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Entry version 97 (08 May 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Probable helicase senataxin

Gene

Setx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (By similarity). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (PubMed:22767893). Involved in DNA double-strand breaks damage response generated by oxidative stress. In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (By similarity). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (PubMed:23593030). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis. May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1939 – 1946ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
Biological processBiological rhythms, Differentiation, DNA damage, DNA recombination, DNA repair, Neurogenesis, Spermatogenesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable helicase senataxinCurated (EC:3.6.4.-)
Alternative name(s):
Amyotrophic lateral sclerosis 4 protein homolog
SEN1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SetxImported
Synonyms:Als4, Kiaa0625
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443480 Setx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Chromosome, Cytoplasm, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable. Male germ cells proceed normally from spermatogonia up to the meiotic pachytene stage but fail to enter into spermiogenesis and form mature spermatids (PubMed:23593030), resulting in male infertility. In particular, during spermatogenesis, male germ cells accumulated DNA:RNA hybrids (R-loops), meiotic DNA double-strand breaks, and fails to produce crossovers and meiotic sex chromosome inactivation (MSCI) (PubMed:23593030).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003077771 – 2646Probable helicase senataxinAdd BLAST2646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei640PhosphoserineBy similarity1
Modified residuei870PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei872PhosphoserineCombined sources1
Modified residuei938PhosphoserineBy similarity1
Modified residuei1002PhosphoserineCombined sources1
Modified residuei1004PhosphoserineCombined sources1
Cross-linki1051Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1318PhosphoserineBy similarity1
Cross-linki1328Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1329Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1398Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1472PhosphoserineCombined sources1
Modified residuei1474PhosphothreonineCombined sources1
Modified residuei2450PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated.By similarity
Sumoylated preferentially with SUMO2 or SUMO3.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AKX3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AKX3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A2AKX3

PeptideAtlas

More...
PeptideAtlasi
A2AKX3

PRoteomics IDEntifications database

More...
PRIDEi
A2AKX3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AKX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AKX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cerebellum, hippocampus, olfactory bulb, Bergmann glial fibers, stellate cells and Purkinje cells. Expressed in the epithelial cells of the lens but not in mature lens fiber cells. Expressed in the retina (highly expressed in inner and outer segments of photoreceptors and outer plexiform layer cells but weakly expressed in the inner plexiform and ganglion cell layers). Expressed in the kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000043535 Expressed in 244 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2AKX3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A2AKX3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). Interacts with PER2; the interaction inhibits termination of circadian target genes (PubMed:22767893). Interacts with CHD4, POLR2A, PRKDC and TRIM28. Does not interact with C14orf178. Interacts with UBE2I. Interacts (via N-terminus domain) with EXOSC9 (via C-terminus region); the interaction enhances SETX sumoylation. Interacts with NCL (via N-terminus domain). Interacts with PABPN1, PABPC1 and SF3B1. Interacts with SMN1/SMN2 and POLR2A; SMN1/SMN2 recruits SETX to POLR2A (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
234629, 7 interactors

Database of interacting proteins

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DIPi
DIP-56995N

Protein interaction database and analysis system

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IntActi
A2AKX3, 4 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000051492

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2632 – 2646Necessary for nuclear localizationBy similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2046 – 2063Bipartite nuclear localization signalBy similarityAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus domain is necessary for S/G2 nuclear foci localization.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA2/NAM7 helicase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1801 Eukaryota
COG1112 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160918

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AKX3

KEGG Orthology (KO)

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KOi
K10706

Database of Orthologous Groups

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OrthoDBi
62494at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A2AKX3

