UniProtKB - A2AJX4 (MALR1_MOUSE)
Protein
MAM and LDL-receptor class A domain-containing protein 1
Gene
Malrd1
Organism
Mus musculus (Mouse)
Status
Functioni
Enhances production and/or transport of FGF15 and thus has a role in regulation of bile acid synthesis.1 Publication
GO - Biological processi
- cholesterol homeostasis Source: MGI
- negative regulation of bile acid biosynthetic process Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: MAM and LDL-receptor class A domain-containing protein 1Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1928271 Malrd1 |
Subcellular locationi
Other locations
- Cytoplasmic vesicle membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Golgi apparatus
- Golgi apparatus Source: MGI
Other locations
- cytoplasm Source: MGI
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 2039 | VesicularCuratedAdd BLAST | 2013 | |
Transmembranei | 2040 – 2060 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2061 – 2123 | CytoplasmicCuratedAdd BLAST | 63 |
Keywords - Cellular componenti
Cytoplasmic vesicle, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5007184230 | 27 – 2123 | MAM and LDL-receptor class A domain-containing protein 1Sequence analysisAdd BLAST | 2097 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 40 ↔ 58 | PROSITE-ProRule annotation | ||
Disulfide bondi | 52 ↔ 67 | PROSITE-ProRule annotation | ||
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 400 ↔ 412 | PROSITE-ProRule annotation | ||
Disulfide bondi | 419 ↔ 436 | PROSITE-ProRule annotation | ||
Disulfide bondi | 789 ↔ 803 | PROSITE-ProRule annotation | ||
Disulfide bondi | 797 ↔ 816 | PROSITE-ProRule annotation | ||
Disulfide bondi | 810 ↔ 825 | PROSITE-ProRule annotation | ||
Glycosylationi | 1015 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1016 ↔ 1029 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1023 ↔ 1042 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1036 ↔ 1051 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1230 ↔ 1242 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1237 ↔ 1255 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1249 ↔ 1266 | PROSITE-ProRule annotation | ||
Glycosylationi | 1380 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1449 ↔ 1461 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1456 ↔ 1474 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1468 ↔ 1483 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1650 ↔ 1663 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1658 ↔ 1676 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1670 ↔ 1685 | PROSITE-ProRule annotation | ||
Glycosylationi | 1749 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1869 ↔ 1882 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1876 ↔ 1895 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1889 ↔ 1904 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1913 ↔ 1925 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1920 ↔ 1938 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1932 ↔ 1947 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1952 ↔ 1965 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1959 ↔ 1978 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1972 ↔ 1988 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1991 ↔ 2002 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1996 ↔ 2011 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2013 ↔ 2022 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | A2AJX4 |
