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Protein

Dedicator of cytokinesis protein 11

Gene

Dock11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399). Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997).5 Publications

Miscellaneous

'Zizim' means 'spike' in Hebrew.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: UniProtKB
  • Rho GTPase binding Source: MGI
  • Rho guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 11Imported
Alternative name(s):
Activated Cdc42-associated guanine nucleotide exchange factor
Short name:
ACG
Zizimin-21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dock11Imported
Synonyms:Ziz21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923224 Dock11

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout mice are viable and fertile (PubMed:25729399). They have higher percentage of early bone marrow B-cells, but a reduced fraction of marginal zone B-cells. Their percentage of thymic CD4+ T-cells is increased and they show an altered of morphologymarginal metallophilic macrophages (PubMed:25729399).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995591 – 2073Dedicator of cytokinesis protein 11Add BLAST2073

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineBy similarity1
Modified residuei16PhosphothreonineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1
Modified residuei248PhosphotyrosineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei445PhosphoserineCombined sources1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1240PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AF47

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A2AF47

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AF47

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AF47

PeptideAtlas

More...
PeptideAtlasi
A2AF47

PRoteomics IDEntifications database

More...
PRIDEi
A2AF47

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AF47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AF47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spleen, thymus, mesenteric lymph nodes (MLN), bone marrow and peripheral blood lymphocytes. Enriched in B-cells from germinal centers. Expressed in B-, T- and dendritic cells as well as Purkinje cells (PubMed:22494997, PubMed:25851601).4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In spleen, expression is down-regulated in aged mice.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In dendritic cells, the expression is upregulated by LPS and anti-Fc-gamma receptor.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031093 Expressed in 234 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

More...
CleanExi
MM_DOCK11

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AF47 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AF47 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDC42.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
217880, 3 interactors

Protein interaction database and analysis system

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IntActi
A2AF47, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033419

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AF47

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AF47

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 272PHPROSITE-ProRule annotationAdd BLAST108
Domaini640 – 818DHR-1PROSITE-ProRule annotationAdd BLAST179
Domaini1609 – 2036DHR-2PROSITE-ProRule annotationAdd BLAST428

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 126Interaction with activated CDC421 PublicationAdd BLAST61

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DHR-2 domain is necessary for the GEF activity.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1997 Eukaryota
ENOG410XNVY LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155658

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231373

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107819

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2AF47

KEGG Orthology (KO)

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KOi
K21853

Database of Orthologous Groups

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OrthoDBi
20156at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313629

