 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2ALU4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A2ALU4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		225549, 8 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000098701

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A2ALU4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		A2ALU4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2ALU4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 108PDZPROSITE-ProRule annotationAdd BLAST83
Domaini705 – 807ASD1PROSITE-ProRule annotationAdd BLAST103
Domaini1185 – 1476ASD2PROSITE-ProRule annotationAdd BLAST292

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni189 – 234DisorderedSequence analysisAdd BLAST46
Regioni250 – 299DisorderedSequence analysisAdd BLAST50
Regioni430 – 501DisorderedSequence analysisAdd BLAST72
Regioni612 – 643DisorderedSequence analysisAdd BLAST32
Regioni717 – 760DisorderedSequence analysisAdd BLAST44
Regioni944 – 983DisorderedSequence analysisAdd BLAST40
Regioni997 – 1051DisorderedSequence analysisAdd BLAST55
Regioni1086 – 1112DisorderedSequence analysisAdd BLAST27
Regioni1139 – 1182DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi189 – 203Polar residuesSequence analysisAdd BLAST15
Compositional biasi213 – 234Polar residuesSequence analysisAdd BLAST22
Compositional biasi251 – 267Polar residuesSequence analysisAdd BLAST17
Compositional biasi430 – 445Polar residuesSequence analysisAdd BLAST16
Compositional biasi737 – 753Polar residuesSequence analysisAdd BLAST17
Compositional biasi953 – 970Polar residuesSequence analysisAdd BLAST18
Compositional biasi997 – 1048Polar residuesSequence analysisAdd BLAST52
Compositional biasi1147 – 1162Pro residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ASD1 domain mediates F-actin binding.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shroom family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUU2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155212

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003220_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2ALU4

Database of Orthologous Groups

More...OrthoDBi		29607at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR027686, Shroom2
IPR027685, Shroom_fam

