Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 185A

Gene

Tmem185a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 185A
Alternative name(s):
Erythropoietin-induced EST 3
Protein FAM11A
Gene namesi
Name:Tmem185a
Synonyms:Ee3, Fam11a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2448555 Tmem185a

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004237801 – 350Transmembrane protein 185AAdd BLAST350

Proteomic databases

PRIDEiA2AF53

PTM databases

iPTMnetiA2AF53
PhosphoSitePlusiA2AF53

Expressioni

Tissue specificityi

Broadly expressed in brain where it is specifically expressed by neurons (at protein level). Also detected in some cells of arterioles, intestine, lung and testis (at protein level).1 Publication

Developmental stagei

Detected at E7, levels increase from E11 to E17.1 Publication

Inductioni

Up-regulated by erythropoietin (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000073139 Expressed in 283 organ(s), highest expression level in primitive streak
ExpressionAtlasiA2AF53 baseline and differential

Interactioni

Subunit structurei

Interacts with MAP1B.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2AF53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 350Mediates interaction with MAP1BBy similarityAdd BLAST53

Sequence similaritiesi

Belongs to the TMEM185 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000008194
HOGENOMiHOG000231372
HOVERGENiHBG051528
InParanoidiA2AF53
OMAiTHITMAI
OrthoDBiEOG091G0CR4

Family and domain databases

InterProiView protein in InterPro
IPR019396 TM_Fragile-X-F-assoc
PANTHERiPTHR13568 PTHR13568, 1 hit
PfamiView protein in Pfam
PF10269 Tmemb_185A, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AF53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW
60 70 80 90 100
KLMVIVGASV GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL
110 120 130 140 150
VCDRIERGSH FWLLVFMPLF FVSPVSVAAC VWGFRHDRSL ELEILCSVNI
160 170 180 190 200
LQFIFIALRL DKIIHWPWLV VCVPLWILMS FLCLVVLYYI VWSVLFLRSM
210 220 230 240 250
DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA FSCIPIFVPL
260 270 280 290 300
WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH
310 320 330 340 350
HEDSEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYVLP PPKLNIEMPD
Length:350
Mass (Da):40,620
Last modified:February 20, 2007 - v1
Checksum:i13FFC0BA9F8328B4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TYW3Q3TYW3_MOUSE
Transmembrane protein 185A
Tmem185a BC023829
322Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672026 Genomic DNA No translation available.
BC138670 mRNA Translation: AAI38671.1
BC145368 mRNA Translation: AAI45369.1
RefSeqiXP_006528044.1, XM_006527981.2
UniGeneiMm.24569

Genome annotation databases

EnsembliENSMUST00000114630; ENSMUSP00000110277; ENSMUSG00000073139
GeneIDi236848
UCSCiuc012hjm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672026 Genomic DNA No translation available.
BC138670 mRNA Translation: AAI38671.1
BC145368 mRNA Translation: AAI45369.1
RefSeqiXP_006528044.1, XM_006527981.2
UniGeneiMm.24569

3D structure databases

ProteinModelPortaliA2AF53
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA2AF53
PhosphoSitePlusiA2AF53

Proteomic databases

PRIDEiA2AF53

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114630; ENSMUSP00000110277; ENSMUSG00000073139
GeneIDi236848
UCSCiuc012hjm.1 mouse

Organism-specific databases

CTDi84548
MGIiMGI:2448555 Tmem185a

Phylogenomic databases

GeneTreeiENSGT00390000008194
HOGENOMiHOG000231372
HOVERGENiHBG051528
InParanoidiA2AF53
OMAiTHITMAI
OrthoDBiEOG091G0CR4

Miscellaneous databases

ChiTaRSiTmem185a mouse
PROiPR:A2AF53
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073139 Expressed in 283 organ(s), highest expression level in primitive streak
ExpressionAtlasiA2AF53 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR019396 TM_Fragile-X-F-assoc
PANTHERiPTHR13568 PTHR13568, 1 hit
PfamiView protein in Pfam
PF10269 Tmemb_185A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT185A_MOUSE
AccessioniPrimary (citable) accession number: A2AF53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again