Slc4a11

Functionⁱ

Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na⁺ and OH^-(H⁺) channel. In the presence of borate functions as an electrogenic Na⁺ coupled borate cotransporter.1 Publication

GO - Molecular functionⁱ

active borate transmembrane transporter activity Source: MGI
anion:anion antiporter activity Source: UniProtKB-KW
bicarbonate transmembrane transporter activity Source: MGI
inorganic anion exchanger activity Source: InterPro
protein dimerization activity Source: UniProtKB
proton channel activity Source: MGI
sodium channel activity Source: MGI
symporter activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bicarbonate transport Source: MGI
borate transport Source: MGI
cellular cation homeostasis Source: MGI
fluid transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20185830
ion homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20185830
proton transmembrane transport Source: MGI
regulation of intracellular pH
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sodium ion transport Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Anion exchange, Ion transport, Symport, Transport

Biological process

Anion exchange, Ion transport, Symport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium bicarbonate transporter-like protein 11 Alternative name(s): Bicarbonate transporter-related protein 1 Sodium borate cotransporter 1 Short name: NaBC1 Solute carrier family 4 member 11
Gene namesⁱ	Name:Slc4a11 Synonyms:BTR1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:2138987 Slc4a11

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	345 – 365	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	385 – 405	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	428 – 448	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	462 – 482	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	543 – 563	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	634 – 654	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	671 – 691	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	727 – 747	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	749 – 769	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	817 – 837	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice show thickening of the stroma and Descement membrane concomitant with increased sodium chloride concentration in the stroma of the cornea. Show impaired urinary concentration, increased urinary volume, and increased urinary sodium loss in the kidney. Also show stress-induced morphological changes of fibrocytes of the inner ear resulting in deafness.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000352350	1 – 862	Sodium bicarbonate transporter-like protein 11Add BLAST		862

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	511	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	519	N-linked (GlcNAc...) asparagineSequence analysis		1

Post-translational modificationⁱ

Glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	A2AJN7
PeptideAtlas More...PeptideAtlasⁱ	A2AJN7
PRIDEⁱ	A2AJN7

PTM databases

iPTMnetⁱ	A2AJN7
PhosphoSitePlusⁱ	A2AJN7

Expressionⁱ

Tissue specificityⁱ

Expressed in the endothelial cells of the cornea. In the inner ear, is located in fibrocytes underlying the stria vascularis. In the kidney, is expressed in the thin descending limb of Henle loop.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000074796 Expressed in 93 organ(s), highest expression level in cochlea
ExpressionAtlasⁱ	A2AJN7 baseline and differential
Genevisibleⁱ	A2AJN7 MM

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

GO - Molecular functionⁱ

protein dimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000096963

STRINGⁱ

10090.ENSMUSP00000096963

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2AJN7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1172 Eukaryota ENOG410XPHD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119021
HOGENOMⁱ	HOG000016966
HOVERGENⁱ	HBG079162
InParanoidⁱ	A2AJN7
KEGG Orthology (KO) More...KOⁱ	K13862
OMAⁱ	TEPDCNL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01E4
PhylomeDBⁱ	A2AJN7
TreeFamⁱ	TF313630

Family and domain databases

Gene3Dⁱ	3.40.930.10, 1 hit
InterProⁱ	View protein in InterPro IPR011531 HCO3_transpt_C IPR003020 HCO3_transpt_euk IPR016152 PTrfase/Anion_transptr
PANTHERⁱ	PTHR11453 PTHR11453, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00955 HCO3_cotransp, 1 hit
PRINTSⁱ	PR01231 HCO3TRNSPORT
SUPFAMⁱ	SSF55804 SSF55804, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

A2AJN7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQNEHCQDS GEYFSAGTQG YFKNNMEDNL EVREDSLGDE VFDTVNSSIV 
        60         70         80         90        100
SGESIRFFVN VNLEVQPSKS DLEAATGGCV LLHTSRKYLK LKNFEEEVRA 
       110        120        130        140        150
HRDLDGFLAQ ASIILNETAT SLDDVLRTML NRFALDPNHA EPDCDLDLLM 
       160        170        180        190        200
AKLFTDAGAP MESKVHLLSD TIQGVTATVR GVQYEQSWLC IICTMKTLQK 
       210        220        230        240        250
RHVCISRLVR PQNWGENSCE VRFVILVLAP PKMKSTKTAM EVARTFATMF 
       260        270        280        290        300
SDITFRQKLL KTRTEEEFKE ALVHQRQLLT MMMPRAAGHS MSSLHTHRHP 
       310        320        330        340        350
QPPKCKDFFP FGKGIWMDIM RRFPVYPMDF TDGIIGKSKS VGKYVTTTLF 
       360        370        380        390        400
LYFACLLPTI AFGSLNDENT NGAIDVQKTI AGQSIGGLLY ALFSGQPLVI 
       410        420        430        440        450
LLTTAPLAIY TQVIRVICDD YNLDFNAFYA WTGLWNSFFL ALYAFLNLSL 
       460        470        480        490        500
LMNLFKRSTE EIIALFISIT FVLDAVKGMV KIFGKYYYGH HYHTKRTSSL 
       510        520        530        540        550
VSLLGIGRSP NSSLHTALNA SLLASPVEMA TTSSPGSTHS GQATAVLSLL 
       560        570        580        590        600
IMLGTLWLGY TLYQFKKSPY LHPCVRETLS DCALPIAVLS FSLIGSYGFQ 
       610        620        630        640        650
EIEMSKFRYN PSESLFEVAQ IHSLSFKAIG SAMGLGFLLS LLFFIEQNLV 
       660        670        680        690        700
AALVNAPENR LVKGTAYHWD LLLLAIINTG LSLFGLPWIH AAYPHSPLHV 
       710        720        730        740        750
RALALVEERV ENGHIYETIV DVKETRLTAL GASVLVGLSL LLLPFPLQWI 
       760        770        780        790        800
PKPVLYGLFL YIALTSLDGN QLFSRVALLL KEQTSYPPTH YIRRVPQRKI 
       810        820        830        840        850
HYFTGLQILQ LLLLCAFGMS SLPYMKMVFP LIMIAMIPIR YNLLPRIIEA 
       860 
KYLDVMDAEH RP