PRIDEi | A2AJX4 |
PTM databases
PhosphoSitePlusi | A2AJX4 |
Expressioni
Tissue specificityi
Strongly expressed in epithelial cells of the small intestine. Also detected in kidney cortex, and testis.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000075520 Expressed in 5 organ(s), highest expression level in colon |
Interactioni
Subunit structurei
Interacts with FGF15.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 68 | LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 71 – 235 | MAM 1PROSITE-ProRule annotationAdd BLAST | 165 | |
Domaini | 234 – 402 | MAM 2PROSITE-ProRule annotationAdd BLAST | 169 | |
Domaini | 399 – 437 | LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 443 – 603 | MAM 3PROSITE-ProRule annotationAdd BLAST | 161 | |
Domaini | 618 – 782 | MAM 4PROSITE-ProRule annotationAdd BLAST | 165 | |
Domaini | 788 – 826 | LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 829 – 990 | MAM 5PROSITE-ProRule annotationAdd BLAST | 162 | |
Domaini | 1015 – 1052 | LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 1054 – 1222 | MAM 6PROSITE-ProRule annotationAdd BLAST | 169 | |
Domaini | 1229 – 1267 | LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1271 – 1431 | MAM 7PROSITE-ProRule annotationAdd BLAST | 161 | |
Domaini | 1448 – 1484 | LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1485 – 1642 | MAM 8PROSITE-ProRule annotationAdd BLAST | 158 | |
Domaini | 1649 – 1686 | LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 1693 – 1858 | MAM 9PROSITE-ProRule annotationAdd BLAST | 166 | |
Domaini | 1868 – 1905 | LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 1912 – 1948 | LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1951 – 1989 | LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1990 – 2023 | EGF-likePROSITE-ProRule annotationAdd BLAST | 34 |
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IGZP Eukaryota ENOG410XPKY LUCA |
GeneTreei | ENSGT00940000158809 |
HOGENOMi | HOG000197794 |
InParanoidi | A2AJX4 |
OMAi | LPPHNCT |
OrthoDBi | 72691at2759 |
TreeFami | TF343455 |
Family and domain databases
CDDi | cd00112 LDLa, 9 hits cd06263 MAM, 8 hits |
InterProi | View protein in InterPro IPR013320 ConA-like_dom_sf IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR000998 MAM_dom |
Pfami | View protein in Pfam PF00057 Ldl_recept_a, 4 hits PF00629 MAM, 9 hits |
PRINTSi | PR00261 LDLRECEPTOR PR00020 MAMDOMAIN |
SMARTi | View protein in SMART SM00181 EGF, 1 hit SM00192 LDLa, 10 hits SM00137 MAM, 8 hits |
SUPFAMi | SSF49899 SSF49899, 9 hits SSF57424 SSF57424, 9 hits |
PROSITEi | View protein in PROSITE PS00022 EGF_1, 1 hit PS01186 EGF_2, 1 hit PS50026 EGF_3, 1 hit PS01209 LDLRA_1, 6 hits PS50068 LDLRA_2, 9 hits PS50060 MAM_2, 9 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A2AJX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLPKAAVSA FSMHGSLCFL WTVCLSISPL SQQGVQAFQC SNGVSLPSDY