TreeFam database of animal gene trees

More...
TreeFami
TF324634

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AKX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTCCWCTPG GSSTIDVLKR YASSTGSSEF QTADEDLCYC LECVAEYHRA
60 70 80 90 100
RDEVPFLHEV LWELETLRLV SHFEKSMKAE AEDDDDLYIV DNNGEEQLFD
110 120 130 140 150
CSGQDFENKL RVPLFEILKY PYLLLHERVN ELCVEALCRM EQNNCSFQVF
160 170 180 190 200
DKYPGIYLFL VHPNEMVRRW AILTARNLGK VDRDDYYDLQ EVLTCLFKVI
210 220 230 240 250
ELGLLESPDI YTSSVLEKGK LILLPAHMYD TTNYKNYWLG ICMLLTILEE
260 270 280 290 300
QAMDSLLLGS DKQNDFMQSI LHTMEKQSDD DSMDPFWPAL HCFMVILDRL
310 320 330 340 350
GSKVWGQLID PIEAFQTIIN NESYNREIQN IRNSSIRTKL EPEPHFDDMV
360 370 380 390 400
TCSQIVYNFN PEKTKKDSGW RSAICPDYCP NMYEEMETLA NVLQSDIGQD
410 420 430 440 450
MRVHNSTFLW FIPFVQSLMD LKDLGVAYIV EVIHHLYSEV KDVLNQTDAV
460 470 480 490 500
CDKVTEFFIL ILISVIELHR NKKCLHLLWV SSQQWVEAVV KCAKLPTTAF
510 520 530 540 550
VRSCEKSPGS TSRGAAIMSS LALHSVQSNS VQLACVQLIR GLLKEGYQLG
560 570 580 590 600
QQTLCKRFWD KLNLFLRGNL SLGWQLTGQE THELQMCLKQ IIRNIKFKMP
610 620 630 640 650
QYSTFGDSTS TFKTPPSFKE ESDKIDRKHK KNIYCLENCS PVSSKEPMKA
660 670 680 690 700
DTHRVLMKVN TTEEENFKQH YIDLNEEEQE PLPAELCLKQ KSEALFSESA
710 720 730 740 750
QEQVKISAEK SGKESSSYAP SNSTSRNGPE WGCDRGVIMS AHSLTDSSSD
760 770 780 790 800
FMEQVSTSNE DVSLKDGSVG KTSKPSFKLQ KDEICAKLSH VIKKQIRKST
810 820 830 840 850
LVDNIIDLEE NTAISDLENC SGTDGGALKE DSIGHNVPSD PVLDDKHEEQ
860 870 880 890 900
KSQNSSLFKK EIKSEELDNS SSDDEDKLQI QEGRADDDLV SFTEVTDTLV
910 920 930 940 950
KAPCEGHVKM VVESRDKEMR ESTALTSNLV EGQVPHDSSK PLVAGRQIDL
960 970 980 990 1000
CNITLISQTT VIQFPSGLSK QNSFQLQKGD KRCLTANQNS AATCRGQVIV
1010 1020 1030 1040 1050
ISDSDEEEDE DEDERSSSEE NIKQSKACIG KDCSEHRSLA VNASVEKQLV
1060 1070 1080 1090 1100
KEEERYPVEF EDSESQVFEF ESSSEVFSVW QDHKIDSKNS LQGEQKSYVT
1110 1120 1130 1140 1150
HVADSTNNNL GCGDSVSEEV VRNKAEGVKE HAGPHSSVSA EEFCKTGVKK
1160 1170 1180 1190 1200
PKRKRYDKVT AEDPQRPSSS VGTDQLPDRR DLTESDLKSA DMGMATPSSS
1210 1220 1230 1240 1250
VERDSTILQK STKSRTHSKP VRKVPASKAT KKTHSDTRRG QSKSSCYISC
1260 1270 1280 1290 1300
RTSPAIVPPK KLRQCPEPTS TVEKLGLKKA PRKAFELSQR SLECIVQLRD
1310 1320 1330 1340 1350
HGKTVGVVDA PKKAKLISPQ TLSIKNNKKL LTSQDLQFQR LMRSRSHKKR
1360 1370 1380 1390 1400
