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Protein

Sodium bicarbonate transporter-like protein 11

Gene

Slc4a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter.1 Publication

GO - Molecular functioni

GO - Biological processi

  • bicarbonate transport Source: MGI
  • borate transport Source: MGI
  • cellular cation homeostasis Source: MGI
  • fluid transport Source: UniProtKB
  • ion homeostasis Source: UniProtKB
  • proton transmembrane transport Source: MGI
  • regulation of intracellular pH Source: GO_Central
  • sodium ion transport Source: MGI

Keywordsi

Biological processAnion exchange, Ion transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium bicarbonate transporter-like protein 11
Alternative name(s):
Bicarbonate transporter-related protein 1
Sodium borate cotransporter 1
Short name:
NaBC1
Solute carrier family 4 member 11
Gene namesi
Name:Slc4a11
Synonyms:BTR1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2138987 Slc4a11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Transmembranei543 – 563HelicalSequence analysisAdd BLAST21
Transmembranei634 – 654HelicalSequence analysisAdd BLAST21
Transmembranei671 – 691HelicalSequence analysisAdd BLAST21
Transmembranei727 – 747HelicalSequence analysisAdd BLAST21
Transmembranei749 – 769HelicalSequence analysisAdd BLAST21
Transmembranei817 – 837HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show thickening of the stroma and Descement membrane concomitant with increased sodium chloride concentration in the stroma of the cornea. Show impaired urinary concentration, increased urinary volume, and increased urinary sodium loss in the kidney. Also show stress-induced morphological changes of fibrocytes of the inner ear resulting in deafness.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003523501 – 862Sodium bicarbonate transporter-like protein 11Add BLAST862

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA2AJN7
PeptideAtlasiA2AJN7
PRIDEiA2AJN7

PTM databases

iPTMnetiA2AJN7
PhosphoSitePlusiA2AJN7

Expressioni

Tissue specificityi

Expressed in the endothelial cells of the cornea. In the inner ear, is located in fibrocytes underlying the stria vascularis. In the kidney, is expressed in the thin descending limb of Henle loop.1 Publication

Gene expression databases

BgeeiENSMUSG00000074796 Expressed in 93 organ(s), highest expression level in cochlea
ExpressionAtlasiA2AJN7 baseline and differential
GenevisibleiA2AJN7 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096963

Structurei

3D structure databases

ProteinModelPortaliA2AJN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00760000119021
HOGENOMiHOG000016966
HOVERGENiHBG079162
InParanoidiA2AJN7
KOiK13862
OMAiTEPDCNL
OrthoDBiEOG091G01E4
PhylomeDBiA2AJN7
TreeFamiTF313630

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
SUPFAMiSSF55804 SSF55804, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AJN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQNEHCQDS GEYFSAGTQG YFKNNMEDNL EVREDSLGDE VFDTVNSSIV
60 70 80 90 100
SGESIRFFVN VNLEVQPSKS DLEAATGGCV LLHTSRKYLK LKNFEEEVRA
110 120 130 140 150
HRDLDGFLAQ ASIILNETAT SLDDVLRTML NRFALDPNHA EPDCDLDLLM
160 170 180 190 200
AKLFTDAGAP MESKVHLLSD TIQGVTATVR GVQYEQSWLC IICTMKTLQK
210 220 230 240 250
RHVCISRLVR PQNWGENSCE VRFVILVLAP PKMKSTKTAM EVARTFATMF
260 270 280 290 300
SDITFRQKLL KTRTEEEFKE ALVHQRQLLT MMMPRAAGHS MSSLHTHRHP
310 320 330 340 350
QPPKCKDFFP FGKGIWMDIM RRFPVYPMDF TDGIIGKSKS VGKYVTTTLF
360 370 380 390 400
LYFACLLPTI AFGSLNDENT NGAIDVQKTI AGQSIGGLLY ALFSGQPLVI
410 420 430 440 450
LLTTAPLAIY TQVIRVICDD YNLDFNAFYA WTGLWNSFFL ALYAFLNLSL
460 470 480 490 500
LMNLFKRSTE EIIALFISIT FVLDAVKGMV KIFGKYYYGH HYHTKRTSSL
510 520 530 540 550
VSLLGIGRSP NSSLHTALNA SLLASPVEMA TTSSPGSTHS GQATAVLSLL
560 570 580 590 600
IMLGTLWLGY TLYQFKKSPY LHPCVRETLS DCALPIAVLS FSLIGSYGFQ
610 620 630 640 650
EIEMSKFRYN PSESLFEVAQ IHSLSFKAIG SAMGLGFLLS LLFFIEQNLV
660 670 680 690 700
AALVNAPENR LVKGTAYHWD LLLLAIINTG LSLFGLPWIH AAYPHSPLHV
710 720 730 740 750
RALALVEERV ENGHIYETIV DVKETRLTAL GASVLVGLSL LLLPFPLQWI
760 770 780 790 800
PKPVLYGLFL YIALTSLDGN QLFSRVALLL KEQTSYPPTH YIRRVPQRKI
810 820 830 840 850
HYFTGLQILQ LLLLCAFGMS SLPYMKMVFP LIMIAMIPIR YNLLPRIIEA
860
KYLDVMDAEH RP
Length:862
Mass (Da):96,751
Last modified:February 20, 2007 - v1
Checksum:iD8118D841B1B8D6A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJN8A2AJN8_MOUSE
Sodium bicarbonate transporter-like...
Slc4a11
164Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151A → T in AAI11885 (PubMed:15489334).Curated1
Sequence conflicti850A → S in AAI11885 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772162 Genomic DNA No translation available.
BC111884 mRNA Translation: AAI11885.1
AK141286 mRNA Translation: BAE24637.1
CCDSiCCDS38244.1
RefSeqiNP_001074631.1, NM_001081162.1
UniGeneiMm.441391

Genome annotation databases

EnsembliENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796
GeneIDi269356
KEGGimmu:269356
UCSCiuc008mjv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772162 Genomic DNA No translation available.
BC111884 mRNA Translation: AAI11885.1
AK141286 mRNA Translation: BAE24637.1
CCDSiCCDS38244.1
RefSeqiNP_001074631.1, NM_001081162.1
UniGeneiMm.441391

3D structure databases

ProteinModelPortaliA2AJN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096963

PTM databases

iPTMnetiA2AJN7
PhosphoSitePlusiA2AJN7

Proteomic databases

PaxDbiA2AJN7
PeptideAtlasiA2AJN7
PRIDEiA2AJN7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796
GeneIDi269356
KEGGimmu:269356
UCSCiuc008mjv.1 mouse

Organism-specific databases

CTDi83959
MGIiMGI:2138987 Slc4a11

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00760000119021
HOGENOMiHOG000016966
HOVERGENiHBG079162
InParanoidiA2AJN7
KOiK13862
OMAiTEPDCNL
OrthoDBiEOG091G01E4
PhylomeDBiA2AJN7
TreeFamiTF313630

Miscellaneous databases

PROiPR:A2AJN7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074796 Expressed in 93 organ(s), highest expression level in cochlea
ExpressionAtlasiA2AJN7 baseline and differential
GenevisibleiA2AJN7 MM

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
SUPFAMiSSF55804 SSF55804, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS4A11_MOUSE
AccessioniPrimary (citable) accession number: A2AJN7
Secondary accession number(s): Q0VG86, Q3URQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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