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Entry version 92 (16 Jan 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Calmodulin-regulated spectrin-associated protein 1

Gene

Camsap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Camsap1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3036242 Camsap1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003168291 – 1581Calmodulin-regulated spectrin-associated protein 1Add BLAST1581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei216PhosphoserineBy similarity1
Modified residuei370PhosphoserineBy similarity1
Modified residuei374PhosphoserineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei511PhosphothreonineBy similarity1
Modified residuei550PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei560PhosphoserineBy similarity1
Modified residuei572PhosphoserineCombined sources1
Modified residuei586PhosphoserineBy similarity1
Modified residuei626PhosphoserineBy similarity1
Modified residuei718PhosphoserineBy similarity1
Modified residuei724PhosphoserineCombined sources1
Modified residuei734PhosphoserineBy similarity1
Modified residuei736PhosphoserineBy similarity1
Modified residuei1069PhosphoserineBy similarity1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1378PhosphoserineBy similarity1
Modified residuei1407PhosphoserineCombined sources1
Modified residuei1516PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AHC3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AHC3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AHC3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AHC3

PeptideAtlas

More...
PeptideAtlasi
A2AHC3

PRoteomics IDEntifications database

More...
PRIDEi
A2AHC3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AHC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AHC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026933 Expressed in 268 organ(s), highest expression level in rostral migratory stream

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AHC3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AHC3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with spectrin via SPTBN1; the interaction is direct. Interacts with calmodulin; calcium-dependent it prevents interaction with spectrin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230653, 2 interactors

Protein interaction database and analysis system

More...
IntActi
A2AHC3, 2 interactors

Molecular INTeraction database

More...
MINTi
A2AHC3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109804

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AHC3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AHC3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini215 – 330Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST116
Domaini1443 – 1576CKKPROSITE-ProRule annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni867 – 888Sufficient for interaction with SPTBN1By similarityAdd BLAST22
Regioni899 – 918Sufficient for interaction with calmodulinBy similarityAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili869 – 905Sequence analysisAdd BLAST37
Coiled coili1005 – 1037Sequence analysisAdd BLAST33
Coiled coili1265 – 1336Sequence analysisAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CKK domain binds microtubules.PROSITE-ProRule annotation

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3654 Eukaryota
ENOG4111D0B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156330

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059671

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107572

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AHC3

KEGG Orthology (KO)

More...
KOi
K17493

Database of Orthologous Groups

More...
OrthoDBi
741937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AHC3

TreeFam database of animal gene trees

More...
TreeFami
TF315529

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
3.10.20.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21595 PTHR21595, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01051 CAMSAP_CKK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AHC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVDAGGRCAA EGWRRMEAPP EGADLVPLDR YDAARAKIAA NLQWICAKAY
60 70 80 90 100
GLDNIPEDLR DPFYIDQYEQ EHIKPPVIKL LLSSELYCRV CSLILKGDQV
110 120 130 140 150
ATLQGHQSVI QALSRKGIYV MESDDTPVTD ADLSQAPIKM SGHMAMVDAL
160 170 180 190 200
MMAYTVEMIS IEKVVASVKR FSTFSASKEL PYDLEDAMVF WINKVNLKMR
210 220 230 240 250
EITEKEVKLK QQPLESPAHQ KVRYRREHLS ARQSPYFPLL EDLMRDGSDG
260 270 280 290 300
AALLAVVHYY CPEQMKLDDI CLKEVPSMAD SLYNIRLLRE FSNEHLNKCF
310 320 330 340 350
YLTLEDMLYA PLVLKPNVMV FIAELFWWFE NVKPDFVQPR DIQELKDAKT
360 370 380 390 400
VLQQKSSRPP VPISNATKRS FLGSPAAMSP ADQPPSTQPL AEGSHRYHLH
410 420 430 440 450
SEEPECLGKG ASTFSPSHPL LPLRQKQQKV SQTEEIPDQR HRSNSLTRVD
460 470 480 490 500
GQPRGAIGAW PDKKNRPVSQ PTSFALHHAA SCDVDPSSGD SVSLARSISK
510 520 530 540 550
DSLASNIIHL TPQNQPHPSA GKSNGKSLLS NVNIEDEDEE LVAIIRTDVS
560 570 580 590 600
PPSPQMPRTS PQAPGLVASI RSPQRQADTL ESKPDSFYLE PLMPAVLRPA
610 620 630 640 650
KEKQITTKED ERGEGRPRTI MAKRPSEGSQ PMVRKKVSGG HGSRDLNRTF
660 670 680 690 700
TPIPCSEFAA SIDLAEVGPQ SAEATGEGQP LALGRFDTLP QGQAADGFFL
710 720 730 740 750
HVGRAEEDEG RWYVGSQSPS SHDSEPWTIL RQDSDSDVVD VEDTEQDFIG
760 770 780 790 800
EDHPVVIPRY AGEEESAKLQ EDMKVKEHED KDDASGRSSP CLSTTSQLSS
810 820 830 840 850
MSMASGSVKM TSFAERKLQR LNSCETKSST SSSQKTTPDA SESCPAPLTT
860 870 880 890 900
WRQKREQSPG RHSKDPASLL ASELVQLHMQ LEEKRRAIEA QKKKMEALSA
910 920 930 940 950
RQRLKLGKAA FLHVVKKGKA DGAPQPLRPE HFTKEFTQHN GEDLDDGTCK
960 970 980 990 1000
TEGFLVKEEQ RDLSDAQDVA FVQLHKPRDP AALHDGEKHR MISTALLEDS
1010 1020 1030 1040 1050
VGEVDVNECD LSIEKLNETI STLQQAILKI SQQQEQLLMK SPTVPTPGTK
1060 1070 1080 1090 1100
NNCQDQKIKA PVHFVEPLSP TGVPGHRKPP RLGQGRNSRS GRPAELKVPK
1110 1120 1130 1140 1150
DRQQGCSRSK TPTPSVETLP QSRSLPPSTH PRSPSDPGGE LPEKCLFDSY
1160 1170 1180 1190 1200
RLHDESNHRT FVLSSCKDAN IVSEQVNFKE GLDTSVKEAG LSSSTITGKE
1210 1220 1230 1240 1250
HTPVEEPLRS KASLIEVDLS DLKAPDEDGE VVGHESSVEL GGDSDQKPGV
1260 1270 1280 1290 1300
GFFFKDEQKA EDELAKKRAA FLLKQQRKAE EARARKQQLE AEVELKRDEA
1310 1320 1330 1340 1350
RRKAEEDRLR KEEEKARREL IKQEYLRRKQ QQALEEQGLG KPKSKPKKPR
1360 1370 1380 1390 1400
PKSVHREESY SDSGTKCSST HNLSQTHSGS SLSLASAATT EPESVYSGGT
1410 1420 1430 1440 1450
PSHRVESLEA LPILSRNPSR STDRDWETAS AASSLASVAE YTGPKLFKEP
1460 1470 1480 1490 1500
SSKSNKPIIH NAISHCCLAG KVNEPHKNSI LELEKCDANH YIILFRDAGC
1510 1520 1530 1540 1550
QFRALYCYQP DTEEIYKLTG TGPKSITKKM IDKLYKYSSD RKQFNLIPAK
1560 1570 1580
TMSVSVDALT IHNHLWQPKR PTVPKKTQTR K
Length:1,581
Mass (Da):175,887
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4293DE86DE3A2585
GO
Isoform 2 (identifier: A2AHC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-221: K → KPGLEHAVMHCMLEPVDFARV
     1058-1062: IKAPV → ASPRR
     1063-1581: Missing.

