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Entry version 114 (16 Oct 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Activating molecule in BECN1-regulated autophagy protein 1

Gene

Ambra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAutophagy, Differentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1632852 Macroautophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Activating molecule in BECN1-regulated autophagy protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ambra1
Synonyms:Kiaa1736
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443564 Ambra1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003157041 – 1300Activating molecule in BECN1-regulated autophagy protein 1Add BLAST1300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei329PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei636PhosphoserineBy similarity1
Modified residuei640PhosphoserineBy similarity1
Modified residuei748Asymmetric dimethylarginineCombined sources1
Modified residuei1206PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AH22

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AH22

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AH22

PeptideAtlas

More...
PeptideAtlasi
A2AH22

PRoteomics IDEntifications database

More...
PRIDEi
A2AH22

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AH22

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AH22

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 8.5 dpc, it is detected throughout the neuroepithelium. At 11.5 dpc, it is highly expressed in the ventral-most part of the spinal cord, the encephalic vesicles, the neural retina, the limbs and the dorsal root ganglia. Later, it is expressed in the entire developing nervous system as well as in other tissues. In brain, strong expression is observed in the cortex, hippocampus and striatum of postnatal brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040506 Expressed in 281 organ(s), highest expression level in primary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AH22 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BECN1 (PubMed:17589504). Probably forms a complex with BECN1 and PIK3C3 (PubMed:17589504).

Interacts with BECN2 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230728, 5 interactors

Protein interaction database and analysis system

More...
IntActi
A2AH22, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000049258

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AH22

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati51 – 90WD 1Add BLAST40
Repeati93 – 133WD 2Add BLAST41
Repeati135 – 175WD 3Add BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi268 – 277Poly-Pro10
Compositional biasi756 – 763Poly-Ser8
Compositional biasi1120 – 1125Poly-Glu6

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0266 Eukaryota
ENOG410ZUDQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016223

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AH22

KEGG Orthology (KO)

More...
KOi
K17985

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPAECCQ

Database of Orthologous Groups

More...
OrthoDBi
488527at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AH22

