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Entry version 96 (13 Feb 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Patatin-like phospholipase domain-containing protein 7

Gene

Pnpla7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy (By similarity). Isoform 1 and isoform 2 have equal enzyme activity. Isoform 3 has no enzyme activity.By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei983NucleophilePROSITE-ProRule annotation1
Active sitei1103Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi170 – 297cNMP 1Add BLAST128
Nucleotide bindingi478 – 602cNMP 2Add BLAST125
Nucleotide bindingi598 – 718cNMP 3Add BLAST121

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: MGI
  • lysophospholipase activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001853

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Patatin-like phospholipase domain-containing protein 7 (EC:3.1.1.-)
Alternative name(s):
Neuropathy target esterase-related esterase
Short name:
NRE
Short name:
NTE-related esterase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pnpla7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385325 Pnpla7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Lysosome, Membrane, Microsome, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3259499

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002934901 – 1352Patatin-like phospholipase domain-containing protein 7Add BLAST1352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei341PhosphoserineCombined sources1
Modified residuei379PhosphoserineBy similarity1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi750N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1036N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1255N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1280PhosphoserineCombined sources1
Modified residuei1284PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AJ88

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AJ88

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AJ88

PeptideAtlas

More...
PeptideAtlasi
A2AJ88

PRoteomics IDEntifications database

More...
PRIDEi
A2AJ88

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AJ88

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AJ88

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1, isoform 2 and isoform 3 are expressed in white adipose tissue, cardiac muscle, skeletal muscle, and testis.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By nutritional conditions. Expression of isoform 3 is switched to the expression of isoform 2 during fasting. In the examined tissues, high expression levels of isoform 3 are detected in fed status, but expression is significantly decreased to about one fourth in fasted status. Isoform 2 expression levels are down-regulated under fed status and are up-regulated in fasted status. Isoform 1 expression levels are not affected by fasting.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036833 Expressed in 238 organ(s), highest expression level in left lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AJ88 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AJ88 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044078

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AJ88

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AJ88

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini950 – 1116PNPLAPROSITE-ProRule annotationAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi954 – 959GXGXXGPROSITE-ProRule annotation6
Motifi981 – 985GXSXGPROSITE-ProRule annotation5
Motifi1103 – 1105DGA/GPROSITE-ProRule annotation3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NTE family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2968 Eukaryota
COG0664 LUCA
COG1752 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156763

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053067

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AJ88

KEGG Orthology (KO)

More...
KOi
K14676

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCITQAD

Database of Orthologous Groups

More...
OrthoDBi
253518at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AJ88

