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Entry version 104 (16 Oct 2019)
Sequence version 1 (05 Feb 2008)
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Protein

Ryanodine receptor 3

Gene

Ryr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca2+ release by other calcium channels. Calcium channel that mediates Ca2+-induced Ca2+ release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity.6 Publications

Miscellaneous

Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg2+ and ruthenium red.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3876Important for activation by Ca(2+)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2672351 Stimuli-sensing channels
R-MMU-5578775 Ion homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ryanodine receptor 3
Short name:
RYR-3
Short name:
RyR3
Alternative name(s):
Brain ryanodine receptor-calcium release channel
Brain-type ryanodine receptor
Type 3 ryanodine receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ryr3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99684 Ryr3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4179CytoplasmicSequence analysisAdd BLAST4179
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4180 – 4200HelicalSequence analysisAdd BLAST21
Transmembranei4403 – 4423HelicalSequence analysisAdd BLAST21
Transmembranei4478 – 4498HelicalSequence analysisAdd BLAST21
Transmembranei4603 – 4623HelicalSequence analysisAdd BLAST21
Transmembranei4626 – 4646HelicalSequence analysisAdd BLAST21
Transmembranei4665 – 4685HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei4716 – 4725Pore-formingBy similarity10
Transmembranei4746 – 4766HelicalSequence analysisAdd BLAST21
Topological domaini4767 – 4863CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No apparent phenotype. Mice are born at the expected Mendelian rate and are fertile. They appear normal, except for increased locomotor activity and decreased social contact duration in social interaction tests.2 Publications

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2365

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004156481 – 4863Ryanodine receptor 3Add BLAST4863

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AGL3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AGL3

PeptideAtlas

More...
PeptideAtlasi
A2AGL3

PRoteomics IDEntifications database

More...
PRIDEi
A2AGL3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AGL3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AGL3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A2AGL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in hippocampus, cerebellum, striatum, frontal brain cortex and parietal brain cortex. Detected in skeletal muscle, diaphragm muscle and myometrium (at protein level). Detected in egg cells. Detected in heart, diaphragm, stomach, spleen, ovary, testis germ cells, brain and cerebellum. Detected in cerebral artery smooth muscle cells.6 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057378 Expressed in 163 organ(s), highest expression level in caudate-putamen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AGL3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AGL3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Isoform 2 can form tetramers with isoform 1. Heterotetramer with RYR2.

Interacts with FKBP1A.

Interacts with CALM.

Interacts with SELENON (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3161 Ryanodine 3 complex

Protein interaction database and analysis system

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IntActi
A2AGL3, 1 interactor

Molecular INTeraction database

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MINTi
A2AGL3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000089426

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AGL3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 155MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini162 – 207MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini215 – 269MIR 3PROSITE-ProRule annotationAdd BLAST55
Domaini275 – 333MIR 4PROSITE-ProRule annotationAdd BLAST59
Domaini343 – 400MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini585 – 796B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST212
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati840 – 9531Add BLAST114
Repeati954 – 10682Add BLAST115
Domaini1012 – 1208B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST197
Domaini1254 – 1466B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST213
Repeati2587 – 27053Add BLAST119
Repeati2706 – 28184Add BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni840 – 28184 X approximate repeatsAdd BLAST1979
Regioni2320 – 2333Interaction with FKBP1ABy similarityAdd BLAST14
Regioni3462 – 3491Interaction with CALMBy similarityAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243 Eukaryota
ENOG410YCNW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155507

