UniProtKB - A2AJT9 (BCLA3_HUMAN)
Protein
BCLAF1 and THRAP3 family member 3
Gene
BCLAF3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: GO_Central
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | A2AJT9 |
Names & Taxonomyi
Protein namesi | Recommended name: BCLAF1 and THRAP3 family member 3Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27413, BCLAF3 |
neXtProti | NX_A2AJT9 |
VEuPathDBi | HostDB:ENSG00000173681.16 |
Subcellular locationi
Mitochondrion
- Mitochondrion Curated
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- mediator complex Source: GO_Central
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000173681 |
PharmGKBi | PA134885371 |
Miscellaneous databases
Pharosi | A2AJT9, Tdark |
Genetic variation databases
BioMutai | BCLAF3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287434 | 1 – 711 | BCLAF1 and THRAP3 family member 3Add BLAST | 711 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 17 | PhosphoserineCombined sources | 1 | |
Modified residuei | 78 | PhosphoserineCombined sources | 1 | |
Modified residuei | 80 | PhosphoserineCombined sources | 1 | |
Modified residuei | 187 | PhosphoserineBy similarity | 1 | |
Cross-linki | 400 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 402 | PhosphoserineCombined sources | 1 | |
Modified residuei | 578 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | A2AJT9 |
jPOSTi | A2AJT9 |
MassIVEi | A2AJT9 |
MaxQBi | A2AJT9 |
PaxDbi | A2AJT9 |
PeptideAtlasi | A2AJT9 |
PRIDEi | A2AJT9 |
ProteomicsDBi | 405 [A2AJT9-1] 406 [A2AJT9-2] 407 [A2AJT9-3] |
PTM databases
iPTMneti | A2AJT9 |
PhosphoSitePlusi | A2AJT9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173681, Expressed in secondary oocyte and 167 other tissues |
ExpressionAtlasi | A2AJT9, baseline and differential |
Genevisiblei | A2AJT9, HS |
Organism-specific databases
HPAi | ENSG00000173681, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129173, 3 interactors |
IntActi | A2AJT9, 3 interactors |
STRINGi | 9606.ENSP00000369009 |
Miscellaneous databases
RNActi | A2AJT9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the BCLAF1/THRAP3 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S4TN, Eukaryota |
GeneTreei | ENSGT00950000183163 |
HOGENOMi | CLU_024256_0_0_1 |
InParanoidi | A2AJT9 |
OMAi | RESDCFN |
OrthoDBi | 442192at2759 |
PhylomeDBi | A2AJT9 |
TreeFami | TF335939 |
Family and domain databases
InterProi | View protein in InterPro IPR029199, THRAP3_BCLAF1 |
PANTHERi | PTHR15268, PTHR15268, 1 hit |
Pfami | View protein in Pfam PF15440, THRAP3_BCLAF1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A2AJT9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARSRSRSPR WKHRSLSPVP RNAEHYKQRH SHGHYGCEYR KDPKRPVAWR
60 70 80 90 100
MDSEKHGQSK PRIPSRGNIY YQSYEHRSPS PNIRNSLENV YMYKPHRGYS
110 120 130 140 150
PGRGDSNRRA QYMPKYSEGI PYKEHERNSY PQKVQGGHSP DDHRVRGSGK
160 170 180 190 200
GGKPPQRSIA DSFRFEGKWH EDELRHQRIQ EEKYSQSTRR GSEDFETRSS
210 220 230 240 250
FQKRYPEDRD FRKYGHTSKR PKDVERYESR EPARNPKWKP EHSLPPYQED
260 270 280 290 300
TDQWNLGPQT YRHAEREHPE TSSATKVSYD YRHKRPKLLD GDQDFSDGRT
310 320 330 340 350
QKYCKEEDRK YSFQKGPLNR ELDCFNTGRG RETQDGQVKE PFKPSKKDSI
360 370 380 390 400
ACTYSNKNDV DLRSSNDKWK EKIKKEGDCR KESNSSSNQL DKSQKLPDVK
410 420 430 440 450
PSPINLRKKS LTVKVDVKKT VDTFRVASSY STERQMSHDL VAVGRKSENF
460 470 480 490 500
HPVFEHLDST QNTENKPTGE FAQEIITIIH QVKANYFPSP GITLHERFST
510 520 530 540 550
MQDIHKADVN EIPLNSDPEI HRRIDMSLAE LQSKQAVIYE SEQTLIKIID
560 570 580 590 600
PNDLRHDIER RRKERLQNED EHIFHIASAA ERDDQNSSFS KVKNVHTDGF
610 620 630 640 650
QKPTHFIKSN FRKCIEKPYM NYTTQRKDII THKPFEVEGN HRNTRVRPFK
660 670 680 690 700
SNFRGGRCQP NYKSGLVQKS LYIQAKYQRL RFTGPRGFIT HKFRERLMRK
710
KKEYTDVATG I
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF2Z385 | F2Z385_HUMAN | BCLAF1 and THRAP3 family member 3 | BCLAF3 | 240 | Annotation score: | ||
H7BXX2 | H7BXX2_HUMAN | BCLAF1 and THRAP3 family member 3 | BCLAF3 | 234 | Annotation score: |
