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Protein

Probable C-mannosyltransferase DPY19L4

Gene

Dpy19l4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.By similarity

GO - Molecular functioni

  • mannosyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L4 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 4
Protein dpy-19 homolog 4
Gene namesi
Name:Dpy19l4
Synonyms:Gm1023
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2685869 Dpy19l4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei160 – 177HelicalSequence analysisAdd BLAST18
Transmembranei183 – 201HelicalSequence analysisAdd BLAST19
Transmembranei246 – 262HelicalSequence analysisAdd BLAST17
Transmembranei268 – 284HelicalSequence analysisAdd BLAST17
Transmembranei291 – 307HelicalSequence analysisAdd BLAST17
Transmembranei313 – 331HelicalSequence analysisAdd BLAST19
Transmembranei351 – 369HelicalSequence analysisAdd BLAST19
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003118822 – 722Probable C-mannosyltransferase DPY19L4Add BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiA2AJQ3
PaxDbiA2AJQ3
PeptideAtlasiA2AJQ3
PRIDEiA2AJQ3

PTM databases

iPTMnetiA2AJQ3
PhosphoSitePlusiA2AJQ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000045205 Expressed in 236 organ(s), highest expression level in quadriceps femoris
CleanExiMM_DPY19L4
ExpressionAtlasiA2AJQ3 baseline and differential
GenevisibleiA2AJQ3 MM

Structurei

3D structure databases

ProteinModelPortaliA2AJQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4587 Eukaryota
ENOG410XRWN LUCA
GeneTreeiENSGT00530000063023
HOGENOMiHOG000007319
HOVERGENiHBG107792
InParanoidiA2AJQ3
OMAiFSLWKEF
OrthoDBiEOG091G02PL
PhylomeDBiA2AJQ3
TreeFamiTF313376

Family and domain databases

InterProiView protein in InterPro
IPR018732 Dpy-19/Dpy-19-like
IPR030040 DPY19L4
PANTHERiPTHR31488 PTHR31488, 1 hit
PTHR31488:SF2 PTHR31488:SF2, 1 hit
PfamiView protein in Pfam
PF10034 Dpy19, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AJQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKEEGTSVE PRQRKKQRTS GSQEAKAEKI RRTPAPERAP KYVSFQRFAK
60 70 80 90 100
IVIGCLAAVI SGMMHVFYLS AYHERKFWFS NRQELEREIT FQGDSAIYYS
110 120 130 140 150
YYKDMLKAPS FERGVYELTH NNKTISLKTI NAMQQMSLYP ELIASVLYQA
160 170 180 190 200
TGSNEVIEPV YFYIGIVFGL QGMYVTALFV TSWLMSGTWL AGMLTVAWFL
210 220 230 240 250
INRVDTTRIE YSIPLRENWA LPYFACQVAA LTGYLKRNLN TYAERFCYLL
260 270 280 290 300
LSTSTYTFMM VWEYSHYVLF LQAVSLLLLD IFSVEQSDKV YEVYKVYIFS
310 320 330 340 350
LFLGYLLQFE NPALLVSPLL SLVGAFMLVK CLQLNGKKGT FVAKVIKVFE
360 370 380 390 400
FYLLCTLPVT LNLIVKMFVP HKENEHVLKF LEVKFGLNMT KNFTLNWLLC
410 420 430 440 450
QESLQAPSQD FFFRLTQSSL LPFYVLVLII CLLSMTQVFF RRMSGKSKKE
460 470 480 490 500
TVTLEDGRIG ERPEIIYHVI HTLLLGSLAM LMEGLKFIWT PYVCMLAAFG
510 520 530 540 550
VCSPELWMTL LKWLRLRTVH PMLLALILSM AVPTIIGLSL WKEFFPRLIT
560 570 580 590 600
ELTELQEFYD PDTVELMTWI KRQAPVAAVF AGSPQLMGVI KLCTGWTVTS
610 620 630 640 650
LPLYSDDDLL QRNENIYQIY SKRSAEDIYK ILTSYKANYL IVEDAICNEL
660 670 680 690 700
GTTRGCRVKD LLDIANGHVV FEEGDKLTYS KYGRFCHEVK INYSPYVNYF
710 720
TRVYWNRSYF VYKVNTVISF QS
Length:722
Mass (Da):83,604
Last modified:February 20, 2007 - v1
Checksum:i029C334E649396D5
GO
Isoform 2 (identifier: A2AJQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-333: Missing.

