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Protein

Bromodomain and WD repeat-containing protein 3

Gene

Brwd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain and WD repeat-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Brwd3
Synonyms:Gm596
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3029414 Brwd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002830901 – 1799Bromodomain and WD repeat-containing protein 3Add BLAST1799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei693PhosphoserineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei885PhosphoserineCombined sources1
Modified residuei1574PhosphoserineBy similarity1
Modified residuei1576PhosphoserineCombined sources1
Modified residuei1760PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AHJ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AHJ4

PeptideAtlas

More...
PeptideAtlasi
A2AHJ4

PRoteomics IDEntifications database

More...
PRIDEi
A2AHJ4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AHJ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AHJ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000063663 Expressed in 232 organ(s), highest expression level in pineal body

CleanEx database of gene expression profiles

More...
CleanExi
MM_BRWD3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AHJ4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AHJ4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
238286, 54 interactors

Protein interaction database and analysis system

More...
IntActi
A2AHJ4, 54 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000123588

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AHJ4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati170 – 209WD 1Add BLAST40
Repeati213 – 251WD 2Add BLAST39
Repeati255 – 297WD 3Add BLAST43
Repeati307 – 347WD 4Add BLAST41
Repeati353 – 393WD 5Add BLAST41
Repeati400 – 452WD 6Add BLAST53
Repeati456 – 495WD 7Add BLAST40
Repeati502 – 542WD 8Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1156 – 1226Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1315 – 1409Bromo 2PROSITE-ProRule annotationAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi764 – 767Poly-Lys4
Compositional biasi806 – 857Ser-richAdd BLAST52
Compositional biasi903 – 906Poly-Lys4
Compositional biasi1451 – 1459Poly-Ser9
Compositional biasi1599 – 1626Ser-richAdd BLAST28
Compositional biasi1666 – 1716Gly-richAdd BLAST51

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IRXR Eukaryota
COG2319 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153647

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000203884

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108248

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AHJ4

KEGG Orthology (KO)

