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Protein

Centriolin

Gene

Cntrl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytoskeletal protein binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centriolin
Alternative name(s):
Centrosomal protein 1
Centrosomal protein of 110 kDa
Short name:
Cep110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cntrl
Synonyms:Cep1, Cep110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1889576 Cntrl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003236761 – 2334CentriolinAdd BLAST2334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei832PhosphoserineCombined sources1
Modified residuei1478PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AL36

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AL36

PeptideAtlas

More...
PeptideAtlasi
A2AL36

PRoteomics IDEntifications database

More...
PRIDEi
A2AL36

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AL36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AL36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057110 Expressed in 213 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

More...
CleanExi
MM_CEP110

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AL36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AL36 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HOOK2. Interacts with EXOC6 and SNAPIN. Associates with the exocyst complex (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
205064, 1 interactor

Protein interaction database and analysis system

More...
IntActi
A2AL36, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000108660

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AL36

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AL36

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati126 – 147LRR 1Add BLAST22
Repeati148 – 169LRR 2Add BLAST22
Repeati170 – 191LRR 3Add BLAST22
Repeati194 – 215LRR 4Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini228 – 266LRRCTAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1951 – 2121Required for centrosome localizationBy similarityAdd BLAST171
Regioni1988 – 2334Sufficient for interaction with HOOK2By similarityAdd BLAST347

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili265 – 343Sequence analysisAdd BLAST79
Coiled coili437 – 800Sequence analysisAdd BLAST364
Coiled coili858 – 1102Sequence analysisAdd BLAST245
Coiled coili1320 – 2169Sequence analysisAdd BLAST850

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi957 – 960Poly-Lys4
Compositional biasi1239 – 1310Pro-richAdd BLAST72

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJGD Eukaryota
ENOG410ZX4Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155434

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101203

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AL36

Database of Orthologous Groups

More...
OrthoDBi
79816at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AL36

