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UniProtKB - A2AIV2 (VIR_MOUSE)

Entry version 88 (02 Dec 2020)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
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Protein

Protein virilizer homolog

Gene

Virma

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein virilizer homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VirmaImported
Synonyms:Kiaa14291 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1913435, Virma

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003086062 – 1811Protein virilizer homologAdd BLAST1810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei133PhosphoserineBy similarity1
Modified residuei138PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei184PhosphothreonineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei913PhosphotyrosineBy similarity1
Modified residuei1578PhosphoserineCombined sources1
Modified residuei1707PhosphothreonineBy similarity1
Modified residuei1722Omega-N-methylarginineCombined sources1
Modified residuei1740Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei1740Omega-N-methylarginine; alternateCombined sources1
Modified residuei1772Asymmetric dimethylarginineCombined sources1
Modified residuei1774Asymmetric dimethylarginineCombined sources1
Modified residuei1792Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A2AIV2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A2AIV2

MaxQB - The MaxQuant DataBase

More...MaxQBi		A2AIV2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2AIV2

PeptideAtlas

More...PeptideAtlasi		A2AIV2

PRoteomics IDEntifications database

More...PRIDEi		A2AIV2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A2AIV2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2AIV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000040720, Expressed in embryo and 291 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2AIV2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A2AIV2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189, PubMed:29547716). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29535189, PubMed:29547716). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29535189, PubMed:29547716).

Interacts with WTAP (By similarity). Also component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity).

Interacts with NUDT21 and CPSF6 (By similarity).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		211281, 26 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1609, WMM N6-adenosine-methyltransferase complex

Protein interaction database and analysis system

More...IntActi		A2AIV2, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000103943

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A2AIV2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2AIV2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi139 – 202Pro-richAdd BLAST64
Compositional biasi208 – 314Glu-richAdd BLAST107
Compositional biasi942 – 945Poly-Pro4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vir family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4822, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002833

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_254686_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2AIV2

Identification of Orthologs from Complete Genome Data

More...OMAi		SIVFRPS

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2AIV2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031801, VIR_N
IPR026736, Virilizer

The PANTHER Classification System

More...PANTHERi		PTHR23185, PTHR23185, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15912, VIR_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AIV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVDSSMELL FLDTFKHPSA EQSSHIDVVR FPCVVYINEV RVIPPGVRAH 
        60         70         80         90        100
SGLPDNRAYG ETSPHTFQLD LFFNNVSKPS APVFDRLGSL EYDENTSIIF 
       110        120        130        140        150
RPNSKVNTDG LVLRGWYNCL TLAIYGSVDR VISHDRDSPP PPPPPPPPPQ 
       160        170        180        190        200
PQPTLKRNLK HADGEKEDQF NGSPPRPQPR GPRTPPGPPP PDDDEDDPMS 
       210        220        230        240        250
LPVSGDKEED VPHREDYFEP ISPDRNSVPQ EGQYSDEGEV EEEPQEEGED 
       260        270        280        290        300
DEDDVDVEEE EDEDEDDCHT VDSIPDDEEE DEEEEGEEDE EGEGDDGYEQ 
       310        320        330        340        350
ISSDEDGIAD LERETFKYPN FDVEYTPEDL ASVPPMTYDP YDRELAPLLY 
       360        370        380        390        400
FSCPYKTTFE IEISRMKDQG PDKENSGAVE ASVKLTELLD LYQEDRGAKW 
       410        420        430        440        450
VTALEEIPSL IIKGLSYLQL KNTEQDSLGQ LVDWTMQALN LQVAFRQPIA 
       460        470        480        490        500
LNVRQLKAGT KLVTSLAECG APGVTELLQA GVINVLFDLL FADHVSSSLK 
       510        520        530        540        550
LNAFKALDSV ISMTEGMEAF LRSTQNEKSG YQRLLELILL DQTVRVVTAG 
       560        570        580        590        600
SAILQKCHFY EILSEIKRLG DHIAEKTSAV PNHSEPDQDT DAVLERANPD 
       610        620        630        640        650
YENEVEASMD MDLLESSIIS EGEIEKLTNL LEEVFHVMET APHTMTQPPV 
       660        670        680        690        700
KSFPTIARIT GPPERDDPYP VLFRYLHSHH FLELVTLLLS IPITSAHQGV 
       710        720        730        740        750
LQATKDVLKF LAQSQKGLLF FMSEYEATNL LIRALCHLYD QDEEEGLQSD 
       760        770        780        790        800
GADDAFALWL QDSTQTLQCI TELFSHFQRC TASEETDHSD LLGTLHNLYL 
       810        820        830        840        850
ITFNPVGRSA VGHVFSLDKN LQSLITLMEY YSKEALGDSK SKKSVAYNYA 
       860        870        880        890        900
CVLTLVVAQS SSGVQMLEQH AASLLKLCKA DENNAKLQEL GKWLEPLKNL 
       910        920        930        940        950
RFEINCIPNL IEYVKQNIDN LMTAEGVGLT TALRVLCNVA CPPPPVEGQQ 
       960        970        980        990       1000
KDLKWNLAVI QLFSAEGMDT FIRVLQKLNS ILTQPWRLHV NMGTTLHRVT 
      1010       1020       1030       1040       1050
TISMARCTLT LLKTMLTELL RGGSFEFKDM RVPSALVTLH MLLCSIPLSG 
      1060       1070       1080       1090       1100
RLDSDEQKIQ NDIIDILLTF TQGVNEKLTI SEETLANNTW SLMLKEVLSS 
      1110       1120       1130       1140       1150
ILKVPEGFFS GLILLSELLP LPLPMQTTQV IEPHDISVAL NTRKLWSMHL 
      1160       1170       1180       1190       1200
HVQAKLLQEI VRSFSGTTCQ PIQHMLRRIC VQLCDLASPT ALLIMRTVLD 
      1210       1220       1230       1240       1250
LIVEDLQSTS EDKEKQYTSQ TTRLLALLDA LASHKACKLA ILHLINGTIK 
      1260       1270       1280       1290       1300
GDERYAEIFQ DLLALVRSPG DSVTRQQCVE YVTSILQSLC DQDIALILPS 
      1310       1320       1330       1340       1350
PSEGPASELE QLSNSLPSKE LMTAICDCLL ATLANSESSY NCLLTCVRTM 
      1360       1370       1380       1390       1400
MFLAEHDYGL FHLKSSLRKN SSALHSLLKR VVSTFSKDTG ELASASLDFM 
      1410       1420       1430       1440       1450
RQILNADAMG CCGDDSGLME VEGAHPPRTM SLNAAELKQL LQSKEESPES 
      1460       1470       1480       1490       1500
LFLELEKLVL EHSKDDDSLE SLLDNVIGLK QMLESSGEPL PLSDQDVEPV 
      1510       1520       1530       1540       1550
LSAPESLQNL FNNRTAYVLA DVMDDQLKSM WFTPFQAEEI DTDLDLVKVD 
      1560       1570       1580       1590       1600
LIELSEKCCS DFDLHSELER SFLSEPSSPG RSKTTKGFKL GKHKHETFIT 
      1610       1620       1630       1640       1650
SSGKSEYIEP AKRAHVVPPP RGRGRGGFGQ GIRPHDIFRQ RKQNTSRPPS 
      1660       1670       1680       1690       1700
MHVDDFVAAE SKEVVPQDGI PPPKRPLKVS QKISSRGGFS GNRGGRGAFH 
      1710       1720       1730       1740       1750
SQNRFFTPPA SKGNYSRREG TRGSSWSAQN TPRGNYNESR GGQSNFNRGP 
      1760       1770       1780       1790       1800
LPPLRPLSST GYRPSPRDRA SRGRGGLGPS WASTNSGSGG SRGKFVSGGS 
      1810 
GRGRHVRSFT R
Length:1,811
Mass (Da):201,439
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F505FADEC3211E3
GO
Isoform 2 (identifier: A2AIV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1139: IEPHDISVA → PLHITCILS
     1140-1811: Missing.

