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Entry version 120 (31 Jul 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

E3 ubiquitin-protein ligase HUWE1

Gene

Huwe1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation EC:2.3.2.26

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4345Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayPROSITE-ProRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
E3 ubiquitin-protein ligase HUWE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Huwe1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1926884 Huwe1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AFQ0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A2AFQ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AFQ0

PeptideAtlas

More...
PeptideAtlasi
A2AFQ0

PRoteomics IDEntifications database

More...
PRIDEi
A2AFQ0

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A2AFQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025261 Expressed in 295 organ(s), highest expression level in embryonic stem cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2AFQ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AFQ0 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AFQ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1316 – 1355UBAInterPro annotationAdd BLAST40
Domaini1603 – 1680WWEInterPro annotationAdd BLAST78
Domaini4042 – 4378HECTInterPro annotationAdd BLAST337

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni706 – 758DisorderedSequence analysisAdd BLAST53
Regioni978 – 1001DisorderedSequence analysisAdd BLAST24
Regioni1018 – 1038DisorderedSequence analysisAdd BLAST21
Regioni1291 – 1320DisorderedSequence analysisAdd BLAST30
Regioni1396 – 1415DisorderedSequence analysisAdd BLAST20
Regioni1690 – 1735DisorderedSequence analysisAdd BLAST46
Regioni2019 – 2066DisorderedSequence analysisAdd BLAST48
Regioni2263 – 2344DisorderedSequence analysisAdd BLAST82
Regioni2356 – 2480DisorderedSequence analysisAdd BLAST125
Regioni2705 – 2971DisorderedSequence analysisAdd BLAST267
Regioni2992 – 3013DisorderedSequence analysisAdd BLAST22
Regioni3037 – 3060DisorderedSequence analysisAdd BLAST24
Regioni3244 – 3267DisorderedSequence analysisAdd BLAST24
Regioni3353 – 3384DisorderedSequence analysisAdd BLAST32
Regioni3406 – 3430DisorderedSequence analysisAdd BLAST25
Regioni3472 – 3515DisorderedSequence analysisAdd BLAST44
Regioni3540 – 3567DisorderedSequence analysisAdd BLAST28
Regioni3739 – 3760DisorderedSequence analysisAdd BLAST22
Regioni3783 – 3851DisorderedSequence analysisAdd BLAST69
Regioni3898 – 3952DisorderedSequence analysisAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2682 – 2704Sequence analysisAdd BLAST23
Coiled coili3091 – 3111Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi737 – 756PolarSequence analysisAdd BLAST20
Compositional biasi987 – 1001PolarSequence analysisAdd BLAST15
Compositional biasi1291 – 1310PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1699 – 1721PolyampholyteSequence analysisAdd BLAST23
Compositional biasi2019 – 2036PolarSequence analysisAdd BLAST18
Compositional biasi2037 – 2061PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2263 – 2294PolarSequence analysisAdd BLAST32
Compositional biasi2385 – 2403PolarSequence analysisAdd BLAST19
Compositional biasi2407 – 2472AcidicSequence analysisAdd BLAST66
Compositional biasi2705 – 2719PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2720 – 2770PolarSequence analysisAdd BLAST51
Compositional biasi2816 – 2868PolarSequence analysisAdd BLAST53
Compositional biasi2878 – 2892PolarSequence analysisAdd BLAST15
Compositional biasi2906 – 2935PolarSequence analysisAdd BLAST30
Compositional biasi2992 – 3010PolarSequence analysisAdd BLAST19
Compositional biasi3042 – 3060PolarSequence analysisAdd BLAST19
Compositional biasi3245 – 3261PolyampholyteSequence analysisAdd BLAST17
Compositional biasi3472 – 3506PolarSequence analysisAdd BLAST35
Compositional biasi3540 – 3558PolarSequence analysisAdd BLAST19
Compositional biasi3785 – 3802PolarSequence analysisAdd BLAST18
Compositional biasi3816 – 3833PolarSequence analysisAdd BLAST18
Compositional biasi3898 – 3915PolyampholyteSequence analysisAdd BLAST18
Compositional biasi3933 – 3952PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0939 Eukaryota
COG5021 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156319

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231388

KEGG Orthology (KO)

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KOi
K10592

Identification of Orthologs from Complete Genome Data

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OMAi
PIYIYRC

Database of Orthologous Groups

More...
OrthoDBi
25515at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323417

