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Protein

Tyrosine-protein phosphatase non-receptor type 3

Gene

Ptpn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act at junctions between the membrane and the cytoskeleton.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei811SubstrateBy similarity1
Active sitei842Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei886SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-MMU-182971 EGFR downregulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 3 (EC:3.1.3.48)
Gene namesi
Name:Ptpn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:105307 Ptpn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003200741 – 913Tyrosine-protein phosphatase non-receptor type 3Add BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei357PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei376PhosphothreonineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei425PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2ALK8
PaxDbiA2ALK8
PeptideAtlasiA2ALK8
PRIDEiA2ALK8

PTM databases

iPTMnetiA2ALK8
PhosphoSitePlusiA2ALK8

Expressioni

Gene expression databases

BgeeiENSMUSG00000038764 Expressed in 233 organ(s), highest expression level in medial dorsal nucleus of thalamus
CleanExiMM_PTPN3
ExpressionAtlasiA2ALK8 baseline and differential
GenevisibleiA2ALK8 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiA2ALK8, 1 interactor
MINTiA2ALK8
STRINGi10090.ENSMUSP00000075063

Structurei

3D structure databases

ProteinModelPortaliA2ALK8
SMRiA2ALK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 312FERMPROSITE-ProRule annotationAdd BLAST284
Domaini510 – 582PDZPROSITE-ProRule annotationAdd BLAST73
Domaini646 – 901Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni842 – 848Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KDUQ Eukaryota
COG5599 LUCA
GeneTreeiENSGT00930000150845
HOGENOMiHOG000007048
HOVERGENiHBG008322
InParanoidiA2ALK8
KOiK18027
OMAiSPADKCI
OrthoDBiEOG091G016K
PhylomeDBiA2ALK8
TreeFamiTF315900

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A2ALK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSRLRALGG RINNTRTSEL PKEKTRSEVI CSIRFLDGLV QTFKVNKQDL
60 70 80 90 100
GQSLLDMAYG HLGVTEKEYF GLQHGDDPVD SPRWLEASKP LRKQLKGGFP
110 120 130 140 150
CTLHFRVRYF IPDPNTLQQE QTRHLYFLQL KMDVCEGRLT CPLNSAVVLA
160 170 180 190 200
SYAVQSHFGD FNSSIHHPGY LADSQFIPDQ NDDFLSKVES LHEQHSGLKQ
210 220 230 240 250
SEAESCYINI ARTLDFYGVE LHGGRDLHNL DLMIGIASAG IAVYRKYICT
260 270 280 290 300
SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS
310 320 330 340 350
CVEHHSFFQA KKLLPQEKNV LSQYWTLGSR NPKKSVNNQY CKKVIGGMVW
360 370 380 390 400
NPVMRRSLSV ERLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA
410 420 430 440 450
NEMTYITETE DVFYTYKGPL SPKDSDSEVS QNHSPHRESL SENNPAQSCL
460 470 480 490 500
TQKSSSSVSP SSNAPGSCSP DGVDQRFLED YHKVTKGGFV EDASQYYCDK
510 520 530 540 550
SDDGDGYLVL IRITPDEEGR FGFNLKGGVD QKMPLVVSRI NPESPADTCM
560 570 580 590 600
PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRKAVR
610 620 630 640 650
SLAEIRSEDE LSQLFPEAMF PACPEGGDSL EGSMELLKKG LESGTVLIQF
660 670 680 690 700
EQLYRKKPGL AVSFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY
710 720 730 740 750
VNMEMPAANL VNKYIATQGP LPNTCAQFWQ VVWDQKLSLV VMLTTLTERG
760 770 780 790 800
RTKCHQYWPD PPDIMDHGIF HIQCQTEDCT IAYVSREMLV TNTETGEEHT
810 820 830 840 850
VTHLQYVAWP DHGVPDDSSD FLEFVKYVRS LRVDGEPALV HCSAGIGRTG
860 870 880 890 900
VLVTMETAMC LIERNLPVYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR
910
VYEEGLVQRL DPS
Length:913
Mass (Da):103,896
Last modified:February 20, 2007 - v1
Checksum:i8D86101FA691142A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ALK9A2ALK9_MOUSE
Tyrosine-protein phosphatase non-re...
Ptpn3
229Annotation score:
A2ALL0A2ALL0_MOUSE
Tyrosine-protein phosphatase non-re...
Ptpn3
57Annotation score:
A2ALL1A2ALL1_MOUSE
Tyrosine-protein phosphatase non-re...
Ptpn3
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805921 Genomic DNA No translation available.
CCDSiCCDS51181.1
RefSeqiNP_035337.2, NM_011207.2
XP_006538161.1, XM_006538098.2
XP_006538162.1, XM_006538099.3
XP_006538163.1, XM_006538100.2
UniGeneiMm.246552

Genome annotation databases

EnsembliENSMUST00000075637; ENSMUSP00000075063; ENSMUSG00000038764
GeneIDi545622
KEGGimmu:545622
UCSCiuc008sya.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805921 Genomic DNA No translation available.
CCDSiCCDS51181.1
RefSeqiNP_035337.2, NM_011207.2
XP_006538161.1, XM_006538098.2
XP_006538162.1, XM_006538099.3
XP_006538163.1, XM_006538100.2
UniGeneiMm.246552

3D structure databases

ProteinModelPortaliA2ALK8
SMRiA2ALK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2ALK8, 1 interactor
MINTiA2ALK8
STRINGi10090.ENSMUSP00000075063

PTM databases

iPTMnetiA2ALK8
PhosphoSitePlusiA2ALK8

Proteomic databases

MaxQBiA2ALK8
PaxDbiA2ALK8
PeptideAtlasiA2ALK8
PRIDEiA2ALK8

Protocols and materials databases

DNASUi545622
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075637; ENSMUSP00000075063; ENSMUSG00000038764
GeneIDi545622
KEGGimmu:545622
UCSCiuc008sya.2 mouse

Organism-specific databases

CTDi5774
MGIiMGI:105307 Ptpn3

Phylogenomic databases

eggNOGiENOG410KDUQ Eukaryota
COG5599 LUCA
GeneTreeiENSGT00930000150845
HOGENOMiHOG000007048
HOVERGENiHBG008322
InParanoidiA2ALK8
KOiK18027
OMAiSPADKCI
OrthoDBiEOG091G016K
PhylomeDBiA2ALK8
TreeFamiTF315900

Enzyme and pathway databases

ReactomeiR-MMU-182971 EGFR downregulation

Miscellaneous databases

PROiPR:A2ALK8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038764 Expressed in 233 organ(s), highest expression level in medial dorsal nucleus of thalamus
CleanExiMM_PTPN3
ExpressionAtlasiA2ALK8 baseline and differential
GenevisibleiA2ALK8 MM

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTN3_MOUSE
AccessioniPrimary (citable) accession number: A2ALK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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