Show »
Length:678
Mass (Da):78,579
Checksum:iFADE460F03F20D52
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJQ2A2AJQ2_MOUSE
Probable C-mannosyltransferase DPY1...
Dpy19l4
496Annotation score:
A2AJQ1A2AJQ1_MOUSE
Probable C-mannosyltransferase DPY1...
Dpy19l4
524Annotation score:
D6RI72D6RI72_MOUSE
Probable C-mannosyltransferase DPY1...
Dpy19l4
286Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029632290 – 333Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772170, AL840625, AL953845 Genomic DNA Translation: CAM20811.1
AL840625, AL772170, AL953845 Genomic DNA Translation: CAM21617.1
AL953845, AL772170, AL840625 Genomic DNA Translation: CAM23148.1
BC147500 mRNA Translation: AAI47501.1
BC157932 mRNA Translation: AAI57933.1
BC157988 mRNA Translation: AAI57989.1
AK172656 mRNA Translation: BAE43116.1
CCDSiCCDS38692.1 [A2AJQ3-1]
RefSeqiNP_001074670.1, NM_001081201.1 [A2AJQ3-1]
UniGeneiMm.331486
Mm.355656

Genome annotation databases

EnsembliENSMUST00000084892; ENSMUSP00000081954; ENSMUSG00000045205 [A2AJQ3-1]
GeneIDi381510
KEGGimmu:381510
UCSCiuc008rzi.1 mouse [A2AJQ3-1]
uc008rzj.1 mouse [A2AJQ3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772170, AL840625, AL953845 Genomic DNA Translation: CAM20811.1
AL840625, AL772170, AL953845 Genomic DNA Translation: CAM21617.1
AL953845, AL772170, AL840625 Genomic DNA Translation: CAM23148.1
BC147500 mRNA Translation: AAI47501.1
BC157932 mRNA Translation: AAI57933.1
BC157988 mRNA Translation: AAI57989.1
AK172656 mRNA Translation: BAE43116.1
CCDSiCCDS38692.1 [A2AJQ3-1]
RefSeqiNP_001074670.1, NM_001081201.1 [A2AJQ3-1]
UniGeneiMm.331486
Mm.355656

3D structure databases

ProteinModelPortaliA2AJQ3
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA2AJQ3
PhosphoSitePlusiA2AJQ3

Proteomic databases

MaxQBiA2AJQ3
PaxDbiA2AJQ3
PeptideAtlasiA2AJQ3
PRIDEiA2AJQ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084892; ENSMUSP00000081954; ENSMUSG00000045205 [A2AJQ3-1]
GeneIDi381510
KEGGimmu:381510
UCSCiuc008rzi.1 mouse [A2AJQ3-1]
uc008rzj.1 mouse [A2AJQ3-2]

Organism-specific databases

CTDi286148
MGIiMGI:2685869 Dpy19l4

Phylogenomic databases

eggNOGiKOG4587 Eukaryota
ENOG410XRWN LUCA
GeneTreeiENSGT00530000063023
HOGENOMiHOG000007319
HOVERGENiHBG107792
InParanoidiA2AJQ3
OMAiFSLWKEF
OrthoDBiEOG091G02PL
PhylomeDBiA2AJQ3
TreeFamiTF313376

Miscellaneous databases

PROiPR:A2AJQ3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045205 Expressed in 236 organ(s), highest expression level in quadriceps femoris
CleanExiMM_DPY19L4
ExpressionAtlasiA2AJQ3 baseline and differential
GenevisibleiA2AJQ3 MM

Family and domain databases

InterProiView protein in InterPro
IPR018732 Dpy-19/Dpy-19-like
IPR030040 DPY19L4
PANTHERiPTHR31488 PTHR31488, 1 hit
PTHR31488:SF2 PTHR31488:SF2, 1 hit
PfamiView protein in Pfam
PF10034 Dpy19, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD19L4_MOUSE
AccessioniPrimary (citable) accession number: A2AJQ3
Secondary accession number(s): B2RW18, Q3T9A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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