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231428

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AGL3

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYELMID

Database of Orthologous Groups

More...
OrthoDBi
5161at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AGL3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AGL3-1) [UniParc]FASTAAdd to basket
Also known as: RYR3L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAGEGGED EIQFLRTEDE VVLQCIANIH KEQRKFCLAA EGLGNRLCFL
60 70 80 90 100
EPTSEAKYIP PDLCVCNFVL EQSLSVRALQ EMLANTVENG GEGAAQGGGH
110 120 130 140 150
RTLLYGHAIL LRHSFSGMYL TCLTTSRSQT DKLAFDVGLR EHATGEACWW
160 170 180 190 200
TIHPASKQRS EGEKVRIGDD LILVSVSSER YLHLSISNGS IQVDASFMQT
210 220 230 240 250
LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD QNDSQHRRVF
260 270 280 290 300
YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
310 320 330 340 350
QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG MGVPEIKYGD
360 370 380 390 400
SVCFVQHVAS GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC
410 420 430 440 450
QQEESQAARI IRNTTALFSQ FVSGNNRTTA PVALPTEEVL QTLQDLIAYF
460 470 480 490 500
QPPEDEMQHE DKQNKLRSLK NRQNLFKEEG MLALVLNCID RLNIYNSVAH
510 520 530 540 550
FAGIVREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN NLDWLISKLD
560 570 580 590 600
RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV
610 620 630 640 650
LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV
660 670 680 690 700
AEGSPQYKKW YFELIIDQVE PFLTAEPTHL RVGWASSSGY APYPGGGEGW
710 720 730 740 750
GGNGVGDDLY SYGFDGLHLW SGRIPRAVAS INQHLLKSDD VVSCCLDLGV
760 770 780 790 800
PSISFRINGQ PVQGMFENFN TDGLFFPVMS FSAGVKVRFL MGGRHGEFKF
810 820 830 840 850
LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT TQFLSQASFI
860 870 880 890 900
PCPIDTSQVV LPLHLEKIRD RLAENIHELW GMNKIELGWT YGKVRDDNKR
910 920 930 940 950
QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK
960 970 980 990 1000
VKLPKNYMMS NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK
1010 1020 1030 1040 1050
QGWTYGIQQD LKNKRNPRLV PYALLDERTK KSNRDSLREA VRTFVGYGYN
1060 1070 1080 1090 1100
IEPSDQELAD PTVEKVSIDK IRFFRVERSY AVKSGKWYFE FEVVTGGDMR
1110 1120 1130 1140 1150
VGWARPGCRP DIELGADDQA FVFEGSRGQR WHQGSGYFGR TWQPGDVVGC
1160 1170 1180 1190 1200
MINLDDASMV FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR
1210 1220 1230 1240 1250
MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAVWFSKR LPTFVNVPKD
1260 1270 1280 1290 1300
HPHIEVVRID GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF
1310 1320 1330 1340 1350
SHSPCLDSEA FQKRKQMQEI LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP
1360 1370 1380 1390 1400
DYHLYSEKFD LNKNCTVTVT LGDERGRVHE SVKRSNCYMV WGGDIVASSQ
1410 1420 1430 1440 1450
RSSRSNVDLE IGCLLDLAMG MLSFSANGKE LGTCYQVEPN TKVFPAVFLQ
1460 1470 1480 1490 1500
PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPTPQCPPRL DVQTIQPVLW