TreeFam database of animal gene trees

More...
TreeFami
TF300519

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038 CAP_ED, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027 cNMP_binding, 3 hits
PF01734 Patatin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100 cNMP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51206 SSF51206, 3 hits
SSF52151 SSF52151, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042 CNMP_BINDING_3, 3 hits
PS51635 PNPLA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AJ88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQNEEDACLE AGYCLGTTLS SWRLHFMEEQ SQSTMLMGIG IGALLTLAFV
60 70 80 90 100
GITFFFVYRR VRRLRRAEPT PQYRFRKRDK VMFYGRKIMR KVTTLPHTLV
110 120 130 140 150
GNTSAPRQRV RKRTKVLSLA KRILRFKKEY PTLQPKEPPP SLLEADLTEF
160 170 180 190 200
DVKNSHLPSE VLYMLKNVRV LGHFEKPLFL ELCKHMVFVQ LQEGEHVFQP
210 220 230 240 250
GEPDISIYVV QDGRLEVCIQ DADGTEVVVK EVLPGDSVHS LLSILDVITG
260 270 280 290 300
HTAPYKTVSA RAAVSSTVLW LPAAAFQGVF EKYPETLVRV VQIIMVRLQR
310 320 330 340 350
VTFLALHNYL GLTTELFNPE SQAIPLLSVA SVAGRAKRQM SYGPEEQLER
360 370 380 390 400
SLRPSEFSSS DHGSSCVTVS GPLLKRSCSV PLPSNHGEVD ELRQSQGSGS
410 420 430 440 450
NTSAFQESHE GATSDLGMAY NRARILPHSD EQLGNSLASK SKKSVVAETP
460 470 480 490 500
SAIFHYSENF RDETGACGKT DAIFRAATKD LLTLMKLDDP SLLDGRVAFL
510 520 530 540 550
HVPAGTLVSK QGDQDVNILF VVSGMLHVYQ QKIDSLEDTC LFLTHPGEMV
560 570 580 590 600
GQLAVLTGEP LMFTIRANRD CSFLSISKAH FYEIMRKRPD VVLGVAHTVV
610 620 630 640 650
KRMSSFVRQI DFALDWMEVE AGRAIYRQGD KSDCTYIVLS GRLRSVIRKD
660 670 680 690 700
DGKKRLAGEY GRGDLVGVVE TLTHQARATT VHAVRDSELA KLPAGALTSI
710 720 730 740 750
KRRYPQVVTR LIHLLGEKIL GSLQQGSATG HQLGFNTASS KWDLGNPPGN
760 770 780 790 800
LSTVAALPAS EDVPLTAFAL ELQHALSAIG PVLLLTSDNI KQRLGSAALD
810 820 830 840 850
SIHEYRLSSW LGQQEDIHRI VLYQADGTLT PWTQRCIRQA DCILIVGLGE
860 870 880 890 900
QEPAVGELEQ MLESTAVRAQ KQLILLHKED GPVPSRTVEW LNMRSWCSGH
910 920 930 940 950
LHLCCPRRVF SKRSLPKLVE MYTRVFQRPP DRHSDFSRLA RMLTGNAIAL
960 970 980 990 1000
VLGGGGARGC AQVGILRALA ECGVPVDIIG GTSIGAFMGA LFAEERSYSQ
1010 1020 1030 1040 1050
TRIRAKQWAE GMTSMMKTIL DLTYPITSMF SGTGFNSSIS NIFKDRQIED
1060 1070 1080 1090 1100
LWLPYFAITT DITASAMRVH TDGSLWRYVR ASMSLSGYMP PLCDPKDGHL
1110 1120 1130 1140 1150
LMDGGYINNL PADVARSMGA KVVIAIDVGS RDETDLTNYG DALSGWWLLW
1160 1170 1180 1190 1200
KRWNPLATKV KVLNMAEIQT RLAYVCCVRQ LEMVKNSDYC EYLRPPIDSY
1210 1220 1230 1240 1250
RTLDFGKFDE ICEVGYQHGR TVFDIWVRSG VLEKMLQDQQ GTSKRKDCGV
1260 1270 1280 1290 1300
FTCPNSSFTD LAEIVSRIEP AKVAAVDDES DYQTEYEEEL PAIPKETYAD
1310 1320 1330 1340 1350
FQSTGIELDS DSEYEPSMLQ GPPSLTSPEQ SQDSFPWLPN QDDQGPRLEH

PS
Length:1,352
Mass (Da):150,494
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADF5362282EA1607
GO
Isoform 2 (identifier: A2AJ88-2) [UniParc]FASTAAdd to basket
Also known as: mNREV1

The sequence of this isoform differs from the canonical sequence as follows:
     1313-1326: EYEPSMLQGPPSLT → VRNMSLRCCKDPPA
     1327-1352: Missing.

Show »
Length:1,326
Mass (Da):147,561
Checksum:i69C4D7B64211DA35
GO
Isoform 3 (identifier: A2AJ88-3) [UniParc]FASTAAdd to basket
Also known as: mNREV2

The sequence of this isoform differs from the canonical sequence as follows:
     780-833: GPVLLLTSDN...QADGTLTPWT → ASMSTGSPVG...SWAWVSKSQQ
     834-1352: Missing.

Show »
Length:833
Mass (Da):91,942
Checksum:iBB7939ED3A7920DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWJ6A0A0A6YWJ6_MOUSE
Patatin-like phospholipase domain-c...
Pnpla7
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0R009B0R009_MOUSE
Patatin-like phospholipase domain-c...
Pnpla7
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0R010B0R010_MOUSE
Patatin-like phospholipase domain-c...
Pnpla7
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UDU9F6UDU9_MOUSE
Patatin-like phospholipase domain-c...
Pnpla7
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0R011B0R011_MOUSE
Patatin-like phospholipase domain-c...
Pnpla7
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH27342 differs from that shown. Intron retention.Curated
The sequence AAH27342 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI41366 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI41367 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC40302 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE28519 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE41783 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113 – 116RTKV → PRVR in AAH25621 (PubMed:15489334).Curated4
Sequence conflicti237S → R in BAE41783 (PubMed:16141072).Curated1
Sequence conflicti604S → P in ABX89593 (PubMed:22326266).Curated1
Sequence conflicti604S → P in ABY82074 (PubMed:22326266).Curated1
Sequence conflicti604S → P in ABY89725 (PubMed:22326266).Curated1
Sequence conflicti1343D → N in BAE28519 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053967780 – 833GPVLL…LTPWT → ASMSTGSPVGWASRRTSNGL CCIRQTAHSHRGPSAASGRL TASSSWAWVSKSQQ in isoform 3. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_053968834 – 1352Missing in isoform 3. 1 PublicationAdd BLAST519
Alternative sequenceiVSP_0265061313 – 1326EYEPS…PPSLT → VRNMSLRCCKDPPA in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_0265071327 – 1352Missing in isoform 2. 2 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK088362 mRNA Translation: BAC40302.1 Different initiation.
AK148380 mRNA Translation: BAE28519.1 Different initiation.
AK170417 mRNA Translation: BAE41783.1 Different initiation.
AL732585 Genomic DNA No translation available.
BC025621 mRNA Translation: AAH25621.1
BC027342 mRNA Translation: AAH27342.1 Sequence problems.
BC064003 mRNA Translation: AAH64003.1
BC080793 mRNA Translation: AAH80793.1
BC141365 mRNA Translation: AAI41366.1 Different initiation.
BC141366 mRNA Translation: AAI41367.1 Different initiation.
EU293208 mRNA Translation: ABX89593.1
EU368675 mRNA Translation: ABY82074.1
EU402948 mRNA Translation: ABY89725.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS50522.1 [A2AJ88-1]

