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Protein

Protein Shroom2

Gene

Shroom2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • beta-catenin binding Source: UniProtKB
  • protein domain specific binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Shroom2
Alternative name(s):
Protein Apxl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shroom2
Synonyms:Apxl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107194 Shroom2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860631 – 1481Protein Shroom2Add BLAST1481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei236PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1
Modified residuei959PhosphoserineCombined sources1
Modified residuei960PhosphoserineCombined sources1
Modified residuei962PhosphoserineCombined sources1
Modified residuei963PhosphothreonineCombined sources1
Modified residuei1041PhosphoserineBy similarity1
Modified residuei1043PhosphoserineBy similarity1
Modified residuei1165PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2ALU4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2ALU4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2ALU4

PeptideAtlas

More...
PeptideAtlasi
A2ALU4

PRoteomics IDEntifications database

More...
PRIDEi
A2ALU4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2ALU4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2ALU4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in kidney tubules and in the vasculature of many tissues (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present in the vasculature and in multiple epithelial populations at E10.5. Present in the cell junctions of the retinal pigmented epithelium at E15.5 (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045180 Expressed in 229 organ(s), highest expression level in central nervous system

CleanEx database of gene expression profiles

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CleanExi
MM_SHROOM2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2ALU4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2ALU4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000098701

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A2ALU4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A2ALU4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 108PDZPROSITE-ProRule annotationAdd BLAST83
Domaini705 – 807ASD1PROSITE-ProRule annotationAdd BLAST103
Domaini1185 – 1476ASD2PROSITE-ProRule annotationAdd BLAST292

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ASD1 domain mediates F-actin binding.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shroom family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II86 Eukaryota
ENOG41113GY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155212

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008235

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG096290

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2ALU4

KEGG Orthology (KO)

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KOi
K18625

Database of Orthologous Groups

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OrthoDBi
29607at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014800 ASD1_dom
IPR014799 ASD2_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR027686 Shroom2
IPR027685 Shroom_fam

