Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arginine/serine-rich protein PNISR

Gene

Pnisr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine/serine-rich protein PNISR
Alternative name(s):
Serine/arginine-rich-splicing regulatory protein 130
Short name:
SRrp130
Splicing factor, arginine/serine-rich 130
Splicing factor, arginine/serine-rich 18
Gene namesi
Name:Pnisr
Synonyms:Sfrs18, Srrp130
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913875 Pnisr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002926551 – 805Arginine/serine-rich protein PNISRAdd BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204PhosphoserineBy similarity1
Modified residuei211PhosphoserineCombined sources1
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei290PhosphoserineBy similarity1
Modified residuei304PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1
Modified residuei467PhosphoserineBy similarity1
Modified residuei485PhosphothreonineBy similarity1
Cross-linki496Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki703Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei726PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiA2AJT4
MaxQBiA2AJT4
PaxDbiA2AJT4
PeptideAtlasiA2AJT4
PRIDEiA2AJT4

PTM databases

iPTMnetiA2AJT4
PhosphoSitePlusiA2AJT4

Expressioni

Gene expression databases

BgeeiENSMUSG00000028248 Expressed in 254 organ(s), highest expression level in metanephric cortical collecting duct
CleanExiMM_SFRS18
ExpressionAtlasiA2AJT4 baseline and differential
GenevisibleiA2AJT4 MM

Interactioni

Subunit structurei

Interacts with PNN.By similarity

Protein-protein interaction databases

IntActiA2AJT4, 1 interactor
MINTiA2AJT4
STRINGi10090.ENSMUSP00000029911

Structurei

3D structure databases

ProteinModelPortaliA2AJT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili237 – 276Sequence analysisAdd BLAST40
Coiled coili427 – 461Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 56Gln-richAdd BLAST53
Compositional biasi100 – 222Pro-richAdd BLAST123
Compositional biasi508 – 636Ser-richAdd BLAST129
Compositional biasi655 – 801Lys/Ser-richAdd BLAST147

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEQY Eukaryota
ENOG4111NIS LUCA
GeneTreeiENSGT00730000111138
HOVERGENiHBG062408
InParanoidiA2AJT4
OMAiQFNGKRP

Family and domain databases

InterProiView protein in InterPro
IPR031937 PNISR
PANTHERiPTHR31518 PTHR31518, 2 hits
PfamiView protein in Pfam
PF15996 PNISR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2AJT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWDQGGQPWQ QWPLNQQQWM QSFQHQQDPS QIDWAALAQA WIAQREASGQ
60 70 80 90 100
QSIVEQPPGM MPNGQDMSAM ESGPNNHGNF QGDSNFNRMW QPEWGMHQQP
110 120 130 140 150
PHPPPEQPWM PPAPGPMDIV PPSEDSNSQD SGEFAPDNRH IFNQNNHNFG
160 170 180 190 200
GPPDNFAVGP VNQFDYQHGA AFGPPQGGFH PPYWQPGPPG PPAPTQNRRE
210 220 230 240 250
RPPSFRDRQR SPIALPVKQE PPQIDAVKRR TLPAWIREGL EKMEREKQKK
260 270 280 290 300
LEKERMEQQR SQLSKKEKKA TEDAEGGDGP RLPQRSKFDS DEEDEDAENL
310 320 330 340 350
EAVSSGKVTR SPSPAPQEEH SEPEMTEEEK EYQMMLLTKM LLTEILLDVT
360 370 380 390 400
DEEIYYVAKD AHRKATKAPA KQLAQSSALA SLTGLGGLGG YGSGDSEDER
410 420 430 440 450
SDRGSESSDT DDEELRHRIR QKQEAFWRKE KEQQLLQDKQ IEEEKQQTER
460 470 480 490 500
VTKEMNEFIH REQNSLSLLE ASEADRDAVN DKKRTPNEAP SVLEPKREHK
510 520 530 540 550
GKEKERGSRS GSSSSGSSSS GSRTSSSSSS VSSSSYSSSS GSSCTSSRSS
560 570 580 590 600
SPKRRKRPSR SRSPPAKARR SRSRSYSRRV KVDSSRTRGK LRDRRRSNRS
610 620 630 640 650
SIERERRRNR SPSRDRRRSR SRSRDRRTNR SSRSRSRDRR KIEDPRGNLS
660 670 680 690 700
GNSHKHKGEA KEQDRKKERS RSVDKDRRKK DKERDRELDK RKEKQKREEK
710 720 730 740 750
DFKFSSQDDR LKRKRESERT FCRSGSISVK VIRHDSRQDS KKNATKDSKR
760 770 780 790 800
HSGSDSSGRS SSESPGSSKE KKAKKPKHSR SRSLEKSQRS GKKASRKHKS

KSRSR
Length:805
Mass (Da):92,115
Last modified:February 20, 2007 - v1
Checksum:iB73F082E7C486D39
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJT5A2AJT5_MOUSE
Arginine/serine-rich protein PNISR
Pnisr
814Annotation score:
A2AJT3A2AJT3_MOUSE
Arginine/serine-rich protein PNISR
Pnisr mCG_2929
373Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti695Q → R in BAB30779 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772187 Genomic DNA No translation available.
AK017507 mRNA Translation: BAB30779.3
UniGeneiMm.100117

Genome annotation databases

EnsembliENSMUST00000098238; ENSMUSP00000095840; ENSMUSG00000028248

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772187 Genomic DNA No translation available.
AK017507 mRNA Translation: BAB30779.3
UniGeneiMm.100117

3D structure databases

ProteinModelPortaliA2AJT4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AJT4, 1 interactor
MINTiA2AJT4
STRINGi10090.ENSMUSP00000029911

PTM databases

iPTMnetiA2AJT4
PhosphoSitePlusiA2AJT4

Proteomic databases

EPDiA2AJT4
MaxQBiA2AJT4
PaxDbiA2AJT4
PeptideAtlasiA2AJT4
PRIDEiA2AJT4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098238; ENSMUSP00000095840; ENSMUSG00000028248

Organism-specific databases

MGIiMGI:1913875 Pnisr

Phylogenomic databases

eggNOGiENOG410IEQY Eukaryota
ENOG4111NIS LUCA
GeneTreeiENSGT00730000111138
HOVERGENiHBG062408
InParanoidiA2AJT4
OMAiQFNGKRP

Miscellaneous databases

PROiPR:A2AJT4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028248 Expressed in 254 organ(s), highest expression level in metanephric cortical collecting duct
CleanExiMM_SFRS18
ExpressionAtlasiA2AJT4 baseline and differential
GenevisibleiA2AJT4 MM

Family and domain databases

InterProiView protein in InterPro
IPR031937 PNISR
PANTHERiPTHR31518 PTHR31518, 2 hits
PfamiView protein in Pfam
PF15996 PNISR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPNISR_MOUSE
AccessioniPrimary (citable) accession number: A2AJT4
Secondary accession number(s): Q9CS92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again