Show »
Length:1,082
Mass (Da):120,300
Checksum:i4B6E596D32FCB67F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQE5A0A0A0MQE5_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap1
1,582Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AHC4A2AHC4_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap1
1,077Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q2D3F6Q2D3_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap1
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6W3X2F6W3X2_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXD7V9GXD7_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap1
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QF29F6QF29_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXT0V9GXT0_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap1
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GWZ6V9GWZ6_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap1
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH54553 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti901R → L in BAC28983 (PubMed:15489334).Curated1
Sequence conflicti1482E → EE in BAC28983 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030802221K → KPGLEHAVMHCMLEPVDFAR V in isoform 2. 1 Publication1
Alternative sequenceiVSP_0308031058 – 1062IKAPV → ASPRR in isoform 2. 1 Publication5
Alternative sequenceiVSP_0308041063 – 1581Missing in isoform 2. 1 PublicationAdd BLAST519

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL731682 Genomic DNA No translation available.
BC054553 mRNA Translation: AAH54553.1 Different initiation.
AK035221 mRNA Translation: BAC28983.1

NCBI Reference Sequences

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RefSeqi
NP_001263288.1, NM_001276359.1
NP_001263289.1, NM_001276360.1
NP_001263290.1, NM_001276361.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.36834

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000091268; ENSMUSP00000088812; ENSMUSG00000026933 [A2AHC3-1]
ENSMUST00000183461; ENSMUSP00000139028; ENSMUSG00000026933 [A2AHC3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
227634

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:227634

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731682 Genomic DNA No translation available.
BC054553 mRNA Translation: AAH54553.1 Different initiation.
AK035221 mRNA Translation: BAC28983.1
RefSeqiNP_001263288.1, NM_001276359.1
NP_001263289.1, NM_001276360.1
NP_001263290.1, NM_001276361.1
UniGeneiMm.36834

3D structure databases

ProteinModelPortaliA2AHC3
SMRiA2AHC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230653, 2 interactors
IntActiA2AHC3, 2 interactors
MINTiA2AHC3
STRINGi10090.ENSMUSP00000109804

PTM databases

iPTMnetiA2AHC3
PhosphoSitePlusiA2AHC3

Proteomic databases

EPDiA2AHC3
jPOSTiA2AHC3
MaxQBiA2AHC3
PaxDbiA2AHC3
PeptideAtlasiA2AHC3
PRIDEiA2AHC3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091268; ENSMUSP00000088812; ENSMUSG00000026933 [A2AHC3-1]
ENSMUST00000183461; ENSMUSP00000139028; ENSMUSG00000026933 [A2AHC3-1]
GeneIDi227634
KEGGimmu:227634

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
157922
MGIiMGI:3036242 Camsap1

Phylogenomic databases

eggNOGiKOG3654 Eukaryota
ENOG4111D0B LUCA
GeneTreeiENSGT00940000156330
HOGENOMiHOG000059671
HOVERGENiHBG107572
InParanoidiA2AHC3
KOiK17493
OrthoDBi741937at2759
PhylomeDBiA2AHC3
TreeFamiTF315529

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Camsap1 mouse

Protein Ontology

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PROi
PR:A2AHC3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026933 Expressed in 268 organ(s), highest expression level in rostral migratory stream
ExpressionAtlasiA2AHC3 baseline and differential
GenevisibleiA2AHC3 MM

Family and domain databases

Gene3Di1.10.418.10, 1 hit
3.10.20.360, 1 hit
InterProiView protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf
PANTHERiPTHR21595 PTHR21595, 1 hit
PfamiView protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit
SMARTiView protein in SMART
SM01051 CAMSAP_CKK, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAMP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AHC3
Secondary accession number(s): Q7TQF8, Q8CBV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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