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Protein

Centriolin

Gene

Cntrl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centriolin
Alternative name(s):
Centrosomal protein 1
Centrosomal protein of 110 kDa
Short name:
Cep110
Gene namesi
Name:Cntrl
Synonyms:Cep1, Cep110
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1889576 Cntrl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003236761 – 2334CentriolinAdd BLAST2334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei832PhosphoserineCombined sources1
Modified residuei1478PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2AL36
PaxDbiA2AL36
PeptideAtlasiA2AL36
PRIDEiA2AL36

PTM databases

iPTMnetiA2AL36
PhosphoSitePlusiA2AL36

Expressioni

Tissue specificityi

Highly expressed in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000057110 Expressed in 213 organ(s), highest expression level in bone marrow
CleanExiMM_CEP110
ExpressionAtlasiA2AL36 baseline and differential
GenevisibleiA2AL36 MM

Interactioni

Subunit structurei

Interacts with HOOK2. Interacts with EXOC6 and SNAPIN. Associates with the exocyst complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi205064, 1 interactor
IntActiA2AL36, 4 interactors
STRINGi10090.ENSMUSP00000108660

Structurei

3D structure databases

ProteinModelPortaliA2AL36
SMRiA2AL36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati126 – 147LRR 1Add BLAST22
Repeati148 – 169LRR 2Add BLAST22
Repeati170 – 191LRR 3Add BLAST22
Repeati194 – 215LRR 4Add BLAST22
Domaini228 – 266LRRCTAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1951 – 2121Required for centrosome localizationBy similarityAdd BLAST171
Regioni1988 – 2334Sufficient for interaction with HOOK2By similarityAdd BLAST347

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili265 – 343Sequence analysisAdd BLAST79
Coiled coili437 – 800Sequence analysisAdd BLAST364
Coiled coili858 – 1102Sequence analysisAdd BLAST245
Coiled coili1320 – 2169Sequence analysisAdd BLAST850

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi957 – 960Poly-Lys4
Compositional biasi1239 – 1310Pro-richAdd BLAST72

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJGD Eukaryota
ENOG410ZX4Y LUCA
GeneTreeiENSGT00930000150857
HOVERGENiHBG101203
InParanoidiA2AL36
OrthoDBiEOG091G0066
PhylomeDBiA2AL36
TreeFamiTF101135

