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Protein

Arginine/serine-rich protein PNISR

Gene

Pnisr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arginine/serine-rich protein PNISR
Alternative name(s):
Serine/arginine-rich-splicing regulatory protein 130
Short name:
SRrp130
Splicing factor, arginine/serine-rich 130
Splicing factor, arginine/serine-rich 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pnisr
Synonyms:Sfrs18, Srrp130
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913875 Pnisr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002926551 – 805Arginine/serine-rich protein PNISRAdd BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei204PhosphoserineBy similarity1
Modified residuei211PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei290PhosphoserineBy similarity1
Modified residuei304PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1
Modified residuei467PhosphoserineBy similarity1
Modified residuei485PhosphothreonineBy similarity1
Cross-linki496Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki703Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei726PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AJT4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AJT4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AJT4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AJT4

PeptideAtlas

More...
PeptideAtlasi
A2AJT4

PRoteomics IDEntifications database

More...
PRIDEi
A2AJT4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AJT4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AJT4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028248 Expressed in 254 organ(s), highest expression level in metanephric cortical collecting duct

CleanEx database of gene expression profiles

More...
CleanExi
MM_SFRS18

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AJT4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AJT4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PNN.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A2AJT4, 1 interactor

Molecular INTeraction database

More...
MINTi
A2AJT4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000029911

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AJT4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili237 – 276Sequence analysisAdd BLAST40
Coiled coili427 – 461Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 56Gln-richAdd BLAST53
Compositional biasi100 – 222Pro-richAdd BLAST123
Compositional biasi508 – 636Ser-richAdd BLAST129
Compositional biasi655 – 801Lys/Ser-richAdd BLAST147

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEQY Eukaryota
ENOG4111NIS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111138

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG062408

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AJT4

Identification of Orthologs from Complete Genome Data

More...
OMAi
QFNGKRP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031937 PNISR

The PANTHER Classification System

More...
PANTHERi
PTHR31518 PTHR31518, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15996 PNISR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2AJT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWDQGGQPWQ QWPLNQQQWM QSFQHQQDPS QIDWAALAQA WIAQREASGQ
60 70 80 90 100
QSIVEQPPGM MPNGQDMSAM ESGPNNHGNF QGDSNFNRMW QPEWGMHQQP
110 120 130 140 150
PHPPPEQPWM PPAPGPMDIV PPSEDSNSQD SGEFAPDNRH IFNQNNHNFG
160 170 180 190 200
GPPDNFAVGP VNQFDYQHGA AFGPPQGGFH PPYWQPGPPG PPAPTQNRRE
210 220 230 240 250
RPPSFRDRQR SPIALPVKQE PPQIDAVKRR TLPAWIREGL EKMEREKQKK
260 270 280 290 300
LEKERMEQQR SQLSKKEKKA TEDAEGGDGP RLPQRSKFDS DEEDEDAENL
310 320 330 340 350
EAVSSGKVTR SPSPAPQEEH SEPEMTEEEK EYQMMLLTKM LLTEILLDVT
360 370 380 390 400
DEEIYYVAKD AHRKATKAPA KQLAQSSALA SLTGLGGLGG YGSGDSEDER
410 420 430 440 450
SDRGSESSDT DDEELRHRIR QKQEAFWRKE KEQQLLQDKQ IEEEKQQTER
460 470 480 490 500
VTKEMNEFIH REQNSLSLLE ASEADRDAVN DKKRTPNEAP SVLEPKREHK
510 520 530 540 550
GKEKERGSRS GSSSSGSSSS GSRTSSSSSS VSSSSYSSSS GSSCTSSRSS
560 570 580 590 600
SPKRRKRPSR SRSPPAKARR SRSRSYSRRV KVDSSRTRGK LRDRRRSNRS
610 620 630 640 650
SIERERRRNR SPSRDRRRSR SRSRDRRTNR SSRSRSRDRR KIEDPRGNLS
660 670 680 690 700
GNSHKHKGEA KEQDRKKERS RSVDKDRRKK DKERDRELDK RKEKQKREEK
710 720 730 740 750
DFKFSSQDDR LKRKRESERT FCRSGSISVK VIRHDSRQDS KKNATKDSKR
760 770 780 790 800
HSGSDSSGRS SSESPGSSKE KKAKKPKHSR SRSLEKSQRS GKKASRKHKS

KSRSR
Length:805
Mass (Da):92,115
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB73F082E7C486D39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJT5A2AJT5_MOUSE
Arginine/serine-rich protein PNISR
Pnisr
814Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AJT3A2AJT3_MOUSE
Arginine/serine-rich protein PNISR
Pnisr mCG_2929
373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti695Q → R in BAB30779 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL772187 Genomic DNA No translation available.
AK017507 mRNA Translation: BAB30779.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.100117

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000098238; ENSMUSP00000095840; ENSMUSG00000028248

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772187 Genomic DNA No translation available.
AK017507 mRNA Translation: BAB30779.3
UniGeneiMm.100117

3D structure databases

ProteinModelPortaliA2AJT4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AJT4, 1 interactor
MINTiA2AJT4
STRINGi10090.ENSMUSP00000029911

PTM databases

iPTMnetiA2AJT4
PhosphoSitePlusiA2AJT4

Proteomic databases

EPDiA2AJT4
jPOSTiA2AJT4
MaxQBiA2AJT4
PaxDbiA2AJT4
PeptideAtlasiA2AJT4
PRIDEiA2AJT4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098238; ENSMUSP00000095840; ENSMUSG00000028248

Organism-specific databases

MGIiMGI:1913875 Pnisr

Phylogenomic databases

eggNOGiENOG410IEQY Eukaryota
ENOG4111NIS LUCA
GeneTreeiENSGT00730000111138
HOVERGENiHBG062408
InParanoidiA2AJT4
OMAiQFNGKRP

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2AJT4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028248 Expressed in 254 organ(s), highest expression level in metanephric cortical collecting duct
CleanExiMM_SFRS18
ExpressionAtlasiA2AJT4 baseline and differential
GenevisibleiA2AJT4 MM

Family and domain databases

InterProiView protein in InterPro
IPR031937 PNISR
PANTHERiPTHR31518 PTHR31518, 2 hits
PfamiView protein in Pfam
PF15996 PNISR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNISR_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AJT4
Secondary accession number(s): Q9CS92
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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