UniProtKB - A2AKB9 (DCA10_MOUSE)
Protein
DDB1- and CUL4-associated factor 10
Gene
Dcaf10
Organism
Mus musculus (Mouse)
Status
Functioni
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-8951664, Neddylation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: DDB1- and CUL4-associated factor 10Alternative name(s): WD repeat-containing protein 32 |
Gene namesi | Name:Dcaf10 Synonyms:Wdr32 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2140179, Dcaf10 |
Subcellular locationi
Other locations
- Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306834 | 1 – 566 | DDB1- and CUL4-associated factor 10Add BLAST | 566 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 50 | PhosphoserineCombined sources | 1 | |
Modified residuei | 57 | PhosphoserineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineBy similarity | 1 | |
Modified residuei | 96 | PhosphoserineCombined sources | 1 | |
Modified residuei | 99 | PhosphoserineBy similarity | 1 | |
Modified residuei | 100 | PhosphoserineCombined sources | 1 | |
Modified residuei | 141 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 356 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | A2AKB9 |
MaxQBi | A2AKB9 |
PaxDbi | A2AKB9 |
PeptideAtlasi | A2AKB9 |
PRIDEi | A2AKB9 |
PTM databases
iPTMneti | A2AKB9 |
PhosphoSitePlusi | A2AKB9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000035572, Expressed in embryo and 255 other tissues |
ExpressionAtlasi | A2AKB9, baseline and differential |
Genevisiblei | A2AKB9, MM |
Interactioni
Subunit structurei
Interacts with DDB1.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000117082 |
Miscellaneous databases
RNActi | A2AKB9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 173 – 212 | WD 1Add BLAST | 40 | |
Repeati | 216 – 254 | WD 2Add BLAST | 39 | |
Repeati | 258 – 297 | WD 3Add BLAST | 40 | |
Repeati | 303 – 342 | WD 4Add BLAST | 40 | |
Repeati | 415 – 455 | WD 5Add BLAST | 41 | |
Repeati | 477 – 515 | WD 6Add BLAST | 39 | |
Repeati | 533 – 566 | WD 7Add BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 3 – 68 | Pro-richAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the WD repeat DCAF10 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0266, Eukaryota KOG4155, Eukaryota |
GeneTreei | ENSGT00390000012666 |
HOGENOMi | CLU_028919_2_0_1 |
InParanoidi | A2AKB9 |
OMAi | ISSPHGF |
OrthoDBi | 1068414at2759 |
PhylomeDBi | A2AKB9 |
TreeFami | TF323434 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR039085, DCA10 IPR000772, Ricin_B_lectin IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR14588, PTHR14588, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: A2AKB9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFPFGPHSPG GDETAGAEEP PPLGGPAAAS RPPSPAPRPA SPQRGADAAS
60 70 80 90 100
PPPVAGSPRL PGGPAVSPAE RAGEFAAPGA LELSAATASA SQAKLSPSSS
110 120 130 140 150
PRRRSRPDWR AGGRSRQGLG AGLGGPGARL FGWLRERSLG RGLFVDPARD
160 170 180 190 200
NFRTMTNLYG SIHPADSVYL STRTHGAVFN LEYSPDGSVL TVACEQTEVL
210 220 230 240 250
LFDPISSKHI KTLSEAHEDC VNNIRFLDNR LFATCSDDTT IALWDLRKLN
260 270 280 290 300
TKVCTLHGHT SWVKNIEYDT NTRLLVTSGF DGNVIIWDTN RCTEDGCPHK
310 320 330 340 350
KFFHTRFLMR MRLTPDCSKM LISTSSGYLL ILHELDLTKS LEVGSYPILR
360 370 380 390 400
ARRTTSSSDL TTTSSSSGSR VSGSPCHHND SNSTEKHMSR ASQREGVSPR
410 420 430 440 450
NSLEVLTPEV PGERDRGNCI TSLQLHPKGW ATLLRCSSNT DDQEWTCVYE
460 470 480 490 500
FQEGAPVRPV SPRCSLRLTH YIEEANVGRG YIKELCFSPD GRMISSPHGY
510 520 530 540 550
GIRLLGFDKQ CSELVDCLPK EASPLRVIRS LYSHNDVVLT TKFSPTHCQI
560
ASGCLSGRVS LYQPKF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketZ4YN28 | Z4YN28_MOUSE | DDB1- and CUL4-associated factor 10 | Dcaf10 | 225 | Annotation score: |
Sequence cautioni