1510 1520 1530 1540 1550
SRMPSSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE
1560 1570 1580 1590 1600
QEDLMQFHYH TLRLYSAVCA LGNSRVASAL CSHVDLSQLF YAIDNKYLPG
1610 1620 1630 1640 1650
LLRSGFYDLL ISIHLANAKE RKLMMKNEYI IPITSATRNI RLYPDESKRH
1660 1670 1680 1690 1700
GLPGVGLRTC LKPGFRFSTP CFVVTSEDHQ KQSPEIPLQI LKTKALSMLT
1710 1720 1730 1740 1750
EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD DDVRQILLLI
1760 1770 1780 1790 1800
DPSVFGEHSG ETEEGVEKEV THAEEKAVEA GEKACKEAPV KGLLQTRLPE
1810 1820 1830 1840 1850
SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KFRYNELMQA
1860 1870 1880 1890 1900
LNMSAALTAR KTREFRSPPQ EQINMLLNFH LGENCPCPEE IREELYDFHE
1910 1920 1930 1940 1950
DLLVHCGVPL EEEEEEEEDT SWTGKLCALV YKIKGPPKPE KEQPTEEEKP
1960 1970 1980 1990 2000
YPTTLKELVS QTMIRWAQEN QIQDAELVRM MFNLLRRQYD SIGELLQALR
2010 2020 2030 2040 2050
KTYTISQASV NDTINLLAAL GQIRSLLSVR MGREEELLMI NGLGDIMNNK
2060 2070 2080 2090 2100
VFYQHPNLMR VLGMHETVME VMVNVLGTEK SQIAFPKMVA SCCRFLCYFC
2110 2120 2130 2140 2150
RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA
2160 2170 2180 2190 2200
LGLEEPDLEK VVTYLAGCGL QSCPMLLARG YPDVGWNPIE GERYLSFLRF
2210 2220 2230 2240 2250
AVFVNSESVE ENASVVVKLL IRRPECFGPA LRGEGGNGLL AAMQGAIKIS
2260 2270 2280 2290 2300
ENPALDLPSQ GYKTEVTQDD GEEEEIVHMG NAIMSFYSAL IDLLGRCAPE
2310 2320 2330 2340 2350
MHLIQTGKGE AIRIRSILRS LVPTEDLVGI ISIPLKLPSL NKDGSVSEPD
2360 2370 2380 2390 2400
MAANFCPDHK APMVLFLDRV YGIKDQTFLL HLLEVGFLPD LRASASLDTV
2410 2420 2430 2440 2450
SLSTTEAALA LNRYLCSAVL PLLTRCAPLF SGTEHCTSLI DSTLQTIYRL
2460 2470 2480 2490 2500
SKGRSLTKAQ RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLSEYCKM
2510 2520 2530 2540 2550
PLKLLTNHYE QCWKYYCLPS GWGSYGLAVE EELHLTEKLF WGIFDSLSHK
2560 2570 2580 2590 2600
KYDLDLFRMA LPCLSAIAGA LPPDYLDTRI TATLEKQVSV DADGNFDPKP
2610 2620 2630 2640 2650
INTMNFSLPE KLEYIVTKYA EHSHDKWACD KSHSGWKYGI SLDENVKTHP
2660 2670 2680 2690 2700
LIRPFKTLTE KEKEIYRWPA RESLKTMLAV GWTVERTKEG EALVQQRENE
2710 2720 2730 2740 2750
KLRCVSQTNQ GNSYSPAPLD LSNVVLSREL QGMVEVVAEN YHNIWAKKKK
2760 2770 2780 2790 2800
LELESKGGGS HPLLVPYDTL TAKEKFRDRE KAQDLFKFLQ VNGILVSRGM
2810 2820 2830 2840 2850
KDLELDASSM EKRFAYKFLK KILKYVDAAQ EFIAHLEAIV SSGKTEKSPH
2860 2870 2880 2890 2900
DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP LKPLSSSGYA SHKEKEMVAS
2910 2920 2930 2940 2950
LFCKLAALVR HRISLFGSDS TTMVSCLHIL AQTLDTRTVM KSGSELVKAG
2960 2970 2980 2990 3000
LRAFFENAAE DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT
3010 3020 3030 3040 3050
SIFEHIAQHQ FGVDLLLSDV QVSCYHILCS LYSLGTGKNI YVERQRPALG
3060 3070 3080 3090 3100
ECLASLAAAI PVAFLEPSLN RHNPLSVFNT KTPRERSILG MPDKVEDMCP
3110 3120 3130 3140 3150
DIPQLEGLMK EINDLAESGA RYTEMPHVIE VILPMLCNYL SYWWERGPEN
3160 3170 3180 3190 3200
LPPSTGPCCT KVTSEHLSLI LGNILKIINN NLGIDEASWM KRIAVYAQPI
3210 3220 3230 3240 3250
ISKARPDLLR SHFIPTLEKL KKKAVKTVQE EEQLKTDGKG DTQEAELLIL