TreeFam database of animal gene trees

More...
TreeFami
TF328981

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2AH22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVVPEKNAV RILWGRERGT RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP
60 70 80 90 100
DSPRSTFLLA FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC
110 120 130 140 150
VTFHPTISGL IASGCLDGEV RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ
160 170 180 190 200
LLLIATANEI HFWDWSRREP FAVVKTASEM ERVRLVRFDP LGHYLLTAIV
210 220 230 240 250
NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL HNFLHMLSSR
260 270 280 290 300
SSGIQVGEQS TVQDSATPSP PPPPPQPSTE RPRTSAYIRL RQRVSYPTTV
310 320 330 340 350
ECCQHPGILC LCSRCAGTRV PSLLPHQDSV PPASARATTP SFSFVQTEPF
360 370 380 390 400
HPPEQASSTQ QDQGLLNRPS AFSTVQSSTA GNTLRNLSLG PTRRSLGGPL
410 420 430 440 450
SSHPSRYHRE LAPGLTGSEW TRTVLTLNSR SEVESMPPPR TSASSVSLLS
460 470 480 490 500
VLRQQEGGSQ ASVYTSATEG RGFPSSGLAT ESDGGNGSSQ NNSGSIRHEL
510 520 530 540 550
QCDLRRFFLE YDRLQELDQS LSGETPQTQQ AQEMLNNNIE SERPGPSHLP
560 570 580 590 600
TPHSSENNSN LSRGHLNRCR ACHNLLTFNN DTLRWERTTP NYSSGEASSS
610 620 630 640 650
WHVSTTFEGM PPSGNQLPPL ERTEGQMPSS SRLELSSSAS SQEERTVGVA
660 670 680 690 700
FNQETGHWER IYTQSSRSGT VSQEALHQDM PEESSEEDSL RRRLLESSLI
710 720 730 740 750
SLSRYDGAGS REHPIYPDPA RLSPAAYYAQ RMIQYLSRRD SIRQRSMRYQ
760 770 780 790 800
QNRLRSSTSS SSSDNQGPSV EGTDLEFEDF EDNGDRSRHR APRNARMSAP
810 820 830 840 850
SLGRFVPRRF LLPEYLPYAG IFHERGQPGL ATHSSVNRVL AGAVIGDGQS
860 870 880 890 900
AVASNIANTT YRLQWWDFTK FDLPEISNAS VNVLVQNCKI YNDASCDISA
910 920 930 940 950
DGQLLAAFIP SSQRGFPDEG ILAVYSLAPH NLGEMLYTKR FGPNAISVSL
960 970 980 990 1000
SPMGRYVMVG LASRRILLHP STEHMVAQVF RLQQAHGGET SMRRVFNVLY
1010 1020 1030 1040 1050
PMPADQRRHV SINSARWLPE PGLGLAYGTN KGDLVICRPE ALNSGIEYYW
1060 1070 1080 1090 1100
DQLSETVFTV HSSSRSSERP GTSRATWRTD RDMGLMNAIG LQPRNPTTSV
1110 1120 1130 1140 1150
TSQGTQTLAL QLQNAETQTE REEEEPGAAS SGPGEGEGSE YGGSGEDALS
1160 1170 1180 1190 1200
RIQRLMAEGG MTAVVQREQS TTMASMGGFG NNIIVSHRIH RSSQTGTESG
1210 1220 1230 1240 1250
AARTSSPQPS TSRGLPSEPG QLAERALSPR TASWDQPSTS GRELPQPALS
1260 1270 1280 1290 1300
SSSPVPIPVP LASNEGPTMH CNVTNNSHLP EGDGSNRGEA AGPSGEPQNR
Length:1,300
Mass (Da):142,879
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i081C4E14166B4985
GO
Isoform 2 (identifier: A2AH22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-345: Missing.

Show »
Length:1,209
Mass (Da):133,111
Checksum:i708F9AC9337B5F66
GO
Isoform 3 (identifier: A2AH22-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     782-1300: Missing.

Show »
Length:781
Mass (Da):86,953
Checksum:iF237DA818E40071C
GO
Isoform 4 (identifier: A2AH22-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     692-720: Missing.
     782-1300: Missing.

Show »
Length:752
Mass (Da):83,715
Checksum:iC094F255D814FDDA
GO
Isoform 5 (identifier: A2AH22-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-345: Missing.
     692-720: Missing.
     1010-1016: VSINSAR → QRSTSLK
     1017-1300: Missing.

Show »
Length:896
Mass (Da):100,023
Checksum:i037ADEC2E55B3BB4
GO
Isoform 6 (identifier: A2AH22-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     722-781: Missing.

Show »
Length:1,240
Mass (Da):135,899
Checksum:i016A6F265466A948
GO
Isoform 7 (identifier: A2AH22-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-345: Missing.
     692-720: Missing.

Show »
Length:1,180
Mass (Da):129,873
Checksum:i8EBA16292AD4243A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111I → T in BAE33303 (PubMed:16141072).Curated1
Sequence conflicti492N → K in BAE33303 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030658255 – 345Missing in isoform 2, isoform 5 and isoform 7. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_030659692 – 720Missing in isoform 4, isoform 5 and isoform 7. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_030660722 – 781Missing in isoform 6. CuratedAdd BLAST60
Alternative sequenceiVSP_030661782 – 1300Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST519
Alternative sequenceiVSP_0306621010 – 1016VSINSAR → QRSTSLK in isoform 5. 1 Publication7
Alternative sequenceiVSP_0306631017 – 1300Missing in isoform 5. 1 PublicationAdd BLAST284

