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Protein

Bromodomain and WD repeat-containing protein 3

Gene

Brwd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).By similarity

GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain and WD repeat-containing protein 3
Gene namesi
Name:Brwd3
Synonyms:Gm596
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3029414 Brwd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830901 – 1799Bromodomain and WD repeat-containing protein 3Add BLAST1799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei693PhosphoserineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei885PhosphoserineCombined sources1
Modified residuei1574PhosphoserineBy similarity1
Modified residuei1576PhosphoserineCombined sources1
Modified residuei1760PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AHJ4
PaxDbiA2AHJ4
PeptideAtlasiA2AHJ4
PRIDEiA2AHJ4

PTM databases

iPTMnetiA2AHJ4
PhosphoSitePlusiA2AHJ4

Expressioni

Gene expression databases

BgeeiENSMUSG00000063663 Expressed in 232 organ(s), highest expression level in pineal body
CleanExiMM_BRWD3
ExpressionAtlasiA2AHJ4 baseline and differential
GenevisibleiA2AHJ4 MM

Interactioni

Protein-protein interaction databases

BioGridi238286, 54 interactors
IntActiA2AHJ4, 54 interactors
STRINGi10090.ENSMUSP00000123588

Structurei

3D structure databases

ProteinModelPortaliA2AHJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati170 – 209WD 1Add BLAST40
Repeati213 – 251WD 2Add BLAST39
Repeati255 – 297WD 3Add BLAST43
Repeati307 – 347WD 4Add BLAST41
Repeati353 – 393WD 5Add BLAST41
Repeati400 – 452WD 6Add BLAST53
Repeati456 – 495WD 7Add BLAST40
Repeati502 – 542WD 8Add BLAST41
Domaini1156 – 1226Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1315 – 1409Bromo 2PROSITE-ProRule annotationAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi764 – 767Poly-Lys4
Compositional biasi806 – 857Ser-richAdd BLAST52
Compositional biasi903 – 906Poly-Lys4
Compositional biasi1451 – 1459Poly-Ser9
Compositional biasi1599 – 1626Ser-richAdd BLAST28
Compositional biasi1666 – 1716Gly-richAdd BLAST51

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IRXR Eukaryota
COG2319 LUCA
GeneTreeiENSGT00930000150879
HOGENOMiHOG000203884
HOVERGENiHBG108248
InParanoidiA2AHJ4
KOiK11798
OMAiYPDYAYL
OrthoDBiEOG091G00HZ
TreeFamiTF324197

