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Protein

Focadhesin

Gene

Focad

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential tumor suppressor in gliomas.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Focadhesin
Gene namesi
Name:Focad
Synonyms:Kiaa1797
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2676921 Focad

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Transmembranei1033 – 1053HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003144581 – 1798FocadhesinAdd BLAST1798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei816N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiA2AKG8
MaxQBiA2AKG8
PaxDbiA2AKG8
PeptideAtlasiA2AKG8
PRIDEiA2AKG8

PTM databases

iPTMnetiA2AKG8
PhosphoSitePlusiA2AKG8

Expressioni

Tissue specificityi

Expressed by glial and neuronal cells in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000038368 Expressed in 236 organ(s), highest expression level in oocyte
CleanExiMM_BC057079
ExpressionAtlasiA2AKG8 baseline and differential
GenevisibleiA2AKG8 MM

Interactioni

Subunit structurei

Interacts with VCL.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095602

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 368Leu-richAdd BLAST175

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II1D Eukaryota
ENOG410YIIU LUCA
GeneTreeiENSGT00390000004438
HOGENOMiHOG000113178
HOVERGENiHBG095600
InParanoidiA2AKG8
OMAiDSHYQPR
OrthoDBiEOG091G00F3
PhylomeDBiA2AKG8
TreeFamiTF323261