3260 3270 3280 3290 3300
DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK SPDPDSDQLF RMVAEVFILW
3310 3320 3330 3340 3350
CKSHNFKREE QNFVIQNEIN NLAFLTGDSK SKMSKSGGQD QERKKTKRRG
3360 3370 3380 3390 3400
DLYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKSRY SCRDTDEEVK
3410 3420 3430 3440 3450
EHLRNNLHLQ EKSDDPAVKW QLNLYKDVLR NDEPSNPEKT VERVQSISAA
3460 3470 3480 3490 3500
LFHLEQVEQP LRSKKAVWHK LLSKQRKRAV VACFRMAPLY NLPRHRSINL
3510 3520 3530 3540 3550
FLHGYQRFWI ETEAHFFEEK LVQDLAKSPR VEDEEEEETE RQPDPLHQII
3560 3570 3580 3590 3600
LHFSRNALTE RSKLEDDPLY TSYSSMMAKS CQSGEDEEEE EDKEKTFEEK
3610 3620 3630 3640 3650
EMEKQKTLYQ QARLHERGAA EMVLQMISAS KGEMSPMVVE TLKLGIAILN
3660 3670 3680 3690 3700
GGNAGVQQKM LDYLKEKKDA GFFQSLSGLM QSCSVLDLNA FERQNKAEGL
3710 3720 3730 3740 3750
GMVTEEGTLI VRERGEKVLQ NDEFTQDLFR FLQLLCEGHN SDFQNFLRTQ
3760 3770 3780 3790 3800
MGNTTTVNII ISTVDYLLRL QESISDFYWY YSGKDIIDES GQHNFSKALA
3810 3820 3830 3840 3850
VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW DAVVGFLHVF ANMQMKLSQD
3860 3870 3880 3890 3900
SSQIELLKEL LDLLQDMVVM LLSLLEGNVV NGTIGKQMVD TLVESSTNVE
3910 3920 3930 3940 3950
MILKFFDMFL KLKDLTSSDT FKEYDPDGKG IISRKEFQKA MEGLKQYTQS
3960 3970 3980 3990 4000
EIDFLLSCTE ADENDMFNYV DFVERFHEPA KDIGFNVAVL LTNLSEHMPN
4010 4020 4030 4040 4050
DSRLKSLLDP AESVLNYFEP YLGRIEIMGG AKKIERVYFE ISESSRTQWE
4060 4070 4080 4090 4100
KPQVKESKRQ FIFDVVNEGG EQEKMELFVN FCEDTIFEMQ LASQISESDS
4110 4120 4130 4140 4150
TDRPEEEEEE DEDSAYSIET EGEEEEKSFE SASAFTMACV SVKRNVTKFL
4160 4170 4180 4190 4200
KRATLKNLRK QYRNVKKMSA KELVKVFFSF FWMLFVGLFQ LLFTIFGGIF
4210 4220 4230 4240 4250
QILWNTVFGG GLVEGAKNIR VTKILGDMPD PTQFGIHDDV IETDRAEVTE
4260 4270 4280 4290 4300
PGVTTELVHF VKGEAGDTDI MSDLFGIHSK KEGGLKQGPE VGLGDLSEII
4310 4320 4330 4340 4350
GKDEPPTLES TVRKKRKAQA AEMKAVHEAE GKAESEKADM EDREKEDKIK
4360 4370 4380 4390 4400
EEGQTDYLWA DVTVKKTRRR GQKAEKPEAF MANFFKGLEI YQTKLLHYLA
4410 4420 4430 4440 4450
RNFYNLRFLA LFVAFAINFI LLFYKVTEEP LEEETEDVAN LWNSFNDDDE
4460 4470 4480 4490 4500
EEAMVFFVLQ ESTGYMAPTL RALAIVHTII SLVCVVGYYC LKVPLVVFKR
4510 4520 4530 4540 4550
EKEIARKLEF DGLYITEQPS EDDIKGQWDR LVINTPSFPN NYWDKFVKRK
4560 4570 4580 4590 4600
VINKYGDLYG AERIAELLGL DKNALDFSPV EEAKAEAASL VSWLSSIDMK
4610 4620 4630 4640 4650
YHIWKLGVVF TDNSFLYLAW YTTMSVLGHY NNFFFAAHLL DIAMGFKTLR
4660 4670 4680 4690 4700
TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDDDEPDM
4710 4720 4730 4740 4750
KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYEMYRI VFDITFFFFV
4760 4770 4780 4790 4800
IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG NDYFDTTPHG
4810 4820 4830 4840 4850
FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA
4860
GDCFRKQYED QLG
Length:4,863
Mass (Da):551,328
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2B086935E99D40B
GO
Isoform 2 (identifier: A2AGL3-2) [UniParc]FASTAAdd to basket
Also known as: RYR3S

