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Entry version 112 (12 Aug 2020)
Sequence version 1 (20 Feb 2007)
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Protein

Hemicentin-2

Gene

Hmcn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSensory transduction
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemicentin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hmcn2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2677838, Hmcn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039510920 – 5100Hemicentin-2Add BLAST5081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi449 ↔ 497By similarity
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi526N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi539 ↔ 588By similarity
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi630 ↔ 678By similarity
Glycosylationi675N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi720 ↔ 766By similarity
Disulfide bondi808 ↔ 859By similarity
Disulfide bondi903 ↔ 952By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei909Omega-N-methylarginineCombined sources1
Modified residuei914Omega-N-methylarginineCombined sources1
Modified residuei915Omega-N-methylarginineCombined sources1
Disulfide bondi994 ↔ 1042By similarity
Glycosylationi1024N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1068N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1091 ↔ 1140By similarity
Disulfide bondi1182 ↔ 1225By similarity
Glycosylationi1264N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1269 ↔ 1319By similarity
Glycosylationi1350N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1363 ↔ 1421By similarity
Disulfide bondi1465 ↔ 1515By similarity
Glycosylationi1542N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1559 ↔ 1608By similarity
Disulfide bondi1653 ↔ 1701By similarity
Glycosylationi1676N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1745 ↔ 1794By similarity
Glycosylationi1787N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1846 ↔ 1899By similarity
Glycosylationi1934N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1941 ↔ 1990By similarity
Disulfide bondi2033 ↔ 2084By similarity
Glycosylationi2034N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2119N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2126 ↔ 2175By similarity
Disulfide bondi2218 ↔ 2269By similarity
Glycosylationi2309N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2314 ↔ 2363By similarity
Glycosylationi2315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2395N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2408 ↔ 2457By similarity
Glycosylationi2469N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2501 ↔ 2550By similarity
Glycosylationi2502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2541N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2597 ↔ 2646By similarity
Glycosylationi2606N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2688N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2695 ↔ 2744By similarity
Disulfide bondi2806 ↔ 2855By similarity
Glycosylationi2892N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2901 ↔ 2950By similarity
Glycosylationi2986N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2993 ↔ 3042By similarity
Disulfide bondi3088 ↔ 3137By similarity
Disulfide bondi3180 ↔ 3229By similarity
Disulfide bondi3273 ↔ 3324By similarity
Disulfide bondi3369 ↔ 3418By similarity
Glycosylationi3430N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3462 ↔ 3507By similarity
Disulfide bondi3551 ↔ 3593By similarity
Glycosylationi3560N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3575N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3637 ↔ 3686By similarity
Glycosylationi3717N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3721N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3728 ↔ 3777By similarity
Glycosylationi3806N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3819 ↔ 3870By similarity
Disulfide bondi3912 ↔ 3961By similarity
Disulfide bondi4003 ↔ 4051By similarity
Disulfide bondi4093 ↔ 4142By similarity
Disulfide bondi4184 ↔ 4231By similarity
Disulfide bondi4274 ↔ 4322By similarity
Glycosylationi4304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4364 ↔ 4412By similarity
Glycosylationi4455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4601N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4672 ↔ 4683By similarity
Disulfide bondi4679 ↔ 4692By similarity
Disulfide bondi4694 ↔ 4707By similarity
Disulfide bondi4713 ↔ 4726By similarity
Disulfide bondi4720 ↔ 4735By similarity
Disulfide bondi4739 ↔ 4752By similarity
Disulfide bondi4758 ↔ 4771By similarity
Disulfide bondi4765 ↔ 4780By similarity
Disulfide bondi4801 ↔ 4812By similarity
Disulfide bondi4808 ↔ 4821By similarity
Disulfide bondi4823 ↔ 4836By similarity
Glycosylationi4845N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4908 ↔ 4918By similarity
Disulfide bondi4914 ↔ 4927By similarity
Disulfide bondi4929 ↔ 4942By similarity
Glycosylationi5035N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Reported to be phosphorylated; however as this position is extracellular, the in vivo relevance is unsure.