NCBI Reference Sequences

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RefSeqi
NP_666363.3, NM_146251.4 [A2AJ88-1]
XP_017173518.1, XM_017318029.1
XP_017173519.1, XM_017318030.1 [A2AJ88-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.389243

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000045295; ENSMUSP00000044078; ENSMUSG00000036833 [A2AJ88-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
241274

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:241274

UCSC genome browser

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UCSCi
uc008ipv.2 mouse [A2AJ88-1]
uc012brs.1 mouse [A2AJ88-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088362 mRNA Translation: BAC40302.1 Different initiation.
AK148380 mRNA Translation: BAE28519.1 Different initiation.
AK170417 mRNA Translation: BAE41783.1 Different initiation.
AL732585 Genomic DNA No translation available.
BC025621 mRNA Translation: AAH25621.1
BC027342 mRNA Translation: AAH27342.1 Sequence problems.
BC064003 mRNA Translation: AAH64003.1
BC080793 mRNA Translation: AAH80793.1
BC141365 mRNA Translation: AAI41366.1 Different initiation.
BC141366 mRNA Translation: AAI41367.1 Different initiation.
EU293208 mRNA Translation: ABX89593.1
EU368675 mRNA Translation: ABY82074.1
EU402948 mRNA Translation: ABY89725.2
CCDSiCCDS50522.1 [A2AJ88-1]
RefSeqiNP_666363.3, NM_146251.4 [A2AJ88-1]
XP_017173518.1, XM_017318029.1
XP_017173519.1, XM_017318030.1 [A2AJ88-2]
UniGeneiMm.389243

3D structure databases

ProteinModelPortaliA2AJ88
SMRiA2AJ88
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044078

Chemistry databases

ChEMBLiCHEMBL3259499
SwissLipidsiSLP:000001853

PTM databases

iPTMnetiA2AJ88
PhosphoSitePlusiA2AJ88

Proteomic databases

jPOSTiA2AJ88
MaxQBiA2AJ88
PaxDbiA2AJ88
PeptideAtlasiA2AJ88
PRIDEiA2AJ88

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045295; ENSMUSP00000044078; ENSMUSG00000036833 [A2AJ88-1]
GeneIDi241274
KEGGimmu:241274
UCSCiuc008ipv.2 mouse [A2AJ88-1]
uc012brs.1 mouse [A2AJ88-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
375775
MGIiMGI:2385325 Pnpla7

Phylogenomic databases

eggNOGiKOG2968 Eukaryota
COG0664 LUCA
COG1752 LUCA
GeneTreeiENSGT00940000156763
HOVERGENiHBG053067
InParanoidiA2AJ88
KOiK14676
OMAiTCITQAD
OrthoDBi253518at2759
PhylomeDBiA2AJ88
TreeFamiTF300519

Miscellaneous databases

Protein Ontology

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PROi
PR:A2AJ88

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036833 Expressed in 238 organ(s), highest expression level in left lobe of liver
ExpressionAtlasiA2AJ88 baseline and differential
GenevisibleiA2AJ88 MM

Family and domain databases

CDDicd00038 CAP_ED, 3 hits
Gene3Di2.60.120.10, 3 hits
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 3 hits
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 3 hits
SUPFAMiSSF51206 SSF51206, 3 hits
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 3 hits
PS51635 PNPLA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPL7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AJ88
Secondary accession number(s): A9YTK0
, B0LS74, B0ZTC6, B9EJ75, Q3TD21, Q3UFP1, Q66JS2, Q6P3F9, Q8BTY7, Q8R064, Q8R3C5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 20, 2007
Last modified: February 13, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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