The PANTHER Classification System

More...
PANTHERi
PTHR15012 PTHR15012, 2 hits
PTHR15012:SF8 PTHR15012:SF8, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF08688 ASD1, 1 hit
PF08687 ASD2, 1 hit
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51306 ASD1, 1 hit
PS51307 ASD2, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A2ALU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGAEPRARP ERLAEAEAPA TDGVRLVEVQ LSGGAPWGFT LKGGREHGEP
60 70 80 90 100
LVITKIEEGS KAAAVDKLLA GDEIVAINDV SLSGFRQEAI CLVKGSHKTL
110 120 130 140 150
KLVVKRKSDP SWRPHSWHAT KYFDVHPEPA ASLFLNTSGS PSWKSQHQAS
160 170 180 190 200
SSSHDLSGSW EHTSLQRTSD HFSSMGSIDS LDHSSQLYPS GHLSSAKSNS
210 220 230 240 250
SIDHLGGHSK RDSAYGSFST CSSTPDHTLP KADASSTENI LYKVGLWEAS
260 270 280 290 300
RPGSSRQSQS TGDPQGLQDR PSCFIPRVPG NSSKSPRPED NVEPKIATHG
310 320 330 340 350
RSNFGPVWYV PDKKKAPSPP PLGLPLRSDS FSVAARGHEK ARGPPFSDLA
360 370 380 390 400
SMQHFITLPH VQPRGDHRME TTDRQWKLTH LSSGKEIGNV GYQSEGHLDC
410 420 430 440 450
RWLCSDDRAG RPSGPPGRLQ FSDVHFLKSY HGSQHQQQCS DESPRAPSSP
460 470 480 490 500
RELLHITPGG GLQEPPEPSQ DDNPTQVRWP GSAHQKLDDR GRSHYFPGSL
510 520 530 540 550
RQPVQGSAQV VIPRGDYWHS DTTPVDLEYP LLRPVGQRTY LQQHEETPAS
560 570 580 590 600
HEKEGYHQLN AGIEGCCSGI QEPPRASRTV RTGLQCPSND FKLVDGESGR
610 620 630 640 650
ISRQRTPMLH SLTQDGTWRP GNSKDCGNDK PPLFDAQVGK PTRRSDRFAT
660 670 680 690 700
TLRNEIQMRR AKLQKSKSTV TLAGDSEAED CAGDWRADVG AVPEGSFPST
710 720 730 740 750
YKEHLKEAQT RVLKATSFQR RDLDPTPADQ YSGPSEHRTF DHSASSSLSS
760 770 780 790 800
FPGEPDSAPR FCETGLAKAP SSGVGVPHVL RIGGRKRFTA EQKLKSYSEP
810 820 830 840 850
EKINEVGLSG DHRPHPTVRT PEDTVGTFAD RWKFFEETSK SLLQKAGHRQ
860 870 880 890 900
VHCGLPREKA ERPQTGHHEC ESTEPWFQKR SLATSCGEIL SDRKVEKASE
910 920 930 940 950
KLNPPRRLGT FAEYQASWKE QKKPLEARSS GRYHSADDIL DAGLDQQQRP
960 970 980 990 1000
QYIHERSRSS PSTDHYSQEV PVEPNRQAED SGDHKEAILC TLQAEEGCSA
1010 1020 1030 1040 1050
PSAQPQDSQH VNEDTTFPQP ETQLSSKCQH LQTSAMETSR SPSPQFAPQK
1060 1070 1080 1090 1100
LTDKPPLLIH EDNSARIERV MDNNTTVKMV PIKIVHSESQ PEKESRQSLA
1110 1120 1130 1140 1150
CPAELPPLPS GLERDQIKTL STSEQCYSRF CVYTRQEVEA PHRARPPEPR
1160 1170 1180 1190 1200
PPSTPAPPVR DSCSSPPSLN YGKAKEKTMD DLKSEELARE IVGKDKSLAD
1210 1220 1230 1240 1250
ILDPSVKIKT TMDLMEGIFP KDEYLLEEAQ QRRKLLPKVP LPRVTEDKKQ
1260 1270 1280 1290 1300
DPGMPGVVSL ATNSTYYSTS APKAELLIKM KDLQEPEEYS AGDLDHDLSV
1310 1320 1330 1340 1350
KKQELIDSIS RKLQVLREAR ESLLEDIQAN NALGDEVEAI VKDVCKPNEF
1360 1370 1380 1390 1400
DKFRMFIGDL DKVVNLLLSL SGRLARVENA LNNLDDNPSP GDRQSLLEKQ
1410 1420 1430 1440 1450
RVLTQQHEDA KELKENLDRR ERIVFDILAT YLSEENLADY EHFVKMKSAL
1460 1470 1480
IIEQRELEDK IHLGEEQLKC LFDSLQPERS K
Length:1,481
Mass (Da):164,703
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C5C96100263E393
GO
Isoform 2 (identifier: A2ALU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1035: Missing.

Show »
Length:446
Mass (Da):50,643
Checksum:iCB52446CCA61912F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7TU71A7TU71_MOUSE
Protein Shroom2
Shroom2
1,487Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABD19518 differs from that shown. Reason: Frameshift at positions 1238, 1244 and 1263.Curated
The sequence BAC26404 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27781 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti274F → S in ABD19518 (PubMed:16141072).Curated1
Sequence conflicti458P → S in ABD19518 (PubMed:16141072).Curated1
Sequence conflicti603R → C in ABD19518 (PubMed:16141072).Curated1
Sequence conflicti1012N → K in BAC27781 (PubMed:16141072).Curated1
Sequence conflicti1100A → S in ABD19518 (PubMed:16141072).Curated1
Sequence conflicti1227E → K in ABD19518 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0249641 – 1035Missing in isoform 2. 1 PublicationAdd BLAST1035