DFDYKNTDTV RVSRIVQGSD VLEADSDEPD DHRVSEPLAI SNEKQLAKCM
1410 1420 1430 1440 1450
LSKTEVAEAS SDPWVTGITC LVNQCESRVL SGGVPTDVVM VSASEDPVDG
1460 1470 1480 1490 1500
GAVTVQVGEV ASVKAAEPAS SSDTDDDDNL FLTQHDPQDM DLCSQLENKT
1510 1520 1530 1540 1550
IIVAHKKDTV QREDSLSRPQ LESLSITKCK YKDCVETTKN QGEYCPRHSE
1560 1570 1580 1590 1600
AKAADDGLFR KPGLPLSVAR PLRPTTTKIF SSSSASRTAN LSKSLESTTL
1610 1620 1630 1640 1650
QQSALKNKSS GAQPNLKVTP PSSMGSQKPV AEVKSLCNIF HFQTPSSSSK
1660 1670 1680 1690 1700
QSCKLTFSEN RPTSAASPVN ILLPSQSIFD TFIKEVLKWK YQMFLNFDKC
1710 1720 1730 1740 1750
GAPTSLCQSI SRPVPVRFQD CAEYFNVFLP LIILNAFETV AQEWLSSPNK
1760 1770 1780 1790 1800
ENFYQLQLRK FPADYKKYWE FLIYLNESEL AKQLHPKEND LVFLAPEKSY
1810 1820 1830 1840 1850
MDRHGMQDCS HYYCGYVHKF RRTSVMRSGK AECSLCIQTQ DTLPASVKNL
1860 1870 1880 1890 1900
TRCIVISSLV TTQRKLKAMS LLSSRNQLAR AVLNPNPMDF CTKDLLTTTS
1910 1920 1930 1940 1950
ERIVAYLKDF NEDQKKAIET AYAMVKHSPS VAKICLIHGP PGTGKSKTIV
1960 1970 1980 1990 2000
GLLYRLLTEN QRKGHSDENF NAKIKQNRVL VCAPSNAAVD ELMKKIILEF
2010 2020 2030 2040 2050
KEKCKDKKNP LGNCGDINLV RLGPEKSINT EVLKFSLDSQ VNHRMKKDLP
2060 2070 2080 2090 2100
SHIQEMLRRK EILDAQLDEL SRQRALCRGG REMQRQELDE HIAIVSKERQ
2110 2120 2130 2140 2150
ELASKIKEVQ GRPQRAQNTI ILESHVICCT LSTSGGLLLE SAFRGQGGVP
2160 2170 2180 2190 2200
FSCVIVDEAG QSCEVETLSP LIHRCNKLIL VGDPKQLPPT VISMKAQEYG
2210 2220 2230 2240 2250
YDQSMMARFC KLLEENVEQN MIGRLPVLQL TIQYRMHPDI CLFPSNYVYN
2260 2270 2280 2290 2300
KNLKTNRLTE SIRCSSEWPF QPYLVFDVGD GSERRDNDSY INVQEIKLVM
2310 2320 2330 2340 2350
EIIKLIKEKR KDISFRNIGI ITHYKAQKTM IQKDLEKEFD KKGPAEVDTV
2360 2370 2380 2390 2400
DAFQGRQKDC IIVTCVRASA VQGSIGFLAS LQRLNVTITR AKYSLFILGH
2410 2420 2430 2440 2450
LRTLMENQHW YELIQDAQKR GAIIKTSDPN YRHDAMKILK LKPVLQRSLT
2460 2470 2480 2490 2500
HPPATAPEAP RPQGGLPSNR LDSGLATTSF AASLYHTPSD TVTSKGPERP
2510 2520 2530 2540 2550
LLQDRLRDPR LLRRLDAEAK GTFLKDPQPV SPQLPGVVHL LGEPGFPVVF
2560 2570 2580 2590 2600
QDLGFVVPPS TAIVAPLGSH RSPMQAEPPP AHPAAAASTS KRKYSDPDAG
2610 2620 2630 2640
LSHKREPRAF SGEQGRHGSV THHVLRSTDW DRRRLDDSSA KRRQFL
Length:2,646
Mass (Da):297,589
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3036F84EFED4A098
GO
Isoform 2 (identifier: A2AKX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: Missing.