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AJ76

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AJ76

PeptideAtlas

More...
PeptideAtlasi
A2AJ76

PRoteomics IDEntifications database

More...
PRIDEi
A2AJ76

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
A2AJ76, 40 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AJ76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AJ76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the pericellular extracellular matrix of epithelial cells in a number of tissues including embryonic trophectoderm and adult skin and tongue. Also present in the extracellular matrix of some, but not all, blood vessels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000055632, Expressed in esophagus and 51 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AJ76, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109160

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A2AJ76, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AJ76

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 211VWFAAdd BLAST175
Domaini426 – 515Ig-like C2-type 1Add BLAST90
Domaini517 – 601Ig-like C2-type 2Add BLAST85
Domaini609 – 692Ig-like C2-type 3Add BLAST84
Domaini699 – 782Ig-like C2-type 4Add BLAST84
Domaini787 – 877Ig-like C2-type 5Add BLAST91
Domaini882 – 968Ig-like C2-type 6Add BLAST87
Domaini973 – 1058Ig-like C2-type 7Add BLAST86
Domaini1063 – 1156Ig-like C2-type 8Add BLAST94
Domaini1161 – 1239Ig-like C2-type 9Add BLAST79
Domaini1246 – 1335Ig-like C2-type 10Add BLAST90
Domaini1340 – 1437Ig-like C2-type 11Add BLAST98
Domaini1442 – 1531Ig-like C2-type 12Add BLAST90
Domaini1536 – 1624Ig-like C2-type 13Add BLAST89
Domaini1629 – 1717Ig-like C2-type 14Add BLAST89
Domaini1722 – 1810Ig-like C2-type 15Add BLAST89
Domaini1825 – 1913Ig-like C2-type 16Add BLAST89
Domaini1920 – 2008Ig-like C2-type 17Add BLAST89
Domaini2011 – 2100Ig-like C2-type 18Add BLAST90
Domaini2105 – 2189Ig-like C2-type 19Add BLAST85
Domaini2196 – 2285Ig-like C2-type 20Add BLAST90
Domaini2290 – 2379Ig-like C2-type 21Add BLAST90
Domaini2384 – 2473Ig-like C2-type 22Add BLAST90
Domaini2478 – 2566Ig-like C2-type 23Add BLAST89
Domaini2571 – 2662Ig-like C2-type 24Add BLAST92
Domaini2667 – 2758Ig-like C2-type 25Add BLAST92
Domaini2781 – 2871Ig-like C2-type 26Add BLAST91
Domaini2875 – 2964Ig-like C2-type 27Add BLAST90
Domaini2971 – 3058Ig-like C2-type 28Add BLAST88
Domaini3063 – 3153Ig-like C2-type 29Add BLAST91
Domaini3157 – 3245Ig-like C2-type 30Add BLAST89
Domaini3250 – 3340Ig-like C2-type 31Add BLAST91
Domaini3345 – 3432Ig-like C2-type 32Add BLAST88
Domaini3438 – 3523Ig-like C2-type 33Add BLAST86
Domaini3528 – 3609Ig-like C2-type 34Add BLAST82
Domaini3614 – 3702Ig-like C2-type 35Add BLAST89
Domaini3707 – 3793Ig-like C2-type 36Add BLAST87
Domaini3798 – 3886Ig-like C2-type 37Add BLAST89
Domaini3891 – 3977Ig-like C2-type 38Add BLAST87
Domaini3982 – 4067Ig-like C2-type 39Add BLAST86
Domaini4071 – 4158Ig-like C2-type 40Add BLAST88
Domaini4163 – 4244Ig-like C2-type 41Add BLAST82
Domaini4252 – 4336Ig-like C2-type 42Add BLAST85
Domaini4343 – 4428Ig-like C2-type 43Add BLAST86
Domaini4432 – 4654Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd BLAST223
Domaini4668 – 4708EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini4709 – 4753EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST45
Domaini4754 – 4789EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini4797 – 4837EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini4904 – 4943EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota
KOG4475, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162328

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000087_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2AJ76

Identification of Orthologs from Complete Genome Data

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OMAi
FLCEARG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 43 hits
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR006605, G2_nidogen/fibulin_G2F
IPR009017, GFP
IPR009030, Growth_fac_rcpt_cys_sf
IPR032984, Hemicentin-2
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR036465, vWFA_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR45889:SF4, PTHR45889:SF4, 10 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 4 hits
PF07474, G2F, 1 hit
PF07679, I-set, 31 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 6 hits
SM00179, EGF_CA, 6 hits
SM00682, G2F, 1 hit
SM00409, IG, 43 hits
SM00408, IGc2, 43 hits
SM00406, IGv, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 42 hits
SSF53300, SSF53300, 1 hit
SSF54511, SSF54511, 1 hit
SSF57184, SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 5 hits
PS50835, IG_LIKE, 43 hits
PS50993, NIDOGEN_G2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AJ76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPGAQLLPL LVAISTAVAA VVTSDAPTKT LSPATGDATL AFVFDVTGSM
60 70 80 90 100
WDDLMQVIDG ASRILERSLS SRSRVIANYA LVPFHDPDIG PVTLTADPVV
110 120 130 140 150
FQRELRELYV QGGGDCPEMS VGAIKAAVEV ANPGSFIYVF SDARAKDYHK
160 170 180 190 200
KKELLQLLQL KQSQVVFVLT GDCGDRTHPG YLVFEEIAST SSGQVFQLDK
210 220 230 240 250
QQVSEVLKWV ESAIQASKVH LLSADHEEEG EHTWRIPFDP SLKEVTIALS
260 270 280 290 300
GPGPEIEVRD PLGRVLQTDE GLNVLLNIPD SAKVVAFKPE HPGLWAIKVY
310 320 330 340 350
SSGRHSVRIS GISNINFRAG FSMQPSLDLN HTIEWPLQGV PISLVINSTG
360 370 380 390 400
LQAPGHLESV ELSHSSGRSL LTLPTQLLSN GSTHQLWAGP PFHVPKERFY
410 420 430 440 450
LKVKGKDHEG NPLLRVSGVS YSAVAPGVPL VSMAPKIHGY LQQPLLVSCS
460 470 480 490 500
VYSTLPFQLQ LQRDGERLGE ERYFQESGNS SWEIPRASKA EEGTYQCIAV
510 520 530 540 550
SRAGSGRASA QIVITDPPPQ LVPGPNVTVS PGETAILSCQ VLGETPYNLT
560 570 580 590 600
WVRDWRALPA TTGRISQLSD LSLEVRSIIP TDGGQYQCVA SNPNGVTRAT
610 620 630 640 650
TWLLVREAPQ VSINARSQRF SQGVEVRVSC SASGYPTPHI SWSREGLALP
660 670 680 690 700
EDSRIHVDAQ GTLIIQGLAP EDAGNYSCQA TNEVGTDEET VTLYYTDPPS
710 720 730 740 750
VSAVNAVVLT AVGEEAVLLC AASGVPPPRV IWYRGGLEVI LAPGDSRSGT
760 770 780 790 800
LRIPEAQERD AGLYTCKAVN ELGDASAEIQ LVVGNAPRLT DPPQDVTVEL
810 820 830 840 850
GKSVFLTCRA TGRPPPIVTW RRGDGQALEP GRGSRTGQRD SGVLVFERVS