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078 HECTc, 1 hit
cd14288 UBA_HUWE1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR010309 E3_Ub_ligase_DUF908
IPR010314 E3_Ub_ligase_DUF913
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR025527 HUWE1/Rev1_UBM
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041918 UBA_HUWE1
IPR004170 WWE-dom
IPR037197 WWE_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06012 DUF908, 1 hit
PF06025 DUF913, 1 hit
PF00632 HECT, 1 hit
PF00627 UBA, 1 hit
PF14377 UBM, 3 hits
PF02825 WWE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119 HECTc, 1 hit
SM00165 UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839 SSF117839, 1 hit
SSF46934 SSF46934, 1 hit
SSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit
PS50030 UBA, 1 hit
PS50918 WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A2AFQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE
60 70 80 90 100
LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT
110 120 130 140 150
ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR
160 170 180 190 200
LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLQMLK YPPSATTLHF
210 220 230 240 250
EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP
260 270 280 290 300
KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI
310 320 330 340 350
LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT
360 370 380 390 400
GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG
410 420 430 440 450
EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH
460 470 480 490 500
SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPSTTQEGEE METDMDGVQC
510 520 530 540 550
IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL KHIISNAEYY
560 570 580 590 600
GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV
610 620 630 640 650
LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD
660 670 680 690 700
PLGDTASNLG SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ
710 720 730 740 750
KPSIQKADGT ATAPPPRSNH AAEEASSEDE EEEEVQAMQS FNSAQQNETE
760 770 780 790 800
PNQQVVGTEE RIPIPLMDYI LNVMKFVESI LSNNTTDDHC QEFVNQKGLL
810 820 830 840 850
PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV LQEGLLQLDL
860 870 880 890 900
ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH
910 920 930 940 950
AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV
960 970 980 990 1000
LLSLCTPNSL PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGTAGS
1010 1020 1030 1040 1050
MDASAQGLLE GIELDGDTLA PMETDEPSSS DSKGKSKITP AMAARIKQIK
1060 1070 1080 1090 1100
PLLSASSRLG RALAELFGLL VKLCVGSPVR QRRSHHAAST TTAPTPAARS
1110 1120 1130 1140 1150
TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP MLFDERKYPY
1160 1170 1180 1190 1200
HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD
1210 1220 1230 1240 1250
AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QSFPQFSALR FLVVTQKAAF
1260 1270 1280 1290 1300
TCIKNLWNRK PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG
1310 1320 1330 1340 1350
EEEAGQEEGG SRREPQVNQQ QLQQLMDMGF TREHAMEALL NTSTMEQATE
1360 1370 1380 1390 1400
YLLTHPPPII GGVVRDLSMS EEDQMMRAIA MSLGQDIPMD QRAESPEEVA
1410 1420 1430 1440 1450
CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT DTMLPGCFHL
1460 1470 1480 1490 1500
LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL
1510 1520 1530 1540 1550
PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES
1560 1570 1580 1590 1600
SGILNVLIKL LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS
1610 1620 1630 1640 1650
KRRAQMTKYL QSNSNNWRWF DDRSGRWCSY SASNNSTIDS AWKSGETSVR
1660 1670 1680 1690 1700
FTAGRRRYTV QFTTMVQVNE ETGNRRPVML TLLRVPRLSK NSKSSNGQEL
1710 1720 1730 1740 1750
EKTLEESKET DIKHKENKGN DIPLALESTN TEKEASLDET KIGEILIQGL
1760 1770 1780 1790 1800
TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS
1810 1820 1830 1840 1850
TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA
1860 1870 1880 1890 1900
GSTTSGVVSG SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP
1910 1920 1930 1940 1950
RGSGTASDDE FENLRIKGPN AVQLVKTTPL KPSSLPVIPD TIKEVIYDML
1960 1970 1980 1990 2000
NALAAYHAPE EADKSDPKPG GTTQEVGQLL QDMGDDVYQQ YRSLTRQSSD
2010 2020 2030 2040 2050
FDTQSGFSLN SQVFAADGAP AETSTTGTSQ GEGASTPEET REGKKDKEGD
2060 2070 2080 2090 2100
RTSEEGKQKS KGSKPLMPTS TILRLLAELV RSYVGIATLI ANYSYTVGQS
2110 2120 2130 2140 2150
ELIKEDCSVL AFVLDHLLPH TQNAEDKDTP ALARLFLASL AAAGSGTDAQ
2160 2170 2180 2190 2200
VALVNEVKAA LGRALAMAES TEKHARLQAV MCIISTIMES CPSTSSFYSS