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ358971 mRNA Translation: ABD19518.1 Frameshift.
AK029338 mRNA Translation: BAC26404.1 Different initiation.
AK032256 mRNA Translation: BAC27781.1 Different initiation.
AK049850 mRNA Translation: BAC33957.1
AL805960, AL807777 Genomic DNA Translation: CAM17589.1
AL807777, AL805960 Genomic DNA Translation: CAM22989.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72455.1 [A2ALU4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001277613.1, NM_001290684.1 [A2ALU4-1]
NP_001277614.1, NM_001290685.1
NP_001277615.1, NM_001290686.1 [A2ALU4-2]
NP_001277616.1, NM_001290687.1 [A2ALU4-2]
NP_766029.2, NM_172441.3
XP_011246074.1, XM_011247772.1
XP_011246075.1, XM_011247773.1
XP_011246076.1, XM_011247774.2 [A2ALU4-2]
XP_011246077.1, XM_011247775.2 [A2ALU4-2]
XP_011246078.1, XM_011247776.2
XP_011246079.1, XM_011247777.2 [A2ALU4-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.40796

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000062317; ENSMUSP00000057500; ENSMUSG00000045180 [A2ALU4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
110380

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:110380

UCSC genome browser

More...
UCSCi
uc009uqj.2 mouse [A2ALU4-2]
uc009uqm.2 mouse [A2ALU4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ358971 mRNA Translation: ABD19518.1 Frameshift.
AK029338 mRNA Translation: BAC26404.1 Different initiation.
AK032256 mRNA Translation: BAC27781.1 Different initiation.
AK049850 mRNA Translation: BAC33957.1
AL805960, AL807777 Genomic DNA Translation: CAM17589.1
AL807777, AL805960 Genomic DNA Translation: CAM22989.1
CCDSiCCDS72455.1 [A2ALU4-1]
RefSeqiNP_001277613.1, NM_001290684.1 [A2ALU4-1]
NP_001277614.1, NM_001290685.1
NP_001277615.1, NM_001290686.1 [A2ALU4-2]
NP_001277616.1, NM_001290687.1 [A2ALU4-2]
NP_766029.2, NM_172441.3
XP_011246074.1, XM_011247772.1
XP_011246075.1, XM_011247773.1
XP_011246076.1, XM_011247774.2 [A2ALU4-2]
XP_011246077.1, XM_011247775.2 [A2ALU4-2]
XP_011246078.1, XM_011247776.2
XP_011246079.1, XM_011247777.2 [A2ALU4-2]
UniGeneiMm.40796

3D structure databases

ProteinModelPortaliA2ALU4
SMRiA2ALU4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098701

PTM databases

iPTMnetiA2ALU4
PhosphoSitePlusiA2ALU4

Proteomic databases

jPOSTiA2ALU4
MaxQBiA2ALU4
PaxDbiA2ALU4
PeptideAtlasiA2ALU4
PRIDEiA2ALU4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062317; ENSMUSP00000057500; ENSMUSG00000045180 [A2ALU4-1]
GeneIDi110380
KEGGimmu:110380
UCSCiuc009uqj.2 mouse [A2ALU4-2]
uc009uqm.2 mouse [A2ALU4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
357
MGIiMGI:107194 Shroom2

Phylogenomic databases

eggNOGiENOG410II86 Eukaryota
ENOG41113GY LUCA
GeneTreeiENSGT00940000155212
HOGENOMiHOG000008235
HOVERGENiHBG096290
InParanoidiA2ALU4
KOiK18625
OrthoDBi29607at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2ALU4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045180 Expressed in 229 organ(s), highest expression level in central nervous system
CleanExiMM_SHROOM2
ExpressionAtlasiA2ALU4 baseline and differential
GenevisibleiA2ALU4 MM

Family and domain databases

InterProiView protein in InterPro
IPR014800 ASD1_dom
IPR014799 ASD2_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR027686 Shroom2
IPR027685 Shroom_fam
PANTHERiPTHR15012 PTHR15012, 2 hits
PTHR15012:SF8 PTHR15012:SF8, 2 hits
PfamiView protein in Pfam
PF08688 ASD1, 1 hit
PF08687 ASD2, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51306 ASD1, 1 hit
PS51307 ASD2, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHRM2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ALU4
Secondary accession number(s): Q2EY23
, Q8C7N1, Q8CCR2, Q8CDZ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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