The PANTHER Classification System

More...PANTHERi		PTHR15012, PTHR15012, 2 hits
PTHR15012:SF8, PTHR15012:SF8, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A2ALU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGAEPRARP ERLAEAEAPA TDGVRLVEVQ LSGGAPWGFT LKGGREHGEP 
        60         70         80         90        100
LVITKIEEGS KAAAVDKLLA GDEIVAINDV SLSGFRQEAI CLVKGSHKTL 
       110        120        130        140        150
KLVVKRKSDP SWRPHSWHAT KYFDVHPEPA ASLFLNTSGS PSWKSQHQAS 
       160        170        180        190        200
SSSHDLSGSW EHTSLQRTSD HFSSMGSIDS LDHSSQLYPS GHLSSAKSNS 
       210        220        230        240        250
SIDHLGGHSK RDSAYGSFST CSSTPDHTLP KADASSTENI LYKVGLWEAS 
       260        270        280        290        300
RPGSSRQSQS TGDPQGLQDR PSCFIPRVPG NSSKSPRPED NVEPKIATHG 
       310        320        330        340        350
RSNFGPVWYV PDKKKAPSPP PLGLPLRSDS FSVAARGHEK ARGPPFSDLA 
       360        370        380        390        400
SMQHFITLPH VQPRGDHRME TTDRQWKLTH LSSGKEIGNV GYQSEGHLDC 
       410        420        430        440        450
RWLCSDDRAG RPSGPPGRLQ FSDVHFLKSY HGSQHQQQCS DESPRAPSSP 
       460        470        480        490        500
RELLHITPGG GLQEPPEPSQ DDNPTQVRWP GSAHQKLDDR GRSHYFPGSL 
       510        520        530        540        550
RQPVQGSAQV VIPRGDYWHS DTTPVDLEYP LLRPVGQRTY LQQHEETPAS 
       560        570        580        590        600
HEKEGYHQLN AGIEGCCSGI QEPPRASRTV RTGLQCPSND FKLVDGESGR 
       610        620        630        640        650
ISRQRTPMLH SLTQDGTWRP GNSKDCGNDK PPLFDAQVGK PTRRSDRFAT 
       660        670        680        690        700
TLRNEIQMRR AKLQKSKSTV TLAGDSEAED CAGDWRADVG AVPEGSFPST 
       710        720        730        740        750
YKEHLKEAQT RVLKATSFQR RDLDPTPADQ YSGPSEHRTF DHSASSSLSS 
       760        770        780        790        800
FPGEPDSAPR FCETGLAKAP SSGVGVPHVL RIGGRKRFTA EQKLKSYSEP 
       810        820        830        840        850
EKINEVGLSG DHRPHPTVRT PEDTVGTFAD RWKFFEETSK SLLQKAGHRQ 
       860        870        880        890        900
VHCGLPREKA ERPQTGHHEC ESTEPWFQKR SLATSCGEIL SDRKVEKASE 
       910        920        930        940        950
KLNPPRRLGT FAEYQASWKE QKKPLEARSS GRYHSADDIL DAGLDQQQRP 
       960        970        980        990       1000
QYIHERSRSS PSTDHYSQEV PVEPNRQAED SGDHKEAILC TLQAEEGCSA 
      1010       1020       1030       1040       1050
PSAQPQDSQH VNEDTTFPQP ETQLSSKCQH LQTSAMETSR SPSPQFAPQK 
      1060       1070       1080       1090       1100
LTDKPPLLIH EDNSARIERV MDNNTTVKMV PIKIVHSESQ PEKESRQSLA 
      1110       1120       1130       1140       1150
CPAELPPLPS GLERDQIKTL STSEQCYSRF CVYTRQEVEA PHRARPPEPR 
      1160       1170       1180       1190       1200
PPSTPAPPVR DSCSSPPSLN YGKAKEKTMD DLKSEELARE IVGKDKSLAD 
      1210       1220       1230       1240       1250
ILDPSVKIKT TMDLMEGIFP KDEYLLEEAQ QRRKLLPKVP LPRVTEDKKQ 
      1260       1270       1280       1290       1300
DPGMPGVVSL ATNSTYYSTS APKAELLIKM KDLQEPEEYS AGDLDHDLSV 
      1310       1320       1330       1340       1350
KKQELIDSIS RKLQVLREAR ESLLEDIQAN NALGDEVEAI VKDVCKPNEF 
      1360       1370       1380       1390       1400
DKFRMFIGDL DKVVNLLLSL SGRLARVENA LNNLDDNPSP GDRQSLLEKQ 
      1410       1420       1430       1440       1450
RVLTQQHEDA KELKENLDRR ERIVFDILAT YLSEENLADY EHFVKMKSAL 
      1460       1470       1480 
IIEQRELEDK IHLGEEQLKC LFDSLQPERS K
Length:1,481
Mass (Da):164,703
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C5C96100263E393
GO
Isoform 2 (identifier: A2ALU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1035: Missing.

Show »
Length:446
Mass (Da):50,643
Checksum:iCB52446CCA61912F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7TU71A7TU71_MOUSE
Protein Shroom2
Shroom2
1,487Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABD19518 differs from that shown. Reason: Frameshift.Curated
The sequence BAC26404 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27781 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti274F → S in ABD19518 (PubMed:16141072).Curated1
Sequence conflicti458P → S in ABD19518 (PubMed:16141072).Curated1
Sequence conflicti603R → C in ABD19518 (PubMed:16141072).Curated1
Sequence conflicti1012N → K in BAC27781 (PubMed:16141072).Curated1
Sequence conflicti1100A → S in ABD19518 (PubMed:16141072).Curated1
Sequence conflicti1227E → K in ABD19518 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0249641 – 1035Missing in isoform 2. 1 PublicationAdd BLAST1035