860 870 880 890 900
LEDQAPYVCE ARNVFGKAQA EARLVVTGHA PPQIANSASV VRVLEGQPVS
910 920 930 940 950
LTCVILAGRP LPERRWLKAG SPLPPGNRHA VRADGSLHLD RALQEDAGRY
960 970 980 990 1000
SCVATNVAGS QHRDVELVVQ VPPRIHPTST HHVTNEGVPA SLPCIASGVP
1010 1020 1030 1040 1050
TPKITWTKET NALTTSGHYS VSRNGTLVIV QPSPQDAGAY VCTATNSVGF
1060 1070 1080 1090 1100
SSQEMWLSVN TKPMIKMNGS QAVDVPLRVT VKAGEEVTLD CEAQGSPTPL
1110 1120 1130 1140 1150
LTWTKDANPL LPVTNRYELL PSGSLRLAQA QVGDNGLYGC TASNPAGATS
1160 1170 1180 1190 1200
RRYVLRVQVP PQVQPGPRVL KVLAGEALDL NCVAEGNPQP QLNWFKDGMA
1210 1220 1230 1240 1250
LMGEGAQGSV HFAAVKTSDA GLYRCEASNS AGTDTWKLEL LVLEPPHWGT
1260 1270 1280 1290 1300
DETKSLLERV AGENASLPCP AQGTPKPRIT WRRGPSSEPL NGRPDVAVLD
1310 1320 1330 1340 1350
EGSLFLSSVS LADSGEYECQ ATNEVGSASR RAKLVVYVPP SIREEGHITN
1360 1370 1380 1390 1400
VSGLAGQPLT LECDINGFPA PEVAWLKDGQ LVGDSGGGWD GEEASGHRLL
1410 1420 1430 1440 1450
DGSRSLHFPR IQESHSGLYS CQAENQAGSA QRDFNLAVFI PPSLLGAGAA
1460 1470 1480 1490 1500
QEVLGLAGAD VTLECQTSGV PTPQVEWTKD GQPILPGDPH ILLQEDGQVL
1510 1520 1530 1540 1550
RIISSHLGDE GQYQCVAFSP AGQQAKDFQL SIHSPPTIWG SNETGEVTVL
1560 1570 1580 1590 1600
EGHTAQLLCE ARGMPSPAIT WYKDGTLLAP SSEVVYSKGG RQLQLVKAQP
1610 1620 1630 1640 1650
SDAGLYTCQA SNPAGITKKS TSLEVYVPPT IEGADGGPYL VQAVAGRPVA
1660 1670 1680 1690 1700
LECVARGHPP PTISWQHEGL PVVDSNGTWL EAGGALQLEN PGEASGGLYS
1710 1720 1730 1740 1750
CVASSPAGEA VLQYSVEMQV PPQLLVAEGM GQVTATVGQS LDLPCQASGS
1760 1770 1780 1790 1800
PVPTIQWLQN GRPAEELAGV QLASQGTILH ISHVELNHSG LFACQATNEA
1810 1820 1830 1840 1850
GTAGAEVEVS VHGKQVSVNL GASFSAHHWW GEPHSPFPAT CNPPVCRHWS
1860 1870 1880 1890 1900
AYPKPSLVER WRGRGNLRGQ PSGTVREPGL TLLSQIEKAD LRDEGVYTCS
1910 1920 1930 1940 1950
ATNLAGESKK DVTLKVLVPP NIEPGPVNKV VLENASVTLE CLASGVPPPD
1960 1970 1980 1990 2000
VSWFKGRQPI STQRRVIVSA DGRVLHIERV QLSDAGSYRC VATNVAGSAG
2010 2020 2030 2040 2050
LKYGLRVNVP PRITLPPNLP GPVLLGTPFR LTCNATGTPR PTLIWLKDGN
2060 2070 2080 2090 2100
PVSPEGIPGL KVFPGGQVLT VASARASDSG SYSCVAVSAV GEDRRDVILQ
2110 2120 2130 2140 2150
VHMPPSILGE ELNMSVVVNE SVTLECQSHA VPPPVLRWQK DGRPLEPHPG
2160 2170 2180 2190 2200
IRLSADKALL EVDRAAVWDA GHYTCEAINQ AGRSEKHFNL HVWVPPAFPS
2210 2220 2230 2240 2250
KEPYTLTVTE GQTARLSCDC QGIPFPKISW RKDGQPLPGE GDSLEQVLAV
2260 2270 2280 2290 2300
GRLLYLGQAQ SAQEGTYTCE CSNAAGTSSQ EQSLEVLVPP QVTGLWEPLT
2310 2320 2330 2340 2350
TVSVIQDGNT TLACNATGKP LPVVTWQRDG QPVSVEPGLR LQNQNHSLHV
2360 2370 2380 2390 2400
ERAQASHAGG YSCVAENTAG RAERRFALSV LAPPHLTGDS DSLTNVTATL
2410 2420 2430 2440 2450
HGSFTLLCEA AGVPAPTVQW FQEGQPISPR EGTYLLAGGW MLKMTQAQEQ
2460 2470 2480 2490 2500
DRGLYSCLAS NEAGEARRNF SVEVLVPPSI ENEDLEEVIK VPEGQTAQLE
2510 2520 2530 2540 2550
CNATGHPPPK VTWFKDGQSL TVEDPYEMSP DGAFLWIPQA NLSNAGHYSC
2560 2570 2580 2590 2600
IASNAVGEKT KHTQLSVLVV PTILGVPEKN ANEEVTVTIN NPISLICEAL
2610 2620 2630 2640 2650
AFPSPNITWM KDGSPFEASK NIQLLPGTHG LQILNAQKED AGQYTCVVTN
2660 2670 2680 2690 2700
ELGEATKNYH VEVLIPPSIS KDDPLGEVSV KEVKTKVNSS LTLECECWAT
2710 2720 2730 2740 2750
PPPSISWYKD GRPVTPSHRL SVLGEGRLLQ IQPTQVSDSG RYLCVATNVA
2760 2770 2780 2790 2800
GEDDQDFNVL IQVPPMFQKM GDVDAGFEPL PHEEEAQGRV TEYREIVENN
2810 2820 2830 2840 2850
PAYLYCDTNA IPPPELTWYR EGQPLSAADG VSVLQGGRIL QLPLVQAEDA
2860 2870 2880 2890 2900
GRYSCKAANE VGEDWLHYEL LVLTPPVIPG DTQELVEEVT VNASSAVSLE
2910 2920 2930 2940 2950
CPALGNPAPA VSWFQNGLPV SPSPRLQVLE EGQVLKVATA EVADAASYMC
2960 2970 2980 2990 3000
VAENQAGSAE KLFTLKVQVP PQISDWTTSQ LTATLNSSVS LPCEVYAHPN
3010 3020 3030 3040 3050
PEVTWYKDGQ PLSLGQEAFL LPGTHTLRLA RAQPADSGTY LCEALNAAGR
3060 3070 3080 3090 3100
DQKMVQLNVL VPPSFKQAPG GPQEAIQVRA GDKAILSCET DSLPEPAVTW
3110 3120 3130 3140 3150
FKDQQPLALG QRIQGLQGGQ TLEILDSQAS DKGVYSCKVS NTAGEAIRTF
3160 3170 3180 3190 3200
VLAIQVPPTF EKPERETVNQ VAGRTLVLAC DVSGIPAPTV TWLKDRLPVE
3210 3220 3230 3240 3250
SSVVHGVVSR GGRLQLSHLQ PAQAGTYTCV AENAQAEARK DFVVSVLVPP
3260 3270 3280 3290 3300
QIQDSGMAQE HNVLEKQEIR LHCEAEGQPP PDITWLKDGG LLDQHVGPHL
3310 3320 3330 3340 3350
RFYLDGSTLV LKGLRTADSG AYTCVAHNPA GEDARLHTVN VLVPPTIKQQ
3360 3370 3380 3390 3400
AGDTGTLVSR TGELVTMVCP VQGSPPIHVS WLKDGLPLPL SQRTLLHSSG
3410 3420 3430 3440 3450
RTLRISQVQL ADSGVFTCVA ASPAGVADRN FTLLVLVPPI LEPVEFQNNV
3460 3470 3480 3490 3500
MAAQGSEVVL PCEARGSPLP LVSWMKDGEP LLPQSLEQGP GLKLESVSVG
3510 3520 3530 3540 3550
DAGTYSCTAA SEAGEARRHF QLTVMDPPHI EESGETSELS LTPGAHLELL
3560 3570 3580 3590 3600
CEARGIPPPN ITWHKDGQAL RRTENDSQAG RVLRVDNAGL YTCLAESPAG
3610 3620 3630 3640 3650
EVEKSFRVRV QAPPNVVGPR GPRSVVGLAP GQLILECSVE AEPAPEIEWH
3660 3670 3680 3690 3700
RGGVLLQADA HTHFPEQGRF LKLQALSTAD GGDYSCTARN RAGSTSVAFR
3710 3720 3730 3740 3750
VEIHTAPTIQ SGPNTVNVSV NRTTLLPCQT HGVPTPLVSW RKDGIPLHPG
3760 3770 3780 3790 3800
SPRLEFLPEG SLRIHPVLAQ DAGHYLCLAS NSAGSDRKGL DLRVFEPPAI
3810 3820 3830 3840 3850
APGPSNLTLT AYSPASLPCE ARGSPKPLVT WWKDGQKLDL RLQQGAYRLL
3860 3870 3880 3890 3900
PSNALFLTAP SPQDSAQFEC VVSNEVGESR RRYQVTVHVP PTIADDQTHF
3910 3920 3930 3940 3950
TVTRMAPVIL TCHSTGSPTP AVSWSKAGTQ LGARGSGYRI LPSGALEIER
3960 3970 3980 3990 4000
ALPLHAGRYT CTARNSAGVA RKHMVLTVQA SPVVKPLPSV VQVVASEEVL
4010 4020 4030 4040 4050
LPCEASGIPQ PMVIWQKEGL SIPEGAHMQV LPSGQLRIMH ASPEDAGNYF
4060 4070 4080 4090 4100
CIAQNSVGSA MAKTRLVVQV PPVIENGLPD LSTIEGSHAL LPCTAKGSPE
4110 4120 4130 4140 4150
PAITWEKDGH LVSGAEGKFT LQPSGELLVK NSEGQDAGTY ICTAENAVGR
4160 4170 4180 4190 4200
ARRRVHLTIL TLPVLTTLPG DRSLRLGDRL WLRCVARGSP TPRIGWTIND
4210 4220 4230 4240 4250
QPVTEGVSEQ DGGSTLQRAA VTREDSGTYT CWAENRVGRV QAVSFVHVKE
4260 4270 4280 4290 4300
APVLQGEAFS YLVEPVGGSI QLHCVVRGDP APDIHWTKDG LPLPISRLHF
4310 4320 4330 4340 4350
QLQNGSLTIL RTKMDDAGRY QCLAVNEMGT VKKVVTVVLQ SAPVFQVEPQ
4360 4370 4380 4390 4400
DVTVRSGVDV ELRCRATGEP VPTIEWLRAG RPLQAGRKLR ALPDGSLWLE
4410 4420 4430 4440 4450
HVEAGDAGVY ECVAHNHLGS VTAKALLAVR GEPRGSRGSM TGVINGQEFG
4460 4470 4480 4490 4500
MATLNISVLQ QGSSEAPTIW SSISQVPASV GPLMRVLVVT IAPIYWALAR
4510 4520 4530 4540 4550
ESGEALNGYS LTGGSFQQES QMEFSTGELL TMTQVARGLD PDGLLLVDMK
4560 4570 4580 4590 4600
INGMIPESLA DGDLRVQDFQ EHYVQTGPGQ LFAGSTQRFL HDSLPASLRC
4610 4620 4630 4640 4650
NHSIQYDETR GLQPQLVQHL RASSISSAFD PEAEALNFQL TTALQTEENE
4660 4670 4680 4690 4700
VGCPEGFEPD VQGAFCVDKD ECSGGPSPCS HTCRNAPGHF SCSCPTGFSL
4710 4720 4730 4740 4750
AWDHRNCRDV DECAGNTHLC QEEQRCVNLL GSYNCLASCR PGFRVTADGS
4760 4770 4780 4790 4800
NCEDVDECLE QLDECHYNQL CENTPGGHHC GCPRGYRQQG HSLPCLDINE
4810 4820 4830 4840 4850
CLQLPTPCVY QCQNLQGSYR CLCPPGQTLL RDGRTCIPLE RNRQNITIVS
4860 4870 4880 4890 4900
HRSPFGPWLR SRVPRPSSSY HTWVSLRPGS GALNSVGRAW CPPGFIRQDG
4910 4920 4930 4940 4950
VCADLDECRV RSLCQHACQN TEGSYYCLCP SGYRLLPSGK NCQDINECEE
4960 4970 4980 4990 5000
DGIECGPGQM CFNTRGSFQC VDTPCPTTYR QGSSPGTCFR RCSQDCSASG
5010 5020 5030 5040 5050
PSTLQYRLLP LPLGVRAHHD VARLAAFSEA GIPANRTELT VLEPDPRSPF
5060 5070 5080 5090 5100
ALRQLRAGQG AVYTRRALTR AGLYRLTVRA AAPRHQSVYI LLIAVSPYPY
Length:5,100
Mass (Da):547,198
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74EAFA906677B3DF
GO
Isoform 2 (identifier: A2AJ76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4439: Missing.

