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Protein

DDB1- and CUL4-associated factor 10

Gene

Dcaf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 10
Alternative name(s):
WD repeat-containing protein 32
Gene namesi
Name:Dcaf10
Synonyms:Wdr32
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140179 Dcaf10

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068341 – 566DDB1- and CUL4-associated factor 10Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei67PhosphoserineBy similarity1
Modified residuei96PhosphoserineCombined sources1
Modified residuei99PhosphoserineBy similarity1
Modified residuei100PhosphoserineCombined sources1
Modified residuei141Omega-N-methylarginineCombined sources1
Modified residuei356PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiA2AKB9
PaxDbiA2AKB9
PeptideAtlasiA2AKB9
PRIDEiA2AKB9

PTM databases

iPTMnetiA2AKB9
PhosphoSitePlusiA2AKB9

Expressioni

Gene expression databases

BgeeiENSMUSG00000035572 Expressed in 238 organ(s), highest expression level in secondary oocyte
CleanExiMM_WDR32
ExpressionAtlasiA2AKB9 baseline and differential
GenevisibleiA2AKB9 MM

Interactioni

Subunit structurei

Interacts with DDB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117082

Structurei

3D structure databases

ProteinModelPortaliA2AKB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati173 – 212WD 1Add BLAST40
Repeati216 – 254WD 2Add BLAST39
Repeati258 – 297WD 3Add BLAST40
Repeati303 – 342WD 4Add BLAST40
Repeati415 – 455WD 5Add BLAST41
Repeati477 – 515WD 6Add BLAST39
Repeati533 – 566WD 7Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 68Pro-richAdd BLAST66

Sequence similaritiesi

Belongs to the WD repeat DCAF10 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4155 Eukaryota
ENOG410XP1Z LUCA
GeneTreeiENSGT00390000012666
HOVERGENiHBG055755
InParanoidiA2AKB9
KOiK11802
OMAiSEWTCIH
OrthoDBiEOG091G09PD
PhylomeDBiA2AKB9
TreeFamiTF323434

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR039085 DCA10
IPR000772 Ricin_B_lectin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR14588 PTHR14588, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AKB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPFGPHSPG GDETAGAEEP PPLGGPAAAS RPPSPAPRPA SPQRGADAAS
60 70 80 90 100
PPPVAGSPRL PGGPAVSPAE RAGEFAAPGA LELSAATASA SQAKLSPSSS
110 120 130 140 150
PRRRSRPDWR AGGRSRQGLG AGLGGPGARL FGWLRERSLG RGLFVDPARD
160 170 180 190 200
NFRTMTNLYG SIHPADSVYL STRTHGAVFN LEYSPDGSVL TVACEQTEVL
210 220 230 240 250
LFDPISSKHI KTLSEAHEDC VNNIRFLDNR LFATCSDDTT IALWDLRKLN
260 270 280 290 300
TKVCTLHGHT SWVKNIEYDT NTRLLVTSGF DGNVIIWDTN RCTEDGCPHK
310 320 330 340 350
KFFHTRFLMR MRLTPDCSKM LISTSSGYLL ILHELDLTKS LEVGSYPILR
360 370 380 390 400
ARRTTSSSDL TTTSSSSGSR VSGSPCHHND SNSTEKHMSR ASQREGVSPR
410 420 430 440 450
NSLEVLTPEV PGERDRGNCI TSLQLHPKGW ATLLRCSSNT DDQEWTCVYE
460 470 480 490 500
FQEGAPVRPV SPRCSLRLTH YIEEANVGRG YIKELCFSPD GRMISSPHGY
510 520 530 540 550
GIRLLGFDKQ CSELVDCLPK EASPLRVIRS LYSHNDVVLT TKFSPTHCQI
560
ASGCLSGRVS LYQPKF
Length:566
Mass (Da):61,558
Last modified:February 20, 2007 - v1
Checksum:i4923778CDA90E6F8
GO
Isoform 2 (identifier: A2AKB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-395: Missing.

Show »
Length:529
Mass (Da):57,614
Checksum:i6DFDC654E4D001EC
GO
Isoform 3 (identifier: A2AKB9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-308: Missing.

Note: No experimental confirmation available.
Show »
Length:258
Mass (Da):28,626
Checksum:i5901B43E00473C8B
GO
Isoform 4 (identifier: A2AKB9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-566: Missing.

