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UniProtKB - A2AK42 (A2AK42_MOUSE)

Entry version 114 (10 Feb 2021)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Predicted gene 13691

Gene

Gm13697

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Predicted gene 13691Imported
Submitted name:
Predicted gene 13693Imported
Submitted name:
Predicted gene 13694Imported
Submitted name:
Predicted gene 13696Imported
Submitted name:
Predicted gene 13697Imported
Submitted name:
Predicted gene 13698Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gm13697Imported
Synonyms:Gm13691Imported, Gm13693Imported, Gm13694Imported, Gm13696Imported, Gm13698Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:3702053, Gm13691
MGI:3702055, Gm13693
MGI:3702064, Gm13694
MGI:3702068, Gm13696
MGI:3702070, Gm13697
MGI:3702072, Gm13698

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A2AK42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000079247, Expressed in epiblast (generic) and 17 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2AK42, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000137026

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2AK42

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini459 – 575MIInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 121DisorderedSequence analysisAdd BLAST121
Regioni404 – 448DisorderedSequence analysisAdd BLAST45
Regioni659 – 830DisorderedSequence analysisAdd BLAST172

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 94PolyampholyteSequence analysisAdd BLAST84
Compositional biasi418 – 442AcidicSequence analysisAdd BLAST25
Compositional biasi668 – 721PolarSequence analysisAdd BLAST54
Compositional biasi727 – 830PolyampholyteSequence analysisAdd BLAST104

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2140, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153458

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006308_1_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		RYTEREW

TreeFam database of animal gene trees

More...TreeFami		TF300510

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51366, MI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AK42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSSVAHMKQ SSGHNRRETH SSYCRSSSPE DRYTEQERFP RDRDYSDYSR 
        60         70         80         90        100
SDYERSRRGY SYDDSMESRS RDREKRRERE RDADHRKRPW KSPSPDRSPA 
       110        120        130        140        150
RGIRQSSPQE EPTWKKKKDE LDPLLTRTGG AYIPPAKLRM MQEQITDKSS 
       160        170        180        190        200
LAYQRMSWEA LKKSINGLIN KVNISNISII IQELLQENIV RGRGLLSRSV 
       210        220        230        240        250
LQAQSASPIF THVYAALVAI INSKFPQIGE LILKRLILNF RKGYRRNDKQ 
       260        270        280        290        300
LCLTASKFVA HLINQNVAHE VLCLEMLTLL LERPTDDSVE VAIGFLKECG 
       310        320        330        340        350
LKLAQVSPRG INAIFERLRN ILHESEIDKR VQYMIEVMFA VRKDGFKDHP 
       360        370        380        390        400
VILEGLDLVE EDDQFTHMLP LEDDYNPEDV LNVFKMDPNF MENEEKYKAI 
       410        420        430        440        450
KKEILDEGDS DSNTDQGAGS SEDEEEEEEE EEEEEEEGED EEGGQKVTIH 
       460        470        480        490        500
DKTEINLVSF RRTIYLAIQS SLDFEECAHK LLKMEFAESQ TKELCNMILD 
       510        520        530        540        550
CCAQQRTYEN FFGLLAGRFC MLEKEYMESF ESIFKEQYDT IHRLETNKLR 
       560        570        580        590        600
NVAKVFAHLL YTDSLPWSVL ECIKLSEETT TSSSRIFVKI FFQELCEYMG 
       610        620        630        640        650
LPKLNARLKD ETLQPFFEGL LPRDNPRNTR FAINFFTSIG LGGLTDELRE 
       660        670        680        690        700
HLKNTPKVIV AQKPEAEQKK TALTSSSSES SSASDSSDSD SDSSESSSES 
       710        720        730        740        750
SSEASDSSSS SSTQSSTSAK GTRKKRQGKA RGEEVDKLAR GHQALERRQG 
       760        770        780        790        800
GREDQRHQEG RTERARSERH RAQNSRDADW RDSLAKHIDD RSHENSHSRV 
       810        820        830
GNGREQGSHR EPEDRHGEPK KKQREKRFFL
Length:830
Mass (Da):95,672
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i309900E1764D8D32
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QNR0J3QNR0_MOUSE
Predicted gene 13693
Gm13697 Gm13693, Gm13694, Gm13696, Gm13698
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL772256 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000099947; ENSMUSP00000097530; ENSMUSG00000079247
ENSMUST00000099948; ENSMUSP00000097531; ENSMUSG00000095824
ENSMUST00000178533; ENSMUSP00000135979; ENSMUSG00000096337
ENSMUST00000178960; ENSMUSP00000136546; ENSMUSG00000094336
ENSMUST00000179192; ENSMUSP00000137026; ENSMUSG00000094125
ENSMUST00000180347; ENSMUSP00000137022; ENSMUSG00000096484

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772256 Genomic DNA No translation available.

3D structure databases

SMRiA2AK42
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137026

Proteomic databases

PRIDEiA2AK42

Genome annotation databases

EnsembliENSMUST00000099947; ENSMUSP00000097530; ENSMUSG00000079247
ENSMUST00000099948; ENSMUSP00000097531; ENSMUSG00000095824
ENSMUST00000178533; ENSMUSP00000135979; ENSMUSG00000096337
ENSMUST00000178960; ENSMUSP00000136546; ENSMUSG00000094336
ENSMUST00000179192; ENSMUSP00000137026; ENSMUSG00000094125
ENSMUST00000180347; ENSMUSP00000137022; ENSMUSG00000096484

Organism-specific databases

MGIiMGI:3702053, Gm13691
MGI:3702055, Gm13693
MGI:3702064, Gm13694
MGI:3702068, Gm13696
MGI:3702070, Gm13697
MGI:3702072, Gm13698

Phylogenomic databases

eggNOGiKOG2140, Eukaryota
GeneTreeiENSGT00940000153458
HOGENOMiCLU_006308_1_0_1
OMAiRYTEREW
TreeFamiTF300510

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Gm13691, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000079247, Expressed in epiblast (generic) and 17 other tissues
ExpressionAtlasiA2AK42, baseline

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
PfamiView protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
SMARTiView protein in SMART
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51366, MI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AK42_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AK42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: February 10, 2021
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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