Show »
Length:661
Mass (Da):72,358
Checksum:i4A0552CA8864F5D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRN3A0A2I3BRN3_MOUSE
Hemicentin-2
Hmcn2
1,449Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VSY0F6VSY0_MOUSE
Hemicentin-2
Hmcn2
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC38997 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5026A → V in BAC38997 (PubMed:16141072).Curated1
Sequence conflicti5068L → V in BAC38997 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0393721 – 4439Missing in isoform 2. 1 PublicationAdd BLAST4439

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK083701 mRNA Translation: BAC38997.1 Frameshift.
AL732564 Genomic DNA No translation available.
AL732572 Genomic DNA No translation available.
AL928861 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000113532; ENSMUSP00000109160; ENSMUSG00000055632 [A2AJ76-1]

UCSC genome browser

More...
UCSCi
uc008jds.3, mouse [A2AJ76-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083701 mRNA Translation: BAC38997.1 Frameshift.
AL732564 Genomic DNA No translation available.
AL732572 Genomic DNA No translation available.
AL928861 Genomic DNA No translation available.

3D structure databases

SMRiA2AJ76
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109160

PTM databases

GlyGeniA2AJ76, 40 sites
iPTMnetiA2AJ76
PhosphoSitePlusiA2AJ76

Proteomic databases

MaxQBiA2AJ76
PaxDbiA2AJ76
PeptideAtlasiA2AJ76
PRIDEiA2AJ76

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
65468, 13 antibodies

Genome annotation databases

EnsembliENSMUST00000113532; ENSMUSP00000109160; ENSMUSG00000055632 [A2AJ76-1]
UCSCiuc008jds.3, mouse [A2AJ76-2]

Organism-specific databases

MGIiMGI:2677838, Hmcn2

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
KOG4475, Eukaryota
GeneTreeiENSGT00940000162328
HOGENOMiCLU_000087_0_0_1
InParanoidiA2AJ76
OMAiFLCEARG

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hmcn2, mouse

Protein Ontology

More...
PROi
PR:A2AJ76
RNActiA2AJ76, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000055632, Expressed in esophagus and 51 other tissues
ExpressionAtlasiA2AJ76, baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 43 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR006605, G2_nidogen/fibulin_G2F
IPR009017, GFP
IPR009030, Growth_fac_rcpt_cys_sf
IPR032984, Hemicentin-2
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR036465, vWFA_dom_sf
PANTHERiPTHR45889:SF4, PTHR45889:SF4, 10 hits
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 4 hits
PF07474, G2F, 1 hit
PF07679, I-set, 31 hits
SMARTiView protein in SMART
SM00181, EGF, 6 hits
SM00179, EGF_CA, 6 hits
SM00682, G2F, 1 hit
SM00409, IG, 43 hits
SM00408, IGc2, 43 hits
SM00406, IGv, 12 hits
SUPFAMiSSF48726, SSF48726, 42 hits
SSF53300, SSF53300, 1 hit
SSF54511, SSF54511, 1 hit
SSF57184, SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 5 hits
PS50835, IG_LIKE, 43 hits
PS50993, NIDOGEN_G2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMCN2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AJ76
Secondary accession number(s): Q8BNH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: February 20, 2007
Last modified: August 12, 2020
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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