More...
KOi
K11798

Identification of Orthologs from Complete Genome Data

More...
OMAi
YPDYAYL

Database of Orthologous Groups

More...
OrthoDBi
240778at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 2 hits
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 2 hits
PF00400 WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 2 hits
SM00320 WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 2 hits
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014 BROMODOMAIN_2, 2 hits
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AHJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG
60 70 80 90 100
KEHRRSFEDL VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV
110 120 130 140 150
GRQSLLRDAK DCKSTLWNGS AFAALHRGRP PELPVNYVKP PNVVNITSAR
160 170 180 190 200
QLTGCSRFSH VFPSSAYQHI KMHKRILGHL SSVYCVAFDR SGRRIFTGSD
210 220 230 240 250
DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG SCDKVVRVWC
260 270 280 290 300
LRTCAPVAVL QGHSASITSI QFCPSTKGTT RYLTSTGADG TICFWQWHVK
310 320 330 340 350
TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE
360 370 380 390 400
IPEKIAELES HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS
410 420 430 440 450
IVLDMATKMS GNNLTSAEDK VTKLKVTMVA WDRYDTTVIT AVNNFLLKVW
460 470 480 490 500
NSVTGQLLHT LSGHDDEVFV LEAHPFDQRI ILSAGHDGNI FIWDLDRGTK
510 520 530 540 550
IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF GFGCSKYYEK
560 570 580 590 600
IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK
610 620 630 640 650
FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQEESILDGI
660 670 680 690 700
IRELQREQDL RLINEGDVPH FPINRSYSVN GALSSPNMDI PSSPNIGLRR
710 720 730 740 750
SGQIEGVRQM HNNAPRSQMA TERDLMAWSR RVVVNELNSG VSRVQEECRN
760 770 780 790 800
AKGDLEVSLY TVEKKKKPSY PIQRNDYQPS CGRSLRRTQR KRQHTYLTRS
810 820 830 840 850
NIEHNSQASS QTSGVQEDSD SSSEEDETVG TSDASVEDPV VEWQSESSSS
860 870 880 890 900
DSSSEYSDWI ADAGINLQPP KRQTRQATQK IYSSSEDENL KLEDRQKKPK
910 920 930 940 950
QTKKKKGGLV SMAGEPNEEW LAPQWILDTI PRRSPFVPQM GDELIYFRQG
960 970 980 990 1000
HEAYVRAVRK SKIYSVNLQK QPWNKMDLRE QEFVKIVGIK YEIGPPTLCC
1010 1020 1030 1040 1050
LKLAFLDPIS GKMTGESFSI KYHDMPDVID FLVLHQFYNE AKERNWQIGD
1060 1070 1080 1090 1100
RFRSIIDDAW WFGTVESQQP FQPEYPDSSF QCYSVHWDNN EREKMSPWDM
1110 1120 1130 1140 1150
EPIPDGTAFP DEVGAGIPVS QEELTALLYK PQEGEWGAHS RDEECERVIQ
1160 1170 1180 1190 1200
GINNLLSLDF ASPFAVPVDL SAYPLYCTVV AYPTDLNTIK QRLENRFYRR
1210 1220 1230 1240 1250
ISALMWEVRY IEHNARTFNE PDSPIVKAAK IVTDVLLRFI GDQSCSDILD
1260 1270 1280 1290 1300
TYNKIKAEDP DSSDLEEDSE MVDLDSDGPG TSSGRRAKCR GRRQSLKCNP
1310 1320 1330 1340 1350
DAWKKQCEEL LSLIYEREDS EPFRQPADPQ SYPVQQQQEG ESSQSVPPDR
1360 1370 1380 1390 1400
QDPSLSEDYQ DGIDTPMDFS TVKETLESGN YDSPLEFYKD VRQIFSNSKA
1410 1420 1430 1440 1450
YTSNKKSRIY SMTLRLSALF ENHIKNIISD YKSAIQSQKR RRPRYRKRLR
1460 1470 1480 1490 1500
SSSSSLSSSR APSPKGKQKQ MKLQPKNDQN TSVAYARTSS PFSSPVSDAA
1510 1520 1530 1540 1550
EGVSLYLLDD EGDGPFSPSS FSGYSRSGNS HDPGKAKSFR NRVLPAKQDH
1560 1570 1580 1590 1600
SLDGPLTNVD GREPRTGAKR KLLSASEEDE SMGGEEKEMK ETKEQVHLSS
1610 1620 1630 1640 1650
SESGELGSSL SSESTSGSDS DSESTSRTDQ DYVDGDHDYS KFIQTRPKRK
1660 1670 1680 1690 1700
LRKQHTNGKR NWKTRGTGGR GRWGRWGRWS RGGRGRGGRG RGGRGRGGGG
1710 1720 1730 1740 1750
GRGRGRGRGG RGASRGSSRA KRARVADDEF DTMFSGRFSR LPRIKTRNQG
1760 1770 1780 1790
RRTVLYNDDS DNDNFVSTED PLNLGTSRSG RVRKMTEKAR VSHLMGWNY
Length:1,799
Mass (Da):202,942
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57E01C1ECBDD2D31
GO
Isoform 2 (identifier: A2AHJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-283: FCPSTKGTTRYL → VRIMISSLPG
     284-1799: Missing.