TreeFam database of animal gene trees

More...
TreeFami
TF101135

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028640 CEP110
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR44555 PTHR44555, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AL36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKGSERRLS KAKMPLSSHF PGPSSLRSSM RSRSLSPLIG SETQPLHPGG
60 70 80 90 100
QWPAQAELTD ESTVPLEPQQ RKGAESYVGV RYITEALIKK LTKQDNLALV
110 120 130 140 150
KSLNLSLSKD GGKKFRYIEN LEKCVKLEVL NLSYNLIVKI EKVDKLLRLR
160 170 180 190 200
ELNLSYNKIS KIEGLENMCN LQKLNLAGNE IEHIPVWFAK KLKSLRVLNL
210 220 230 240 250
KGNKISSLQD VSKLKPLQDL TSLVLIDNPV VALPHYLQFI IFHLRSLESL
260 270 280 290 300
EGQPVTTQDR QEAFERFSLE EIERLEKDLE KKTVETEELK NKQTKFLEEI
310 320 330 340 350
KNQDKLNKSL KEEAMLQKQS CEELESDLST KKELLKQKTV ELTRACQKQY
360 370 380 390 400
ELEQELAFYK IDAKFEPLNY YPSEYAEIDK YPDESPYIGK SRYKRNMFAT
410 420 430 440 450
ETYIVSDAQA VQIRKMVPEG GQLRHEHTPP RVQAPPDLQL EDTEKKISAA
460 470 480 490 500
QTRLSELHHE IETAEQKVLR ATQEFKQLEE AIQQKKISEA EKDLLLKQLS
510 520 530 540 550
GRLQHLNRLR QEALDLEIQM EKQRKEIAEK HEEINTVQLA TDSLDPKDPK
560 570 580 590 600
HSHMKAQKRG KEQQLDIMNR QYTQLESRLD EILCRIAKET EEIKDLEQQL
610 620 630 640 650
TDGQIAANEA LKKDLEGVIS GLQEYLGTIK GQATQAQNEC RKLQDEKETL
660 670 680 690 700
LQRLTEVQQE KEELELIAMD AENMRKELAE LESALQEQHE VNASLQQAQG
710 720 730 740 750
DLSAYETELE TQLKLKDAET SQLKQELEKL LRRTQLEQSV LQTELEKERE
760 770 780 790 800
SLRDALGKAQ SSEEKQQENN ELRTQLKQLQ DDNSLLKKQL KEFQNHLNHV
810 820 830 840 850
VDGLIHPEEV AARVDELRKR LKLGAGEMRI HSPSDVLGKS LADLQKQFSE
860 870 880 890 900
ILARSQWEKE EAQVRERKLH EEMALQQEKL ANGQEEFRQA CERALEARIK
910 920 930 940 950
FDKRQHNARI QQLENEIHYL QENLKSMEKI QGLTDLQLQE ADEEKERILA
960 970 980 990 1000
QLQELEKKKK REDARSQEQF LGLDEELKSL KKAVAASDKL AAAELTIAKD
1010 1020 1030 1040 1050
QLKSLHGTVV RINQERAEEL QEAERFSREA MQAAKDLSRA EAEIELLQHL
1060 1070 1080 1090 1100
LREREGQFRD EMENADLGAK GANSQLLEIE ALNEAMAKQR AEITRLRDVL
1110 1120 1130 1140 1150
NLTGAGTKGG IENVLEEIAE LRHAVSAQNE YISSMADPFR RQGWWYFMPP
1160 1170 1180 1190 1200
APSSKVSSHS SQATKDSGLG LKYTASTPLR KPQPGQQEEK DSSGPLPASG
1210 1220 1230 1240 1250
YWVYSPIRST LHKSFSKRED ADSGGDSQEE SGLDDQEEPP FVPPPGYIMY
1260 1270 1280 1290 1300
TVLPDGSPVP QGVALYAPSP PLPNSSHPLT PGTVVYGPPP AGAPIIYGPP
1310 1320 1330 1340 1350
PANFAVPLVP AGVQHCNIPE HHNLENEVSR LEDIMQHLKS KQREERRQKA
1360 1370 1380 1390 1400
STQHSEEEVD GLHRDIDDLL QEKKELELEV EELHRTIERH QQRKDFIDGH
1410 1420 1430 1440 1450
VENLMTELEI EKSLKHHEDI VDEIECLEKT LLKRRSELRE ADRLLAEAEN
1460 1470 1480 1490 1500
ELACTKEKTK SAVEKFTDAK RNLLQTESDA EALEKRAQET ALNLVKAEQQ
1510 1520 1530 1540 1550
LRLLQADAED LEQHKIKQEE ILKEINKVVA AKDADFQCLN EKKEKLTEEL
1560 1570 1580 1590 1600
QSLQRDIKAA QHSEDHHLQV LRESETLLQA KRAELETLKS QVTSQQQELA
1610 1620 1630 1640 1650
VLDSELGHRR EELLLLQDSL AQAKADLQEA LTLGETEVAE KCSHIREVKS
1660 1670 1680 1690 1700
LLEELSFQKG ELNVHISEKK TQLALIQQEM EKEEKNLQVV LQQLSRHKTE
1710 1720 1730 1740 1750
LKNVADILQL ETSELQGLKL QHDQKVVELE KAQVDVLEEK LELENLQQAT
1760 1770 1780 1790 1800
QQQRRELERQ RQLLERDRRE TERVRAESQA LQSCVECLSK EKEDLQGQCE
1810 1820 1830 1840 1850
SWEKKSSHAQ RVLAATEESN KMEQSNLGKL ELSVRKLRQE LEQLSQDKLA
1860 1870 1880 1890 1900
LHSEVAEVQQ QLQGKQEAIN SLQEELDSTQ DHLDLAKQDL IHTTKCQNEL
1910 1920 1930 1940 1950
LNEQTQLQED ISKWMARLES CQKETETKEQ QVQQLQDEIR ESKLRLDQQE
1960 1970 1980 1990 2000
MMFQKLQKER EREEQKFEAG KVTLEQQQRQ LEKELTDQKS RLKQLLTDVS
2010 2020 2030 2040 2050
AAEGRLGTLQ EEERRIEGLE RMLSQAKQQL SEREQQLMAK SGELLALQKE
2060 2070 2080 2090 2100
ADDMRADFSL LRNQFLTERK KAEKQVAGLK EALKIQRSQL EKNLLEQKQE
2110 2120 2130 2140 2150
NSCMQKEMAT IELVAQDNHE RARRLMKELS QMQQEYLELK KQVANQKDLE
2160 2170 2180 2190 2200
RRQMEVSDAM RTLKSEVKDE IRTSLRNLNQ FLPELPADLA SILERNENLR
2210 2220 2230 2240 2250
ELESLKENFP FTTKERIFEE KSNFPQVHIM DEHWRGEALR QRLRRHEDQL
2260 2270 2280 2290 2300
KAQLRHCMSK QAEVLIKGKQ QTEGTLHSLR RQVDALGELV TSTSTDSASS
2310 2320 2330
PSLPSLVEDS QHGHSQSSFQ VLQVPLEEPN SYRH
Length:2,334
Mass (Da):268,880
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43C2CDA65A295857
GO
Isoform 2 (identifier: A2AL36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     552-559: SHMKAQKR → VSKMGNLD
     560-2334: Missing.