Sequence cautioni
The sequence BAC04399 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC87094 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 3 (identifier: A2AJT9-3) | |||||
Sequence conflicti | 617 | S → G in BAC04399 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 622 | Q → R in BAC04399 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025458 | 592 – 711 | VKNVH…VATGI → GLALSPRLECGVTITAYCSL YLQDSSYLPPQPPE in isoform 3. 1 PublicationAdd BLAST | 120 | |
Alternative sequenceiVSP_025459 | 592 – 620 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL772197 Genomic DNA No translation available. AK094661 mRNA Translation: BAC04399.1 Different initiation. AK127709 mRNA Translation: BAC87094.1 Different initiation. BC126172 mRNA Translation: AAI26173.1 |
CCDSi | CCDS14194.2 [A2AJT9-2] |
RefSeqi | NP_938020.2, NM_198279.3 [A2AJT9-2] XP_005274530.1, XM_005274473.3 [A2AJT9-1] XP_011543777.1, XM_011545475.2 [A2AJT9-1] XP_011543778.1, XM_011545476.2 [A2AJT9-1] XP_011543779.1, XM_011545477.2 [A2AJT9-2] |
Genome annotation databases
Ensembli | ENST00000379682; ENSP00000369004; ENSG00000173681 [A2AJT9-1] ENST00000379687; ENSP00000369009; ENSG00000173681 [A2AJT9-2] |
GeneIDi | 256643 |
KEGGi | hsa:256643 |
UCSCi | uc004czp.4, human [A2AJT9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL772197 Genomic DNA No translation available. AK094661 mRNA Translation: BAC04399.1 Different initiation. AK127709 mRNA Translation: BAC87094.1 Different initiation. BC126172 mRNA Translation: AAI26173.1 |
CCDSi | CCDS14194.2 [A2AJT9-2] |
RefSeqi | NP_938020.2, NM_198279.3 [A2AJT9-2] XP_005274530.1, XM_005274473.3 [A2AJT9-1] XP_011543777.1, XM_011545475.2 [A2AJT9-1] XP_011543778.1, XM_011545476.2 [A2AJT9-1] XP_011543779.1, XM_011545477.2 [A2AJT9-2] |
3D structure databases
SMRi | A2AJT9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129173, 3 interactors |
IntActi | A2AJT9, 3 interactors |
STRINGi | 9606.ENSP00000369009 |
PTM databases
iPTMneti | A2AJT9 |
PhosphoSitePlusi | A2AJT9 |
Genetic variation databases
BioMutai | BCLAF3 |
Proteomic databases
EPDi | A2AJT9 |
jPOSTi | A2AJT9 |
MassIVEi | A2AJT9 |
MaxQBi | A2AJT9 |
PaxDbi | A2AJT9 |
PeptideAtlasi | A2AJT9 |
PRIDEi | A2AJT9 |
ProteomicsDBi | 405 [A2AJT9-1] 406 [A2AJT9-2] 407 [A2AJT9-3] |
Protocols and materials databases
Antibodypediai | 9758, 34 antibodies |
Genome annotation databases
Ensembli | ENST00000379682; ENSP00000369004; ENSG00000173681 [A2AJT9-1] ENST00000379687; ENSP00000369009; ENSG00000173681 [A2AJT9-2] |
GeneIDi | 256643 |
KEGGi | hsa:256643 |
UCSCi | uc004czp.4, human [A2AJT9-1] |
Organism-specific databases
CTDi | 256643 |
GeneCardsi | BCLAF3 |
HGNCi | HGNC:27413, BCLAF3 |
HPAi | ENSG00000173681, Low tissue specificity |
neXtProti | NX_A2AJT9 |
OpenTargetsi | ENSG00000173681 |
PharmGKBi | PA134885371 |
VEuPathDBi | HostDB:ENSG00000173681.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4TN, Eukaryota |
GeneTreei | ENSGT00950000183163 |
HOGENOMi | CLU_024256_0_0_1 |
InParanoidi | A2AJT9 |
OMAi | RESDCFN |
OrthoDBi | 442192at2759 |
PhylomeDBi | A2AJT9 |
TreeFami | TF335939 |
Enzyme and pathway databases
PathwayCommonsi | A2AJT9 |
Miscellaneous databases
BioGRID-ORCSi | 256643, 6 hits in 504 CRISPR screens |
ChiTaRSi | CXorf23, human |
GenomeRNAii | 256643 |
Pharosi | A2AJT9, Tdark |
PROi | PR:A2AJT9 |
RNActi | A2AJT9, protein |
Gene expression databases
Bgeei | ENSG00000173681, Expressed in secondary oocyte and 167 other tissues |
ExpressionAtlasi | A2AJT9, baseline and differential |
Genevisiblei | A2AJT9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029199, THRAP3_BCLAF1 |
PANTHERi | PTHR15268, PTHR15268, 1 hit |
Pfami | View protein in Pfam PF15440, THRAP3_BCLAF1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCLA3_HUMAN | |
Accessioni | A2AJT9Primary (citable) accession number: A2AJT9 Secondary accession number(s): A1A4E8 Q8N1W7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families