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ358971 mRNA Translation: ABD19518.1 Frameshift.
AK029338 mRNA Translation: BAC26404.1 Different initiation.
AK032256 mRNA Translation: BAC27781.1 Different initiation.
AK049850 mRNA Translation: BAC33957.1
AL805960 Genomic DNA No translation available.
AL807777 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS72455.1 [A2ALU4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001277613.1, NM_001290684.1 [A2ALU4-1]
NP_001277614.1, NM_001290685.1
NP_001277615.1, NM_001290686.1 [A2ALU4-2]
NP_001277616.1, NM_001290687.1 [A2ALU4-2]
NP_766029.2, NM_172441.3
XP_011246074.1, XM_011247772.1
XP_011246075.1, XM_011247773.1
XP_011246076.1, XM_011247774.2 [A2ALU4-2]
XP_011246077.1, XM_011247775.2 [A2ALU4-2]
XP_011246078.1, XM_011247776.2
XP_011246079.1, XM_011247777.2 [A2ALU4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000062317; ENSMUSP00000057500; ENSMUSG00000045180 [A2ALU4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		110380

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:110380

UCSC genome browser

More...UCSCi		uc009uqj.2, mouse [A2ALU4-2]
uc009uqm.2, mouse [A2ALU4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ358971 mRNA Translation: ABD19518.1 Frameshift.
AK029338 mRNA Translation: BAC26404.1 Different initiation.
AK032256 mRNA Translation: BAC27781.1 Different initiation.
AK049850 mRNA Translation: BAC33957.1
AL805960 Genomic DNA No translation available.
AL807777 Genomic DNA No translation available.
CCDSiCCDS72455.1 [A2ALU4-1]
RefSeqiNP_001277613.1, NM_001290684.1 [A2ALU4-1]
NP_001277614.1, NM_001290685.1
NP_001277615.1, NM_001290686.1 [A2ALU4-2]
NP_001277616.1, NM_001290687.1 [A2ALU4-2]
NP_766029.2, NM_172441.3
XP_011246074.1, XM_011247772.1
XP_011246075.1, XM_011247773.1
XP_011246076.1, XM_011247774.2 [A2ALU4-2]
XP_011246077.1, XM_011247775.2 [A2ALU4-2]
XP_011246078.1, XM_011247776.2
XP_011246079.1, XM_011247777.2 [A2ALU4-2]

3D structure databases

AlphaFoldDBiA2ALU4
SMRiA2ALU4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi225549, 8 interactors
STRINGi10090.ENSMUSP00000098701

PTM databases

iPTMnetiA2ALU4
PhosphoSitePlusiA2ALU4

Proteomic databases

MaxQBiA2ALU4
PaxDbiA2ALU4
PeptideAtlasiA2ALU4
PRIDEiA2ALU4
ProteomicsDBi257162 [A2ALU4-1]
257163 [A2ALU4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23655, 175 antibodies from 26 providers

Genome annotation databases

EnsembliENSMUST00000062317; ENSMUSP00000057500; ENSMUSG00000045180 [A2ALU4-1]
GeneIDi110380
KEGGimmu:110380
UCSCiuc009uqj.2, mouse [A2ALU4-2]
uc009uqm.2, mouse [A2ALU4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		357
MGIiMGI:107194, Shroom2
VEuPathDBiHostDB:ENSMUSG00000045180

Phylogenomic databases

eggNOGiENOG502QUU2, Eukaryota
GeneTreeiENSGT00940000155212
HOGENOMiCLU_003220_0_0_1
InParanoidiA2ALU4
OrthoDBi29607at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		110380, 4 hits in 72 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Shroom2, mouse

Protein Ontology

More...PROi		PR:A2ALU4
RNActiA2ALU4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000045180, Expressed in central nervous system and 253 other tissues
ExpressionAtlasiA2ALU4, baseline and differential
GenevisibleiA2ALU4, MM

Family and domain databases

Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR027686, Shroom2
IPR027685, Shroom_fam
PANTHERiPTHR15012, PTHR15012, 2 hits
PTHR15012:SF8, PTHR15012:SF8, 2 hits
PfamiView protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit
PS50106, PDZ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHRM2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ALU4
Secondary accession number(s): Q2EY23
, Q8C7N1, Q8CCR2, Q8CDZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: May 25, 2022
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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