2210 2220 2230 2240 2250
ATAKTQHNGM NNIIRLFLKK GLVNDLARVP HSLDLSSPNM ANTVNAALKP
2260 2270 2280 2290 2300
LETLSRIVNQ PSSLFGSKSA SSKNKSEQDA QGASQDSSSH QQDPGEPGEA
2310 2320 2330 2340 2350
EVQEEDHDVT QTEVADGDIM DGEAETDSVV IAGQPEVLSS QEMQVENELE
2360 2370 2380 2390 2400
DLIDELLERD GGSGNSTIIV SRSGEDESQE DVLMDEAPSN LSQASTLQAN
2410 2420 2430 2440 2450
REDSMNILDP EDEEEHTQEE DSSGSNEDED DSQDEEEEEE EDEEDDQEDD
2460 2470 2480 2490 2500
EGEEGDEDDD DDGSEMELDE DYPDMNASPL VRFERFDRED DLIIEFDNMF
2510 2520 2530 2540 2550
SSATDIPPSP GNIPTTHPLM VRHADHSSLT LGSGSSTTRL TQGIGRSQRT
2560 2570 2580 2590 2600
LRQLTANTGH TIHVHYPGNR QPNPPLILQR LLGPSAAADI LQLSSSLPLQ
2610 2620 2630 2640 2650
SRGRARLLVG NDDVHIIARS DDELLDDFFH DQSTATSQAG TLSSIPTALT
2660 2670 2680 2690 2700
RWTEECKVLD AESMHDCVSV VKVPIVNHLE FLRDEELEER REKRRKQLAE
2710 2720 2730 2740 2750
EETKIIDKGK EDKENRDQSA QCTVTKTNDS TEQNVSDGTP MPDSYPTTPS
2760 2770 2780 2790 2800
STDAPTSESK ETLGTLQPSQ QQPALPPPPS LGEIPQELQS PAEEVANSTQ
2810 2820 2830 2840 2850
LLMPIELEEL GPTRPSGEAE TTQMELSPAP TITSLSPERA EDSDALTAVS
2860 2870 2880 2890 2900
SQLEGSPMDT SSLASCTLEE AVGDTPAAGS SEQPTAGSST PGDAPSVVAE
2910 2920 2930 2940 2950
VQGRPDVSRE SNQPPEDSSP PASSESSSTR DSAVAISGAD SRGILEEPLP
2960 2970 2980 2990 3000
STSSEEEDPL AGISLPEGVD PSFLAALPDD IRREVLQNQL GIRPPTRSAP
3010 3020 3030 3040 3050
SSNSSAPAVV GNPGVTEVSP EFLAALPPAI QEEVLAQQRA EQQRRELAQN
3060 3070 3080 3090 3100
ASSDTPMDPV TFIQTLPSDL RRSVLEDMED SVLAVMPPDI AAEAQALRRE
3110 3120 3130 3140 3150
QEARQRQLMH ERLFGHSSTS ALSAILRSPA FTSRLSGNRG VQYTRLAVQR
3160 3170 3180 3190 3200
GGTFQMGGSS SHNRPSGSNV DTLLRLRGRL LLDHEALSCL LVLLFVDEPK
3210 3220 3230 3240 3250
LNTSRLHRVL RNLCYHAQTR HWVIRSLLSI LQRSSESELC IETPKLSTSE
3260 3270 3280 3290 3300
ERGKKSSKSC ASSSHENRPL DLLHKMESKS SNQLSWLSVS MDAALGCRTN
3310 3320 3330 3340 3350
IFQIQRSGGR KHTEKHASSG STVHIHPQAA PVVCRHVLDT LIQLAKVFPS
3360 3370 3380 3390 3400
HFTQQRTKET NCESDRERGS KQACSPCSSQ SSSSGICTDF WDLLVKLDNM
3410 3420 3430 3440 3450
NVSRKGKNSV KSVPVSSGGE GETSPHSLEA SPLGQLMNML SHPVIRRSSL
3460 3470 3480 3490 3500
LTEKLLRLLS LISIALPENK VSEVQTNSSN SGSSTAATSN TSTTTTTTTT
3510 3520 3530 3540 3550
ATAPTPTPPA ATTPVTSAPA LVAATAISTI TVAASTTVTT PTTATTTVST
3560 3570 3580 3590 3600
STTKGSKSPA KVGEGGSGID FKMVSSGLTE NQLQLSVEVL TSHSCSEEGL
3610 3620 3630 3640 3650
EDAANVLLQL SRGDSGTRDT VLKLLLNGAR HLGYTLCKQI GTLLAELREY
3660 3670 3680 3690 3700
NLEQQRRAQC ETLSPDGLPE EQPQTTKLKG KMQSRFDMAE NVVIVASQKR
3710 3720 3730 3740 3750
PLGGRELQLP SMSMLTSKTS TQKFFLRVLQ VIIQLRDDTR RANKKAKQTG
3760 3770 3780 3790 3800
RLGSSGLGSA SSIQAAVRQL EAEADAIIQM VREGQRARRQ QQAATSESSN
3810 3820 3830 3840 3850
QSETSVRREE SPMDVDQPSP SAQDTQSIVI SDGTPQGEKE KEEKPPELPL
3860 3870 3880 3890 3900
LSEQLSLDEL WDMLGECLKE LEESHDQHAV LVLQPAVEAF FLVHATERES
3910 3920 3930 3940 3950
KPPVRDTRES QLAHIKDEPP PLSPAPLTPA TPSSLDPFFS REPSSMHISS
3960 3970 3980 3990 4000
SLPPDTQKFL RFAETHRTVL NQILRQSTTH LADGPFAVLV DYIRVLDFDV
4010 4020 4030 4040 4050
KRKYFRQELE RLDEGLRKED MAVHVRRDHV FEDSYRELHR KSPEEMKNRL
4060 4070 4080 4090 4100
YIVFEGEEGQ DAGGLLREWY MIISREMFNP MYALFRTSPG DRVTYTINPS
4110 4120 4130 4140 4150
SHCNPNHLSY FKFVGRIVAK AVYDNRLLEC YFTRSFYKHI LGKSVRYTDM
4160 4170 4180 4190 4200
ESEDYHFYQG LVYLLENDVS TLGYDLTFST EVQEFGVCEV RDLKPNGANI
4210 4220 4230 4240 4250
LVTEENKKEY VHLVCQMRMT GAIRKQLAAF LEGFYEIIPK RLISIFTEQE
4260 4270 4280 4290 4300
LELLISGLPT IDIDDLKSNT EYHKYQSNSI QIQWFWRALR SFDQADRAKF
4310 4320 4330 4340 4350
LQFVTGTSKV PLQGFAALEG MNGIQKFQIH RDDRSTDRLP SAHTCFNQLD
4360 4370
LPAYESFEKL RHMLLLAIQE CSEGFGLA
Length:4,378
Mass (Da):482,692
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30A58688BD7298C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TMY8HUWE1_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1 Kiaa0312, Ureb1
4,377Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XP90F6XP90_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1
1,176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UYC1F6UYC1_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JD97A0A0G2JD97_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDF2D6RDF2_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL672180 Genomic DNA No translation available.
AL954855 Genomic DNA No translation available.
BX571795 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_067498.4, NM_021523.4
XP_006529012.1, XM_006528949.3
XP_011246160.1, XM_011247858.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000026292; ENSMUSP00000026292; ENSMUSG00000025261

