UniProtKB - A2AJN7 (S4A11_MOUSE)
Protein
Sodium bicarbonate transporter-like protein 11
Gene
Slc4a11
Organism
Mus musculus (Mouse)
Status
Functioni
Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter.1 Publication
GO - Molecular functioni
- active borate transmembrane transporter activity Source: MGI
- anion:anion antiporter activity Source: UniProtKB-KW
- bicarbonate transmembrane transporter activity Source: MGI
- inorganic anion exchanger activity Source: InterPro
- protein dimerization activity Source: UniProtKB
- proton channel activity Source: MGI
- sodium channel activity Source: MGI
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- bicarbonate transport Source: MGI
- borate transport Source: MGI
- cellular cation homeostasis Source: MGI
- fluid transport Source: UniProtKB
- ion homeostasis Source: UniProtKB
- proton transmembrane transport Source: MGI
- regulation of intracellular pH Source: GO_Central
- sodium ion transport Source: MGI
Keywordsi
Biological process | Anion exchange, Ion transport, Symport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium bicarbonate transporter-like protein 11Alternative name(s): Bicarbonate transporter-related protein 1 Sodium borate cotransporter 1 Short name: NaBC1 Solute carrier family 4 member 11 |
Gene namesi | Name:Slc4a11 Synonyms:BTR1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2138987 Slc4a11 |
Subcellular locationi
Plasma membrane
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 345 – 365 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 385 – 405 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 428 – 448 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 462 – 482 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 543 – 563 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 634 – 654 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 671 – 691 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 727 – 747 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 749 – 769 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 817 – 837 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mice show thickening of the stroma and Descement membrane concomitant with increased sodium chloride concentration in the stroma of the cornea. Show impaired urinary concentration, increased urinary volume, and increased urinary sodium loss in the kidney. Also show stress-induced morphological changes of fibrocytes of the inner ear resulting in deafness.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000352350 | 1 – 862 | Sodium bicarbonate transporter-like protein 11Add BLAST | 862 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 511 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 519 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | A2AJN7 |
PeptideAtlasi | A2AJN7 |
PRIDEi | A2AJN7 |
PTM databases
iPTMneti | A2AJN7 |
PhosphoSitePlusi | A2AJN7 |
Expressioni
Tissue specificityi
Expressed in the endothelial cells of the cornea. In the inner ear, is located in fibrocytes underlying the stria vascularis. In the kidney, is expressed in the thin descending limb of Henle loop.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000074796 Expressed in 93 organ(s), highest expression level in cochlea |
ExpressionAtlasi | A2AJN7 baseline and differential |
Genevisiblei | A2AJN7 MM |
Interactioni
Subunit structurei
Homodimer.By similarity
GO - Molecular functioni
- protein dimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000096963 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1172 Eukaryota ENOG410XPHD LUCA |
GeneTreei | ENSGT00940000154894 |
HOGENOMi | HOG000016966 |
HOVERGENi | HBG079162 |
InParanoidi | A2AJN7 |
KOi | K13862 |
OMAi | TEPDCNL |
OrthoDBi | 265068at2759 |
PhylomeDBi | A2AJN7 |
TreeFami | TF313630 |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR011531 HCO3_transpt_C IPR003020 HCO3_transpt_euk IPR016152 PTrfase/Anion_transptr |
PANTHERi | PTHR11453 PTHR11453, 1 hit |
Pfami | View protein in Pfam PF00955 HCO3_cotransp, 1 hit |
PRINTSi | PR01231 HCO3TRNSPORT |
SUPFAMi | SSF55804 SSF55804, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A2AJN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQNEHCQDS GEYFSAGTQG YFKNNMEDNL EVREDSLGDE VFDTVNSSIV
60 70 80 90 100
SGESIRFFVN VNLEVQPSKS DLEAATGGCV LLHTSRKYLK LKNFEEEVRA
110 120 130 140 150
HRDLDGFLAQ ASIILNETAT SLDDVLRTML NRFALDPNHA EPDCDLDLLM
160 170 180 190 200
AKLFTDAGAP MESKVHLLSD TIQGVTATVR GVQYEQSWLC IICTMKTLQK
210 220 230 240 250
RHVCISRLVR PQNWGENSCE VRFVILVLAP PKMKSTKTAM EVARTFATMF
260 270 280 290 300
SDITFRQKLL KTRTEEEFKE ALVHQRQLLT MMMPRAAGHS MSSLHTHRHP
310 320 330 340 350
QPPKCKDFFP FGKGIWMDIM RRFPVYPMDF TDGIIGKSKS VGKYVTTTLF
360 370 380 390 400
LYFACLLPTI AFGSLNDENT NGAIDVQKTI AGQSIGGLLY ALFSGQPLVI
410 420 430 440 450
LLTTAPLAIY TQVIRVICDD YNLDFNAFYA WTGLWNSFFL ALYAFLNLSL
460 470 480 490 500
LMNLFKRSTE EIIALFISIT FVLDAVKGMV KIFGKYYYGH HYHTKRTSSL
510 520 530 540 550
VSLLGIGRSP NSSLHTALNA SLLASPVEMA TTSSPGSTHS GQATAVLSLL
560 570 580 590 600
IMLGTLWLGY TLYQFKKSPY LHPCVRETLS DCALPIAVLS FSLIGSYGFQ
610 620 630 640 650
EIEMSKFRYN PSESLFEVAQ IHSLSFKAIG SAMGLGFLLS LLFFIEQNLV
660 670 680 690 700
AALVNAPENR LVKGTAYHWD LLLLAIINTG LSLFGLPWIH AAYPHSPLHV
710 720 730 740 750
RALALVEERV ENGHIYETIV DVKETRLTAL GASVLVGLSL LLLPFPLQWI
760 770 780 790 800
PKPVLYGLFL YIALTSLDGN QLFSRVALLL KEQTSYPPTH YIRRVPQRKI
810 820 830 840 850
HYFTGLQILQ LLLLCAFGMS SLPYMKMVFP LIMIAMIPIR YNLLPRIIEA
860
KYLDVMDAEH RP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2AJN8 | A2AJN8_MOUSE | Sodium bicarbonate transporter-like... | Slc4a11 | 164 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 151 | A → T in AAI11885 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 850 | A → S in AAI11885 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL772162 Genomic DNA No translation available. BC111884 mRNA Translation: AAI11885.1 AK141286 mRNA Translation: BAE24637.1 |
CCDSi | CCDS38244.1 |
RefSeqi | NP_001074631.1, NM_001081162.1 |
UniGenei | Mm.441391 |
Genome annotation databases
Ensembli | ENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796 |
GeneIDi | 269356 |
KEGGi | mmu:269356 |
UCSCi | uc008mjv.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL772162 Genomic DNA No translation available. BC111884 mRNA Translation: AAI11885.1 AK141286 mRNA Translation: BAE24637.1 |
CCDSi | CCDS38244.1 |
RefSeqi | NP_001074631.1, NM_001081162.1 |
UniGenei | Mm.441391 |
3D structure databases
ProteinModelPortali | A2AJN7 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000096963 |
PTM databases
iPTMneti | A2AJN7 |
PhosphoSitePlusi | A2AJN7 |
Proteomic databases
PaxDbi | A2AJN7 |
PeptideAtlasi | A2AJN7 |
PRIDEi | A2AJN7 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796 |
GeneIDi | 269356 |
KEGGi | mmu:269356 |
UCSCi | uc008mjv.1 mouse |
Organism-specific databases
CTDi | 83959 |
MGIi | MGI:2138987 Slc4a11 |
Phylogenomic databases
eggNOGi | KOG1172 Eukaryota ENOG410XPHD LUCA |
GeneTreei | ENSGT00940000154894 |
HOGENOMi | HOG000016966 |
HOVERGENi | HBG079162 |
InParanoidi | A2AJN7 |
KOi | K13862 |
OMAi | TEPDCNL |
OrthoDBi | 265068at2759 |
PhylomeDBi | A2AJN7 |
TreeFami | TF313630 |
Miscellaneous databases
PROi | PR:A2AJN7 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000074796 Expressed in 93 organ(s), highest expression level in cochlea |
ExpressionAtlasi | A2AJN7 baseline and differential |
Genevisiblei | A2AJN7 MM |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR011531 HCO3_transpt_C IPR003020 HCO3_transpt_euk IPR016152 PTrfase/Anion_transptr |
PANTHERi | PTHR11453 PTHR11453, 1 hit |
Pfami | View protein in Pfam PF00955 HCO3_cotransp, 1 hit |
PRINTSi | PR01231 HCO3TRNSPORT |
SUPFAMi | SSF55804 SSF55804, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | S4A11_MOUSE | |
Accessioni | A2AJN7Primary (citable) accession number: A2AJN7 Secondary accession number(s): Q0VG86, Q3URQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 14, 2008 |
Last sequence update: | February 20, 2007 | |
Last modified: | January 16, 2019 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot