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Entry version 76 (08 May 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Apical junction component 1 homolog

Gene

Ajm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the control of adherens junction integrity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apical junction component 1 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ajm1
Synonyms:Gm996
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685842 Ajm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003925451 – 974Apical junction component 1 homologAdd BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei322Omega-N-methylarginineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei749Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei749Omega-N-methylarginine; alternateCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AJA9

PeptideAtlas

More...
PeptideAtlasi
A2AJA9

PRoteomics IDEntifications database

More...
PRIDEi
A2AJA9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AJA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AJA9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A2AJA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029419 Expressed in 75 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AJA9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AJA9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109855

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AJA9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi68 – 422Pro-richAdd BLAST355

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEQ7 Eukaryota
ENOG4110VJZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016543

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231560

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AJA9

Identification of Orthologs from Complete Genome Data

More...
OMAi
REPDMET

Database of Orthologous Groups

More...
OrthoDBi
71355at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AJA9

TreeFam database of animal gene trees

More...
TreeFami
TF323946

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038825 Apical_junction

The PANTHER Classification System

More...
PANTHERi
PTHR21517 PTHR21517, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AJA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTRTDPPDLL VSTVYQDIKV VDPGLTSKRQ PCERSVARPA APTPFNKRHC
60 70 80 90 100
RSFDFLEALD EPTMETHPEP PPPEPAPPRA RPRDSEPRRR TRSKSAPRAS
110 120 130 140 150
QGLATAPASP PVLQRRGREA QRAVRVEGSP RREPSYPALR ALANELHPIK
160 170 180 190 200
LQPQRGGPGR IAPLCATPGR CAPPEPPSGP VPHVRCRLDI KPDEAVLQHA
210 220 230 240 250
ARSSRSCAPR ETTSWARTAP QFHGLTVPGP RHVALSRTPT PSDLYCTDPR
260 270 280 290 300
TLYCDGPLPG PRDYLEHRSQ PFTTPPGPTQ FFYTEEPEGY AGSFTTSPGL
310 320 330 340 350
PFDGYCSRPY LSEEPPRPSP RRGGSYYAGE VRTFPIQEPP SRSYYGETTR
360 370 380 390 400
AYGMPFVPRY VPEEPRAHPG ARTFYTEDFG RYRERDVLAR TYPHPRSSPP
410 420 430 440 450
WADWGPRPYR TLQVMPPPAP GPLLASWHGG TGTSPPRLAT DSRHYSRSWD
460 470 480 490 500
NILAPGPRRE DPLGRGRSYE NLLGREVRDT RGSSPEGRRP PVVVNLSTSP
510 520 530 540 550
RRYAALSLSE TSLTEKGRAG ESLGRNWYVT PEITITDNDL RSVDRPTAKG
560 570 580 590 600
WELPGGRPRQ PVSTVPEGPA SSRQRSLEQL DELITDLVID SRSPAQAPEP
610 620 630 640 650
AAEGLGRQLR RLLDSRAAGP GGATLLAPSR SPPASAGSTE EPTGSGEAAD
660 670 680 690 700
ASPEPSADED DLMTCSNARC RRTETMFNAC LYFKSCHSCY TYYCSRLCRR
710 720 730 740 750
EDWDAHKARC VYGRVGSVCR HVLQFCRDSS PVHRAFSRIA RVGFLSRGRG
760 770 780 790 800
VLFLGFPSPG SADNFLRFGL EGLLLSPTYL SLRELATHAA PLGSYARELA
810 820 830 840 850
AAGRLYEPAE CFLLSVSVAV GPSAAPPGAA ARPAPRTPGP TVRKFAKVAL
860 870 880 890 900
AAGSPTRPPP ARGGEPDMET LILTPPPGTA GLDEEGEAGR RAREVAFIHI
910 920 930 940 950
QRELRMRGVF LRHEFPRVYE QLCEFVEANR RFTPTTIYPT DRRTGRPFMC
960 970
MIMAASEPRA LDWVASANLL DDIM
Length:974
Mass (Da):107,186
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C1D6C006770E3CC
GO
Isoform 2 (identifier: A2AJA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-234: Missing.

Show »
Length:941
Mass (Da):103,586
Checksum:i5F1BDCCE43F54287
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WP25A0A087WP25_MOUSE
Apical junction component 1 homolog
Ajm1 Gm996
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038820202 – 234Missing in isoform 2. CuratedAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL732590 Genomic DNA No translation available.
BC065698 mRNA Translation: AAH65698.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50532.1 [A2AJA9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001005424.2, NM_001005424.2 [A2AJA9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000114217; ENSMUSP00000109855; ENSMUSG00000029419 [A2AJA9-1]
ENSMUST00000188161; ENSMUSP00000140763; ENSMUSG00000029419 [A2AJA9-1]
ENSMUST00000191602; ENSMUSP00000140109; ENSMUSG00000029419 [A2AJA9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
381353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:381353

UCSC genome browser

More...
UCSCi
uc008isq.1 mouse [A2AJA9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732590 Genomic DNA No translation available.
BC065698 mRNA Translation: AAH65698.1
CCDSiCCDS50532.1 [A2AJA9-1]
RefSeqiNP_001005424.2, NM_001005424.2 [A2AJA9-1]

3D structure databases

SMRiA2AJA9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109855

PTM databases

iPTMnetiA2AJA9
PhosphoSitePlusiA2AJA9
SwissPalmiA2AJA9

Proteomic databases

PaxDbiA2AJA9
PeptideAtlasiA2AJA9
PRIDEiA2AJA9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114217; ENSMUSP00000109855; ENSMUSG00000029419 [A2AJA9-1]
ENSMUST00000188161; ENSMUSP00000140763; ENSMUSG00000029419 [A2AJA9-1]
ENSMUST00000191602; ENSMUSP00000140109; ENSMUSG00000029419 [A2AJA9-1]
GeneIDi381353
KEGGimmu:381353
UCSCiuc008isq.1 mouse [A2AJA9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389813
MGIiMGI:2685842 Ajm1

Phylogenomic databases

eggNOGiENOG410IEQ7 Eukaryota
ENOG4110VJZ LUCA
GeneTreeiENSGT00390000016543
HOGENOMiHOG000231560
InParanoidiA2AJA9
OMAiREPDMET
OrthoDBi71355at2759
PhylomeDBiA2AJA9
TreeFamiTF323946

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2AJA9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029419 Expressed in 75 organ(s), highest expression level in cerebellum
ExpressionAtlasiA2AJA9 baseline and differential
GenevisibleiA2AJA9 MM

Family and domain databases

InterProiView protein in InterPro
IPR038825 Apical_junction
PANTHERiPTHR21517 PTHR21517, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAJM1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AJA9
Secondary accession number(s): Q6P0A3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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