60 70 80 90 100
VCDFTDHCGD NSEEQQCWSY GRCNFEDRLC SMTEDQTLQP GWTRRSGIIS
110 120 130 140 150
NSPPFWDHNG NISAHFLALV SRVDSISSNL RSRIFLPTND QQVCQITFYN
160 170 180 190 200
FSSNQNGKLI AGLQTLCGDP IEHLWQKTEI LQSRWERNVI TVQSSQQFQV
210 220 230 240 250
IFQAQMLATH GQEEVIAIDD ISFSSGCLPA DVCQTCGFDL DTCGLATEAS
260 270 280 290 300
AGRTSWMCTK VREIPSLDSV PWQDQRGHDE GSFVWMRAGH ASVSRLVESS
310 320 330 340 350
AYLNSSVCHC MDGNCRLQFN YTMENSILRV RLYNDKEEKK TWTFNTSTYS
360 370 380 390 400
TWMKADVLIP EDLKAFKVVL EGTVLSQKSF IGIDQLLVYN FGQTHSQKLC
410 420 430 440 450
SVNEYTPASR QCLTHSSVCD SGMDHSNGID EDSEACASLL TWDFESGFCG
460 470 480 490 500
WEPFPTEDSH WEVVRGLSNG EHLFLEAGHT VSRNQGSFIY FGPQKSTAVA
510 520 530 540 550
RLGSPILTKS LTTFTPCQVR FWYHLSEHSS LSVFTRTSVD GSLLKQSEVT
560 570 580 590 600
QFSDSQWSQA KVDLHAKAEE STLPFQLVLE ATILSSNATV AVDDISISHE
610 620 630 640 650
CEISYKSLRS TSIQNKVADC DFEANSCGWF EASGGDHFDW VWSSQSNLSA
660 670 680 690 700
DLEQQAPPRD HTHGTAQGHF MFILKTSNSL FQTAKLQSPT FSQTGPGCTM
710 720 730 740 750
SFWFYNYGLS VGAAELQLHL ENSRDTTALW RVLYNQGNQW SEATVQLGRL
760 770 780 790 800
TQPFYLSLEK VSLAVYSGVS AVDDIHFENC ALPPPVESCD EPDHFWCRQT
810 820 830 840 850
KACIGRHQLC DLVDDCGDYT DETGCAPGLQ CNFENGICNW EQSTKDDFNW
860 870 880 890 900
TRYQGPTSTM NTGPMKDHTL GTAKGHYLYI ETSGPQGFQD KAVLLSPILN
910 920 930 940 950
ATEAKVCTFR LYYHMFGKHI YRLAIYQRIW SNTKGQLLWQ IFGDQGNRWI
960 970 980 990 1000
RKDLSITSRK PFQILIMASV GDGFTGDIAI DDLSFMDCTL YPDNLPMDIP
1010 1020 1030 1040 1050
SPPETSVPVT LPPNNCTDDQ FVCRSNGHCV GNIQKCDFRY DCIDKSDESS
1060 1070 1080 1090 1100
CVLEVCTFEE RKLCKWYQPI PANSLHDSNT FRWGLGNGIS IHHGEENHRP
1110 1120 1130 1140 1150
SVDHTKNTTD GWYLYADSSN GKFGDLADIV TPVISLMGPR CTLVFWTYMN
1160 1170 1180 1190 1200
GATVGSLQVL IKMGNTISKV WAQSGQQGPQ WKKAEVFLGI HSHVEIVFRA
1210 1220 1230 1240 1250
KRGVSYIGDV AVDDVSFQNC SPLLSTNRKC TTDEFMCANK HCIEKDKLCD
1260 1270 1280 1290 1300
FVNDCADNSD ETTFICGTSS GRCDFEFDLC TWEQDQDEDI DWNLKASNIP
1310 1320 1330 1340 1350
ATSTEPAVDH TLGNSSGHYI ILKSFFPQQP VKTGRISSPV ISKRSKDCKI
1360 1370 1380 1390 1400
IFNYHMYGSG IAALLLLQVT VTNHTRVLLN LTKEQGNFWQ RKELSLSSDE
1410 1420 1430 1440 1450
DFRVKFEGRV GEGIRGNIAL DDIVLTKSCL PSHHSTREEP AFPLPTGFCP
1460 1470 1480 1490 1500
RGYEECQNGR CYSPEQRCNF VDDCGDNSDE NECGGSCTFE KGWCGWKNSL
1510 1520 1530 1540 1550
AENSDWVLGI GSYKSQRPPK DHTLGNEHGH FMYLEATPVG LHGDKAHFKS
1560 1570 1580 1590 1600
ATWQESSAAC TMSFWYFISA KATGSIQILI KTDKGLWEVW QQSKPDPGNH
1610 1620 1630 1640 1650
WRRATILLGK LRNFEVIFQG IRTRDLGGGA AIDDIEFNNC TTVGETTDIC
1660 1670 1680 1690 1700
SEETDFLCQD KKCIASHLVC DYKPDCSDTS DEAHCGYYTS TAGSCNFETT
1710 1720 1730 1740 1750
SGDWTVECGL TQDPEDDLDW SIGSIIPTEG LSRDSDHTPG SGRHFLYVNT
1760 1770 1780 1790 1800
SLAEEGSTAR IITSHFFPAS LGICTVRFWF YMVDPHIVGI LKVYLIEKSG
1810 1820 1830 1840 1850
LNILMWSMMR NKNTGWTYAH VPLSSNSPFK VAFEADLGGK EDIFIALDDI
1860 1870 1880 1890 1900
TFTPTCASGG PALPQPPLCE EGQFACIYAL QCVSASEKCD GQEDCIDGSD
1910 1920 1930 1940 1950
EMNCSLGPSP QPCSDTEFQC FESQCIPSLL LCDGVADCQF NEDESSCVNQ
1960 1970 1980 1990 2000
SCPSGALACN SSGLCIPAHQ RCDGTAHCKD IQVDESSCSE CPIHYCRNGG
2010 2020 2030 2040 2050
TCVIENIGPT CRCVQGWTGN RCHIRSNLST EGSVHTQNYI WTLLGIGLGF