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR022542 DUF3730
IPR021392 Focadhesin
PfamiView protein in Pfam
PF12530 DUF3730, 1 hit
PF11229 Focadhesin, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AKG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDDIKKRFD FPNSLIQSQA VGHLIAAVLK EHGVSEKIHQ STNQTAALNL
60 70 80 90 100
LWEKCCSDHV VVRTACSEGL VALVAQGHAE FSYVLNGILN LTPSARNMSG
110 120 130 140 150
LIKALMKLLQ MQALREGQSG EKDIQDIYSI RNPPQPLITV LEHRPDCWPL
160 170 180 190 200
LLQQLTAFFQ QCPERSEASC VQIMAPFLWY LYCEPSQLEE YAKLRLSLLK
210 220 230 240 250
VLLQPRGVCE EAQLSVREQS TLQLCCSMLP CLQMKDLMQT TEMMLFVEEV
260 270 280 290 300
YLSLLRHPGF WKSQLTQLTL QLLCICEVSL KITGECSSLI HLLERSVELL
310 320 330 340 350
GEDFPVELVI IGIALLLLQM PASQQKPLLN LALKLLSLTE GQKIPKASLL
360 370 380 390 400
LLVPLLQILS STALEDCLAM GEEGPSRQQL ALSLVEVLQK ERHGDDSHTI
410 420 430 440 450
SCRLAFPVSS MYGSIFTAWR ILDVIGEESA TSDWLATVES LLSATTVIPP
460 470 480 490 500
HVFLLLAYLL VEDVGQNLQQ ILRVTTQLAQ ADSSQVPNLI PVLMFKLGRP
510 520 530 540 550
LDPVSYNHIL YTLPTLGVHK VCVGQILRVI QLLGTTPRLR AVTLRLLTSL
560 570 580 590 600
WEKQDRVYPE LQRFMAVSDA PSLSVGKELQ WEKLIAKAAS IRDICKQRPY
610 620 630 640 650
QHGADMLAAI SQVLNECTKP DQATPAALVL QGLHALCQAE VVCIRSTWNA
660 670 680 690 700
LSPKLSCDMR PLILKTLSEL FSLVPSLTVN TVEYENFKVQ VLSFLWTHTQ
710 720 730 740 750
NKNPTVASAA YKSLSHFSAG EHTILHLPEK IRPEMPVPGE LDEEESVDLS
760 770 780 790 800
IPGACFLRLL TITAPSVLPA LEEFFTSLVR QEMVNMPRGI YHSALKGGVR
810 820 830 840 850
SDQGKTVAGI PNFILKTYET NKQPGLKPGL AGGMLFCYDL AMYQSKDGKP
860 870 880 890 900
LNRLMASRGR SFKQTTLALI HEVHVQLSEW HRAIFLPQAW LAYMTRAYHA
910 920 930 940 950
ILQGRIAELE LQLQHGKEGP EEVQYKRSTA WLWVRDMLTD EITKTAAKES
960 970 980 990 1000
PVVKANALLA LSSLAVVVSK HEASLCSDSD GVLEIQPNFL PVKEWVSMVL
1010 1020 1030 1040 1050
NTLLVIVDSH YHPSGQLFTC FYHKSYSGEN TASAIARSAA ATALSLLVPV
1060 1070 1080 1090 1100
FIISCKEKVE EILNMLTARL PGKPSADESQ AVQIHMGLAL GMFLSRLCEE
1110 1120 1130 1140 1150
KLSDMSGQQM NLLLMKSLDA LESCCFDPSL EYNTGCILGV GLALSLMSHS
1160 1170 1180 1190 1200
SHTESRVHVA ASLRKLSTYL DESGSQSRTF QEVLVYTLSC VCTSAFSAGI
1210 1220 1230 1240 1250
IEAAEAEDIM SKLQLLVENN QQTSGFALAL GNLVYGLSVC GHGKAEDLGN
1260 1270 1280 1290 1300
RLRPSWIKVV LTEGAPTMLC LAALHGLVAL VGSDVDVMQL KSEAIQNTHF
1310 1320 1330 1340 1350
QARLNEVIRT LTEVISVSGV IGLQSNAIWL LGHLHLSTLS SNQSRTSVPT
1360 1370 1380 1390 1400
DYSYLPEGSF IRAAIGFFIT GGKKGPEAVP PSLLKVVMKP IATVGESYQY
1410 1420 1430 1440 1450
PPANLAALLS PLMRLNFGEE IQQLCLEIAV TQAPSSQSAA SLLGLWVMPP
1460 1470 1480 1490 1500
LIHGLSLNIK KYLLVSMPLW AKHVSDEQIQ GFVENLMVEV FKTASQPCHP
1510 1520 1530 1540 1550
EMCLSALQGL SQAMKLPSPS HHLWSLLCDA TGRIFDLLPN RIRRNDLELY
1560 1570 1580 1590 1600
ISIAKCLSEM TDEGVNQVSQ ITKDNIEKAA FVKLYLVSQG RLPLMSLTDL
1610 1620 1630 1640 1650
LTAAMQHPEK ETLAWMILHS LYQARIVNHA NTGVLKRLEW LLELMGYVRN
1660 1670 1680 1690 1700
IAYQSAPIQN VAPEEALDFL MLIFAAAVVA WADHEAPLLL GLSASWLPWH
1710 1720 1730 1740 1750
QQNGPGGPAA ALLGRSPMHR VTVQEVLTQL PRSMLLLLQK EPWKEQTQKF
1760 1770 1780 1790
IDWLLSIMEI PNKAFAAKSK DLLKATLLSL RVLPEFKKKA VWTRAYGW
Length:1,798
Mass (Da):198,950
Last modified:February 20, 2007 - v1
Checksum:i129DC68F61647C09
GO
Isoform 2 (identifier: A2AKG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-335: ALKL → GASK
     336-1798: Missing.

Show »
Length:335
Mass (Da):37,646
Checksum:iDFA5969805E95DD1
GO
Isoform 3 (identifier: A2AKG8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1594: Missing.

Show »
Length:204
Mass (Da):23,097
Checksum:i536F37C0A395B85A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYJ6E9PYJ6_MOUSE
Focadhesin
Focad BC057079
1,712Annotation score:

Sequence cautioni

The sequence BAE26929 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE27017 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti638Q → R in AAH57079 (PubMed:15489334).Curated1
Sequence conflicti679V → A in AAH57079 (PubMed:15489334).Curated1
Sequence conflicti1180F → I in AAH57079 (PubMed:15489334).Curated1
Sequence conflicti1521H → R in BAE26929 (PubMed:16141072).Curated1
Sequence conflicti1521H → R in BAE27017 (PubMed:16141072).Curated1
Sequence conflicti1623Q → K in BAE26929 (PubMed:16141072).Curated1
Sequence conflicti1623Q → K in BAE27017 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0302741 – 1594Missing in isoform 3. 1 PublicationAdd BLAST1594
Alternative sequenceiVSP_030275332 – 335ALKL → GASK in isoform 2. 1 Publication4
Alternative sequenceiVSP_030276336 – 1798Missing in isoform 2. 1 PublicationAdd BLAST1463

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146138 mRNA Translation: BAE26929.1 Different initiation.
AK146256 mRNA Translation: BAE27017.1 Different initiation.
AK164030 mRNA Translation: BAE37596.1
AL772316 Genomic DNA Translation: CAM17295.1
AL772316
, AL772296, AL831756, BX572638 Genomic DNA Translation: CAM17298.1
BX572638
, AL772296, AL772316, AL831756 Genomic DNA Translation: CAM18365.1
AL831756
, AL772296, AL772316, BX572638 Genomic DNA Translation: CAM20204.1
AL772296
, AL772316, AL831756, BX572638 Genomic DNA Translation: CAM26596.1
BC039622 mRNA Translation: AAH39622.1
BC057079 mRNA Translation: AAH57079.1
CCDSiCCDS38798.1 [A2AKG8-1]
RefSeqiNP_001074653.1, NM_001081184.1 [A2AKG8-1]
UniGeneiMm.287210

Genome annotation databases

EnsembliENSMUST00000097992; ENSMUSP00000095602; ENSMUSG00000038368 [A2AKG8-1]
ENSMUST00000107147; ENSMUSP00000102765; ENSMUSG00000038368 [A2AKG8-3]
GeneIDi230393
KEGGimmu:230393
UCSCiuc008tmt.1 mouse [A2AKG8-2]
uc008tmu.1 mouse [A2AKG8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146138 mRNA Translation: BAE26929.1 Different initiation.
AK146256 mRNA Translation: BAE27017.1 Different initiation.
AK164030 mRNA Translation: BAE37596.1
AL772316 Genomic DNA Translation: CAM17295.1
AL772316
, AL772296, AL831756, BX572638 Genomic DNA Translation: CAM17298.1
BX572638
, AL772296, AL772316, AL831756 Genomic DNA Translation: CAM18365.1
AL831756
, AL772296, AL772316, BX572638 Genomic DNA Translation: CAM20204.1
AL772296
, AL772316, AL831756, BX572638 Genomic DNA Translation: CAM26596.1
BC039622 mRNA Translation: AAH39622.1
BC057079 mRNA Translation: AAH57079.1
CCDSiCCDS38798.1 [A2AKG8-1]
RefSeqiNP_001074653.1, NM_001081184.1 [A2AKG8-1]
UniGeneiMm.287210

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095602

PTM databases

iPTMnetiA2AKG8
PhosphoSitePlusiA2AKG8

Proteomic databases

EPDiA2AKG8
MaxQBiA2AKG8
PaxDbiA2AKG8
PeptideAtlasiA2AKG8
PRIDEiA2AKG8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097992; ENSMUSP00000095602; ENSMUSG00000038368 [A2AKG8-1]
ENSMUST00000107147; ENSMUSP00000102765; ENSMUSG00000038368 [A2AKG8-3]
GeneIDi230393
KEGGimmu:230393
UCSCiuc008tmt.1 mouse [A2AKG8-2]
uc008tmu.1 mouse [A2AKG8-1]

Organism-specific databases

CTDi54914
MGIiMGI:2676921 Focad
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410II1D Eukaryota
ENOG410YIIU LUCA
GeneTreeiENSGT00390000004438
HOGENOMiHOG000113178
HOVERGENiHBG095600
InParanoidiA2AKG8
OMAiDSHYQPR
OrthoDBiEOG091G00F3
PhylomeDBiA2AKG8
TreeFamiTF323261

Miscellaneous databases

ChiTaRSiFocad mouse
PROiPR:A2AKG8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038368 Expressed in 236 organ(s), highest expression level in oocyte
CleanExiMM_BC057079
ExpressionAtlasiA2AKG8 baseline and differential
GenevisibleiA2AKG8 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR022542 DUF3730
IPR021392 Focadhesin
PfamiView protein in Pfam
PF12530 DUF3730, 1 hit
PF11229 Focadhesin, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOCAD_MOUSE
AccessioniPrimary (citable) accession number: A2AKG8
Secondary accession number(s): Q0P620
, Q3TPY9, Q3UJY8, Q3UK73, Q6PGE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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