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR028640 CEP110
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR44555 PTHR44555, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AL36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKGSERRLS KAKMPLSSHF PGPSSLRSSM RSRSLSPLIG SETQPLHPGG
60 70 80 90 100
QWPAQAELTD ESTVPLEPQQ RKGAESYVGV RYITEALIKK LTKQDNLALV
110 120 130 140 150
KSLNLSLSKD GGKKFRYIEN LEKCVKLEVL NLSYNLIVKI EKVDKLLRLR
160 170 180 190 200
ELNLSYNKIS KIEGLENMCN LQKLNLAGNE IEHIPVWFAK KLKSLRVLNL
210 220 230 240 250
KGNKISSLQD VSKLKPLQDL TSLVLIDNPV VALPHYLQFI IFHLRSLESL
260 270 280 290 300
EGQPVTTQDR QEAFERFSLE EIERLEKDLE KKTVETEELK NKQTKFLEEI
310 320 330 340 350
KNQDKLNKSL KEEAMLQKQS CEELESDLST KKELLKQKTV ELTRACQKQY
360 370 380 390 400
ELEQELAFYK IDAKFEPLNY YPSEYAEIDK YPDESPYIGK SRYKRNMFAT
410 420 430 440 450
ETYIVSDAQA VQIRKMVPEG GQLRHEHTPP RVQAPPDLQL EDTEKKISAA
460 470 480 490 500
QTRLSELHHE IETAEQKVLR ATQEFKQLEE AIQQKKISEA EKDLLLKQLS
510 520 530 540 550
GRLQHLNRLR QEALDLEIQM EKQRKEIAEK HEEINTVQLA TDSLDPKDPK
560 570 580 590 600
HSHMKAQKRG KEQQLDIMNR QYTQLESRLD EILCRIAKET EEIKDLEQQL
610 620 630 640 650
TDGQIAANEA LKKDLEGVIS GLQEYLGTIK GQATQAQNEC RKLQDEKETL
660 670 680 690 700
LQRLTEVQQE KEELELIAMD AENMRKELAE LESALQEQHE VNASLQQAQG
710 720 730 740 750
DLSAYETELE TQLKLKDAET SQLKQELEKL LRRTQLEQSV LQTELEKERE
760 770 780 790 800
SLRDALGKAQ SSEEKQQENN ELRTQLKQLQ DDNSLLKKQL KEFQNHLNHV
810 820 830 840 850
VDGLIHPEEV AARVDELRKR LKLGAGEMRI HSPSDVLGKS LADLQKQFSE
860 870 880 890 900
ILARSQWEKE EAQVRERKLH EEMALQQEKL ANGQEEFRQA CERALEARIK
910 920 930 940 950
FDKRQHNARI QQLENEIHYL QENLKSMEKI QGLTDLQLQE ADEEKERILA
960 970 980 990 1000
QLQELEKKKK REDARSQEQF LGLDEELKSL KKAVAASDKL AAAELTIAKD
1010 1020 1030 1040 1050
QLKSLHGTVV RINQERAEEL QEAERFSREA MQAAKDLSRA EAEIELLQHL
1060 1070 1080 1090 1100
LREREGQFRD EMENADLGAK GANSQLLEIE ALNEAMAKQR AEITRLRDVL
1110 1120 1130 1140 1150
NLTGAGTKGG IENVLEEIAE LRHAVSAQNE YISSMADPFR RQGWWYFMPP
1160 1170 1180 1190 1200
APSSKVSSHS SQATKDSGLG LKYTASTPLR KPQPGQQEEK DSSGPLPASG
1210 1220 1230 1240 1250
YWVYSPIRST LHKSFSKRED ADSGGDSQEE SGLDDQEEPP FVPPPGYIMY
1260 1270 1280 1290 1300
TVLPDGSPVP QGVALYAPSP PLPNSSHPLT PGTVVYGPPP AGAPIIYGPP
1310 1320 1330 1340 1350
PANFAVPLVP AGVQHCNIPE HHNLENEVSR LEDIMQHLKS KQREERRQKA
1360 1370 1380 1390 1400
STQHSEEEVD GLHRDIDDLL QEKKELELEV EELHRTIERH QQRKDFIDGH
1410 1420 1430 1440 1450
VENLMTELEI EKSLKHHEDI VDEIECLEKT LLKRRSELRE ADRLLAEAEN
1460 1470 1480 1490 1500
ELACTKEKTK SAVEKFTDAK RNLLQTESDA EALEKRAQET ALNLVKAEQQ
1510 1520 1530 1540 1550
LRLLQADAED LEQHKIKQEE ILKEINKVVA AKDADFQCLN EKKEKLTEEL
1560 1570 1580 1590 1600
QSLQRDIKAA QHSEDHHLQV LRESETLLQA KRAELETLKS QVTSQQQELA
1610 1620 1630 1640 1650
VLDSELGHRR EELLLLQDSL AQAKADLQEA LTLGETEVAE KCSHIREVKS
1660 1670 1680 1690 1700
LLEELSFQKG ELNVHISEKK TQLALIQQEM EKEEKNLQVV LQQLSRHKTE
1710 1720 1730 1740 1750
LKNVADILQL ETSELQGLKL QHDQKVVELE KAQVDVLEEK LELENLQQAT
1760 1770 1780 1790 1800
QQQRRELERQ RQLLERDRRE TERVRAESQA LQSCVECLSK EKEDLQGQCE
1810 1820 1830 1840 1850
SWEKKSSHAQ RVLAATEESN KMEQSNLGKL ELSVRKLRQE LEQLSQDKLA
1860 1870 1880 1890 1900
LHSEVAEVQQ QLQGKQEAIN SLQEELDSTQ DHLDLAKQDL IHTTKCQNEL
1910 1920 1930 1940 1950
LNEQTQLQED ISKWMARLES CQKETETKEQ QVQQLQDEIR ESKLRLDQQE
1960 1970 1980 1990 2000
MMFQKLQKER EREEQKFEAG KVTLEQQQRQ LEKELTDQKS RLKQLLTDVS
2010 2020 2030 2040 2050
AAEGRLGTLQ EEERRIEGLE RMLSQAKQQL SEREQQLMAK SGELLALQKE
2060 2070 2080 2090 2100
ADDMRADFSL LRNQFLTERK KAEKQVAGLK EALKIQRSQL EKNLLEQKQE
2110 2120 2130 2140 2150
NSCMQKEMAT IELVAQDNHE RARRLMKELS QMQQEYLELK KQVANQKDLE
2160 2170 2180 2190 2200
RRQMEVSDAM RTLKSEVKDE IRTSLRNLNQ FLPELPADLA SILERNENLR
2210 2220 2230 2240 2250
ELESLKENFP FTTKERIFEE KSNFPQVHIM DEHWRGEALR QRLRRHEDQL
2260 2270 2280 2290 2300
KAQLRHCMSK QAEVLIKGKQ QTEGTLHSLR RQVDALGELV TSTSTDSASS
2310 2320 2330
PSLPSLVEDS QHGHSQSSFQ VLQVPLEEPN SYRH
Length:2,334
Mass (Da):268,880
Last modified:March 18, 2008 - v2
Checksum:i43C2CDA65A295857
GO
Isoform 2 (identifier: A2AL36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     552-559: SHMKAQKR → VSKMGNLD
     560-2334: Missing.