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08697 C2_Dock-D, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2AF47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKLV EPLDYENVIT
60 70 80 90 100
QRKTQIYSDP LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF
110 120 130 140 150
VKECIKTYST DWHVVNYKYE DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC
160 170 180 190 200
EKDEDSSSLC SQKGGVIKQG WLHKANVNST ITVTMKVFKR RYFYLTQLPD
210 220 230 240 250
GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF ELKMLDKYSH
260 270 280 290 300
YLAAETEQEM EEWLIMLKKI IQINTDSLVQ EKKDTVEAIQ EEETSSQGKA
310 320 330 340 350
ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS
360 370 380 390 400
GIEPDVKPFE EKCNKRFMVN CHDLTFNILG HIGDNAKGPP TNVEPFFINL
410 420 430 440 450
ALFDVKNNCK ISADFHVDLN PPSVREMLWG TSTQLSNDGN AKGFSPESLI
460 470 480 490 500
HGIAESQLCY IKQGIFSVTN PHPEIFLVVR IEKVLQGNIT HCAEPYIKNS
510 520 530 540 550
DPIKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDVQG SLDLDGRFSP
560 570 580 590 600
LYKQDSSKLS NEDILKLLSE YKKPEKTKLQ IIPGQLSITV ECVPVDLPNC
610 620 630 640 650
ITSSYVPLKP FEKNCQNITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL
660 670 680 690 700
KYDSQKSFAK ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV
710 720 730 740 750
VSHHNQNPEF YDEIKIELPI HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT
760 770 780 790 800
VETPVGFAWV PLLKDGRVIT LEQQLPVSAN LPPGYLNVND AESRRQSNAD
810 820 830 840 850
IKWVDGAKPL LKIKTHLEST IYTQDLHVHK FFHHCQLIQS GSKEVPGELI
860 870 880 890 900
KYLKCLHAME IQVMIQFLPV ILMQLFRVLT NMTHEDDVPI NCTMVLLHIV
910 920 930 940 950
SKCHEEGLES YLRSFIKYSF RPEKPSTLQA QLIHETLATT MIAILKQSAD
960 970 980 990 1000
FLAINKLLKY SWFFFEIIAK SMATYLLEEN KIKLPRGQRF PEAYHHVLHS
1010 1020 1030 1040 1050
LLLAIIPHVT IRYAEIPDES RNGNYSLASF LKRCLTLMDR GFVFNLINDY
1060 1070 1080 1090 1100
ISGFSPKDPK VLAEYKFEFL QTICNHEHYI PLNLPMAFAK PKLQRVQDSN
1110 1120 1130 1140 1150
LEYSLSDEYC KHHFLVGLLL RETSIALQDN YEIRYTAISV IKNLLIKHAF
1160 1170 1180 1190 1200
DTRYQHKNQQ AKIAQLYLPF VGLLLENIQR LAGRDTLYSC AAMPSSASRD
1210 1220 1230 1240 1250
EFPCGFVSPT NRGSLASDKD TAYGSFQNGH GIKREDSRGS LIPEGATGFP
1260 1270 1280 1290 1300
DPGSTSENTR QSSSRSSVSQ YNRLDQYEIR NLLMCYLYIV KMISEDTLLT
1310 1320 1330 1340 1350
YWNKVSPQEL INILVLLEVC LFHFRYMGKR NIARVHDAWL SKHFGIDRKS
1360 1370 1380 1390 1400
QTMPALRNRS GVMQARLQHL SSLESSFTLN HSSATTEADI FHQALLEGNT
1410 1420 1430 1440 1450
ATEVSLTVLD TISFFTQCFK NQLLNNDGHN PLMKKVFDIH LAFLKNGQSE
1460 1470 1480 1490 1500
VSLKHVFASL RSFISKFPSA FFKGRVNMCA AFCYEVLKCC TSKISSTRNE
1510 1520 1530 1540 1550
ASALLYLLMR NNFEYTKRKT FLRTHLQIII AVSQLIADVA LSGGSRFQES
1560 1570 1580 1590 1600
LFIINNFANS DRPMKATAFP TEVKDLTKRI RTVLMATAQM KEHEKDPEML
1610 1620 1630 1640 1650
IDLQYSLAKS YASTPELRKT WLDSMAKIHI KNGDFSEAAM CYVHVAALVA
1660 1670 1680 1690 1700
EFLHRKKLFP SGCSAFKKIT PNIDEEGAMK EDAGMMDVHY SEEVLLELLE
1710 1720 1730 1740 1750
QCVDGLWKAE RYEVISEISK LIIPIYEKRR EFEKLTQVYR TLHGAYTKIL
1760 1770 1780 1790 1800
EVMHTKKRLL GTFFRVAFYG QSFFEEEDGK EYIYKEPKLT GLSEISLRLV
1810 1820 1830 1840 1850
KLYGEKFGTE NVKIIQDSDK VNAKELDPKF AHIQVTYVKP YFDDKELTER
1860 1870 1880 1890 1900
KTEFERNHNI NRFVFEAPYT LSGKKQGCIE EQCKRRTILT TSNSFPYVKK
1910 1920 1930 1940 1950
RIPINCEQQV NLKPIDVATD EIKDKTAELH KLCSSVDVDM IQLQLKLQGC
1960 1970 1980 1990 2000
VSVQVNAGPL AYARAFLNES QANKYPPKKV NELKDMFRKF IQACSIALEL
2010 2020 2030 2040 2050
NERLIKEDQI EYHEGLKSNF RDMVKELSDI IHEQILQEDT MHSPWMNNTL
2060 2070
HVFCAISGTS SNRGYGSPRY AEV
Length:2,073
Mass (Da):237,771
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2907066969A6A8F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AF67A2AF67_MOUSE
Dedicator of cytokinesis protein 11
Dock11
1,902Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AF65A2AF65_MOUSE
Dedicator of cytokinesis protein 11
Dock11
527Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1608A → T in BAD83670 (PubMed:15710388).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB116935 mRNA Translation: BAD83670.1
AL672038, AL672023 Genomic DNA Translation: CAM20638.1
AL672023, AL672038 Genomic DNA Translation: CAM21480.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40923.1

NCBI Reference Sequences

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RefSeqi
NP_001009947.2, NM_001009947.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.32873

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033419; ENSMUSP00000033419; ENSMUSG00000031093

Database of genes from NCBI RefSeq genomes

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GeneIDi
75974

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:75974

UCSC genome browser

More...
UCSCi
uc009sxi.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116935 mRNA Translation: BAD83670.1
AL672038, AL672023 Genomic DNA Translation: CAM20638.1
AL672023, AL672038 Genomic DNA Translation: CAM21480.1
CCDSiCCDS40923.1
RefSeqiNP_001009947.2, NM_001009947.3
UniGeneiMm.32873

3D structure databases

ProteinModelPortaliA2AF47
SMRiA2AF47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217880, 3 interactors
IntActiA2AF47, 1 interactor
STRINGi10090.ENSMUSP00000033419

PTM databases

iPTMnetiA2AF47
PhosphoSitePlusiA2AF47

Proteomic databases

EPDiA2AF47
jPOSTiA2AF47
MaxQBiA2AF47
PaxDbiA2AF47
PeptideAtlasiA2AF47
PRIDEiA2AF47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033419; ENSMUSP00000033419; ENSMUSG00000031093
GeneIDi75974
KEGGimmu:75974
UCSCiuc009sxi.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
139818
MGIiMGI:1923224 Dock11

Phylogenomic databases

eggNOGiKOG1997 Eukaryota
ENOG410XNVY LUCA
GeneTreeiENSGT00940000155658
HOGENOMiHOG000231373
HOVERGENiHBG107819
InParanoidiA2AF47
KOiK21853
OrthoDBi20156at2759
TreeFamiTF313629

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

Protein Ontology

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PROi
PR:A2AF47

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031093 Expressed in 234 organ(s), highest expression level in bone marrow
CleanExiMM_DOCK11
ExpressionAtlasiA2AF47 baseline and differential
GenevisibleiA2AF47 MM

Family and domain databases

CDDicd08697 C2_Dock-D, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOC11_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AF47
Secondary accession number(s): Q5KTP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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