UniProtKB - A2AH25 (A2AH25_MOUSE)
Protein
Submitted name:
Rho GTPase-activating protein 1
Gene
Arhgap1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- GTPase activator activity Source: Ensembl
- Rab GTPase binding Source: Ensembl
GO - Biological processi
- endosomal transport Source: Ensembl
- negative regulation of endocytic recycling Source: Ensembl
- small GTPase mediated signal transduction Source: Ensembl
- transferrin transport Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Rho GTPase-activating protein 1Imported |
Gene namesi | Name:Arhgap1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2445003, Arhgap1 |
Subcellular locationi
Endosome
- endosome membrane Source: Ensembl
- sorting endosome Source: Ensembl
Other locations
- perinuclear region of cytoplasm Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027247, Expressed in fibroblast and 308 other tissues |
ExpressionAtlasi | A2AH25, baseline and differential |
Genevisiblei | A2AH25, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 258 | CRAL-TRIOInterPro annotationAdd BLAST | 156 | |
Domaini | 284 – 471 | Rho-GAPInterPro annotationAdd BLAST | 188 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 71 – 95 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 71 – 92 | PolyampholyteSequence analysisAdd BLAST | 22 |
Phylogenomic databases
GeneTreei | ENSGT00940000160630 |
OrthoDBi | 1511935at2759 |
PhylomeDBi | A2AH25 |
TreeFami | TF324164 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 1.10.555.10, 1 hit 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF13716, CRAL_TRIO_2, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit PS50238, RHOGAP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A2AH25-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEVVGELGA PEGAVPIPIS EPDVCRALTG VAEEALPERA MDPLSELQDD
60 70 80 90 100
LTLDDTSQAL NQLKLASIDE KNWPSDEMPD FPKSDDSKSS SPEPVTHLKW
110 120 130 140 150
DDPYYDIARH QIVEVAGDDK YGRKIIVFSA CRMPPSHQLD HSKLLGYLKH
160 170 180 190 200
TLDQYVESDY TLLYLHHGLT SDNKPSLSWL RDAYREFDRK YKKNIKALYI
210 220 230 240 250
VHPTMFIKTL LILFKPLISF KFGRKIFYVN YLSELSEHVK LEQLGIPRQV
260 270 280 290 300
LKYDDFLKST QKSPATAPKP MPPRPPLPNQ QFGVSLQHLQ EKSPGQDPIP
310 320 330 340 350
IVLRETVAYL QAHALTTEGI FRRSANTQVV REVQQKYNMG LPVDFDQYNE
360 370 380 390 400
LHLPAVILKT FLRELPEPLL TFDLYPHVVG FLNIDESQRV EVTQQVLQTL
410 420 430 440 450
PEENYQVLHF LTAFLVQISA HCDQNKMTNT NLAVVFGPNL LWAKDAAITL
460 470
KAINPINTFT KFLLDHQGEL FPSTDAQGV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5FWK3 | RHG01_MOUSE | Rho GTPase-activating protein 1 | Arhgap1 | 439 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL691489 Genomic DNA No translation available. AL714023 Genomic DNA No translation available. |
RefSeqi | NP_001139374.1, NM_001145902.1 |
Genome annotation databases
Ensembli | ENSMUST00000111331; ENSMUSP00000106963; ENSMUSG00000027247 |
GeneIDi | 228359 |
UCSCi | uc008kwk.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL691489 Genomic DNA No translation available. AL714023 Genomic DNA No translation available. |
RefSeqi | NP_001139374.1, NM_001145902.1 |
3D structure databases
SMRi | A2AH25 |
ModBasei | Search... |
Proteomic databases
jPOSTi | A2AH25 |
MaxQBi | A2AH25 |
PeptideAtlasi | A2AH25 |
PRIDEi | A2AH25 |
Protocols and materials databases
Antibodypediai | 1399, 218 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000111331; ENSMUSP00000106963; ENSMUSG00000027247 |
GeneIDi | 228359 |
UCSCi | uc008kwk.2, mouse |
Organism-specific databases
CTDi | 392 |
MGIi | MGI:2445003, Arhgap1 |
Phylogenomic databases
GeneTreei | ENSGT00940000160630 |
OrthoDBi | 1511935at2759 |
PhylomeDBi | A2AH25 |
TreeFami | TF324164 |
Miscellaneous databases
BioGRID-ORCSi | 228359, 2 hits in 19 CRISPR screens |
ChiTaRSi | Arhgap1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027247, Expressed in fibroblast and 308 other tissues |
ExpressionAtlasi | A2AH25, baseline and differential |
Genevisiblei | A2AH25, MM |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 1.10.555.10, 1 hit 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF13716, CRAL_TRIO_2, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit PS50238, RHOGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2AH25_MOUSE | |
Accessioni | A2AH25Primary (citable) accession number: A2AH25 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 31, 2011 |
Last sequence update: | May 31, 2011 | |
Last modified: | December 2, 2020 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |