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UniProtKB - A2AJX4 (MALR1_MOUSE)

Entry version 92 (16 Oct 2019)
Sequence version 2 (04 Feb 2015)
Previous versions | rss
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Protein

MAM and LDL-receptor class A domain-containing protein 1

Gene

Malrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances production and/or transport of FGF15 and thus has a role in regulation of bile acid synthesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAM and LDL-receptor class A domain-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Malrd1Imported
Synonyms:Diet11 Publication, Gm13318Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1928271 Malrd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 2039VesicularCuratedAdd BLAST2013
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2040 – 2060HelicalSequence analysisAdd BLAST21
Topological domaini2061 – 2123CytoplasmicCuratedAdd BLAST63

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable, with enhanced resistance to diet-induced hypercholesterolemia and atherosclerosis (PubMed:10744778). Increased bile acid levels in blood, liver and gastrointestinal tract, associated with significantly reduced levels of FGF15 in the ileum (PubMed:23747249).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500718423027 – 2123MAM and LDL-receptor class A domain-containing protein 1Sequence analysisAdd BLAST2097

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 58PROSITE-ProRule annotation
Disulfide bondi52 ↔ 67PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi400 ↔ 412PROSITE-ProRule annotation
Disulfide bondi419 ↔ 436PROSITE-ProRule annotation
Disulfide bondi789 ↔ 803PROSITE-ProRule annotation
Disulfide bondi797 ↔ 816PROSITE-ProRule annotation
Disulfide bondi810 ↔ 825PROSITE-ProRule annotation
Glycosylationi1015N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1016 ↔ 1029PROSITE-ProRule annotation
Disulfide bondi1023 ↔ 1042PROSITE-ProRule annotation
Disulfide bondi1036 ↔ 1051PROSITE-ProRule annotation
Disulfide bondi1230 ↔ 1242PROSITE-ProRule annotation
Disulfide bondi1237 ↔ 1255PROSITE-ProRule annotation
Disulfide bondi1249 ↔ 1266PROSITE-ProRule annotation
Glycosylationi1380N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1449 ↔ 1461PROSITE-ProRule annotation
Disulfide bondi1456 ↔ 1474PROSITE-ProRule annotation
Disulfide bondi1468 ↔ 1483PROSITE-ProRule annotation
Disulfide bondi1650 ↔ 1663PROSITE-ProRule annotation
Disulfide bondi1658 ↔ 1676PROSITE-ProRule annotation
Disulfide bondi1670 ↔ 1685PROSITE-ProRule annotation
Glycosylationi1749N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1869 ↔ 1882PROSITE-ProRule annotation
Disulfide bondi1876 ↔ 1895PROSITE-ProRule annotation
Disulfide bondi1889 ↔ 1904PROSITE-ProRule annotation
Disulfide bondi1913 ↔ 1925PROSITE-ProRule annotation
Disulfide bondi1920 ↔ 1938PROSITE-ProRule annotation
Disulfide bondi1932 ↔ 1947PROSITE-ProRule annotation
Disulfide bondi1952 ↔ 1965PROSITE-ProRule annotation
Disulfide bondi1959 ↔ 1978PROSITE-ProRule annotation
Disulfide bondi1972 ↔ 1988PROSITE-ProRule annotation
Disulfide bondi1991 ↔ 2002PROSITE-ProRule annotation
Disulfide bondi1996 ↔ 2011PROSITE-ProRule annotation
Disulfide bondi2013 ↔ 2022PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2AJX4

PRoteomics IDEntifications database

More...PRIDEi		A2AJX4

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2AJX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in epithelial cells of the small intestine. Also detected in kidney cortex, and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000075520 Expressed in 5 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FGF15.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000116869

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2AJX4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 68LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST42
Domaini71 – 235MAM 1PROSITE-ProRule annotationAdd BLAST165
Domaini234 – 402MAM 2PROSITE-ProRule annotationAdd BLAST169
Domaini399 – 437LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST39
Domaini443 – 603MAM 3PROSITE-ProRule annotationAdd BLAST161
Domaini618 – 782MAM 4PROSITE-ProRule annotationAdd BLAST165
Domaini788 – 826LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini829 – 990MAM 5PROSITE-ProRule annotationAdd BLAST162
Domaini1015 – 1052LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini1054 – 1222MAM 6PROSITE-ProRule annotationAdd BLAST169
Domaini1229 – 1267LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST39
Domaini1271 – 1431MAM 7PROSITE-ProRule annotationAdd BLAST161
Domaini1448 – 1484LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST37
Domaini1485 – 1642MAM 8PROSITE-ProRule annotationAdd BLAST158
Domaini1649 – 1686LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST38
Domaini1693 – 1858MAM 9PROSITE-ProRule annotationAdd BLAST166
Domaini1868 – 1905LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST38
Domaini1912 – 1948LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST37
Domaini1951 – 1989LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST39
Domaini1990 – 2023EGF-likePROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IGZP Eukaryota
ENOG410XPKY LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158809

