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UniProtKB - A2AGX3 (PRD11_MOUSE)
Protein
PR domain-containing protein 11
Gene
Prdm11
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcription regulation.
By similarityGO - Molecular functioni
- chromatin binding Source: MGI
- methyltransferase activity Source: UniProtKB-KW
GO - Biological processi
- methylation Source: UniProtKB-KW
- negative regulation of cell growth Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of fibroblast apoptotic process Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of cell cycle Source: UniProtKB
- regulation of gene expression Source: GO_Central
- regulation of MAPK cascade Source: UniProtKB
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Prdm11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685553, Prdm11 |
VEuPathDBi | HostDB:ENSMUSG00000075028 |
Pathology & Biotechi
Disruption phenotypei
Mutant mice are born in expected Mendelian ratios and exhibit no apparent phenotype. Mutant embryonic fibroblasts show an increased oncogenic transformation capacity.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000416113 | 1 – 565 | PR domain-containing protein 11Add BLAST | 565 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 29 | PhosphoserineCombined sources | 1 | |
Cross-linki | 54 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 121 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 138 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 166 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 180 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | A2AGX3 |
MaxQBi | A2AGX3 |
PaxDbi | A2AGX3 |
PRIDEi | A2AGX3 |
ProteomicsDBi | 289837 |
PTM databases
iPTMneti | A2AGX3 |
PhosphoSitePlusi | A2AGX3 |
Expressioni
Tissue specificityi
Widely expressed, with the highest levels in spleen, lung, mesenteric lymph node and kidney. Among splenocytes, predominantly expressed by B-cells (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000075028, Expressed in lumbar subsegment of spinal cord and 210 other tissues |
ExpressionAtlasi | A2AGX3, baseline and differential |
Genevisiblei | A2AGX3, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 786018, 1 interactor |
STRINGi | 10090.ENSMUSP00000106905 |
Miscellaneous databases
RNActi | A2AGX3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 115 – 226 | SETPROSITE-ProRule annotationAdd BLAST | 112 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 371 – 399 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 477 – 506 | DisorderedSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG2461, Eukaryota |
GeneTreei | ENSGT00940000159837 |
HOGENOMi | CLU_593911_0_0_1 |
InParanoidi | A2AGX3 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A2AGX3 |
TreeFami | TF316279 |
Family and domain databases
CDDi | cd19195, PR-SET_PRDM11, 1 hit |
Gene3Di | 2.170.270.10, 1 hit |
InterProi | View protein in InterPro IPR044405, PRDM11_PR/SET IPR001214, SET_dom IPR046341, SET_dom_sf |
Pfami | View protein in Pfam PF00856, SET, 1 hit |
SUPFAMi | SSF82199, SSF82199, 1 hit |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A2AGX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTENMKECLA HTKAAVGDMV TVVKTEVCSP LRDQEYGQPC SRRLEPSSME
60 70 80 90 100
VEPKKLKGKR DLIVTKSFQQ VDFWFCESCQ EYFVDECPNH GPPVFVSDTP
110 120 130 140 150
VPVGIPDRAA LTIPQGMEVV KDAGGESDVR CINEVIPKGH IFGPYEGQIS
160 170 180 190 200
TQDKSAGFFS WLIVDKNNRY KSIDGSDETK ANWMRYVVIS REEREQNLLA
210 220 230 240 250
FQHSERIYFR ACRDIRPGER LRVWYSEDYM KRLHSMSQET IHRNLARGEK
260 270 280 290 300
RLQREKAEQA LENPEDLRGP TQFPVLKQGR SPYKRSFDEG DIHPQAKKKK
310 320 330 340 350