The sequence AAH27317 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH85101 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38912 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM20443 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 202 | F → L in BAE38101 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 235 | C → S in AAH27317 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 323 | S → P in BAC38912 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028514 | 1 – 308 | Missing in isoform 3. 1 PublicationAdd BLAST | 308 | |
Alternative sequenceiVSP_028515 | 226 – 566 | Missing in isoform 4. 1 PublicationAdd BLAST | 341 | |
Alternative sequenceiVSP_028516 | 359 – 395 | Missing in isoform 2. CuratedAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045241 mRNA Translation: BAC32276.1 AK076417 mRNA Translation: BAC36330.1 AK083428 mRNA Translation: BAC38912.1 Different initiation. AK165246 mRNA Translation: BAE38101.1 AL772376, AL772285 Genomic DNA Translation: CAM20447.1 AL772285, AL772376 Genomic DNA Translation: CAM26867.1 AL772376 Genomic DNA Translation: CAM20443.1 Sequence problems. BC027317 mRNA Translation: AAH27317.1 Different initiation. BC085101 mRNA Translation: AAH85101.1 Different initiation. |
CCDSi | CCDS38754.1 [A2AKB9-1] |
RefSeqi | NP_694807.2, NM_153167.2 [A2AKB9-1] |
Genome annotation databases
Ensembli | ENSMUST00000155551; ENSMUSP00000117082; ENSMUSG00000035572 [A2AKB9-1] |
GeneIDi | 242418 |
KEGGi | mmu:242418 |
UCSCi | uc008ssm.1, mouse [A2AKB9-4] uc008ssn.1, mouse [A2AKB9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045241 mRNA Translation: BAC32276.1 AK076417 mRNA Translation: BAC36330.1 AK083428 mRNA Translation: BAC38912.1 Different initiation. AK165246 mRNA Translation: BAE38101.1 AL772376, AL772285 Genomic DNA Translation: CAM20447.1 AL772285, AL772376 Genomic DNA Translation: CAM26867.1 AL772376 Genomic DNA Translation: CAM20443.1 Sequence problems. BC027317 mRNA Translation: AAH27317.1 Different initiation. BC085101 mRNA Translation: AAH85101.1 Different initiation. |
CCDSi | CCDS38754.1 [A2AKB9-1] |
RefSeqi | NP_694807.2, NM_153167.2 [A2AKB9-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000117082 |
PTM databases
iPTMneti | A2AKB9 |
PhosphoSitePlusi | A2AKB9 |
Proteomic databases
EPDi | A2AKB9 |
MaxQBi | A2AKB9 |
PaxDbi | A2AKB9 |
PeptideAtlasi | A2AKB9 |
PRIDEi | A2AKB9 |
Protocols and materials databases
Antibodypediai | 12056, 93 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000155551; ENSMUSP00000117082; ENSMUSG00000035572 [A2AKB9-1] |
GeneIDi | 242418 |
KEGGi | mmu:242418 |
UCSCi | uc008ssm.1, mouse [A2AKB9-4] uc008ssn.1, mouse [A2AKB9-1] |
Organism-specific databases
CTDi | 79269 |
MGIi | MGI:2140179, Dcaf10 |
Phylogenomic databases
eggNOGi | KOG0266, Eukaryota KOG4155, Eukaryota |
GeneTreei | ENSGT00390000012666 |
HOGENOMi | CLU_028919_2_0_1 |
InParanoidi | A2AKB9 |
OMAi | ISSPHGF |
OrthoDBi | 1068414at2759 |
PhylomeDBi | A2AKB9 |
TreeFami | TF323434 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-8951664, Neddylation |
Miscellaneous databases
BioGRID-ORCSi | 242418, 0 hits in 17 CRISPR screens |
ChiTaRSi | Dcaf10, mouse |
PROi | PR:A2AKB9 |
RNActi | A2AKB9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035572, Expressed in embryo and 255 other tissues |
ExpressionAtlasi | A2AKB9, baseline and differential |
Genevisiblei | A2AKB9, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR039085, DCA10 IPR000772, Ricin_B_lectin IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR14588, PTHR14588, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCA10_MOUSE | |
Accessioni | A2AKB9Primary (citable) accession number: A2AKB9 Secondary accession number(s): A2AKV8 Q8K3A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families