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK037516 mRNA Translation: BAC29823.1
AK083596 mRNA Translation: BAC38965.1
AK148887 mRNA Translation: BAE28691.1
AK155513 mRNA Translation: BAE33303.1
AK169280 mRNA Translation: BAE41038.1
AL714023 Genomic DNA No translation available.
AL731772 Genomic DNA No translation available.
AK129433 mRNA Translation: BAC98243.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38179.1 [A2AH22-1]
CCDS38180.1 [A2AH22-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001074223.1, NM_001080754.1 [A2AH22-2]
NP_766257.3, NM_172669.3 [A2AH22-1]
XP_006499316.1, XM_006499253.1 [A2AH22-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000045699; ENSMUSP00000048898; ENSMUSG00000040506 [A2AH22-7]
ENSMUST00000045705; ENSMUSP00000049258; ENSMUSG00000040506 [A2AH22-1]
ENSMUST00000099712; ENSMUSP00000097299; ENSMUSG00000040506 [A2AH22-2]
ENSMUST00000111316; ENSMUSP00000106948; ENSMUSG00000040506 [A2AH22-6]
ENSMUST00000111317; ENSMUSP00000106949; ENSMUSG00000040506 [A2AH22-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
228361

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:228361

UCSC genome browser

More...
UCSCi
uc008kwq.1 mouse [A2AH22-1]
uc008kwr.1 mouse [A2AH22-4]
uc008kws.1 mouse [A2AH22-7]
uc008kwt.1 mouse [A2AH22-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037516 mRNA Translation: BAC29823.1
AK083596 mRNA Translation: BAC38965.1
AK148887 mRNA Translation: BAE28691.1
AK155513 mRNA Translation: BAE33303.1
AK169280 mRNA Translation: BAE41038.1
AL714023 Genomic DNA No translation available.
AL731772 Genomic DNA No translation available.
AK129433 mRNA Translation: BAC98243.1
CCDSiCCDS38179.1 [A2AH22-1]
CCDS38180.1 [A2AH22-2]
RefSeqiNP_001074223.1, NM_001080754.1 [A2AH22-2]
NP_766257.3, NM_172669.3 [A2AH22-1]
XP_006499316.1, XM_006499253.1 [A2AH22-7]

3D structure databases

SMRiA2AH22
ModBaseiSearch...

Protein-protein interaction databases

BioGridi230728, 5 interactors
IntActiA2AH22, 3 interactors
STRINGi10090.ENSMUSP00000049258

PTM databases

iPTMnetiA2AH22
PhosphoSitePlusiA2AH22

Proteomic databases

EPDiA2AH22
MaxQBiA2AH22
PaxDbiA2AH22
PeptideAtlasiA2AH22
PRIDEiA2AH22

Genome annotation databases

EnsembliENSMUST00000045699; ENSMUSP00000048898; ENSMUSG00000040506 [A2AH22-7]
ENSMUST00000045705; ENSMUSP00000049258; ENSMUSG00000040506 [A2AH22-1]
ENSMUST00000099712; ENSMUSP00000097299; ENSMUSG00000040506 [A2AH22-2]
ENSMUST00000111316; ENSMUSP00000106948; ENSMUSG00000040506 [A2AH22-6]
ENSMUST00000111317; ENSMUSP00000106949; ENSMUSG00000040506 [A2AH22-7]
GeneIDi228361
KEGGimmu:228361
UCSCiuc008kwq.1 mouse [A2AH22-1]
uc008kwr.1 mouse [A2AH22-4]
uc008kws.1 mouse [A2AH22-7]
uc008kwt.1 mouse [A2AH22-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55626
MGIiMGI:2443564 Ambra1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410ZUDQ LUCA
GeneTreeiENSGT00390000016223
InParanoidiA2AH22
KOiK17985
OMAiPPAECCQ
OrthoDBi488527at2759
PhylomeDBiA2AH22
TreeFamiTF328981

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ambra1 mouse

Protein Ontology

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PROi
PR:A2AH22

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000040506 Expressed in 281 organ(s), highest expression level in primary oocyte
GenevisibleiA2AH22 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMRA1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AH22
Secondary accession number(s): A2AH21
, A2AH24, Q3TF60, Q3U239, Q3UF70, Q6ZPJ1, Q8BJJ8, Q8BYW8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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