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000197794

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2AJX4

Identification of Orthologs from Complete Genome Data

More...OMAi		MWTDIAL

Database of Orthologous Groups

More...OrthoDBi		72691at2759

TreeFam database of animal gene trees

More...TreeFami		TF343455

Family and domain databases

Conserved Domains Database

More...CDDi		cd00112 LDLa, 9 hits
cd06263 MAM, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.400.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR000998 MAM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00057 Ldl_recept_a, 4 hits
PF00629 MAM, 9 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00261 LDLRECEPTOR
PR00020 MAMDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181 EGF, 1 hit
SM00192 LDLa, 10 hits
SM00137 MAM, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899 SSF49899, 9 hits
SSF57424 SSF57424, 9 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01209 LDLRA_1, 6 hits
PS50068 LDLRA_2, 9 hits
PS50060 MAM_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A2AJX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLPKAAVSA FSMHGSLCFL WTVCLSISPL SQQGVQAFQC SNGVSLPSDY 
        60         70         80         90        100
VCDFTDHCGD NSEEQQCWSY GRCNFEDRLC SMTEDQTLQP GWTRRSGIIS 
       110        120        130        140        150
NSPPFWDHNG NISAHFLALV SRVDSISSNL RSRIFLPTND QQVCQITFYN 
       160        170        180        190        200
FSSNQNGKLI AGLQTLCGDP IEHLWQKTEI LQSRWERNVI TVQSSQQFQV 
       210        220        230        240        250
IFQAQMLATH GQEEVIAIDD ISFSSGCLPA DVCQTCGFDL DTCGLATEAS 
       260        270        280        290        300
AGRTSWMCTK VREIPSLDSV PWQDQRGHDE GSFVWMRAGH ASVSRLVESS 
       310        320        330        340        350
AYLNSSVCHC MDGNCRLQFN YTMENSILRV RLYNDKEEKK TWTFNTSTYS 
       360        370        380        390        400
TWMKADVLIP EDLKAFKVVL EGTVLSQKSF IGIDQLLVYN FGQTHSQKLC 
       410        420        430        440        450
SVNEYTPASR QCLTHSSVCD SGMDHSNGID EDSEACASLL TWDFESGFCG 
       460        470        480        490        500
WEPFPTEDSH WEVVRGLSNG EHLFLEAGHT VSRNQGSFIY FGPQKSTAVA 
       510        520        530        540        550
RLGSPILTKS LTTFTPCQVR FWYHLSEHSS LSVFTRTSVD GSLLKQSEVT 
       560        570        580        590        600
QFSDSQWSQA KVDLHAKAEE STLPFQLVLE ATILSSNATV AVDDISISHE 
       610        620        630        640        650
CEISYKSLRS TSIQNKVADC DFEANSCGWF EASGGDHFDW VWSSQSNLSA 
       660        670        680        690        700
DLEQQAPPRD HTHGTAQGHF MFILKTSNSL FQTAKLQSPT FSQTGPGCTM 
       710        720        730        740        750
SFWFYNYGLS VGAAELQLHL ENSRDTTALW RVLYNQGNQW SEATVQLGRL 
       760        770        780        790        800
TQPFYLSLEK VSLAVYSGVS AVDDIHFENC ALPPPVESCD EPDHFWCRQT 
       810        820        830        840        850
KACIGRHQLC DLVDDCGDYT DETGCAPGLQ CNFENGICNW EQSTKDDFNW 
       860        870        880        890        900
TRYQGPTSTM NTGPMKDHTL GTAKGHYLYI ETSGPQGFQD KAVLLSPILN 
       910        920        930        940        950
ATEAKVCTFR LYYHMFGKHI YRLAIYQRIW SNTKGQLLWQ IFGDQGNRWI 
       960        970        980        990       1000
RKDLSITSRK PFQILIMASV GDGFTGDIAI DDLSFMDCTL YPDNLPMDIP 
      1010       1020       1030       1040       1050
SPPETSVPVT LPPNNCTDDQ FVCRSNGHCV GNIQKCDFRY DCIDKSDESS 
      1060       1070       1080       1090       1100
CVLEVCTFEE RKLCKWYQPI PANSLHDSNT FRWGLGNGIS IHHGEENHRP 
      1110       1120       1130       1140       1150
SVDHTKNTTD GWYLYADSSN GKFGDLADIV TPVISLMGPR CTLVFWTYMN 
      1160       1170       1180       1190       1200
GATVGSLQVL IKMGNTISKV WAQSGQQGPQ WKKAEVFLGI HSHVEIVFRA 
      1210       1220       1230       1240       1250
KRGVSYIGDV AVDDVSFQNC SPLLSTNRKC TTDEFMCANK HCIEKDKLCD 
      1260       1270       1280       1290       1300
FVNDCADNSD ETTFICGTSS GRCDFEFDLC TWEQDQDEDI DWNLKASNIP 
      1310       1320       1330       1340       1350
ATSTEPAVDH TLGNSSGHYI ILKSFFPQQP VKTGRISSPV ISKRSKDCKI 
      1360       1370       1380       1390       1400
IFNYHMYGSG IAALLLLQVT VTNHTRVLLN LTKEQGNFWQ RKELSLSSDE 
      1410       1420       1430       1440       1450
DFRVKFEGRV GEGIRGNIAL DDIVLTKSCL PSHHSTREEP AFPLPTGFCP 
      1460       1470       1480       1490       1500
RGYEECQNGR CYSPEQRCNF VDDCGDNSDE NECGGSCTFE KGWCGWKNSL 
      1510       1520       1530       1540       1550
AENSDWVLGI GSYKSQRPPK DHTLGNEHGH FMYLEATPVG LHGDKAHFKS 
      1560       1570       1580       1590       1600
ATWQESSAAC TMSFWYFISA KATGSIQILI KTDKGLWEVW QQSKPDPGNH 
      1610       1620       1630       1640       1650
WRRATILLGK LRNFEVIFQG IRTRDLGGGA AIDDIEFNNC TTVGETTDIC 
      1660       1670       1680       1690       1700
SEETDFLCQD KKCIASHLVC DYKPDCSDTS DEAHCGYYTS TAGSCNFETT 
      1710       1720       1730       1740       1750
SGDWTVECGL TQDPEDDLDW SIGSIIPTEG LSRDSDHTPG SGRHFLYVNT 
      1760       1770       1780       1790       1800
SLAEEGSTAR IITSHFFPAS LGICTVRFWF YMVDPHIVGI LKVYLIEKSG 
      1810       1820       1830       1840       1850
LNILMWSMMR NKNTGWTYAH VPLSSNSPFK VAFEADLGGK EDIFIALDDI 
      1860       1870       1880       1890       1900
TFTPTCASGG PALPQPPLCE EGQFACIYAL QCVSASEKCD GQEDCIDGSD 
      1910       1920       1930       1940       1950
EMNCSLGPSP QPCSDTEFQC FESQCIPSLL LCDGVADCQF NEDESSCVNQ 
      1960       1970       1980       1990       2000
SCPSGALACN SSGLCIPAHQ RCDGTAHCKD IQVDESSCSE CPIHYCRNGG 
      2010       2020       2030       2040       2050
TCVIENIGPT CRCVQGWTGN RCHIRSNLST EGSVHTQNYI WTLLGIGLGF 
      2060       2070       2080       2090       2100
LLTHIAVAIL CSLGIRRRPM RKSEGVGNHS FINPVYRNCI NQEKTQSSIY 
      2110       2120 
SFPNPFYGAA SGSLETVSHH LKS
Length:2,123
Mass (Da):236,194
Last modified:February 4, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD6937E5F0C08F21
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KC836882 mRNA Translation: AGN95783.1
AL772224 Genomic DNA No translation available.
AL844839 Genomic DNA No translation available.
AL845271 Genomic DNA No translation available.
AL845417 Genomic DNA No translation available.
AL845543 Genomic DNA No translation available.
AL928841 Genomic DNA No translation available.
AL935116 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS79736.1

