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Protein

Leucine zipper putative tumor suppressor 3

Gene

Lzts3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 3Curated
Alternative name(s):
ProSAP-interacting protein 1By similarity
Short name:
ProSAPiP1By similarity
Gene namesi
Name:Lzts3Imported
Synonyms:Prosapip1By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2656976 Lzts3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003941991 – 700Leucine zipper putative tumor suppressor 3Add BLAST700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei343PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AHG0
PaxDbiA2AHG0
PeptideAtlasiA2AHG0
PRIDEiA2AHG0

PTM databases

iPTMnetiA2AHG0
PhosphoSitePlusiA2AHG0

Expressioni

Gene expression databases

BgeeiENSMUSG00000037703 Expressed in 215 organ(s), highest expression level in dorsal striatum
GenevisibleiA2AHG0 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232338, 3 interactors
IntActiA2AHG0, 3 interactors
STRINGi10090.ENSMUSP00000037109

Structurei

3D structure databases

ProteinModelPortaliA2AHG0
SMRiA2AHG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili345 – 523Sequence analysisAdd BLAST179
Coiled coili597 – 666Sequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi215 – 333Gly/Ser-richAdd BLAST119

Sequence similaritiesi

Belongs to the LZTS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFZY Eukaryota
ENOG410Z2V9 LUCA
GeneTreeiENSGT00510000046769
HOGENOMiHOG000230889
HOVERGENiHBG052381
InParanoidiA2AHG0
OMAiVGYNGIS
OrthoDBiEOG091G03L2
PhylomeDBiA2AHG0
TreeFamiTF331420

Family and domain databases

InterProiView protein in InterPro
IPR033295 LZTS3
PANTHERiPTHR19354:SF6 PTHR19354:SF6, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2AHG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPADLASEG PKLEDPPAPH LFGKCPSGLI MAKLETLPVR ADPGRDPLLA
60 70 80 90 100
FAPRPSELGP PDPRLTMGSV GSGVTHAQEF PMKSVGTRTG GGGNQGSFPG
110 120 130 140 150
PRSGGSGANR ERPGRYPSED KVLANSLYLN GELRGSDHTD VCGNVVGSSG
160 170 180 190 200
GSSSSGGSDK APPQYREPNH PPKLLTTSGK LDQCSEPLVR PSAFKPVVPK
210 220 230 240 250
NFHSMQNLCP PQTNGTPEGR QGPAGLKGGL DKSRTMTPAG GSGGGLSDSG
260 270 280 290 300
RNSLTSLPTY SSSYSQHLAP LSASTSHINR IGTAGYSSGS SGGGSGYQDL
310 320 330 340 350
GTSDSGRASS KSGSSSSMGR SGHLGSGEGG NGGLPFAACS PPSPSALIQE
360 370 380 390 400
LEERLWEKEQ EVAALRRSLE QSEAAVAQVL EERQKAWERE LAELRQGCSG
410 420 430 440 450
KLQQVARRAQ RAQQGLQLQV LRLQQDKKQL QEEAAQLIRQ REELEDKVAV
460 470 480 490 500
CQKEQADFLP RMEETKWEVC QKAGEISLLK QQLKDSQADV SQKLSEIVGL
510 520 530 540 550
RSQLREGRAS LREKEEQLLS LRDSFGSKQA SLELSEGELP PACLKPALTP
560 570 580 590 600
VDLVEPQEAL ASCESDEAKM RRQAGVAAAA SLVSVDGEVE AGGEGGTRAL
610 620 630 640 650
RREVGRLQAE LAAERRARER QGASFAEERR VWLEEKEKVI EYQKQLQLSY
660 670 680 690 700
VEMYQRNQQL ERRLRERGAA GGSSTPTPQH GEEKKAWTPS RLERIESTEI
Length:700
Mass (Da):74,986
Last modified:February 20, 2007 - v1
Checksum:i2DD613B6F77BB6A2
GO
Isoform 2 (identifier: A2AHG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-183: Missing.

Show »
Length:586
Mass (Da):63,407
Checksum:i449757156E557C02
GO
Isoform 3 (identifier: A2AHG0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     589-591: VEA → IAG
     592-700: Missing.