Show »
Length:559
Mass (Da):64,469
Checksum:i2579D4875C1CFC46
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GML3R4GML3_MOUSE
Centriolin
Cntrl Cep110
2,333Annotation score:
R4GML4R4GML4_MOUSE
Centriolin
Cntrl Cep110
987Annotation score:
A2AS42A2AS42_MOUSE
Centriolin
Cntrl
481Annotation score:
E9Q9E7E9Q9E7_MOUSE
Centriolin
Cntrl
1,780Annotation score:
F6QP53F6QP53_MOUSE
Centriolin
Cntrl
635Annotation score:
A0A0G2JE96A0A0G2JE96_MOUSE
Centriolin
Cntrl
139Annotation score:
A0A0J9YTY9A0A0J9YTY9_MOUSE
Centriolin
Cntrl
122Annotation score:
A0A0G2JFA2A0A0G2JFA2_MOUSE
Centriolin
Cntrl
71Annotation score:

Sequence cautioni

The sequence CAM17906 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM17908 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8R → K in AAH38386 (PubMed:15489334).Curated1
Sequence conflicti169C → G in BAB32012 (PubMed:16141072).Curated1
Sequence conflicti1219Missing in BAD21389 (PubMed:15449545).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032051552 – 559SHMKAQKR → VSKMGNLD in isoform 2. 2 Publications8
Alternative sequenceiVSP_032052560 – 2334Missing in isoform 2. 2 PublicationsAdd BLAST1775

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020148 mRNA Translation: BAB32012.3
AK031338 mRNA Translation: BAC27353.1
AK041715 mRNA Translation: BAC31039.1
BC038386 mRNA Translation: AAH38386.1
AL773523, AL845534 Genomic DNA Translation: CAM16866.1
AL773523, AL845534 Genomic DNA Translation: CAM16867.1
AL773523, AL845534 Genomic DNA Translation: CAM16870.1
AL845534, AL773523 Genomic DNA Translation: CAM17903.1
AL845534 Genomic DNA Translation: CAM17904.1
AL845534, AL773523 Genomic DNA Translation: CAM17906.1 Sequence problems.
AL845534, AL773523 Genomic DNA Translation: CAM17908.1 Sequence problems.
AK131139 mRNA Translation: BAD21389.1
RefSeqiXP_006498131.1, XM_006498068.2 [A2AL36-1]
UniGeneiMm.231332

Genome annotation databases

EnsembliENSMUST00000028235; ENSMUSP00000028235; ENSMUSG00000057110 [A2AL36-2]
ENSMUST00000028237; ENSMUSP00000028237; ENSMUSG00000057110 [A2AL36-1]
ENSMUST00000156933; ENSMUSP00000118731; ENSMUSG00000057110 [A2AL36-1]
GeneIDi26920
UCSCiuc008jjr.2 mouse [A2AL36-1]
uc008jjs.2 mouse [A2AL36-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020148 mRNA Translation: BAB32012.3
AK031338 mRNA Translation: BAC27353.1
AK041715 mRNA Translation: BAC31039.1
BC038386 mRNA Translation: AAH38386.1
AL773523, AL845534 Genomic DNA Translation: CAM16866.1
AL773523, AL845534 Genomic DNA Translation: CAM16867.1
AL773523, AL845534 Genomic DNA Translation: CAM16870.1
AL845534, AL773523 Genomic DNA Translation: CAM17903.1
AL845534 Genomic DNA Translation: CAM17904.1
AL845534, AL773523 Genomic DNA Translation: CAM17906.1 Sequence problems.
AL845534, AL773523 Genomic DNA Translation: CAM17908.1 Sequence problems.
AK131139 mRNA Translation: BAD21389.1
RefSeqiXP_006498131.1, XM_006498068.2 [A2AL36-1]
UniGeneiMm.231332

3D structure databases

ProteinModelPortaliA2AL36
SMRiA2AL36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205064, 1 interactor
IntActiA2AL36, 4 interactors
STRINGi10090.ENSMUSP00000108660

PTM databases

iPTMnetiA2AL36
PhosphoSitePlusiA2AL36

Proteomic databases

EPDiA2AL36
PaxDbiA2AL36
PeptideAtlasiA2AL36
PRIDEiA2AL36

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028235; ENSMUSP00000028235; ENSMUSG00000057110 [A2AL36-2]
ENSMUST00000028237; ENSMUSP00000028237; ENSMUSG00000057110 [A2AL36-1]
ENSMUST00000156933; ENSMUSP00000118731; ENSMUSG00000057110 [A2AL36-1]
GeneIDi26920
UCSCiuc008jjr.2 mouse [A2AL36-1]
uc008jjs.2 mouse [A2AL36-2]

Organism-specific databases

CTDi11064
MGIiMGI:1889576 Cntrl

Phylogenomic databases

eggNOGiENOG410IJGD Eukaryota
ENOG410ZX4Y LUCA
GeneTreeiENSGT00930000150857
HOVERGENiHBG101203
InParanoidiA2AL36
OrthoDBiEOG091G0066
PhylomeDBiA2AL36
TreeFamiTF101135

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

PROiPR:A2AL36
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057110 Expressed in 213 organ(s), highest expression level in bone marrow
CleanExiMM_CEP110
ExpressionAtlasiA2AL36 baseline and differential
GenevisibleiA2AL36 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR028640 CEP110
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR44555 PTHR44555, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCNTRL_MOUSE
AccessioniPrimary (citable) accession number: A2AL36
Secondary accession number(s): A0A4W6
, A0A4X1, A2AL37, A2AL40, Q6KAR8, Q8CHX3, Q9CRM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 7, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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