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UniProtKB - A2AJN7 (S4A11_MOUSE)

Entry version 102 (29 Sep 2021)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
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Protein

Solute carrier family 4 member 11

Gene

Slc4a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional transporter with an impact in cell morphology and differentiation (PubMed:20185830).

In the presence of borate B(OH)4-, acts as a voltage-dependent electrogenic Na+-coupled B(OH)4- cotransporter controlling boron homeostasis (By similarity).

At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (PubMed:33247189).

In the absence of B(OH)4-, acts as a Na+-coupled OH- or H+ permeable channel with implications in cellular redox balance. Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species. In response to hypo-osmotic challenge, also acts as water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor. In the presence of ammonia, acts as an electrogenic NH3/H+ cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (By similarity).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Ion transport, Symport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 4 member 11
Alternative name(s):
Sodium borate cotransporter 1
Short name:
NaBC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc4a11
Synonyms:BTR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2138987, Slc4a11

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000074796

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 343CytoplasmicBy similarityAdd BLAST343
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei344 – 366HelicalSequence analysisAdd BLAST23
Topological domaini367 – 379ExtracellularBy similarityAdd BLAST13
Transmembranei380 – 393HelicalSequence analysisAdd BLAST14
Topological domaini394 – 398CytoplasmicBy similarity5
Transmembranei399 – 415HelicalSequence analysisAdd BLAST17
Topological domaini416 – 428ExtracellularBy similarityAdd BLAST13
Transmembranei429 – 452HelicalSequence analysisAdd BLAST24
Topological domaini453 – 460CytoplasmicBy similarity8
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 542ExtracellularBy similarityAdd BLAST61
Transmembranei543 – 564HelicalSequence analysisAdd BLAST22
Topological domaini565 – 577CytoplasmicBy similarityAdd BLAST13
Transmembranei578 – 599HelicalSequence analysisAdd BLAST22
Topological domaini600 – 627ExtracellularBy similarityAdd BLAST28
Transmembranei628 – 645HelicalSequence analysisAdd BLAST18
Topological domaini646 – 670CytoplasmicBy similarityAdd BLAST25
Transmembranei671 – 691HelicalSequence analysisAdd BLAST21
Topological domaini692 – 721ExtracellularBy similarityAdd BLAST30
Transmembranei722 – 746HelicalSequence analysisAdd BLAST25
Topological domaini747 – 752CytoplasmicBy similarity6
Transmembranei753 – 770HelicalSequence analysisAdd BLAST18
Topological domaini771 – 774ExtracellularBy similarity4
Transmembranei775 – 797HelicalSequence analysisAdd BLAST23
Topological domaini798 – 802CytoplasmicBy similarity5
Transmembranei803 – 819HelicalSequence analysisAdd BLAST17
Topological domaini820 – 823ExtracellularBy similarity4
Transmembranei824 – 844HelicalSequence analysisAdd BLAST21
Topological domaini845 – 862CytoplasmicBy similarityAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant mice show corneal defects characterized by progressive thickening of the stroma and descement membrane concomitant with increased sodium chloride concentration in the stroma (PubMed:20185830, PubMed:23813972). Show impaired urinary concentration, increased urinary volume, and increased urinary sodium loss in the kidney. Also show stress-induced morphological changes of fibrocytes of the inner ear resulting in deafness.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003523501 – 862Solute carrier family 4 member 11Add BLAST862

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A2AJN7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2AJN7

PeptideAtlas

More...PeptideAtlasi		A2AJN7

PRoteomics IDEntifications database

More...PRIDEi		A2AJN7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		256825

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		A2AJN7, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A2AJN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2AJN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the endothelial cells of the cornea. In the inner ear, is located in fibrocytes underlying the stria vascularis. In the kidney, is expressed in the thin descending limb of Henle loop.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000074796, Expressed in cochlea and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2AJN7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A2AJN7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000096963

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A2AJN7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1172, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154894

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002289_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2AJN7

Identification of Orthologs from Complete Genome Data

More...OMAi		YDHNVSS

Database of Orthologous Groups

More...OrthoDBi		265068at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2AJN7