Note: No experimental confirmation available.
Show »
Length:2,265
Mass (Da):253,320
Checksum:iAA0DCF08E90FAEED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6R186F6R186_MOUSE
Probable helicase senataxin
Setx
381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQJ0A0A0A0MQJ0_MOUSE
Probable helicase senataxin
Setx
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC32054 differs from that shown. Reason: Frameshift at position 699.Curated
The sequence BAC97987 differs from that shown. The sequence differs from that shown because it is derived from pre-RNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti644S → C in BAC32054 (PubMed:16141072).Curated1
Sequence conflicti1048Q → R in BAC33309 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0288271 – 381Missing in isoform 2. 1 PublicationAdd BLAST381

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL772379 Genomic DNA No translation available.
AL845267 Genomic DNA No translation available.
AK044730 mRNA Translation: BAC32054.1 Frameshift.
AK048354 mRNA Translation: BAC33309.2
AK077911 mRNA Translation: BAC37058.1
BC046382 mRNA Translation: AAH46382.1
BC058109 mRNA Translation: AAH58109.2
BC079604 mRNA Translation: AAH79604.2
AK129177 Transcribed RNA Translation: BAC97987.1 Sequence problems.
BK001523 mRNA Translation: DAA01946.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38090.1 [A2AKX3-1]

NCBI Reference Sequences

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RefSeqi
NP_932150.2, NM_198033.2 [A2AKX3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061578; ENSMUSP00000051492; ENSMUSG00000043535 [A2AKX3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
269254

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:269254

UCSC genome browser

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UCSCi
uc008izm.1 mouse [A2AKX3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772379 Genomic DNA No translation available.
AL845267 Genomic DNA No translation available.
AK044730 mRNA Translation: BAC32054.1 Frameshift.
AK048354 mRNA Translation: BAC33309.2
AK077911 mRNA Translation: BAC37058.1
BC046382 mRNA Translation: AAH46382.1
BC058109 mRNA Translation: AAH58109.2
BC079604 mRNA Translation: AAH79604.2
AK129177 Transcribed RNA Translation: BAC97987.1 Sequence problems.
BK001523 mRNA Translation: DAA01946.1
CCDSiCCDS38090.1 [A2AKX3-1]
RefSeqiNP_932150.2, NM_198033.2 [A2AKX3-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi234629, 7 interactors
DIPiDIP-56995N
IntActiA2AKX3, 4 interactors
STRINGi10090.ENSMUSP00000051492

PTM databases

iPTMnetiA2AKX3
PhosphoSitePlusiA2AKX3

Proteomic databases

EPDiA2AKX3
MaxQBiA2AKX3
PaxDbiA2AKX3
PeptideAtlasiA2AKX3
PRIDEiA2AKX3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061578; ENSMUSP00000051492; ENSMUSG00000043535 [A2AKX3-1]
GeneIDi269254
KEGGimmu:269254
UCSCiuc008izm.1 mouse [A2AKX3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23064
MGIiMGI:2443480 Setx

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1801 Eukaryota
COG1112 LUCA
GeneTreeiENSGT00940000160918
InParanoidiA2AKX3
KOiK10706
OrthoDBi62494at2759
PhylomeDBiA2AKX3
TreeFamiTF324634

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2AKX3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000043535 Expressed in 244 organ(s), highest expression level in testis
ExpressionAtlasiA2AKX3 baseline and differential
GenevisibleiA2AKX3 MM

Family and domain databases

InterProiView protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSETX_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AKX3
Secondary accession number(s): A2AKX4
, A2AR33, Q6IMG6, Q6PED8, Q6ZQ81, Q80V90, Q8C5P1, Q8C859, Q8C8P6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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