UniProtKB - A2AKG8 (FOCAD_MOUSE)
Protein
Focadhesin
Gene
Focad
Organism
Mus musculus (Mouse)
Status
Functioni
Potential tumor suppressor in gliomas.1 Publication
Names & Taxonomyi
Protein namesi | Recommended name: Focadhesin |
Gene namesi | Name:Focad Synonyms:Kiaa1797 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2676921 Focad |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
- focal adhesion
Note: Colocalizes with VCL in astrocytes.By similarity
Other locations
- focal adhesion Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 441 – 461 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1033 – 1053 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000314458 | 1 – 1798 | FocadhesinAdd BLAST | 1798 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 816 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | A2AKG8 |
MaxQBi | A2AKG8 |
PaxDbi | A2AKG8 |
PeptideAtlasi | A2AKG8 |
PRIDEi | A2AKG8 |
PTM databases
iPTMneti | A2AKG8 |
PhosphoSitePlusi | A2AKG8 |
Expressioni
Tissue specificityi
Expressed by glial and neuronal cells in brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000038368 Expressed in 236 organ(s), highest expression level in oocyte |
ExpressionAtlasi | A2AKG8 baseline and differential |
Genevisiblei | A2AKG8 MM |
Interactioni
Subunit structurei
Interacts with VCL.By similarity
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000095602 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 194 – 368 | Leu-richAdd BLAST | 175 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410II1D Eukaryota ENOG410YIIU LUCA |
GeneTreei | ENSGT00390000004438 |
HOGENOMi | HOG000113178 |
HOVERGENi | HBG095600 |
InParanoidi | A2AKG8 |
OMAi | DSHYQPR |
OrthoDBi | 187102at2759 |
PhylomeDBi | A2AKG8 |
TreeFami | TF323261 |
Family and domain databases
InterProi | View protein in InterPro IPR016024 ARM-type_fold IPR022542 DUF3730 IPR021392 Focadhesin |
Pfami | View protein in Pfam PF12530 DUF3730, 1 hit PF11229 Focadhesin, 1 hit |
SUPFAMi | SSF48371 SSF48371, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: A2AKG8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSDDIKKRFD FPNSLIQSQA VGHLIAAVLK EHGVSEKIHQ STNQTAALNL
60 70 80 90 100
LWEKCCSDHV VVRTACSEGL VALVAQGHAE FSYVLNGILN LTPSARNMSG
110 120 130 140 150
LIKALMKLLQ MQALREGQSG EKDIQDIYSI RNPPQPLITV LEHRPDCWPL
160 170 180 190 200
LLQQLTAFFQ QCPERSEASC VQIMAPFLWY LYCEPSQLEE YAKLRLSLLK
210 220 230 240 250
VLLQPRGVCE EAQLSVREQS TLQLCCSMLP CLQMKDLMQT TEMMLFVEEV
260 270 280 290 300
YLSLLRHPGF WKSQLTQLTL QLLCICEVSL KITGECSSLI HLLERSVELL
310 320 330 340 350
GEDFPVELVI IGIALLLLQM PASQQKPLLN LALKLLSLTE GQKIPKASLL
360 370 380 390 400
LLVPLLQILS STALEDCLAM GEEGPSRQQL ALSLVEVLQK ERHGDDSHTI
410 420 430 440 450
SCRLAFPVSS MYGSIFTAWR ILDVIGEESA TSDWLATVES LLSATTVIPP
460 470 480 490 500
HVFLLLAYLL VEDVGQNLQQ ILRVTTQLAQ ADSSQVPNLI PVLMFKLGRP
510 520 530 540 550
LDPVSYNHIL YTLPTLGVHK VCVGQILRVI QLLGTTPRLR AVTLRLLTSL
560 570 580 590 600
WEKQDRVYPE LQRFMAVSDA PSLSVGKELQ WEKLIAKAAS IRDICKQRPY
610 620 630 640 650
QHGADMLAAI SQVLNECTKP DQATPAALVL QGLHALCQAE VVCIRSTWNA
