UniProtKB - A2AGH9 (A2AGH9_MOUSE)
Protein
Submitted name:
Mediator of RNA polymerase II transcription subunit 12
Gene
Med12
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- beta-catenin binding Source: InterPro
- transcription coregulator activity Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | ActivatorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Mediator of RNA polymerase II transcription subunit 12Imported |
Gene namesi | Name:Med12Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1926212, Med12 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- mediator complex Source: InterPro
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000079487, Expressed in bone marrow and 53 other tissues |
ExpressionAtlasi | A2AGH9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 161 | Med12InterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 324 – 345 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 628 – 670 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 688 – 714 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1242 – 1267 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 1395 – 1416 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1451 – 1475 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1740 – 1833 | DisorderedSequence analysisAdd BLAST | 94 | |
Regioni | 1961 – 2003 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 2115 – 2154 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 2163 – 2182 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 2053 – 2088 | Sequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 639 – 655 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1451 – 1472 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1740 – 1762 | Pro-richSequence analysisAdd BLAST | 23 | |
Compositional biasi | 2115 – 2132 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 2139 – 2154 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the Mediator complex subunit 12 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00440000037505 |
Family and domain databases
InterProi | View protein in InterPro IPR019035, Mediator_Med12 IPR021989, Mediator_Med12_catenin-bd IPR021990, Mediator_Med12_LCEWAV |
Pfami | View protein in Pfam PF09497, Med12, 1 hit PF12145, Med12-LCEWAV, 1 hit PF12144, Med12-PQL, 1 hit |
SMARTi | View protein in SMART SM01281, Med12, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A2AGH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAFGILSYE HRPLKRLRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA
60 70 80 90 100
VSGDEHGSAK NVNFNPAKIS SNFSSIIAEK LRCNTLSDTG RRKSLMNQKD
110 120 130 140 150
NFWLVTARSQ SAINTWFTDL AGTKPLTHLA KKVPIFSKKE EVFGYLAKYT
160 170 180 190 200
VPVMRAAWLI KMTCAYYAAM SETKVKKKNT ADPFTEWTQI ITKYLWEQLQ
210 220 230 240 250
KMAEYYRPGP AGSGGCGSTI GPLPHDVEMA IRQWDYNEKL ALFMFQDGML
260 270 280 290 300
DRHEFLTWVL ECFEKIRPGE DELLKLLLPL LLRYSGEFVQ SAYLSRRLAY
310 320 330 340 350
FCTRRLALQL DGVSSHSSHV IAAQSTSSLP TTPAPQPPTS STPSTPFSDL
360 370 380 390 400
LMCPQHRPLV FGLSCILQTI LLCCPSALVW HYSLTDSRIK TGSPLDHLPI
410 420 430 440 450
APSNLPMPEG NSAFTQQVRA KLREIEQQIK ERGQAVEVRW SFDKCQEATA
460 470 480 490 500
GFTIGRVLHT LEVLDSHSFE RSDFSNSLDS LCNRIFGLGP SKDGHEISSD
510 520 530 540 550
DDAVVSLLCE WAVSCKRSGR HRAMVVAKLL EKRQAEIEAE RCGESEAADE
560 570 580 590 600
KGSVASGSLS APSAPIFQDV LLQFLDTQAP MLTDPRSESE RVEFFNLVLL
610 620 630 640 650
FCELIRHDVF SHNMYTCTLI SRGDLAFGAP GPRPPSPFDD PTDDPERKEA
660 670 680 690 700
EGSSSSKLED PGLSESMDID PSSSVLFEDM EKPDFSLFSP TMPCEGKGSP
710 720 730 740 750
SPEKPDVEKE VKPPAKEKIE GTLGILYDQP RHVQYATHFP IPQEESCSHE
760 770 780 790 800
CNQRLVVLFG VGKQRDDARH AIKKITKDIL KVLNRKGTAE TDQLAPIVPL
810 820 830 840 850