Show »
Length:1,139
Mass (Da):127,461
Checksum:i90063C903B5C0D85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZY8E9PZY8_MOUSE
Protein virilizer homolog
Virma 1110037F02Rik
1,861Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH28830 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti97S → Y in BAE41548 (PubMed:16141072).Curated1
Sequence conflicti373K → E in BAC35017 (PubMed:16141072).Curated1
Sequence conflicti1520A → T in AAH28830 (PubMed:15489334).Curated1
Sequence conflicti1582S → T in AAH28830 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0290221131 – 1139IEPHDISVA → PLHITCILS in isoform 2. 1 Publication9
Alternative sequenceiVSP_0290231140 – 1811Missing in isoform 2. 1 PublicationAdd BLAST672

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK012768 mRNA Translation: BAB28456.1
AK052499 mRNA Translation: BAC35017.2
AK155623 mRNA Translation: BAE33351.1
AK162531 mRNA Translation: BAE36958.1
AK170075 mRNA Translation: BAE41548.1
AL732538 Genomic DNA No translation available.
AL772170 Genomic DNA No translation available.
AK122509 mRNA Translation: BAC65791.1
BC028830 mRNA Translation: AAH28830.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS84705.1 [A2AIV2-1]

NCBI Reference Sequences

More...RefSeqi		NP_001333984.1, NM_001347055.1 [A2AIV2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000055372; ENSMUSP00000063188; ENSMUSG00000040720 [A2AIV2-2]
ENSMUST00000059914; ENSMUSP00000058078; ENSMUSG00000040720 [A2AIV2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		66185

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:66185

UCSC genome browser

More...UCSCi		uc008rzo.1, mouse [A2AIV2-2]
uc008rzq.1, mouse [A2AIV2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012768 mRNA Translation: BAB28456.1
AK052499 mRNA Translation: BAC35017.2
AK155623 mRNA Translation: BAE33351.1
AK162531 mRNA Translation: BAE36958.1
AK170075 mRNA Translation: BAE41548.1
AL732538 Genomic DNA No translation available.
AL772170 Genomic DNA No translation available.
AK122509 mRNA Translation: BAC65791.1
BC028830 mRNA Translation: AAH28830.1 Different initiation.
CCDSiCCDS84705.1 [A2AIV2-1]
RefSeqiNP_001333984.1, NM_001347055.1 [A2AIV2-1]

3D structure databases

SMRiA2AIV2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi211281, 26 interactors
ComplexPortaliCPX-1609, WMM N6-adenosine-methyltransferase complex
IntActiA2AIV2, 2 interactors
STRINGi10090.ENSMUSP00000103943

PTM databases

iPTMnetiA2AIV2
PhosphoSitePlusiA2AIV2

Proteomic databases

EPDiA2AIV2
jPOSTiA2AIV2
MaxQBiA2AIV2
PaxDbiA2AIV2
PeptideAtlasiA2AIV2
PRIDEiA2AIV2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25815, 44 antibodies

Genome annotation databases

EnsembliENSMUST00000055372; ENSMUSP00000063188; ENSMUSG00000040720 [A2AIV2-2]
ENSMUST00000059914; ENSMUSP00000058078; ENSMUSG00000040720 [A2AIV2-1]
GeneIDi66185
KEGGimmu:66185
UCSCiuc008rzo.1, mouse [A2AIV2-2]
uc008rzq.1, mouse [A2AIV2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25962
MGIiMGI:1913435, Virma

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG4822, Eukaryota
GeneTreeiENSGT00390000002833
HOGENOMiCLU_254686_0_0_1
InParanoidiA2AIV2
OMAiSIVFRPS
PhylomeDBiA2AIV2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		66185, 11 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		1110037F02Rik, mouse

Protein Ontology

More...PROi		PR:A2AIV2
RNActiA2AIV2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000040720, Expressed in embryo and 291 other tissues
ExpressionAtlasiA2AIV2, baseline and differential
GenevisibleiA2AIV2, MM

Family and domain databases

InterProiView protein in InterPro
IPR031801, VIR_N
IPR026736, Virilizer
PANTHERiPTHR23185, PTHR23185, 1 hit
PfamiView protein in Pfam
PF15912, VIR_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVIR_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AIV2
Secondary accession number(s): A2AIV1
, Q3TDQ3, Q3TRR9, Q3U1Z2, Q80TD6, Q8C758, Q8K151, Q9CSI3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: December 2, 2020
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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