Note: No experimental confirmation available.
Show »
Length:281
Mass (Da):31,091
Checksum:i2743DB889746285D
GO
Isoform 3 (identifier: A2AHJ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-181: VNITSARQLT...MHKRILGHLS → GFFFVALTVL...VCHMTSYITF
     182-1799: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):20,156
Checksum:iBB5B42040090F1B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UXF9G3UXF9_MOUSE
Bromodomain and WD repeat-containin...
Brwd3
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZT0G3UZT0_MOUSE
Bromodomain and WD repeat-containin...
Brwd3
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024308144 – 181VNITS…LGHLS → GFFFVALTVLELYVDQAGLC LSSAGIKVVCHMTSYITF in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_024309182 – 1799Missing in isoform 3. 1 PublicationAdd BLAST1618
Alternative sequenceiVSP_024310272 – 283FCPST…TTRYL → VRIMISSLPG in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_024311284 – 1799Missing in isoform 2. 1 PublicationAdd BLAST1516

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK050539 mRNA Translation: BAC34314.1
AK139563 mRNA Translation: BAE24064.1
AK163354 mRNA Translation: BAE37315.1
BX000698, AL731764 Genomic DNA Translation: CAM25065.1
AL731764, BX000698 Genomic DNA Translation: CAM26827.1
AL731764 Genomic DNA Translation: CAM26828.1
BC082562 mRNA Translation: AAH82562.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41100.1 [A2AHJ4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001074946.1, NM_001081477.1 [A2AHJ4-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.100112
Mm.426127

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000101283; ENSMUSP00000098841; ENSMUSG00000063663 [A2AHJ4-3]
ENSMUST00000150434; ENSMUSP00000123588; ENSMUSG00000063663 [A2AHJ4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
382236

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:382236

UCSC genome browser

More...
UCSCi
uc009ucm.1 mouse [A2AHJ4-1]
uc009ucn.1 mouse [A2AHJ4-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050539 mRNA Translation: BAC34314.1
AK139563 mRNA Translation: BAE24064.1
AK163354 mRNA Translation: BAE37315.1
BX000698, AL731764 Genomic DNA Translation: CAM25065.1
AL731764, BX000698 Genomic DNA Translation: CAM26827.1
AL731764 Genomic DNA Translation: CAM26828.1
BC082562 mRNA Translation: AAH82562.1
CCDSiCCDS41100.1 [A2AHJ4-1]
RefSeqiNP_001074946.1, NM_001081477.1 [A2AHJ4-1]
UniGeneiMm.100112
Mm.426127

3D structure databases

ProteinModelPortaliA2AHJ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi238286, 54 interactors
IntActiA2AHJ4, 54 interactors
STRINGi10090.ENSMUSP00000123588

PTM databases

iPTMnetiA2AHJ4
PhosphoSitePlusiA2AHJ4

Proteomic databases

MaxQBiA2AHJ4
PaxDbiA2AHJ4
PeptideAtlasiA2AHJ4
PRIDEiA2AHJ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101283; ENSMUSP00000098841; ENSMUSG00000063663 [A2AHJ4-3]
ENSMUST00000150434; ENSMUSP00000123588; ENSMUSG00000063663 [A2AHJ4-1]
GeneIDi382236
KEGGimmu:382236
UCSCiuc009ucm.1 mouse [A2AHJ4-1]
uc009ucn.1 mouse [A2AHJ4-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
254065
MGIiMGI:3029414 Brwd3

Phylogenomic databases

eggNOGiENOG410IRXR Eukaryota
COG2319 LUCA
GeneTreeiENSGT00940000153647
HOGENOMiHOG000203884
HOVERGENiHBG108248
InParanoidiA2AHJ4
KOiK11798
OMAiYPDYAYL
OrthoDBi240778at2759
TreeFamiTF324197

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Brwd3 mouse

Protein Ontology

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PROi
PR:A2AHJ4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000063663 Expressed in 232 organ(s), highest expression level in pineal body
CleanExiMM_BRWD3
ExpressionAtlasiA2AHJ4 baseline and differential
GenevisibleiA2AHJ4 MM

Family and domain databases

Gene3Di1.20.920.10, 2 hits
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF00400 WD40, 5 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SM00320 WD40, 8 hits
SUPFAMiSSF47370 SSF47370, 2 hits
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 2 hits
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRWD3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AHJ4
Secondary accession number(s): Q3TQR7
, Q3UTB6, Q640P3, Q8C7D5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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