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Entry version 116 (02 Dec 2020)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Ubiquitin carboxyl-terminal hydrolase 8

Gene

Usp8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseARBA annotation
Biological processUbl conjugation pathwayARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin carboxyl-terminal hydrolase 8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1934029, Usp8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AI52

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AI52

PeptideAtlas

More...
PeptideAtlasi
A2AI52

PRoteomics IDEntifications database

More...
PRIDEi
A2AI52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027363, Expressed in testis and 295 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AI52, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AI52, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AI52

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini206 – 324RhodaneseInterPro annotationAdd BLAST119
Domaini750 – 1082USPInterPro annotationAdd BLAST333

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni131 – 187DisorderedSequence analysisAdd BLAST57
Regioni390 – 466DisorderedSequence analysisAdd BLAST77
Regioni479 – 616DisorderedSequence analysisAdd BLAST138
Regioni653 – 721DisorderedSequence analysisAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili850 – 883Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi131 – 179PolyampholyteSequence analysisAdd BLAST49
Compositional biasi423 – 439PolyampholyteSequence analysisAdd BLAST17
Compositional biasi440 – 458PolarSequence analysisAdd BLAST19
Compositional biasi479 – 548PolyampholyteSequence analysisAdd BLAST70
Compositional biasi558 – 572PolyampholyteSequence analysisAdd BLAST15
Compositional biasi656 – 670Pro-richSequence analysisAdd BLAST15
Compositional biasi673 – 688PolyampholyteSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009980_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
561804at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AI52

TreeFam database of animal gene trees

More...
TreeFami
TF106277

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.250.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR001763, Rhodanese-like_dom
IPR036873, Rhodanese-like_dom_sf
IPR015063, USP8_dimer
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00581, Rhodanese, 1 hit
PF00443, UCH, 1 hit
PF08969, USP8_dimer, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00450, RHOD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52821, SSF52821, 1 hit
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50206, RHODANESE_3, 1 hit
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AI52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK TSTKNTKFCK FSSFLSYIHS
60 70 80 90 100
AQKIFKTAEE CRLDRDEERA YVLYMKYVAV YNLIKKRPDF KQQQDYYLSI
110 120 130 140 150
LGPANIKKAI EEAERLSESL KLRYEEAEVR KQLEEKDRRE EEQLQQQKRQ
160 170 180 190 200
EMGREDSGAA AKRSVENLLD SKTKTQRING EKSEGAAAAE RGAITAKELY
210 220 230 240 250
TMMMDKNTSL IIMDARKIQD YQHSCILDSL SVPEEAISPG VTASWIEANL
260 270 280 290 300
SDDSKDTWKK RGSVDYVVLL DWFSSAKDLL LGTTLRSLKD ALFKWESKTV
310 320 330 340 350
LRHEPLVLEG GYENWLLCYP QFTTNAKVTP PPRSRAEEVS VSLDFTYPSL
360 370 380 390 400
EEPVPSKLPT QMPPPPIETN EKALLVTDQD EKLRLSTQPA LAGPGAAPRA
410 420 430 440 450
EASPIIQPAP ATKSVPQVDR TKKPSVKLPE DHRIKSENTD QSGRVLSDRS
460 470 480 490 500
TKPVFPSPTT MLTDEEKARI HQETALLMEK NKQEKELWDK QQKEQKEKLR
510 520 530 540 550
REEQERKAGK TQDADERDST ENQHKAKDGQ EKKDSKQTKT EDRELSADGA
560 570 580 590 600
QEATGTQRQS KSEHEASDAK VPVEGKRCPT SEAQKRPADV SPASVSGELN
610 620 630 640 650
AGKAQREPLT RARSEEMGRI VPGLPLGWAK FLDPITGTFR YYHSPTNTVH
660 670 680 690 700
MYPPEMAPSS APPSTPPTHK VKPQVPAERD REPSKLKRSY SSPDITQALQ
710 720 730 740 750
EEEKRRPAVT PMVNRENKPP CYPKAEISRL SASQIRNLNP VFGGSGPALT
760 770 780 790 800
GLRNLGNTCY MNSILQCLCN APHLADYFNR NCYQDDINRS NLLGHKGEVA
810 820 830 840 850
EEFGIIMKAL WTGQYRYISP KDFKVTIGKI NDQFAGSSQQ DSQELLLFLM
860 870 880 890 900
DGLHEDLNKA DNRKRHKEEN NEHLDDLQAA EHAWQKHKQL NESIIVALFQ
910 920 930 940 950
GQFKSTVQCL TCRRRSRTFE AFMYLSLPLA STSKCTLQDC LRLFSKEEKL
960 970 980 990 1000
TDNNRFYCSH CRARRDSLKK IEIWKLPPVL LVHLKRFSYD GRWKQKLQTS
1010 1020 1030 1040 1050
VDFPLENLDL SQYVIGPKNS LKKYNLFSVS NHYGGLDGGH YTAYCKNAAR
1060 1070 1080 1090
QRWFKFDDHE VSDISVSSVR SSAAYILFYT SLGPRITDVA T
Length:1,091
Mass (Da):123,887
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D99F40AEEC4E209
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80U87UBP8_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp8 Kiaa0055, Ubpy
1,080Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL732330 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001239509.1, NM_001252580.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000110416; ENSMUSP00000106046; ENSMUSG00000027363

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84092

UCSC genome browser

More...
UCSCi
uc012cdj.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732330 Genomic DNA No translation available.
RefSeqiNP_001239509.1, NM_001252580.1

3D structure databases

SMRiA2AI52
ModBaseiSearch...

Proteomic databases

jPOSTiA2AI52
MaxQBiA2AI52
PeptideAtlasiA2AI52
PRIDEiA2AI52

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1385, 260 antibodies

Genome annotation databases

EnsembliENSMUST00000110416; ENSMUSP00000106046; ENSMUSG00000027363
GeneIDi84092
UCSCiuc012cdj.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9101
MGIiMGI:1934029, Usp8

Phylogenomic databases

GeneTreeiENSGT00940000157542
HOGENOMiCLU_009980_0_0_1
OrthoDBi561804at2759
PhylomeDBiA2AI52
TreeFamiTF106277

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84092, 8 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Usp8, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027363, Expressed in testis and 295 other tissues
ExpressionAtlasiA2AI52, baseline and differential
GenevisibleiA2AI52, MM

Family and domain databases

Gene3Di3.40.250.10, 1 hit
InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR001763, Rhodanese-like_dom
IPR036873, Rhodanese-like_dom_sf
IPR015063, USP8_dimer
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF00581, Rhodanese, 1 hit
PF00443, UCH, 1 hit
PF08969, USP8_dimer, 1 hit
SMARTiView protein in SMART
SM00450, RHOD, 1 hit
SUPFAMiSSF52821, SSF52821, 1 hit
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50206, RHODANESE_3, 1 hit
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AI52_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AI52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: December 2, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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