Family and domain databases

Gene3Di1.20.920.10, 2 hits
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF00400 WD40, 5 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SM00320 WD40, 8 hits
SUPFAMiSSF47370 SSF47370, 2 hits
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 2 hits
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AHJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG
60 70 80 90 100
KEHRRSFEDL VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV
110 120 130 140 150
GRQSLLRDAK DCKSTLWNGS AFAALHRGRP PELPVNYVKP PNVVNITSAR
160 170 180 190 200
QLTGCSRFSH VFPSSAYQHI KMHKRILGHL SSVYCVAFDR SGRRIFTGSD
210 220 230 240 250
DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG SCDKVVRVWC
260 270 280 290 300
LRTCAPVAVL QGHSASITSI QFCPSTKGTT RYLTSTGADG TICFWQWHVK
310 320 330 340 350
TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE
360 370 380 390 400
IPEKIAELES HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS
410 420 430 440 450
IVLDMATKMS GNNLTSAEDK VTKLKVTMVA WDRYDTTVIT AVNNFLLKVW
460 470 480 490 500
NSVTGQLLHT LSGHDDEVFV LEAHPFDQRI ILSAGHDGNI FIWDLDRGTK
510 520 530 540 550
IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF GFGCSKYYEK
560 570 580 590 600
IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK
610 620 630 640 650
FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQEESILDGI
660 670 680 690 700
IRELQREQDL RLINEGDVPH FPINRSYSVN GALSSPNMDI PSSPNIGLRR
710 720 730 740 750
SGQIEGVRQM HNNAPRSQMA TERDLMAWSR RVVVNELNSG VSRVQEECRN
760 770 780 790 800
AKGDLEVSLY TVEKKKKPSY PIQRNDYQPS CGRSLRRTQR KRQHTYLTRS
810 820 830 840 850
NIEHNSQASS QTSGVQEDSD SSSEEDETVG TSDASVEDPV VEWQSESSSS
860 870 880 890 900
DSSSEYSDWI ADAGINLQPP KRQTRQATQK IYSSSEDENL KLEDRQKKPK
910 920 930 940 950
QTKKKKGGLV SMAGEPNEEW LAPQWILDTI PRRSPFVPQM GDELIYFRQG
960 970 980 990 1000
HEAYVRAVRK SKIYSVNLQK QPWNKMDLRE QEFVKIVGIK YEIGPPTLCC
1010 1020 1030 1040 1050
LKLAFLDPIS GKMTGESFSI KYHDMPDVID FLVLHQFYNE AKERNWQIGD
1060 1070 1080 1090 1100
RFRSIIDDAW WFGTVESQQP FQPEYPDSSF QCYSVHWDNN EREKMSPWDM
1110 1120 1130 1140 1150
EPIPDGTAFP DEVGAGIPVS QEELTALLYK PQEGEWGAHS RDEECERVIQ
1160 1170 1180 1190 1200
GINNLLSLDF ASPFAVPVDL SAYPLYCTVV AYPTDLNTIK QRLENRFYRR
1210 1220 1230 1240 1250
ISALMWEVRY IEHNARTFNE PDSPIVKAAK IVTDVLLRFI GDQSCSDILD
1260 1270 1280 1290 1300
TYNKIKAEDP DSSDLEEDSE MVDLDSDGPG TSSGRRAKCR GRRQSLKCNP
1310 1320 1330 1340 1350
DAWKKQCEEL LSLIYEREDS EPFRQPADPQ SYPVQQQQEG ESSQSVPPDR
1360 1370 1380 1390 1400
QDPSLSEDYQ DGIDTPMDFS TVKETLESGN YDSPLEFYKD VRQIFSNSKA
1410 1420 1430 1440 1450
YTSNKKSRIY SMTLRLSALF ENHIKNIISD YKSAIQSQKR RRPRYRKRLR
1460 1470 1480 1490 1500
SSSSSLSSSR APSPKGKQKQ MKLQPKNDQN TSVAYARTSS PFSSPVSDAA
1510 1520 1530 1540 1550
EGVSLYLLDD EGDGPFSPSS FSGYSRSGNS HDPGKAKSFR NRVLPAKQDH
1560 1570 1580 1590 1600
SLDGPLTNVD GREPRTGAKR KLLSASEEDE SMGGEEKEMK ETKEQVHLSS
1610 1620 1630 1640 1650
SESGELGSSL SSESTSGSDS DSESTSRTDQ DYVDGDHDYS KFIQTRPKRK
1660 1670 1680 1690 1700
LRKQHTNGKR NWKTRGTGGR GRWGRWGRWS RGGRGRGGRG RGGRGRGGGG
1710 1720 1730 1740 1750
GRGRGRGRGG RGASRGSSRA KRARVADDEF DTMFSGRFSR LPRIKTRNQG
1760 1770 1780 1790
RRTVLYNDDS DNDNFVSTED PLNLGTSRSG RVRKMTEKAR VSHLMGWNY
Length:1,799
Mass (Da):202,942
Last modified:February 20, 2007 - v1
Checksum:i57E01C1ECBDD2D31
GO
Isoform 2 (identifier: A2AHJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-283: FCPSTKGTTRYL → VRIMISSLPG
     284-1799: Missing.

Note: No experimental confirmation available.
Show »
Length:281
Mass (Da):31,091
Checksum:i2743DB889746285D
GO
Isoform 3 (identifier: A2AHJ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-181: VNITSARQLT...MHKRILGHLS → GFFFVALTVL...VCHMTSYITF
     182-1799: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):20,156
Checksum:iBB5B42040090F1B2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UXF9G3UXF9_MOUSE
Bromodomain and WD repeat-containin...
Brwd3
60Annotation score:
G3UZT0G3UZT0_MOUSE
Bromodomain and WD repeat-containin...
Brwd3
84Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024308144 – 181VNITS…LGHLS → GFFFVALTVLELYVDQAGLC LSSAGIKVVCHMTSYITF in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_024309182 – 1799Missing in isoform 3. 1 PublicationAdd BLAST1618
Alternative sequenceiVSP_024310272 – 283FCPST…TTRYL → VRIMISSLPG in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_024311284 – 1799Missing in isoform 2. 1 PublicationAdd BLAST1516

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050539 mRNA Translation: BAC34314.1
AK139563 mRNA Translation: BAE24064.1
AK163354 mRNA Translation: BAE37315.1
BX000698, AL731764 Genomic DNA Translation: CAM25065.1
AL731764, BX000698 Genomic DNA Translation: CAM26827.1
AL731764 Genomic DNA Translation: CAM26828.1
BC082562 mRNA Translation: AAH82562.1
CCDSiCCDS41100.1 [A2AHJ4-1]
RefSeqiNP_001074946.1, NM_001081477.1 [A2AHJ4-1]
UniGeneiMm.100112
Mm.426127

Genome annotation databases

EnsembliENSMUST00000101283; ENSMUSP00000098841; ENSMUSG00000063663 [A2AHJ4-3]
ENSMUST00000150434; ENSMUSP00000123588; ENSMUSG00000063663 [A2AHJ4-1]
GeneIDi382236
KEGGimmu:382236
UCSCiuc009ucm.1 mouse [A2AHJ4-1]
uc009ucn.1 mouse [A2AHJ4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050539 mRNA Translation: BAC34314.1
AK139563 mRNA Translation: BAE24064.1
AK163354 mRNA Translation: BAE37315.1
BX000698, AL731764 Genomic DNA Translation: CAM25065.1
AL731764, BX000698 Genomic DNA Translation: CAM26827.1
AL731764 Genomic DNA Translation: CAM26828.1
BC082562 mRNA Translation: AAH82562.1
CCDSiCCDS41100.1 [A2AHJ4-1]
RefSeqiNP_001074946.1, NM_001081477.1 [A2AHJ4-1]
UniGeneiMm.100112
Mm.426127

3D structure databases

ProteinModelPortaliA2AHJ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi238286, 54 interactors
IntActiA2AHJ4, 54 interactors
STRINGi10090.ENSMUSP00000123588

PTM databases

iPTMnetiA2AHJ4
PhosphoSitePlusiA2AHJ4

Proteomic databases

MaxQBiA2AHJ4
PaxDbiA2AHJ4
PeptideAtlasiA2AHJ4
PRIDEiA2AHJ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101283; ENSMUSP00000098841; ENSMUSG00000063663 [A2AHJ4-3]
ENSMUST00000150434; ENSMUSP00000123588; ENSMUSG00000063663 [A2AHJ4-1]
GeneIDi382236
KEGGimmu:382236
UCSCiuc009ucm.1 mouse [A2AHJ4-1]
uc009ucn.1 mouse [A2AHJ4-2]

Organism-specific databases

CTDi254065
MGIiMGI:3029414 Brwd3

Phylogenomic databases

eggNOGiENOG410IRXR Eukaryota
COG2319 LUCA
GeneTreeiENSGT00930000150879
HOGENOMiHOG000203884
HOVERGENiHBG108248
InParanoidiA2AHJ4
KOiK11798
OMAiYPDYAYL
OrthoDBiEOG091G00HZ
TreeFamiTF324197

Miscellaneous databases

ChiTaRSiBrwd3 mouse
PROiPR:A2AHJ4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063663 Expressed in 232 organ(s), highest expression level in pineal body
CleanExiMM_BRWD3
ExpressionAtlasiA2AHJ4 baseline and differential
GenevisibleiA2AHJ4 MM

Family and domain databases

Gene3Di1.20.920.10, 2 hits
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF00400 WD40, 5 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SM00320 WD40, 8 hits
SUPFAMiSSF47370 SSF47370, 2 hits
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 2 hits
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBRWD3_MOUSE
AccessioniPrimary (citable) accession number: A2AHJ4
Secondary accession number(s): Q3TQR7
, Q3UTB6, Q640P3, Q8C7D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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