NPGDLTFLGG EDGQKRRRNR PEAFPTAEDI FAKFQHLSHY DQHQVTAQVS
860 870 880 890 900
RNVLEQITSF ALGMSYHLPL VQHVQFIFDL MEYSLSISGL IDFAIQLLNE
910 920 930 940 950
LSVVEAELLL KSSDLVGSYT TSLCLCIVAV LRHYHACLIL NQDQMAQVFE
960 970 980 990 1000
GLCGVVKHGM NRSDGSSAER CILAYLYDLY TSCSHLKSKF GELFSDFCSK
1010 1020 1030 1040 1050
VKNTIYCNVE PSESNMRWAP EFMIDTLENP AAHTFTYTGL GKSLSENPAN
1060 1070 1080 1090 1100
RYSFVCNALM HVCVGHHDPD RVNDIAILCA ELTGYCKSLS AEWLGVLKAL
1110 1120 1130 1140 1150
CCSSNNGTCG FNDLLCNVDV SDLSFHDSLA TFVAILIARQ CLLLEDLIRC
1160 1170 1180 1190 1200
AAIPSLLNAA CSEQDSEPGA RLTCRILLHL FKTPQLNPCQ SDGNKPTVGI
1210 1220 1230 1240 1250
RSSCDRHLLA ASQNRIVDGA VFAVLKAVFV LGDAELKGSG FTVPGGTEEL
1260 1270 1280 1290 1300
PEEEGGGGSS GRRQGGRNIS VETASLDVYA KYVLRSICQQ EWVGERCLKS
1310 1320 1330 1340 1350
LCEDSNDLQD PVLSSAQAQR LMQLICYPHR LLDNEDGENP QRQRIKRILK
1360 1370 1380 1390 1400
NLDQWTMRQS SLELQLMIKQ TPNTEMNSLL ENIAKATIEV FQQSAETGSS
1410 1420 1430 1440 1450
SGSTASNMPS SSKTKPVLSS LERSGVWLVA PLIAKLPTSV QGHVLKAAGE
1460 1470 1480 1490 1500
ELEKGQHLGS SSRKERDRQK QKSMSLLSQQ PFLSLVLTCL KGQDEQREGL
1510 1520 1530 1540 1550
LASLHSQVHQ IVINWRENQY LDDCKPKQLM HEALKLRLNL VGGMFDTVQR
1560 1570 1580 1590 1600
STQQTTEWAQ LLLEIIISGT VDMQSNNELF TTVLDMLSVL INGTLAADMS
1610 1620 1630 1640 1650
SISQGSMEEN KRAYMNLVKK LQKDLGERQS DSLEKVHQLL PLPKQNRDVI
1660 1670 1680 1690 1700
TCEPQGSLID TKGNKIAGFD SIFKKEGLQV STKQKISPWE LFEGLKPSTA
1710 1720 1730 1740 1750
PLSWAWFGTV RVDRRVARGE EQQRLLLYHT HLRPRPRAYY LEPLPLPPED
1760 1770 1780 1790 1800
EEPPAPALLE PEKKAPEPPK TDKPGAAPPS TEERKKKSTK GKKRSQPATK
1810 1820 1830 1840 1850
NEDYGMGPGR SGPYGVTVPP DLLHHANPGS ISHLSYRQSS MGLYTQNQPL
1860 1870 1880 1890 1900
PAGGPRVDPY RPVRLPMQKL PTRPTYPGVL PTTMSTVMGL EPSSYKTSVY
1910 1920 1930 1940 1950
RQQQPTVPQG QRLRQQLQAK IQSQGMLGQS SVHQMTPSSS YGLQTSQGYT
1960 1970 1980 1990 2000
SYVSHVGLQQ HTGPAGTMVP PSYSSQPYQS THPSTNPTLV DPTRHLQQRP
2010 2020 2030 2040 2050
SGYVHQQAPT YGHGLTSTQR FSHQTLQQTP MMGTMTPLSA QGVQAGVRST
2060 2070 2080 2090 2100
SILPEQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQYH IRQQQQQQQM
2110 2120 2130 2140 2150
LRQQQQQQQQ QQQQQQQQQQ QPHQQQQQAA PPQPQPQSQP QFQRQGLQQT
2160 2170 2180
QQQQQTAALV RQLQQQLSNT QPQPSTNIFG RY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AGH6 | MED12_MOUSE | Mediator of RNA polymerase II trans... | Med12 Kiaa0192, Mopa, Tnrc11, Trap230 | 2,190 | Annotation score: | ||
A2AGH8 | A2AGH8_MOUSE | Mediator of RNA polymerase II trans... | Med12 | 2,157 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL683892 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000117203; ENSMUSP00000112729; ENSMUSG00000079487 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL683892 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | A2AGH9 |
PRIDEi | A2AGH9 |
Protocols and materials databases
Antibodypediai | 562, 208 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000117203; ENSMUSP00000112729; ENSMUSG00000079487 |
Organism-specific databases
MGIi | MGI:1926212, Med12 |
Phylogenomic databases
GeneTreei | ENSGT00440000037505 |
Miscellaneous databases
ChiTaRSi | Med12, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000079487, Expressed in bone marrow and 53 other tissues |
ExpressionAtlasi | A2AGH9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR019035, Mediator_Med12 IPR021989, Mediator_Med12_catenin-bd IPR021990, Mediator_Med12_LCEWAV |
Pfami | View protein in Pfam PF09497, Med12, 1 hit PF12145, Med12-LCEWAV, 1 hit PF12144, Med12-PQL, 1 hit |
SMARTi | View protein in SMART SM01281, Med12, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2AGH9_MOUSE | |
Accessioni | A2AGH9Primary (citable) accession number: A2AGH9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |