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Entry version 109 (13 Nov 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Synaptotagmin-like 5

Gene

Sytl5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Synaptotagmin-like 5Imported
Submitted name:
Synaptotagmin-like 5, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sytl5Imported
ORF Names:mCG_52542Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2668451 Sytl5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000054453 Expressed in 13 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 123RabBDInterPro annotationAdd BLAST117
Domaini446 – 534C2InterPro annotationAdd BLAST89
Domaini612 – 701C2InterPro annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni145 – 279DisorderedSequence analysisAdd BLAST135
Regioni297 – 359DisorderedSequence analysisAdd BLAST63
Regioni380 – 404DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili32 – 59Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi146 – 175PolarSequence analysisAdd BLAST30
Compositional biasi210 – 279PolarSequence analysisAdd BLAST70
Compositional biasi303 – 323PolarSequence analysisAdd BLAST21
Compositional biasi324 – 342PolyampholyteSequence analysisAdd BLAST19
Compositional biasi380 – 395PolarSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IT3S Eukaryota
ENOG410Y1U8 LUCA

KEGG Orthology (KO)

More...
KOi
K17598

Database of Orthologous Groups

More...
OrthoDBi
916843at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04029 C2A_SLP-4_5, 1 hit
cd15766 FYVE_Slp5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR041282 FYVE_2
IPR010911 Rab_BD
IPR037303 SLP-4/5_C2A
IPR028702 Slp5
IPR042783 SYTL5_FYVE
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45716:SF6 PTHR45716:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits
PF02318 FYVE_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50916 RABBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2AF58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK
60 70 80 90 100
RRSGKTHQEA SRVCVHCHKT LGLIFDRGDP CQACSLRVCS ECRVTGLDGS
110 120 130 140 150
WKCTVCAKVA QLRIISGEWF LEEKAKRFKQ VNVLGTDVVR QSILRRSPGS
160 170 180 190 200
EETQNQEQAQ QCVDKSDTLS SVRQKTTHDG PKKKGFLLSK FRSATRGEIR
210 220 230 240 250
TPKPESGRSY SLDLDSQNLQ SFKSASGSDR GSTTSSDLID QEAGRRTSKS
260 270 280 290 300
SYSNGGIPVT QRSPVPSAHS VTSINSREHG FENSMALATI ENTCEELTKS
310 320 330 340 350
HRRNTSGTPS IAVSGTSLSS ERSRSEVDLS ESFAEDLEDT SSIRSRSVPG
360 370 380 390 400
ALDKDLNSLE DTEDGVDLVS SRFSANTHSL ASGLSTNSQA GSDRKRSYLN
410 420 430 440 450
VPDADSDTTS LNSMMSVYSE TGDYGNVKVT GEILLHISYC YKTGGLYIFV
460 470 480 490 500
KSCRNLATGD EKKQRTDAYV KSYLLPDKSR NNKRKTKIRT GTNPEFNETL
510 520 530 540 550
KYTISHTQLE TRTLQLSVWH YDRFGRNSFL GEVEIAFDSW NFENPCDEWF
560 570 580 590 600
VLQPKVELAP DISLQYKGEL TIVLRYIPPE ENLIFPAGQR QEKKIFKRGK
610 620 630 640 650
KKESSSISGG ILEVFIKKAK NLTAVKSGGT SDSFVKGYLL PDDNKATKHK
660 670 680 690 700
TAVVKKSVNP EWNHTFIFSG LYPQDIKNAC LELTIWDKEA FSSNVFLGGV
710 720 730 740 750
RLNSGSGMSY GKTVDWMDSH GEEQRLWQKM ADNPGTSVEG VLMLRSSMAK

CRL
Length:753
Mass (Da):84,089
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1560AB677818B57
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC150158 mRNA Translation: AAI50159.1
BC150480 mRNA Translation: AAI50481.1
CH466584 Genomic DNA Translation: EDL35668.1

NCBI Reference Sequences

More...
RefSeqi
NP_808372.1, NM_177704.3
XP_006527667.1, XM_006527604.3
XP_006527670.1, XM_006527607.3
XP_006527671.1, XM_006527608.3
XP_011245762.1, XM_011247460.2
XP_011245765.1, XM_011247463.2
XP_011245766.1, XM_011247464.1
XP_011245767.1, XM_011247465.1
XP_011245770.1, XM_011247468.1
XP_011245771.1, XM_011247469.2
XP_011245772.1, XM_011247470.2
XP_011245773.1, XM_011247471.2
XP_017173956.1, XM_017318467.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
236643

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:236643

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150158 mRNA Translation: AAI50159.1
BC150480 mRNA Translation: AAI50481.1
CH466584 Genomic DNA Translation: EDL35668.1
RefSeqiNP_808372.1, NM_177704.3
XP_006527667.1, XM_006527604.3
XP_006527670.1, XM_006527607.3
XP_006527671.1, XM_006527608.3
XP_011245762.1, XM_011247460.2
XP_011245765.1, XM_011247463.2
XP_011245766.1, XM_011247464.1
XP_011245767.1, XM_011247465.1
XP_011245770.1, XM_011247468.1
XP_011245771.1, XM_011247469.2
XP_011245772.1, XM_011247470.2
XP_011245773.1, XM_011247471.2
XP_017173956.1, XM_017318467.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi236643
KEGGimmu:236643

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94122
MGIiMGI:2668451 Sytl5

Phylogenomic databases

eggNOGiENOG410IT3S Eukaryota
ENOG410Y1U8 LUCA
KOiK17598
OrthoDBi916843at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sytl5 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000054453 Expressed in 13 organ(s), highest expression level in liver

Family and domain databases

CDDicd04029 C2A_SLP-4_5, 1 hit
cd15766 FYVE_Slp5, 1 hit
Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR041282 FYVE_2
IPR010911 Rab_BD
IPR037303 SLP-4/5_C2A
IPR028702 Slp5
IPR042783 SYTL5_FYVE
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR45716:SF6 PTHR45716:SF6, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF02318 FYVE_2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50916 RABBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AF58_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AF58
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 13, 2019
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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