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Entry version 72 (08 May 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Protein FAM166B

Gene

Fam166b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM166B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fam166b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2445194 Fam166b

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003423841 – 273Protein FAM166BAdd BLAST273

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AIP0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AIP0

PRoteomics IDEntifications database

More...
PRIDEi
A2AIP0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AIP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AIP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042788 Expressed in 19 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AIP0 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AIP0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0605 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPQ1 Eukaryota
ENOG4111J2F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154822

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231525

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AIP0

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTYGHLT

Database of Orthologous Groups

More...
OrthoDBi
851402at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AIP0

TreeFam database of animal gene trees

More...
TreeFami
TF325739

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018902 UPF0573/UPF0605

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10629 DUF2475, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AIP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVVNTSIPG LSGENPHYIP GYTGHCPLLR FSMGQTYGQV TGQLLRGPPG
60 70 80 90 100
LAWPPAHRTL LPPIQSPRSP VISKGRLPPR RGHERLSSSI IPGYTGFIPR
110 120 130 140 150
AQFIFAKNCN QVWAEAMSEF TRRHGEQESH QLPDGAKGER EVEEDQLREA
160 170 180 190 200
EEPPLKQELA HASPYSMDDT DPHKFFMSGF TGYVPRARFL FGSSFPVLTN
210 220 230 240 250
QALQEFGQMC SRGRAHKDPK PLSPLPRPTF QNLGLLPHYG GYVPGYKFQF
260 270
GGTFGHLTHD ALGLSITQKQ LPA
Length:273
Mass (Da):30,251
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26B9A6855F415281
GO
Isoform 2 (identifier: A2AIP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-161: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):27,909
Checksum:i49B64FD5E9A1A9BF
GO
Isoform 3 (identifier: A2AIP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-223: FTGYVPRARF...RAHKDPKPLS → IAGIWADVLT...TSLRRLRARI
     224-273: Missing.

Show »
Length:223
Mass (Da):24,415
Checksum:iDFA606B62F458751
GO
Isoform 4 (identifier: A2AIP0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-161: Missing.
     180-223: FTGYVPRARF...RAHKDPKPLS → IAGIWADVLT...TSLRRLRARI
     224-273: Missing.

Show »
Length:203
Mass (Da):22,072
Checksum:iC5E985CBD191B874
GO
Isoform 5 (identifier: A2AIP0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-244: FTGYVPRARF...LLPHYGGYVP → ERKWVATKGE...LYTCQTLGHA

Show »
Length:379
Mass (Da):42,172
Checksum:iECA125CBE8E0D275
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q4G6E9Q4G6_MOUSE
Protein FAM166B
Fam166b
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UXM7G3UXM7_MOUSE
Protein FAM166B
Fam166b
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZ27G3UZ27_MOUSE
Protein FAM166B
Fam166b
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101A → V in BAC26451 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034440142 – 161Missing in isoform 2 and isoform 4. CuratedAdd BLAST20
Alternative sequenceiVSP_034441180 – 244FTGYV…GGYVP → ERKWVATKGEGRPQDVLTQH LPHPQVSRAMCPVPASSLAP ASLCLPTRHCRNLGRCAHGA GRTRTPNLSPHFPGPRFRIW VSYLTTEATCQVRRAREGLR ELRCVCGWGVLWQRELTDTE RCPTLGFSFREETLRQFSGE LGADFKGQFGGSTQLAFSCL WLYTCQTLGHA in isoform 5. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_034442180 – 223FTGYV…PKPLS → IAGIWADVLTGPGAQGPQTS LPTSQAHVSESGSPTSLRRL RARI in isoform 3 and isoform 4. CuratedAdd BLAST44
Alternative sequenceiVSP_034443224 – 273Missing in isoform 3 and isoform 4. CuratedAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK029435 mRNA Translation: BAC26451.1
AK053208 mRNA Translation: BAC35311.1
AL732506 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51162.1 [A2AIP0-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001155853.1, NM_001162381.1
NP_796351.2, NM_177377.5 [A2AIP0-5]
XP_006538074.1, XM_006538011.3 [A2AIP0-5]
XP_006538075.1, XM_006538012.3 [A2AIP0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000052829; ENSMUSP00000058980; ENSMUSG00000042788 [A2AIP0-5]
ENSMUST00000107928; ENSMUSP00000103561; ENSMUSG00000042788 [A2AIP0-2]
ENSMUST00000107929; ENSMUSP00000103562; ENSMUSG00000042788 [A2AIP0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
329831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:329831

UCSC genome browser

More...
UCSCi
uc008spp.1 mouse [A2AIP0-5]
uc012dda.1 mouse [A2AIP0-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029435 mRNA Translation: BAC26451.1
AK053208 mRNA Translation: BAC35311.1
AL732506 Genomic DNA No translation available.
CCDSiCCDS51162.1 [A2AIP0-5]
RefSeqiNP_001155853.1, NM_001162381.1
NP_796351.2, NM_177377.5 [A2AIP0-5]
XP_006538074.1, XM_006538011.3 [A2AIP0-5]
XP_006538075.1, XM_006538012.3 [A2AIP0-1]

3D structure databases

SMRiA2AIP0
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA2AIP0
PhosphoSitePlusiA2AIP0

Proteomic databases

MaxQBiA2AIP0
PaxDbiA2AIP0
PRIDEiA2AIP0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052829; ENSMUSP00000058980; ENSMUSG00000042788 [A2AIP0-5]
ENSMUST00000107928; ENSMUSP00000103561; ENSMUSG00000042788 [A2AIP0-2]
ENSMUST00000107929; ENSMUSP00000103562; ENSMUSG00000042788 [A2AIP0-1]
GeneIDi329831
KEGGimmu:329831
UCSCiuc008spp.1 mouse [A2AIP0-5]
uc012dda.1 mouse [A2AIP0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
730112
MGIiMGI:2445194 Fam166b

Phylogenomic databases

eggNOGiENOG410IPQ1 Eukaryota
ENOG4111J2F LUCA
GeneTreeiENSGT00940000154822
HOGENOMiHOG000231525
InParanoidiA2AIP0
OMAiHTYGHLT
OrthoDBi851402at2759
PhylomeDBiA2AIP0
TreeFamiTF325739

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2AIP0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042788 Expressed in 19 organ(s), highest expression level in lung
ExpressionAtlasiA2AIP0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR018902 UPF0573/UPF0605
PfamiView protein in Pfam
PF10629 DUF2475, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF166B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AIP0
Secondary accession number(s): A2AIP2
, B0R005, B0R006, Q8C6T2, Q8CDW8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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