2060 2070 2080 2090 2100
LLTHIAVAIL CSLGIRRRPM RKSEGVGNHS FINPVYRNCI NQEKTQSSIY
2110 2120
SFPNPFYGAA SGSLETVSHH LKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC836882 mRNA Translation: AGN95783.1 AL772224 Genomic DNA No translation available. AL844839 Genomic DNA No translation available. AL845271 Genomic DNA No translation available. AL845417 Genomic DNA No translation available. AL845543 Genomic DNA No translation available. AL928841 Genomic DNA No translation available. AL935116 Genomic DNA No translation available. |
CCDSi | CCDS79736.1 |
RefSeqi | NP_001297384.1, NM_001310455.1 |
Genome annotation databases
Ensembli | ENSMUST00000146205; ENSMUSP00000116869; ENSMUSG00000075520 |
GeneIDi | 102635496 |
KEGGi | mmu:102635496 |
UCSCi | uc033hll.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC836882 mRNA Translation: AGN95783.1 AL772224 Genomic DNA No translation available. AL844839 Genomic DNA No translation available. AL845271 Genomic DNA No translation available. AL845417 Genomic DNA No translation available. AL845543 Genomic DNA No translation available. AL928841 Genomic DNA No translation available. AL935116 Genomic DNA No translation available. |
CCDSi | CCDS79736.1 |
RefSeqi | NP_001297384.1, NM_001310455.1 |
3D structure databases
SMRi | A2AJX4 |
ModBasei | Search... |
MobiDBi | Search... |
PTM databases
PhosphoSitePlusi | A2AJX4 |
Proteomic databases
PaxDbi | A2AJX4 |
PRIDEi | A2AJX4 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000146205; ENSMUSP00000116869; ENSMUSG00000075520 |
GeneIDi | 102635496 |
KEGGi | mmu:102635496 |
UCSCi | uc033hll.1 mouse |
Organism-specific databases
CTDi | 340895 |
MGIi | MGI:1928271 Malrd1 |
Phylogenomic databases
eggNOGi | ENOG410IGZP Eukaryota ENOG410XPKY LUCA |
GeneTreei | ENSGT00940000158809 |
HOGENOMi | HOG000197794 |
InParanoidi | A2AJX4 |
OMAi | LPPHNCT |
OrthoDBi | 72691at2759 |
TreeFami | TF343455 |
Miscellaneous databases
ChiTaRSi | Malrd1 mouse |
PROi | PR:A2AJX4 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000075520 Expressed in 5 organ(s), highest expression level in colon |
Family and domain databases
CDDi | cd00112 LDLa, 9 hits cd06263 MAM, 8 hits |
InterProi | View protein in InterPro IPR013320 ConA-like_dom_sf IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR000998 MAM_dom |
Pfami | View protein in Pfam PF00057 Ldl_recept_a, 4 hits PF00629 MAM, 9 hits |
PRINTSi | PR00261 LDLRECEPTOR PR00020 MAMDOMAIN |
SMARTi | View protein in SMART SM00181 EGF, 1 hit SM00192 LDLa, 10 hits SM00137 MAM, 8 hits |
SUPFAMi | SSF49899 SSF49899, 9 hits SSF57424 SSF57424, 9 hits |
PROSITEi | View protein in PROSITE PS00022 EGF_1, 1 hit PS01186 EGF_2, 1 hit PS50026 EGF_3, 1 hit PS01209 LDLRA_1, 6 hits PS50068 LDLRA_2, 9 hits PS50060 MAM_2, 9 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | MALR1_MOUSE | |
Accessioni | A2AJX4Primary (citable) accession number: A2AJX4 Secondary accession number(s): R9W764 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 6, 2016 |
Last sequence update: | February 4, 2015 | |
Last modified: | January 16, 2019 | |
This is version 89 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot