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Protein
Submitted name:

Glutamate receptor ionotropic, NMDA3A

Gene

Grin3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate receptor ionotropic, NMDA3AImported
Gene namesi
Name:Grin3aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1933206 Grin3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Transmembranei716 – 734HelicalSequence analysisAdd BLAST19
Transmembranei746 – 769HelicalSequence analysisAdd BLAST24
Transmembranei934 – 956HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3832634

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500264267527 – 1135Sequence analysisAdd BLAST1109

Proteomic databases

MaxQBiA2AIR5
PRIDEiA2AIR5

Expressioni

Gene expression databases

BgeeiENSMUSG00000039579 Expressed in 146 organ(s), highest expression level in pedal digit 2 phalanx
ExpressionAtlasiA2AIR5 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA2AIR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini557 – 622Lig_chan-Glu_bdInterPro annotationAdd BLAST66
Domaini565 – 910PBPeInterPro annotationAdd BLAST346

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1085 – 1119Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000231528
HOVERGENiHBG052634
InParanoidiA2AIR5
OrthoDBiEOG091G00PT
PhylomeDBiA2AIR5

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AIR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV
60 70 80 90 100
GAVHLQPWTT APRAASRAQD GGRAGAQRDE PESGTWRPPA PSQGARWLGS
110 120 130 140 150
ALHGRGPPGS RKLGEGAGTE TLWPRDALLF AVENLNRVEG LLPYNLSLEV
160 170 180 190 200
VMAIEAGLGD LPLMPFSSPS SPWSSDPFSF LQSVCHTVVV QGVSALLAFP
210 220 230 240 250
QSQGEMMELD LVSSVLHIPV LSIVRHEFPR ESQNPLHLQL SLENSLSSDA
260 270 280 290 300
DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTENNSKFH LESIINITAN
310 320 330 340 350
LSSTKDLLSF LQVQLENIRN STPTMVMFGC DMGSIRQIFE MSTQFGLSPP
360 370 380 390 400
DLHWVLGDSQ NVEELRTEGL PLGLIAHGKT TQSVFEYYVQ DAMELVARAV
410 420 430 440 450
ATATMIQPEL ALLPSTMNCM DVKTTNLTSG QYLSRFLANT TFRGLSGSIK
460 470 480 490 500
VKGSTIVSSE NNFFIWNLQY DPMGKPMWTR LGSWQGGRIV MDSGIWPEQA
510 520 530 540 550
QRHKTHFHHP NKLHLRVVTL IEHPFVFTRE VDDEGLCPAG QLCLDPMTND
560 570 580 590 600
SSILDSLFSS LHSSNDTVPI KFKKCCYGYC IDLLEQLAED MNFDFDLYIV
610 620 630 640 650
GDGKYGAWKN GHWTGLVGDL LSGTANMAVT SFSINTARSQ VIDFTSPFFS
660 670 680 690 700
TSLGILVRTR DTAAPIGAFM WPLHWTMWLG IFVALHITAI FLTLYEWKSP
710 720 730 740 750
FGMTPKGRNR NKVFSFSSAL NVCYALLFGR TAAIKPPKCW TGRFLMNLWA
760 770 780 790 800
IFCMFCLSTY TANLAAVMVG EKIYEELSGI HDPKLHHPSQ GFRFGTVRES
810 820 830 840 850
SAEDYVRQSF PEMHEYMRRY NVPATPDGVQ YLKNDPEKLD AFIMDKALLD
860 870 880 890 900
YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTSNISEL ISQYKSHGFM
910 920 930 940 950
DVLHDKWYKV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI
960 970 980 990 1000
GEHIVYRLLL PRIKNKSKLQ YWLHTSQRFH RALNTSFVEE KQPCSKTKRV
1010 1020 1030 1040 1050
EKSRWRRWTC KTEGDSELSL FPRSNMGPQQ LMVWNTSNLS HDNQRKYIFN
1060 1070 1080 1090 1100
DEEGQNQLGT QTHQDIPLPP RRRELPASLT TNGKADSLNV ARNSVMQELS
1110 1120 1130
ELEKQIQVIR QELQLAVSRK TELEEYQRTN RTCES
Length:1,135
Mass (Da):127,542
Last modified:February 20, 2007 - v1
Checksum:i71DBEF3EDFFA2A7E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AIR4A2AIR4_MOUSE
Glutamate receptor ionotropic, NMDA...
Grin3a
1,115Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732521 Genomic DNA No translation available.
AL807392 Genomic DNA No translation available.
RefSeqiNP_001263284.1, NM_001276355.1
UniGeneiMm.440095

Genome annotation databases

EnsembliENSMUST00000093859; ENSMUSP00000091381; ENSMUSG00000039579
GeneIDi242443
UCSCiuc033ica.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732521 Genomic DNA No translation available.
AL807392 Genomic DNA No translation available.
RefSeqiNP_001263284.1, NM_001276355.1
UniGeneiMm.440095

3D structure databases

ProteinModelPortaliA2AIR5
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL3832634

Proteomic databases

MaxQBiA2AIR5
PRIDEiA2AIR5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093859; ENSMUSP00000091381; ENSMUSG00000039579
GeneIDi242443
UCSCiuc033ica.1 mouse

Organism-specific databases

CTDi116443
MGIiMGI:1933206 Grin3a

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000231528
HOVERGENiHBG052634
InParanoidiA2AIR5
OrthoDBiEOG091G00PT
PhylomeDBiA2AIR5

Miscellaneous databases

ChiTaRSiGrin3a mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039579 Expressed in 146 organ(s), highest expression level in pedal digit 2 phalanx
ExpressionAtlasiA2AIR5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AIR5_MOUSE
AccessioniPrimary (citable) accession number: A2AIR5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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