TreeFam database of animal gene trees

More...TreeFami		TF313630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

More...PANTHERi		PTHR11453, PTHR11453, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01231, HCO3TRNSPORT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55804, SSF55804, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AJN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQNEHCQDS GEYFSAGTQG YFKNNMEDNL EVREDSLGDE VFDTVNSSIV 
        60         70         80         90        100
SGESIRFFVN VNLEVQPSKS DLEAATGGCV LLHTSRKYLK LKNFEEEVRA 
       110        120        130        140        150
HRDLDGFLAQ ASIILNETAT SLDDVLRTML NRFALDPNHA EPDCDLDLLM 
       160        170        180        190        200
AKLFTDAGAP MESKVHLLSD TIQGVTATVR GVQYEQSWLC IICTMKTLQK 
       210        220        230        240        250
RHVCISRLVR PQNWGENSCE VRFVILVLAP PKMKSTKTAM EVARTFATMF 
       260        270        280        290        300
SDITFRQKLL KTRTEEEFKE ALVHQRQLLT MMMPRAAGHS MSSLHTHRHP 
       310        320        330        340        350
QPPKCKDFFP FGKGIWMDIM RRFPVYPMDF TDGIIGKSKS VGKYVTTTLF 
       360        370        380        390        400
LYFACLLPTI AFGSLNDENT NGAIDVQKTI AGQSIGGLLY ALFSGQPLVI 
       410        420        430        440        450
LLTTAPLAIY TQVIRVICDD YNLDFNAFYA WTGLWNSFFL ALYAFLNLSL 
       460        470        480        490        500
LMNLFKRSTE EIIALFISIT FVLDAVKGMV KIFGKYYYGH HYHTKRTSSL 
       510        520        530        540        550
VSLLGIGRSP NSSLHTALNA SLLASPVEMA TTSSPGSTHS GQATAVLSLL 
       560        570        580        590        600
IMLGTLWLGY TLYQFKKSPY LHPCVRETLS DCALPIAVLS FSLIGSYGFQ 
       610        620        630        640        650
EIEMSKFRYN PSESLFEVAQ IHSLSFKAIG SAMGLGFLLS LLFFIEQNLV 
       660        670        680        690        700
AALVNAPENR LVKGTAYHWD LLLLAIINTG LSLFGLPWIH AAYPHSPLHV 
       710        720        730        740        750
RALALVEERV ENGHIYETIV DVKETRLTAL GASVLVGLSL LLLPFPLQWI 
       760        770        780        790        800
PKPVLYGLFL YIALTSLDGN QLFSRVALLL KEQTSYPPTH YIRRVPQRKI 
       810        820        830        840        850
HYFTGLQILQ LLLLCAFGMS SLPYMKMVFP LIMIAMIPIR YNLLPRIIEA 
       860 
KYLDVMDAEH RP
Length:862
Mass (Da):96,751
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8118D841B1B8D6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJN8A2AJN8_MOUSE
Sodium bicarbonate transporter-like...
Slc4a11
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti151A → T in AAI11885 (PubMed:15489334).Curated1
Sequence conflicti850A → S in AAI11885 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL772162 Genomic DNA No translation available.
BC111884 mRNA Translation: AAI11885.1
AK141286 mRNA Translation: BAE24637.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38244.1

NCBI Reference Sequences

More...RefSeqi		NP_001074631.1, NM_001081162.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796

Database of genes from NCBI RefSeq genomes

More...GeneIDi		269356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:269356

UCSC genome browser

More...UCSCi		uc008mjv.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772162 Genomic DNA No translation available.
BC111884 mRNA Translation: AAI11885.1
AK141286 mRNA Translation: BAE24637.1
CCDSiCCDS38244.1
RefSeqiNP_001074631.1, NM_001081162.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096963

PTM databases

GlyGeniA2AJN7, 2 sites
iPTMnetiA2AJN7
PhosphoSitePlusiA2AJN7

Proteomic databases

EPDiA2AJN7
PaxDbiA2AJN7
PeptideAtlasiA2AJN7
PRIDEiA2AJN7
ProteomicsDBi256825

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7351, 111 antibodies

Genome annotation databases

EnsembliENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796
GeneIDi269356
KEGGimmu:269356
UCSCiuc008mjv.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83959
MGIiMGI:2138987, Slc4a11
VEuPathDBiHostDB:ENSMUSG00000074796

Phylogenomic databases

eggNOGiKOG1172, Eukaryota
GeneTreeiENSGT00940000154894
HOGENOMiCLU_002289_6_0_1
InParanoidiA2AJN7
OMAiYDHNVSS
OrthoDBi265068at2759
PhylomeDBiA2AJN7
TreeFamiTF313630

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		269356, 2 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Slc4a11, mouse

Protein Ontology

More...PROi		PR:A2AJN7
RNActiA2AJN7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000074796, Expressed in cochlea and 133 other tissues
ExpressionAtlasiA2AJN7, baseline and differential
GenevisibleiA2AJN7, MM

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PfamiView protein in Pfam
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR01231, HCO3TRNSPORT
SUPFAMiSSF55804, SSF55804, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4A11_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AJN7
Secondary accession number(s): Q0VG86, Q3URQ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: February 20, 2007
Last modified: September 29, 2021
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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