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Entry version 97 (05 Jun 2019)
Sequence version 1 (05 Feb 2008)
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Protein
Submitted name:

Dedicator of cytokinesis protein 11

Gene

Dock11

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dedicator of cytokinesis protein 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dock11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923224 Dock11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AF67

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AF67

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AF67

PeptideAtlas

More...
PeptideAtlasi
A2AF67

PRoteomics IDEntifications database

More...
PRIDEi
A2AF67

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031093 Expressed in 234 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AF67 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AF67

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 88PHInterPro annotationAdd BLAST88
Domaini456 – 634DHR-1InterPro annotationAdd BLAST179
Domaini1438 – 1865DHR-2InterPro annotationAdd BLAST428

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1056 – 1096DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1080 – 1096PolarSequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1997 Eukaryota
ENOG410XNVY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155658

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231373

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGQVGDN

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08697 C2_Dock-D, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2AF67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVFKRRYFY LTQLPDGSYI LNSYKDEKNS KESKGCIYLD ACIDVVQCPK
60 70 80 90 100
MRRHAFELKM LDKYSHYLAA ETEQEMEEWL IMLKKIIQIN TDSLVQEKKD
110 120 130 140 150
TVEAIQEEET SSQGKAENIM ASLERSMHPE LMKYGRETEQ LNKLSRGDGR
160 170 180 190 200
QNLFSFDSEV QRLDFSGIEP DVKPFEEKCN KRFMVNCHDL TFNILGHIGD
210 220 230 240 250
NAKGPPTNVE PFFINLALFD VKNNCKISAD FHVDLNPPSV REMLWGTSTQ
260 270 280 290 300
LSNDGNAKGF SPESLIHGIA ESQLCYIKQG IFSVTNPHPE IFLVVRIEKV
310 320 330 340 350
LQGNITHCAE PYIKNSDPIK TAQKVHRTAK QVCSRLGQYR MPFAWAARPI
360 370 380 390 400
FKDVQGSLDL DGRFSPLYKQ DSSKLSNEDI LKLLSEYKKP EKTKLQIIPG
410 420 430 440 450
QLSITVECVP VDLPNCITSS YVPLKPFEKN CQNITVEVEE FVPEMTKYCY
460 470 480 490 500
PFTIYKNHLY VYPLQLKYDS QKSFAKARNI AVCVEFRDSD ESDASALKCI
510 520 530 540 550
YGKPAGSVFT TNAYAVVSHH NQNPEFYDEI KIELPIHLHQ KHHLLFTFYH
560 570 580 590 600
VSCEINTKGT TKKQDTVETP VGFAWVPLLK DGRVITLEQQ LPVSANLPPG
610 620 630 640 650
YLNVNDAESR RQSNADIKWV DGAKPLLKIK THLESTIYTQ DLHVHKFFHH
660 670 680 690 700
CQLIQSGSKE VPGELIKYLK CLHAMEIQVM IQFLPVILMQ LFRVLTNMTH
710 720 730 740 750
EDDVPINCTM VLLHIVSKCH EEGLESYLRS FIKYSFRPEK PSTLQAQLIH
760 770 780 790 800
ETLATTMIAI LKQSADFLAI NKLLKYSWFF FEIIAKSMAT YLLEENKIKL
810 820 830 840 850
PRGQRFPEAY HHVLHSLLLA IIPHVTIRYA EIPDESRNGN YSLASFLKRC
860 870 880 890 900
LTLMDRGFVF NLINDYISGF SPKDPKVLAE YKFEFLQTIC NHEHYIPLNL
910 920 930 940 950
PMAFAKPKLQ RVQDFFSFAV DRLTSVDSNL EYSLSDEYCK HHFLVGLLLR
960 970 980 990 1000
ETSIALQDNY EIRYTAISVI KNLLIKHAFD TRYQHKNQQA KIAQLYLPFV
1010 1020 1030 1040 1050
GLLLENIQRL AGRDTLYSCA AMPSSASRDE FPCGFVSPTN RGSLASDKDT
1060 1070 1080 1090 1100
AYGSFQNGHG IKREDSRGSL IPEGATGFPD PGSTSENTRQ SSSRSSVSQY
1110 1120 1130 1140 1150
NRLDQYEIRN LLMCYLYIVK MISEDTLLTY WNKVSPQELI NILVLLEVCL
1160 1170 1180 1190 1200
FHFRYMGKRN IARVHDAWLS KHFGIDRKSQ TMPALRNRSG VMQARLQHLS
1210 1220 1230 1240 1250
SLESSFTLNH SSATTEADIF HQALLEGNTA TEVSLTVLDT ISFFTQCFKN
1260 1270 1280 1290 1300
QLLNNDGHNP LMKKVFDIHL AFLKNGQSEV SLKHVFASLR SFISKFPSAF
1310 1320 1330 1340 1350
FKGRVNMCAA FCYEVLKCCT SKISSTRNEA SALLYLLMRN NFEYTKRKTF
1360 1370 1380 1390 1400
LRTHLQIIIA VSQLIADVAL SGGSRFQESL FIINNFANSD RPMKATAFPT
1410 1420 1430 1440 1450
EVKDLTKRIR TVLMATAQMK EHEKDPEMLI DLQYSLAKSY ASTPELRKTW
1460 1470 1480 1490 1500
LDSMAKIHIK NGDFSEAAMC YVHVAALVAE FLHRKKLFPS GCSAFKKITP
1510 1520 1530 1540 1550
NIDEEGAMKE DAGMMDVHYS EEVLLELLEQ CVDGLWKAER YEVISEISKL
1560 1570 1580 1590 1600
IIPIYEKRRE FEKLTQVYRT LHGAYTKILE VMHTKKRLLG TFFRVAFYGQ
1610 1620 1630 1640 1650
SFFEEEDGKE YIYKEPKLTG LSEISLRLVK LYGEKFGTEN VKIIQDSDKV
1660 1670 1680 1690 1700
NAKELDPKFA HIQVTYVKPY FDDKELTERK TEFERNHNIN RFVFEAPYTL
1710 1720 1730 1740 1750
SGKKQGCIEE QCKRRTILTT SNSFPYVKKR IPINCEQQVN LKPIDVATDE
1760 1770 1780 1790 1800
IKDKTAELHK LCSSVDVDMI QLQLKLQGCV SVQVNAGPLA YARAFLNESQ
1810 1820 1830 1840 1850
ANKYPPKKVN ELKDMFRKFI QACSIALELN ERLIKEDQIE YHEGLKSNFR
1860 1870 1880 1890 1900
DMVKELSDII HEQILQEDTM HSPWMNNTLH VFCAISGTSS NRGYGSPRYA

EV
Length:1,902
Mass (Da):218,244
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i019B4D61A8DB843F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AF47DOC11_MOUSE
Dedicator of cytokinesis protein 11
Dock11 Ziz2
2,073Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AF65A2AF65_MOUSE
Dedicator of cytokinesis protein 11
Dock11
527Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL672023 Genomic DNA No translation available.
AL672038 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000115266; ENSMUSP00000110921; ENSMUSG00000031093

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672023 Genomic DNA No translation available.
AL672038 Genomic DNA No translation available.

3D structure databases

SMRiA2AF67
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiA2AF67
jPOSTiA2AF67
MaxQBiA2AF67
PeptideAtlasiA2AF67
PRIDEiA2AF67

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115266; ENSMUSP00000110921; ENSMUSG00000031093

Organism-specific databases

MGIiMGI:1923224 Dock11

Phylogenomic databases

eggNOGiKOG1997 Eukaryota
ENOG410XNVY LUCA
GeneTreeiENSGT00940000155658
HOGENOMiHOG000231373
OMAiLGQVGDN

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031093 Expressed in 234 organ(s), highest expression level in bone marrow
ExpressionAtlasiA2AF67 baseline and differential

Family and domain databases

CDDicd08697 C2_Dock-D, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AF67_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AF67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 5, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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