Show »
Length:591
Mass (Da):62,278
Checksum:i8DC121DBB0CED7BC
GO

Sequence cautioni

The sequence AAH58280 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97S → G in BAE36545 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03920370 – 183Missing in isoform 2. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_039204589 – 591VEA → IAG in isoform 3. 1 Publication3
Alternative sequenceiVSP_039205592 – 700Missing in isoform 3. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731707 Genomic DNA Translation: CAM13272.1
AL731707 Genomic DNA Translation: CAM13273.1
CH466519 Genomic DNA Translation: EDL28282.1
CH466519 Genomic DNA Translation: EDL28283.1
AK161711 mRNA Translation: BAE36545.1
BC058280 mRNA Translation: AAH58280.1 Different initiation.
CCDSiCCDS50714.1 [A2AHG0-1]
CCDS71145.1 [A2AHG0-2]
RefSeqiNP_001277956.1, NM_001291027.1
NP_001277957.1, NM_001291028.1 [A2AHG0-2]
NP_922936.3, NM_197945.4 [A2AHG0-1]
XP_017173693.1, XM_017318204.1 [A2AHG0-1]
UniGeneiMm.440130

Genome annotation databases

EnsembliENSMUST00000045761; ENSMUSP00000037109; ENSMUSG00000037703 [A2AHG0-1]
ENSMUST00000089561; ENSMUSP00000086990; ENSMUSG00000037703 [A2AHG0-1]
ENSMUST00000110260; ENSMUSP00000105889; ENSMUSG00000037703 [A2AHG0-2]
GeneIDi241638
KEGGimmu:241638
UCSCiuc008mjo.3 mouse [A2AHG0-2]
uc008mjq.3 mouse [A2AHG0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731707 Genomic DNA Translation: CAM13272.1
AL731707 Genomic DNA Translation: CAM13273.1
CH466519 Genomic DNA Translation: EDL28282.1
CH466519 Genomic DNA Translation: EDL28283.1
AK161711 mRNA Translation: BAE36545.1
BC058280 mRNA Translation: AAH58280.1 Different initiation.
CCDSiCCDS50714.1 [A2AHG0-1]
CCDS71145.1 [A2AHG0-2]
RefSeqiNP_001277956.1, NM_001291027.1
NP_001277957.1, NM_001291028.1 [A2AHG0-2]
NP_922936.3, NM_197945.4 [A2AHG0-1]
XP_017173693.1, XM_017318204.1 [A2AHG0-1]
UniGeneiMm.440130

3D structure databases

ProteinModelPortaliA2AHG0
SMRiA2AHG0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232338, 3 interactors
IntActiA2AHG0, 3 interactors
STRINGi10090.ENSMUSP00000037109

PTM databases

iPTMnetiA2AHG0
PhosphoSitePlusiA2AHG0

Proteomic databases

MaxQBiA2AHG0
PaxDbiA2AHG0
PeptideAtlasiA2AHG0
PRIDEiA2AHG0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045761; ENSMUSP00000037109; ENSMUSG00000037703 [A2AHG0-1]
ENSMUST00000089561; ENSMUSP00000086990; ENSMUSG00000037703 [A2AHG0-1]
ENSMUST00000110260; ENSMUSP00000105889; ENSMUSG00000037703 [A2AHG0-2]
GeneIDi241638
KEGGimmu:241638
UCSCiuc008mjo.3 mouse [A2AHG0-2]
uc008mjq.3 mouse [A2AHG0-1]

Organism-specific databases

CTDi9762
MGIiMGI:2656976 Lzts3

Phylogenomic databases

eggNOGiENOG410IFZY Eukaryota
ENOG410Z2V9 LUCA
GeneTreeiENSGT00510000046769
HOGENOMiHOG000230889
HOVERGENiHBG052381
InParanoidiA2AHG0
OMAiVGYNGIS
OrthoDBiEOG091G03L2
PhylomeDBiA2AHG0
TreeFamiTF331420

Miscellaneous databases

PROiPR:A2AHG0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037703 Expressed in 215 organ(s), highest expression level in dorsal striatum
GenevisibleiA2AHG0 MM

Family and domain databases

InterProiView protein in InterPro
IPR033295 LZTS3
PANTHERiPTHR19354:SF6 PTHR19354:SF6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLZTS3_MOUSE
AccessioniPrimary (citable) accession number: A2AHG0
Secondary accession number(s): A2AHF9, Q3TSY0, Q6PE51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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