Show »
Length:559
Mass (Da):64,469
Checksum:i2579D4875C1CFC46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GML3R4GML3_MOUSE
Centriolin
Cntrl Cep110
2,333Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GML4R4GML4_MOUSE
Centriolin
Cntrl Cep110
987Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AS42A2AS42_MOUSE
Centriolin
Cntrl
481Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9E7E9Q9E7_MOUSE
Centriolin
Cntrl
1,780Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QP53F6QP53_MOUSE
Centriolin
Cntrl
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JE96A0A0G2JE96_MOUSE
Centriolin
Cntrl
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFA2A0A0G2JFA2_MOUSE
Centriolin
Cntrl
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YTY9A0A0J9YTY9_MOUSE
Centriolin
Cntrl
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM17906 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM17908 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8R → K in AAH38386 (PubMed:15489334).Curated1
Sequence conflicti169C → G in BAB32012 (PubMed:16141072).Curated1
Sequence conflicti1219Missing in BAD21389 (PubMed:15449545).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032051552 – 559SHMKAQKR → VSKMGNLD in isoform 2. 2 Publications8
Alternative sequenceiVSP_032052560 – 2334Missing in isoform 2. 2 PublicationsAdd BLAST1775

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK020148 mRNA Translation: BAB32012.3
AK031338 mRNA Translation: BAC27353.1
AK041715 mRNA Translation: BAC31039.1
BC038386 mRNA Translation: AAH38386.1
AL773523, AL845534 Genomic DNA Translation: CAM16866.1
AL773523, AL845534 Genomic DNA Translation: CAM16867.1
AL773523, AL845534 Genomic DNA Translation: CAM16870.1
AL845534, AL773523 Genomic DNA Translation: CAM17903.1
AL845534 Genomic DNA Translation: CAM17904.1
AL845534, AL773523 Genomic DNA Translation: CAM17906.1 Sequence problems.
AL845534, AL773523 Genomic DNA Translation: CAM17908.1 Sequence problems.
AK131139 mRNA Translation: BAD21389.1

NCBI Reference Sequences

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RefSeqi
XP_006498131.1, XM_006498068.2 [A2AL36-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.231332

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000028235; ENSMUSP00000028235; ENSMUSG00000057110 [A2AL36-2]
ENSMUST00000028237; ENSMUSP00000028237; ENSMUSG00000057110 [A2AL36-1]
ENSMUST00000156933; ENSMUSP00000118731; ENSMUSG00000057110 [A2AL36-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26920

UCSC genome browser

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UCSCi
uc008jjr.2 mouse [A2AL36-1]
uc008jjs.2 mouse [A2AL36-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020148 mRNA Translation: BAB32012.3
AK031338 mRNA Translation: BAC27353.1
AK041715 mRNA Translation: BAC31039.1
BC038386 mRNA Translation: AAH38386.1
AL773523, AL845534 Genomic DNA Translation: CAM16866.1
AL773523, AL845534 Genomic DNA Translation: CAM16867.1
AL773523, AL845534 Genomic DNA Translation: CAM16870.1
AL845534, AL773523 Genomic DNA Translation: CAM17903.1
AL845534 Genomic DNA Translation: CAM17904.1
AL845534, AL773523 Genomic DNA Translation: CAM17906.1 Sequence problems.
AL845534, AL773523 Genomic DNA Translation: CAM17908.1 Sequence problems.
AK131139 mRNA Translation: BAD21389.1
RefSeqiXP_006498131.1, XM_006498068.2 [A2AL36-1]
UniGeneiMm.231332

3D structure databases

ProteinModelPortaliA2AL36
SMRiA2AL36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205064, 1 interactor
IntActiA2AL36, 4 interactors
STRINGi10090.ENSMUSP00000108660

PTM databases

iPTMnetiA2AL36
PhosphoSitePlusiA2AL36

Proteomic databases

EPDiA2AL36
PaxDbiA2AL36
PeptideAtlasiA2AL36
PRIDEiA2AL36

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028235; ENSMUSP00000028235; ENSMUSG00000057110 [A2AL36-2]
ENSMUST00000028237; ENSMUSP00000028237; ENSMUSG00000057110 [A2AL36-1]
ENSMUST00000156933; ENSMUSP00000118731; ENSMUSG00000057110 [A2AL36-1]
GeneIDi26920
UCSCiuc008jjr.2 mouse [A2AL36-1]
uc008jjs.2 mouse [A2AL36-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11064
MGIiMGI:1889576 Cntrl

Phylogenomic databases

eggNOGiENOG410IJGD Eukaryota
ENOG410ZX4Y LUCA
GeneTreeiENSGT00940000155434
HOVERGENiHBG101203
InParanoidiA2AL36
OrthoDBi79816at2759
PhylomeDBiA2AL36
TreeFamiTF101135

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

Protein Ontology

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PROi
PR:A2AL36

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057110 Expressed in 213 organ(s), highest expression level in bone marrow
CleanExiMM_CEP110
ExpressionAtlasiA2AL36 baseline and differential
GenevisibleiA2AL36 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR028640 CEP110
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR44555 PTHR44555, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTRL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AL36
Secondary accession number(s): A0A4W6
, A0A4X1, A2AL37, A2AL40, Q6KAR8, Q8CHX3, Q9CRM3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: January 16, 2019
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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