Database of genes from NCBI RefSeq genomes

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GeneIDi
59026

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:59026

UCSC genome browser

More...
UCSCi
uc009upn.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672180 Genomic DNA No translation available.
AL954855 Genomic DNA No translation available.
BX571795 Genomic DNA No translation available.
RefSeqiNP_067498.4, NM_021523.4
XP_006529012.1, XM_006528949.3
XP_011246160.1, XM_011247858.1

3D structure databases

SMRiA2AFQ0
ModBaseiSearch...

PTM databases

SwissPalmiA2AFQ0

Proteomic databases

EPDiA2AFQ0
jPOSTiA2AFQ0
MaxQBiA2AFQ0
PeptideAtlasiA2AFQ0
PRIDEiA2AFQ0

Genome annotation databases

EnsembliENSMUST00000026292; ENSMUSP00000026292; ENSMUSG00000025261
GeneIDi59026
KEGGimmu:59026
UCSCiuc009upn.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10075
MGIiMGI:1926884 Huwe1

Phylogenomic databases

eggNOGiKOG0939 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000156319
HOGENOMiHOG000231388
KOiK10592
OMAiPIYIYRC
OrthoDBi25515at2759
TreeFamiTF323417

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Huwe1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025261 Expressed in 295 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiA2AFQ0 baseline and differential
GenevisibleiA2AFQ0 MM

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd14288 UBA_HUWE1, 1 hit
Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR010309 E3_Ub_ligase_DUF908
IPR010314 E3_Ub_ligase_DUF913
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR025527 HUWE1/Rev1_UBM
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041918 UBA_HUWE1
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
PfamiView protein in Pfam
PF06012 DUF908, 1 hit
PF06025 DUF913, 1 hit
PF00632 HECT, 1 hit
PF00627 UBA, 1 hit
PF14377 UBM, 3 hits
PF02825 WWE, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
SSF46934 SSF46934, 1 hit
SSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS50030 UBA, 1 hit
PS50918 WWE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AFQ0_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AFQ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 31, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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