IDLIFKDVLE ASLESGNVEA RQLALSTSLV IRKVPKYQDD DYGRAALTQG
360 370 380 390 400
ICRTPGEGDW KVPQRVAKEL GPLEDEEEEP TSFKADSPAE ASLASDPHEL
410 420 430 440 450
PTTSFCPNCI RLKKKVRELQ AELDMLKSGK LPEPSLLPPQ VLELPEFSDP
460 470 480 490 500
AGKFLRMRLL LKGRVCSATR AHCVEGGPER SALSQPPARR PEECNSAEAA
510 520 530 540 550
PSWGGSPVPQ VTEAGWLEDR GREGIACANL YILLVNKICP ICRRAVCCVL
560
DLVFSLGGGA HCCLP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F8MPE3 | A0A5F8MPE3_MOUSE | PR domain-containing protein 11 | Prdm11 | 1,172 | Annotation score: | ||
A0A0A0MQD9 | A0A0A0MQD9_MOUSE | PR domain-containing protein 11 | Prdm11 | 461 | Annotation score: | ||
A0A0A0MQL7 | A0A0A0MQL7_MOUSE | PR domain-containing protein 11 | Prdm11 | 162 | Annotation score: |
Sequence cautioni
The sequence CAM14370 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM14372 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL713913 Genomic DNA Translation: CAM14370.1 Sequence problems. AL713913 Genomic DNA Translation: CAM14371.1 AL713913 Genomic DNA Translation: CAM14372.1 Sequence problems. |
CCDSi | CCDS50647.1 |
RefSeqi | NP_001171007.1, NM_001177536.1 |
Genome annotation databases
Ensembli | ENSMUST00000111274; ENSMUSP00000106905; ENSMUSG00000075028 ENSMUST00000178666; ENSMUSP00000136795; ENSMUSG00000075028 |
GeneIDi | 100042784 |
KEGGi | mmu:100042784 |
UCSCi | uc012bzp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL713913 Genomic DNA Translation: CAM14370.1 Sequence problems. AL713913 Genomic DNA Translation: CAM14371.1 AL713913 Genomic DNA Translation: CAM14372.1 Sequence problems. |
CCDSi | CCDS50647.1 |
RefSeqi | NP_001171007.1, NM_001177536.1 |
3D structure databases
AlphaFoldDBi | A2AGX3 |
SMRi | A2AGX3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 786018, 1 interactor |
STRINGi | 10090.ENSMUSP00000106905 |
PTM databases
iPTMneti | A2AGX3 |
PhosphoSitePlusi | A2AGX3 |
Proteomic databases
EPDi | A2AGX3 |
MaxQBi | A2AGX3 |
PaxDbi | A2AGX3 |
PRIDEi | A2AGX3 |
ProteomicsDBi | 289837 |
Protocols and materials databases
Antibodypediai | 26153, 147 antibodies from 26 providers |
Genome annotation databases
Ensembli | ENSMUST00000111274; ENSMUSP00000106905; ENSMUSG00000075028 ENSMUST00000178666; ENSMUSP00000136795; ENSMUSG00000075028 |
GeneIDi | 100042784 |
KEGGi | mmu:100042784 |
UCSCi | uc012bzp.1, mouse |
Organism-specific databases
CTDi | 56981 |
MGIi | MGI:2685553, Prdm11 |
VEuPathDBi | HostDB:ENSMUSG00000075028 |
Phylogenomic databases
eggNOGi | KOG2461, Eukaryota |
GeneTreei | ENSGT00940000159837 |
HOGENOMi | CLU_593911_0_0_1 |
InParanoidi | A2AGX3 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A2AGX3 |
TreeFami | TF316279 |
Miscellaneous databases
BioGRID-ORCSi | 100042784, 1 hit in 74 CRISPR screens |
ChiTaRSi | Prdm11, mouse |
PROi | PR:A2AGX3 |
RNActi | A2AGX3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000075028, Expressed in lumbar subsegment of spinal cord and 210 other tissues |
ExpressionAtlasi | A2AGX3, baseline and differential |
Genevisiblei | A2AGX3, MM |
Family and domain databases
CDDi | cd19195, PR-SET_PRDM11, 1 hit |
Gene3Di | 2.170.270.10, 1 hit |
InterProi | View protein in InterPro IPR044405, PRDM11_PR/SET IPR001214, SET_dom IPR046341, SET_dom_sf |
Pfami | View protein in Pfam PF00856, SET, 1 hit |
SUPFAMi | SSF82199, SSF82199, 1 hit |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRD11_MOUSE | |
Accessioni | A2AGX3Primary (citable) accession number: A2AGX3 Secondary accession number(s): A2AGX2, A2AGX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2012 |
Last sequence update: | February 20, 2007 | |
Last modified: | May 25, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families