NCBI Reference Sequences

More...RefSeqi		NP_001297384.1, NM_001310455.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000146205; ENSMUSP00000116869; ENSMUSG00000075520

Database of genes from NCBI RefSeq genomes

More...GeneIDi		102635496

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:102635496

UCSC genome browser

More...UCSCi		uc033hll.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC836882 mRNA Translation: AGN95783.1
AL772224 Genomic DNA No translation available.
AL844839 Genomic DNA No translation available.
AL845271 Genomic DNA No translation available.
AL845417 Genomic DNA No translation available.
AL845543 Genomic DNA No translation available.
AL928841 Genomic DNA No translation available.
AL935116 Genomic DNA No translation available.
CCDSiCCDS79736.1
RefSeqiNP_001297384.1, NM_001310455.1

3D structure databases

SMRiA2AJX4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116869

PTM databases

PhosphoSitePlusiA2AJX4

Proteomic databases

PaxDbiA2AJX4
PRIDEiA2AJX4

Genome annotation databases

EnsembliENSMUST00000146205; ENSMUSP00000116869; ENSMUSG00000075520
GeneIDi102635496
KEGGimmu:102635496
UCSCiuc033hll.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		340895
MGIiMGI:1928271 Malrd1

Phylogenomic databases

eggNOGiENOG410IGZP Eukaryota
ENOG410XPKY LUCA
GeneTreeiENSGT00940000158809
HOGENOMiHOG000197794
InParanoidiA2AJX4
OMAiMWTDIAL
OrthoDBi72691at2759
TreeFamiTF343455

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Malrd1 mouse

Protein Ontology

More...PROi		PR:A2AJX4

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000075520 Expressed in 5 organ(s), highest expression level in colon

Family and domain databases

CDDicd00112 LDLa, 9 hits
cd06263 MAM, 8 hits
Gene3Di4.10.400.10, 9 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR000998 MAM_dom
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 4 hits
PF00629 MAM, 9 hits
PRINTSiPR00261 LDLRECEPTOR
PR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00192 LDLa, 10 hits
SM00137 MAM, 8 hits
SUPFAMiSSF49899 SSF49899, 9 hits
SSF57424 SSF57424, 9 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01209 LDLRA_1, 6 hits
PS50068 LDLRA_2, 9 hits
PS50060 MAM_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMALR1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AJX4
Secondary accession number(s): R9W764
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: February 4, 2015
Last modified: October 16, 2019
This is version 92 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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