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Protein

NADH dehydrogenase (ubiquinone) complex I, assembly factor 6

Gene

Ndufaf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
Gene namesi
Name:Ndufaf6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924197 Ndufaf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44MitochondrionSequence analysisAdd BLAST44
ChainiPRO_000029177345 – 333NADH dehydrogenase (ubiquinone) complex I, assembly factor 6Add BLAST289

Proteomic databases

EPDiA2AIL4
MaxQBiA2AIL4
PaxDbiA2AIL4
PeptideAtlasiA2AIL4
PRIDEiA2AIL4

PTM databases

iPTMnetiA2AIL4
PhosphoSitePlusiA2AIL4

Expressioni

Gene expression databases

BgeeiENSMUSG00000050323 Expressed in 187 organ(s), highest expression level in quadriceps femoris
GenevisibleiA2AIL4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062039

Structurei

3D structure databases

ProteinModelPortaliA2AIL4
SMRiA2AIL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDUFAF6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4411 Eukaryota
COG1562 LUCA
GeneTreeiENSGT00510000048688
HOGENOMiHOG000146031
HOVERGENiHBG080309
InParanoidiA2AIL4
KOiK18163
OMAiKIQQVDF
OrthoDBiEOG091G0H0S
PhylomeDBiA2AIL4
TreeFamiTF300084

Family and domain databases

Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
SUPFAMiSSF48576 SSF48576, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2AIL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSMLGSVR GPRPFGLANL FHRQPPRDAW ERVRRLPGPS AVRRSVAAAS
60 70 80 90 100
GPGIPGSHLY CLELLRKRDY ESYLCSLLFP AECQRSASAL RAFNVELAQV
110 120 130 140 150
KDSVSEKTIG LMRMQFWKKA VEDMYCDNPP HQPVAIELWK AVKKHNLTKR
160 170 180 190 200
WLMRIIDERE KNLDDKAYRS MQELENYAEN TQGSLLYLTL EVLGVKDLHA
210 220 230 240 250
DHAASHIGKA QGIVTCLRAT PYHSSRRQVF LPMDVCVQHG VSQEDFLRRN
260 270 280 290 300
QDKNVRDVVY DIASQAHLHL KHARSFHRSV PAEAFPAFLQ TVSLEDYLKK
310 320 330
IQRVDFDIFH PSLQQKNMLL PLSLYIQSWR KRY
Length:333
Mass (Da):38,362
Last modified:February 20, 2007 - v1
Checksum:i2E457A8D07702BF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732497 Genomic DNA No translation available.
CCDSiCCDS38691.1
RefSeqiNP_001078962.1, NM_001085493.2
UniGeneiMm.275265

Genome annotation databases

EnsembliENSMUST00000058183; ENSMUSP00000062039; ENSMUSG00000050323
GeneIDi76947
KEGGimmu:76947
UCSCiuc008ryx.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732497 Genomic DNA No translation available.
CCDSiCCDS38691.1
RefSeqiNP_001078962.1, NM_001085493.2
UniGeneiMm.275265

3D structure databases

ProteinModelPortaliA2AIL4
SMRiA2AIL4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062039

PTM databases

iPTMnetiA2AIL4
PhosphoSitePlusiA2AIL4

Proteomic databases

EPDiA2AIL4
MaxQBiA2AIL4
PaxDbiA2AIL4
PeptideAtlasiA2AIL4
PRIDEiA2AIL4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058183; ENSMUSP00000062039; ENSMUSG00000050323
GeneIDi76947
KEGGimmu:76947
UCSCiuc008ryx.3 mouse

Organism-specific databases

CTDi137682
MGIiMGI:1924197 Ndufaf6

Phylogenomic databases

eggNOGiKOG4411 Eukaryota
COG1562 LUCA
GeneTreeiENSGT00510000048688
HOGENOMiHOG000146031
HOVERGENiHBG080309
InParanoidiA2AIL4
KOiK18163
OMAiKIQQVDF
OrthoDBiEOG091G0H0S
PhylomeDBiA2AIL4
TreeFamiTF300084

Enzyme and pathway databases

ReactomeiR-MMU-6799198 Complex I biogenesis

Miscellaneous databases

PROiPR:A2AIL4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050323 Expressed in 187 organ(s), highest expression level in quadriceps femoris
GenevisibleiA2AIL4 MM

Family and domain databases

Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
SUPFAMiSSF48576 SSF48576, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUF6_MOUSE
AccessioniPrimary (citable) accession number: A2AIL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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