UniProtKB - A2AIV2 (VIR_MOUSE)
Protein virilizer homolog
Virma
Functioni
GO - Biological processi
- mRNA alternative polyadenylation Source: UniProtKB
- mRNA methylation Source: UniProtKB
- mRNA processing Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- RNA splicing Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | mRNA processing, mRNA splicing |
Names & Taxonomyi
Protein namesi | Recommended name: Protein virilizer homologCurated |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913435, Virma |
Subcellular locationi
Nucleus
- Nucleus speckle By similarity
- nucleoplasm 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Mainly nuclear with some fraction located in the cytoplasm (PubMed:29547716). ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus (PubMed:29547716).1 Publication
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear body Source: MGI
- nuclear speck Source: UniProtKB
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- RNA N6-methyladenosine methyltransferase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000308606 | 2 – 1811 | Protein virilizer homologAdd BLAST | 1810 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 133 | PhosphoserineBy similarity | 1 | |
Modified residuei | 138 | PhosphoserineCombined sources | 1 | |
Modified residuei | 173 | PhosphoserineCombined sources | 1 | |
Modified residuei | 184 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 222 | PhosphoserineBy similarity | 1 | |
Modified residuei | 913 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1578 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1707 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1722 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 1740 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 1740 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 1772 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1774 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1792 | Asymmetric dimethylarginineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | A2AIV2 |
jPOSTi | A2AIV2 |
MaxQBi | A2AIV2 |
PaxDbi | A2AIV2 |
PeptideAtlasi | A2AIV2 |
PRIDEi | A2AIV2 |
PTM databases
iPTMneti | A2AIV2 |
PhosphoSitePlusi | A2AIV2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040720, Expressed in embryo and 291 other tissues |
ExpressionAtlasi | A2AIV2, baseline and differential |
Genevisiblei | A2AIV2, MM |
Interactioni
Subunit structurei
Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189, PubMed:29547716). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29535189, PubMed:29547716). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29535189, PubMed:29547716).
Interacts with WTAP (By similarity). Also component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity).
Interacts with NUDT21 and CPSF6 (By similarity).
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 211281, 26 interactors |
ComplexPortali | CPX-1609, WMM N6-adenosine-methyltransferase complex |
IntActi | A2AIV2, 2 interactors |
STRINGi | 10090.ENSMUSP00000103943 |
Miscellaneous databases
RNActi | A2AIV2, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 139 – 202 | Pro-richAdd BLAST | 64 | |
Compositional biasi | 208 – 314 | Glu-richAdd BLAST | 107 | |
Compositional biasi | 942 – 945 | Poly-Pro | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4822, Eukaryota |
GeneTreei | ENSGT00390000002833 |
HOGENOMi | CLU_254686_0_0_1 |
InParanoidi | A2AIV2 |
OMAi | SIVFRPS |
PhylomeDBi | A2AIV2 |
Family and domain databases
InterProi | View protein in InterPro IPR031801, VIR_N IPR026736, Virilizer |
PANTHERi | PTHR23185, PTHR23185, 1 hit |
Pfami | View protein in Pfam PF15912, VIR_N, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVDSSMELL FLDTFKHPSA EQSSHIDVVR FPCVVYINEV RVIPPGVRAH
60 70 80 90 100
SGLPDNRAYG ETSPHTFQLD LFFNNVSKPS APVFDRLGSL EYDENTSIIF
110 120 130 140 150
RPNSKVNTDG LVLRGWYNCL TLAIYGSVDR VISHDRDSPP PPPPPPPPPQ
160 170 180 190 200
PQPTLKRNLK HADGEKEDQF NGSPPRPQPR GPRTPPGPPP PDDDEDDPMS
210 220 230 240 250
LPVSGDKEED VPHREDYFEP ISPDRNSVPQ EGQYSDEGEV EEEPQEEGED
260 270 280 290 300
DEDDVDVEEE EDEDEDDCHT VDSIPDDEEE DEEEEGEEDE EGEGDDGYEQ
310 320 330 340 350
ISSDEDGIAD LERETFKYPN FDVEYTPEDL ASVPPMTYDP YDRELAPLLY
360 370 380 390 400
FSCPYKTTFE IEISRMKDQG PDKENSGAVE ASVKLTELLD LYQEDRGAKW
410 420 430 440 450
VTALEEIPSL IIKGLSYLQL KNTEQDSLGQ LVDWTMQALN LQVAFRQPIA
460 470 480 490 500
LNVRQLKAGT KLVTSLAECG APGVTELLQA GVINVLFDLL FADHVSSSLK
510 520 530 540 550
LNAFKALDSV ISMTEGMEAF LRSTQNEKSG YQRLLELILL DQTVRVVTAG
560 570 580 590 600
SAILQKCHFY EILSEIKRLG DHIAEKTSAV PNHSEPDQDT DAVLERANPD
610 620 630 640 650
YENEVEASMD MDLLESSIIS EGEIEKLTNL LEEVFHVMET APHTMTQPPV
660 670 680 690 700
KSFPTIARIT GPPERDDPYP VLFRYLHSHH FLELVTLLLS IPITSAHQGV
710 720 730 740 750
LQATKDVLKF LAQSQKGLLF FMSEYEATNL LIRALCHLYD QDEEEGLQSD
760 770 780 790 800
GADDAFALWL QDSTQTLQCI TELFSHFQRC TASEETDHSD LLGTLHNLYL
810 820 830 840 850
ITFNPVGRSA VGHVFSLDKN LQSLITLMEY YSKEALGDSK SKKSVAYNYA
860 870 880 890 900
CVLTLVVAQS SSGVQMLEQH AASLLKLCKA DENNAKLQEL GKWLEPLKNL
910 920 930 940 950
RFEINCIPNL IEYVKQNIDN LMTAEGVGLT TALRVLCNVA CPPPPVEGQQ
960 970 980 990 1000
KDLKWNLAVI QLFSAEGMDT FIRVLQKLNS ILTQPWRLHV NMGTTLHRVT
1010 1020 1030 1040 1050
TISMARCTLT LLKTMLTELL RGGSFEFKDM RVPSALVTLH MLLCSIPLSG
1060 1070 1080 1090 1100
RLDSDEQKIQ NDIIDILLTF TQGVNEKLTI SEETLANNTW SLMLKEVLSS
1110 1120 1130 1140 1150
ILKVPEGFFS GLILLSELLP LPLPMQTTQV IEPHDISVAL NTRKLWSMHL
1160 1170 1180 1190 1200
HVQAKLLQEI VRSFSGTTCQ PIQHMLRRIC VQLCDLASPT ALLIMRTVLD
1210 1220 1230 1240 1250
LIVEDLQSTS EDKEKQYTSQ TTRLLALLDA LASHKACKLA ILHLINGTIK
1260 1270 1280 1290 1300
GDERYAEIFQ DLLALVRSPG DSVTRQQCVE YVTSILQSLC DQDIALILPS
1310 1320 1330 1340 1350
PSEGPASELE QLSNSLPSKE LMTAICDCLL ATLANSESSY NCLLTCVRTM
1360 1370 1380 1390 1400
MFLAEHDYGL FHLKSSLRKN SSALHSLLKR VVSTFSKDTG ELASASLDFM
1410 1420 1430 1440 1450
RQILNADAMG CCGDDSGLME VEGAHPPRTM SLNAAELKQL LQSKEESPES
1460 1470 1480 1490 1500
LFLELEKLVL EHSKDDDSLE SLLDNVIGLK QMLESSGEPL PLSDQDVEPV
1510 1520 1530 1540 1550
LSAPESLQNL FNNRTAYVLA DVMDDQLKSM WFTPFQAEEI DTDLDLVKVD
1560 1570 1580 1590 1600
LIELSEKCCS DFDLHSELER SFLSEPSSPG RSKTTKGFKL GKHKHETFIT
1610 1620 1630 1640 1650
SSGKSEYIEP AKRAHVVPPP RGRGRGGFGQ GIRPHDIFRQ RKQNTSRPPS
1660 1670 1680 1690 1700
MHVDDFVAAE SKEVVPQDGI PPPKRPLKVS QKISSRGGFS GNRGGRGAFH
1710 1720 1730 1740 1750
SQNRFFTPPA SKGNYSRREG TRGSSWSAQN TPRGNYNESR GGQSNFNRGP
1760 1770 1780 1790 1800
LPPLRPLSST GYRPSPRDRA SRGRGGLGPS WASTNSGSGG SRGKFVSGGS
1810
GRGRHVRSFT R
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PZY8 | E9PZY8_MOUSE | Protein virilizer homolog | Virma 1110037F02Rik | 1,861 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 97 | S → Y in BAE41548 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 373 | K → E in BAC35017 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1520 | A → T in AAH28830 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1582 | S → T in AAH28830 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029022 | 1131 – 1139 | IEPHDISVA → PLHITCILS in isoform 2. 1 Publication | 9 | |
Alternative sequenceiVSP_029023 | 1140 – 1811 | Missing in isoform 2. 1 PublicationAdd BLAST | 672 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012768 mRNA Translation: BAB28456.1 AK052499 mRNA Translation: BAC35017.2 AK155623 mRNA Translation: BAE33351.1 AK162531 mRNA Translation: BAE36958.1 AK170075 mRNA Translation: BAE41548.1 AL732538 Genomic DNA No translation available. AL772170 Genomic DNA No translation available. AK122509 mRNA Translation: BAC65791.1 BC028830 mRNA Translation: AAH28830.1 Different initiation. |
CCDSi | CCDS84705.1 [A2AIV2-1] |
RefSeqi | NP_001333984.1, NM_001347055.1 [A2AIV2-1] |
Genome annotation databases
Ensembli | ENSMUST00000055372; ENSMUSP00000063188; ENSMUSG00000040720 [A2AIV2-2] ENSMUST00000059914; ENSMUSP00000058078; ENSMUSG00000040720 [A2AIV2-1] |
GeneIDi | 66185 |
KEGGi | mmu:66185 |
UCSCi | uc008rzo.1, mouse [A2AIV2-2] uc008rzq.1, mouse [A2AIV2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012768 mRNA Translation: BAB28456.1 AK052499 mRNA Translation: BAC35017.2 AK155623 mRNA Translation: BAE33351.1 AK162531 mRNA Translation: BAE36958.1 AK170075 mRNA Translation: BAE41548.1 AL732538 Genomic DNA No translation available. AL772170 Genomic DNA No translation available. AK122509 mRNA Translation: BAC65791.1 BC028830 mRNA Translation: AAH28830.1 Different initiation. |
CCDSi | CCDS84705.1 [A2AIV2-1] |
RefSeqi | NP_001333984.1, NM_001347055.1 [A2AIV2-1] |
3D structure databases
SMRi | A2AIV2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211281, 26 interactors |
ComplexPortali | CPX-1609, WMM N6-adenosine-methyltransferase complex |
IntActi | A2AIV2, 2 interactors |
STRINGi | 10090.ENSMUSP00000103943 |
PTM databases
iPTMneti | A2AIV2 |
PhosphoSitePlusi | A2AIV2 |
Proteomic databases
EPDi | A2AIV2 |
jPOSTi | A2AIV2 |
MaxQBi | A2AIV2 |
PaxDbi | A2AIV2 |
PeptideAtlasi | A2AIV2 |
PRIDEi | A2AIV2 |
Protocols and materials databases
Antibodypediai | 25815, 44 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000055372; ENSMUSP00000063188; ENSMUSG00000040720 [A2AIV2-2] ENSMUST00000059914; ENSMUSP00000058078; ENSMUSG00000040720 [A2AIV2-1] |
GeneIDi | 66185 |
KEGGi | mmu:66185 |
UCSCi | uc008rzo.1, mouse [A2AIV2-2] uc008rzq.1, mouse [A2AIV2-1] |
Organism-specific databases
CTDi | 25962 |
MGIi | MGI:1913435, Virma |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG4822, Eukaryota |
GeneTreei | ENSGT00390000002833 |
HOGENOMi | CLU_254686_0_0_1 |
InParanoidi | A2AIV2 |
OMAi | SIVFRPS |
PhylomeDBi | A2AIV2 |
Miscellaneous databases
BioGRID-ORCSi | 66185, 11 hits in 18 CRISPR screens |
ChiTaRSi | 1110037F02Rik, mouse |
PROi | PR:A2AIV2 |
RNActi | A2AIV2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040720, Expressed in embryo and 291 other tissues |
ExpressionAtlasi | A2AIV2, baseline and differential |
Genevisiblei | A2AIV2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR031801, VIR_N IPR026736, Virilizer |
PANTHERi | PTHR23185, PTHR23185, 1 hit |
Pfami | View protein in Pfam PF15912, VIR_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VIR_MOUSE | |
Accessioni | A2AIV2Primary (citable) accession number: A2AIV2 Secondary accession number(s): A2AIV1 Q9CSI3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families