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):23,289
Checksum:i028BF807BA1FE6EB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YN28Z4YN28_MOUSE
DDB1- and CUL4-associated factor 10
Dcaf10
225Annotation score:

Sequence cautioni

The sequence AAH27317 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH85101 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38912 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM20443 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202F → L in BAE38101 (PubMed:16141072).Curated1
Sequence conflicti235C → S in AAH27317 (PubMed:15489334).Curated1
Sequence conflicti323S → P in BAC38912 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0285141 – 308Missing in isoform 3. 1 PublicationAdd BLAST308
Alternative sequenceiVSP_028515226 – 566Missing in isoform 4. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_028516359 – 395Missing in isoform 2. CuratedAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045241 mRNA Translation: BAC32276.1
AK076417 mRNA Translation: BAC36330.1
AK083428 mRNA Translation: BAC38912.1 Different initiation.
AK165246 mRNA Translation: BAE38101.1
AL772376, AL772285 Genomic DNA Translation: CAM20447.1
AL772285, AL772376 Genomic DNA Translation: CAM26867.1
AL772376 Genomic DNA Translation: CAM20443.1 Sequence problems.
BC027317 mRNA Translation: AAH27317.1 Different initiation.
BC085101 mRNA Translation: AAH85101.1 Different initiation.
CCDSiCCDS38754.1 [A2AKB9-1]
RefSeqiNP_694807.2, NM_153167.2 [A2AKB9-1]
UniGeneiMm.317668

Genome annotation databases

EnsembliENSMUST00000155551; ENSMUSP00000117082; ENSMUSG00000035572 [A2AKB9-1]
GeneIDi242418
KEGGimmu:242418
UCSCiuc008ssm.1 mouse [A2AKB9-4]
uc008ssn.1 mouse [A2AKB9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045241 mRNA Translation: BAC32276.1
AK076417 mRNA Translation: BAC36330.1
AK083428 mRNA Translation: BAC38912.1 Different initiation.
AK165246 mRNA Translation: BAE38101.1
AL772376, AL772285 Genomic DNA Translation: CAM20447.1
AL772285, AL772376 Genomic DNA Translation: CAM26867.1
AL772376 Genomic DNA Translation: CAM20443.1 Sequence problems.
BC027317 mRNA Translation: AAH27317.1 Different initiation.
BC085101 mRNA Translation: AAH85101.1 Different initiation.
CCDSiCCDS38754.1 [A2AKB9-1]
RefSeqiNP_694807.2, NM_153167.2 [A2AKB9-1]
UniGeneiMm.317668

3D structure databases

ProteinModelPortaliA2AKB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117082

PTM databases

iPTMnetiA2AKB9
PhosphoSitePlusiA2AKB9

Proteomic databases

MaxQBiA2AKB9
PaxDbiA2AKB9
PeptideAtlasiA2AKB9
PRIDEiA2AKB9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000155551; ENSMUSP00000117082; ENSMUSG00000035572 [A2AKB9-1]
GeneIDi242418
KEGGimmu:242418
UCSCiuc008ssm.1 mouse [A2AKB9-4]
uc008ssn.1 mouse [A2AKB9-1]

Organism-specific databases

CTDi79269
MGIiMGI:2140179 Dcaf10

Phylogenomic databases

eggNOGiKOG4155 Eukaryota
ENOG410XP1Z LUCA
GeneTreeiENSGT00390000012666
HOVERGENiHBG055755
InParanoidiA2AKB9
KOiK11802
OMAiSEWTCIH
OrthoDBiEOG091G09PD
PhylomeDBiA2AKB9
TreeFamiTF323434

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation

Miscellaneous databases

ChiTaRSiDcaf10 mouse
PROiPR:A2AKB9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035572 Expressed in 238 organ(s), highest expression level in secondary oocyte
CleanExiMM_WDR32
ExpressionAtlasiA2AKB9 baseline and differential
GenevisibleiA2AKB9 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR039085 DCA10
IPR000772 Ricin_B_lectin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR14588 PTHR14588, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCA10_MOUSE
AccessioniPrimary (citable) accession number: A2AKB9
Secondary accession number(s): A2AKV8
, Q3TNI7, Q5U4G6, Q8BHQ2, Q8BHS1, Q8BHX4, Q8K3A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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