The sequence of this isoform differs from the canonical sequence as follows:
     4397-4425: Missing.

Note: Lacks a predicted transmembrane segment and is not expected to form functional calcium channels.
Show »
Length:4,834
Mass (Da):547,747
Checksum:iED773D40A48B773A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LJK7A0A140LJK7_MOUSE
Ryanodine receptor 3
Ryr3
4,868Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PW34E9PW34_MOUSE
Ryanodine receptor 3
Ryr3
4,888Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LJF7A0A140LJF7_MOUSE
Ryanodine receptor 3
Ryr3
4,858Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LI87A0A140LI87_MOUSE
Ryanodine receptor 3
Ryr3
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4169S → I in AAF21940 (Ref. 3) Curated1
Sequence conflicti4214E → Q in AAF21940 (Ref. 3) Curated1
Sequence conflicti4427T → A in AAF21940 (Ref. 3) Curated1
Sequence conflicti4450E → V in BAE21181 (PubMed:16141072).Curated1
Sequence conflicti4457F → L in CAA58786 (PubMed:7876312).Curated1
Sequence conflicti4469T → N in CAA58786 (PubMed:7876312).Curated1
Sequence conflicti4602H → N in AAA64957 (PubMed:7635066).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0423044397 – 4425Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL929348 Genomic DNA No translation available.
AL672250 Genomic DNA No translation available.
AL691423 Genomic DNA No translation available.
AL732316 Genomic DNA No translation available.
BX649564 Genomic DNA No translation available.
D84237 mRNA Translation: BAA12286.1
AF111166 mRNA Translation: AAF21940.1
AK132464 mRNA Translation: BAE21181.1
X83934 mRNA Translation: CAA58786.1
U23756 mRNA Translation: AAA64957.1
D38218 mRNA Translation: BAA07393.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I48743
S56107

NCBI Reference Sequences

More...
RefSeqi
XP_017172194.1, XM_017316705.1 [A2AGL3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000080673; ENSMUSP00000079503; ENSMUSG00000057378 [A2AGL3-1]
ENSMUST00000208151; ENSMUSP00000146449; ENSMUSG00000057378 [A2AGL3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20192

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929348 Genomic DNA No translation available.
AL672250 Genomic DNA No translation available.
AL691423 Genomic DNA No translation available.
AL732316 Genomic DNA No translation available.
BX649564 Genomic DNA No translation available.
D84237 mRNA Translation: BAA12286.1
AF111166 mRNA Translation: AAF21940.1
AK132464 mRNA Translation: BAE21181.1
X83934 mRNA Translation: CAA58786.1
U23756 mRNA Translation: AAA64957.1
D38218 mRNA Translation: BAA07393.1
PIRiI48743
S56107
RefSeqiXP_017172194.1, XM_017316705.1 [A2AGL3-1]

3D structure databases

SMRiA2AGL3
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3161 Ryanodine 3 complex
IntActiA2AGL3, 1 interactor
MINTiA2AGL3
STRINGi10090.ENSMUSP00000089426

Chemistry databases

ChEMBLiCHEMBL2365

PTM databases

iPTMnetiA2AGL3
PhosphoSitePlusiA2AGL3
SwissPalmiA2AGL3

Proteomic databases

MaxQBiA2AGL3
PaxDbiA2AGL3
PeptideAtlasiA2AGL3
PRIDEiA2AGL3

Genome annotation databases

EnsembliENSMUST00000080673; ENSMUSP00000079503; ENSMUSG00000057378 [A2AGL3-1]
ENSMUST00000208151; ENSMUSP00000146449; ENSMUSG00000057378 [A2AGL3-2]
GeneIDi20192

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6263
MGIiMGI:99684 Ryr3

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00940000155507
HOGENOMiHOG000231428
InParanoidiA2AGL3
OMAiYYELMID
OrthoDBi5161at2759
PhylomeDBiA2AGL3

Enzyme and pathway databases

ReactomeiR-MMU-2672351 Stimuli-sensing channels
R-MMU-5578775 Ion homeostasis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ryr3 mouse

Protein Ontology

More...
PROi
PR:A2AGL3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057378 Expressed in 163 organ(s), highest expression level in caudate-putamen
ExpressionAtlasiA2AGL3 baseline and differential
GenevisibleiA2AGL3 MM

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRYR3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AGL3
Secondary accession number(s): P70184
, P70185, Q3V1H0, Q4JFC4, Q60836, Q62175, Q62198, Q9QY91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 5, 2008
Last modified: October 16, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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