Length:862

Mass (Da):96,751

Last modified:February 20, 2007 - v1

Checksum:ⁱD8118D841B1B8D6A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2AJN8	A2AJN8_MOUSE		Sodium bicarbonate transporter-like... Sodium bicarbonate transporter-like protein 11	Slc4a11	164	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	151	A → T in AAI11885 (PubMed:15489334).Curated		1
Sequence conflictⁱ	850	A → S in AAI11885 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL772162 Genomic DNA No translation available. BC111884 mRNA Translation: AAI11885.1 AK141286 mRNA Translation: BAE24637.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS38244.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001074631.1, NM_001081162.1
UniGeneⁱ	Mm.441391

Genome annotation databases

Ensemblⁱ	ENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796
GeneIDⁱ	269356
KEGGⁱ	mmu:269356
UCSC genome browser More...UCSCⁱ	uc008mjv.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A2AJN7	Solute carrier family 4 member 11		RAT		862	UniRef90_A2AJN7
sodium bicarbonate transporter-like protein 11		MESAU		862
Uncharacterized protein		ICTTR		862
UPI0003332AA9		JACJA		894
UPI00077DC373		PERMB		885
+11

Protein	Similar proteins		Species	Score	Length	Source
A2AJN7	Sodium bicarbonate transporter-like protein 11		HUMAN		891	UniRef50_Q8NBS3
SLC4A11 isoform 8		PANTR		922
Uncharacterized protein		RHIBE		922
Uncharacterized protein		MACNE		921
Uncharacterized protein		CERAT		921
+774

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL772162 Genomic DNA No translation available. BC111884 mRNA Translation: AAI11885.1 AK141286 mRNA Translation: BAE24637.1
CCDSⁱ	CCDS38244.1
RefSeqⁱ	NP_001074631.1, NM_001081162.1
UniGeneⁱ	Mm.441391

3D structure databases

ProteinModelPortalⁱ	A2AJN7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000096963

STRINGⁱ

10090.ENSMUSP00000096963

PTM databases

iPTMnetⁱ	A2AJN7
PhosphoSitePlusⁱ	A2AJN7

Proteomic databases

PaxDbⁱ	A2AJN7
PeptideAtlasⁱ	A2AJN7
PRIDEⁱ	A2AJN7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796
GeneIDⁱ	269356
KEGGⁱ	mmu:269356
UCSCⁱ	uc008mjv.1 mouse

Organism-specific databases

CTDⁱ	83959
MGIⁱ	MGI:2138987 Slc4a11

Phylogenomic databases

eggNOGⁱ	KOG1172 Eukaryota ENOG410XPHD LUCA
GeneTreeⁱ	ENSGT00760000119021
HOGENOMⁱ	HOG000016966
HOVERGENⁱ	HBG079162
InParanoidⁱ	A2AJN7
KOⁱ	K13862
OMAⁱ	TEPDCNL
OrthoDBⁱ	EOG091G01E4
PhylomeDBⁱ	A2AJN7
TreeFamⁱ	TF313630

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:A2AJN7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000074796 Expressed in 93 organ(s), highest expression level in cochlea
ExpressionAtlasⁱ	A2AJN7 baseline and differential
Genevisibleⁱ	A2AJN7 MM

Family and domain databases

Gene3Dⁱ	3.40.930.10, 1 hit
InterProⁱ	View protein in InterPro IPR011531 HCO3_transpt_C IPR003020 HCO3_transpt_euk IPR016152 PTrfase/Anion_transptr
PANTHERⁱ	PTHR11453 PTHR11453, 1 hit
Pfamⁱ	View protein in Pfam PF00955 HCO3_cotransp, 1 hit
PRINTSⁱ	PR01231 HCO3TRNSPORT
SUPFAMⁱ	SSF55804 SSF55804, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S4A11_MOUSE
Accessionⁱ	A2AJN7Primary (citable) accession number: A2AJN7 Secondary accession number(s): Q0VG86, Q3URQ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
	Last sequence update:	February 20, 2007
	Last modified:	November 7, 2018
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - A2AJN7 (S4A11_MOUSE)

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Sodium bicarbonate transporter-like protein 11

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