660 670 680 690 700
LSPKLSCDMR PLILKTLSEL FSLVPSLTVN TVEYENFKVQ VLSFLWTHTQ
710 720 730 740 750
NKNPTVASAA YKSLSHFSAG EHTILHLPEK IRPEMPVPGE LDEEESVDLS
760 770 780 790 800
IPGACFLRLL TITAPSVLPA LEEFFTSLVR QEMVNMPRGI YHSALKGGVR
810 820 830 840 850
SDQGKTVAGI PNFILKTYET NKQPGLKPGL AGGMLFCYDL AMYQSKDGKP
860 870 880 890 900
LNRLMASRGR SFKQTTLALI HEVHVQLSEW HRAIFLPQAW LAYMTRAYHA
910 920 930 940 950
ILQGRIAELE LQLQHGKEGP EEVQYKRSTA WLWVRDMLTD EITKTAAKES
960 970 980 990 1000
PVVKANALLA LSSLAVVVSK HEASLCSDSD GVLEIQPNFL PVKEWVSMVL
1010 1020 1030 1040 1050
NTLLVIVDSH YHPSGQLFTC FYHKSYSGEN TASAIARSAA ATALSLLVPV
1060 1070 1080 1090 1100
FIISCKEKVE EILNMLTARL PGKPSADESQ AVQIHMGLAL GMFLSRLCEE
1110 1120 1130 1140 1150
KLSDMSGQQM NLLLMKSLDA LESCCFDPSL EYNTGCILGV GLALSLMSHS
1160 1170 1180 1190 1200
SHTESRVHVA ASLRKLSTYL DESGSQSRTF QEVLVYTLSC VCTSAFSAGI
1210 1220 1230 1240 1250
IEAAEAEDIM SKLQLLVENN QQTSGFALAL GNLVYGLSVC GHGKAEDLGN
1260 1270 1280 1290 1300
RLRPSWIKVV LTEGAPTMLC LAALHGLVAL VGSDVDVMQL KSEAIQNTHF
1310 1320 1330 1340 1350
QARLNEVIRT LTEVISVSGV IGLQSNAIWL LGHLHLSTLS SNQSRTSVPT
1360 1370 1380 1390 1400
DYSYLPEGSF IRAAIGFFIT GGKKGPEAVP PSLLKVVMKP IATVGESYQY
1410 1420 1430 1440 1450
PPANLAALLS PLMRLNFGEE IQQLCLEIAV TQAPSSQSAA SLLGLWVMPP
1460 1470 1480 1490 1500
LIHGLSLNIK KYLLVSMPLW AKHVSDEQIQ GFVENLMVEV FKTASQPCHP
1510 1520 1530 1540 1550
EMCLSALQGL SQAMKLPSPS HHLWSLLCDA TGRIFDLLPN RIRRNDLELY
1560 1570 1580 1590 1600
ISIAKCLSEM TDEGVNQVSQ ITKDNIEKAA FVKLYLVSQG RLPLMSLTDL
1610 1620 1630 1640 1650
LTAAMQHPEK ETLAWMILHS LYQARIVNHA NTGVLKRLEW LLELMGYVRN
1660 1670 1680 1690 1700
IAYQSAPIQN VAPEEALDFL MLIFAAAVVA WADHEAPLLL GLSASWLPWH
1710 1720 1730 1740 1750
QQNGPGGPAA ALLGRSPMHR VTVQEVLTQL PRSMLLLLQK EPWKEQTQKF
1760 1770 1780 1790
IDWLLSIMEI PNKAFAAKSK DLLKATLLSL RVLPEFKKKA VWTRAYGW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PYJ6 | E9PYJ6_MOUSE | Focadhesin | Focad BC057079 | 1,712 | Annotation score: |
Sequence cautioni
The sequence BAE26929 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE27017 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 638 | Q → R in AAH57079 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 679 | V → A in AAH57079 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1180 | F → I in AAH57079 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1521 | H → R in BAE26929 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1521 | H → R in BAE27017 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1623 | Q → K in BAE26929 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1623 | Q → K in BAE27017 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030274 | 1 – 1594 | Missing in isoform 3. 1 PublicationAdd BLAST | 1594 | |
Alternative sequenceiVSP_030275 | 332 – 335 | ALKL → GASK in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_030276 | 336 – 1798 | Missing in isoform 2. 1 PublicationAdd BLAST | 1463 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146138 mRNA Translation: BAE26929.1 Different initiation. AK146256 mRNA Translation: BAE27017.1 Different initiation. AK164030 mRNA Translation: BAE37596.1 AL772316 Genomic DNA Translation: CAM17295.1 AL772316 BX572638 Genomic DNA Translation: CAM17298.1 BX572638 AL831756 Genomic DNA Translation: CAM18365.1 AL831756 BX572638 Genomic DNA Translation: CAM20204.1 AL772296 BX572638 Genomic DNA Translation: CAM26596.1 BC039622 mRNA Translation: AAH39622.1 BC057079 mRNA Translation: AAH57079.1 |
CCDSi | CCDS38798.1 [A2AKG8-1] |
RefSeqi | NP_001074653.1, NM_001081184.1 [A2AKG8-1] |
UniGenei | Mm.287210 |
Genome annotation databases
Ensembli | ENSMUST00000097992; ENSMUSP00000095602; ENSMUSG00000038368 [A2AKG8-1] ENSMUST00000107147; ENSMUSP00000102765; ENSMUSG00000038368 [A2AKG8-3] |
GeneIDi | 230393 |
KEGGi | mmu:230393 |
UCSCi | uc008tmt.1 mouse [A2AKG8-2] uc008tmu.1 mouse [A2AKG8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146138 mRNA Translation: BAE26929.1 Different initiation. AK146256 mRNA Translation: BAE27017.1 Different initiation. AK164030 mRNA Translation: BAE37596.1 AL772316 Genomic DNA Translation: CAM17295.1 AL772316 BX572638 Genomic DNA Translation: CAM17298.1 BX572638 AL831756 Genomic DNA Translation: CAM18365.1 AL831756 BX572638 Genomic DNA Translation: CAM20204.1 AL772296 BX572638 Genomic DNA Translation: CAM26596.1 BC039622 mRNA Translation: AAH39622.1 BC057079 mRNA Translation: AAH57079.1 |
CCDSi | CCDS38798.1 [A2AKG8-1] |
RefSeqi | NP_001074653.1, NM_001081184.1 [A2AKG8-1] |
UniGenei | Mm.287210 |
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000095602 |
PTM databases
iPTMneti | A2AKG8 |
PhosphoSitePlusi | A2AKG8 |
Proteomic databases
EPDi | A2AKG8 |
MaxQBi | A2AKG8 |
PaxDbi | A2AKG8 |
PeptideAtlasi | A2AKG8 |
PRIDEi | A2AKG8 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000097992; ENSMUSP00000095602; ENSMUSG00000038368 [A2AKG8-1] ENSMUST00000107147; ENSMUSP00000102765; ENSMUSG00000038368 [A2AKG8-3] |
GeneIDi | 230393 |
KEGGi | mmu:230393 |
UCSCi | uc008tmt.1 mouse [A2AKG8-2] uc008tmu.1 mouse [A2AKG8-1] |
Organism-specific databases
CTDi | 54914 |
MGIi | MGI:2676921 Focad |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG410II1D Eukaryota ENOG410YIIU LUCA |
GeneTreei | ENSGT00390000004438 |
HOGENOMi | HOG000113178 |
HOVERGENi | HBG095600 |
InParanoidi | A2AKG8 |
OMAi | DSHYQPR |
OrthoDBi | 187102at2759 |
PhylomeDBi | A2AKG8 |
TreeFami | TF323261 |
Miscellaneous databases
ChiTaRSi | Focad mouse |
PROi | PR:A2AKG8 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038368 Expressed in 236 organ(s), highest expression level in oocyte |
ExpressionAtlasi | A2AKG8 baseline and differential |
Genevisiblei | A2AKG8 MM |
Family and domain databases
InterProi | View protein in InterPro IPR016024 ARM-type_fold IPR022542 DUF3730 IPR021392 Focadhesin |
Pfami | View protein in Pfam PF12530 DUF3730, 1 hit PF11229 Focadhesin, 1 hit |
SUPFAMi | SSF48371 SSF48371, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | FOCAD_MOUSE | |
Accessioni | A2AKG8Primary (citable) accession number: A2AKG8 Secondary accession number(s): Q0P620 Q6PGE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 13, 2019 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot