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Protein

Coiled-coil domain-containing protein 120

Gene

Ccdc120

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth (By similarity). Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity).By similarity1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 120Curated
Gene namesi
Name:Ccdc120Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859619 Ccdc120

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004427691 – 629Coiled-coil domain-containing protein 120Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei355PhosphoserineBy similarity1
Modified residuei357PhosphoserineCombined sources1
Modified residuei432Omega-N-methylarginineCombined sources1

Post-translational modificationi

Ubiquitinated; interaction with CYTH2 may prevent ubiquitination.By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiA2AEV7
PaxDbiA2AEV7
PeptideAtlasiA2AEV7
PRIDEiA2AEV7

PTM databases

iPTMnetiA2AEV7
PhosphoSitePlusiA2AEV7

Expressioni

Gene expression databases

BgeeiENSMUSG00000031150 Expressed in 181 organ(s), highest expression level in zone of skin
ExpressionAtlasiA2AEV7 baseline and differential

Interactioni

Subunit structurei

Interacts with NIN and CEP170; leading to recruit them to centrosomes (By similarity). Interacts with CYTH2; this interaction is direct and stabilizes CCDC120, possibly by preventing ubiquitination (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033490

Structurei

3D structure databases

ProteinModelPortaliA2AEV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 70Involved in CYTH2-bindingBy similarityAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili109 – 173Sequence analysisAdd BLAST65

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3529 Eukaryota
ENOG410XQFP LUCA
GeneTreeiENSGT00920000149019
HOGENOMiHOG000231367
HOVERGENiHBG080242
InParanoidiA2AEV7
OMAiPHPNPAH
OrthoDBiEOG091G05R8
PhylomeDBiA2AEV7
TreeFamiTF328984

Family and domain databases

InterProiView protein in InterPro
IPR039108 CC120
IPR021774 DUF3338
PANTHERiPTHR16093:SF5 PTHR16093:SF5, 1 hit
PfamiView protein in Pfam
PF11819 DUF3338, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AEV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKGQLISS PTFTAPAALF GEAAPLVKSD RLRGLLDRQR ALQEALSVKL
60 70 80 90 100
QELRKVCLQE AELTGQLPPE CPLEPGERPQ LVRRRPPAAR AYPPPHPNPA
110 120 130 140 150
HHSLCPAEEL ALEALEREVS VQQQIAAAAR RLALAPDLNG EQRRRRRQVQ
160 170 180 190 200
VDALRRLHEL EEQLRDFRAR LGLPVLQPLP LSAGALVNAQ GVCLGTRLAQ
210 220 230 240 250
LSQEDVVLHS ESSSLSESGA SHDNEEPHSC FPLTERPSPP KAWDQFRAVS
260 270 280 290 300
GGSPERRAPW KPPPSDIYGD LKSRRNSVAS PTSPTRSLPR SASSFEGRSV
310 320 330 340 350
PATPVLTRGS GPRLCKPEGL HSRQWSGSQD SQMGFPRPDP ASDRASLFAA
360 370 380 390 400
RTRRSNSSEA LLVDRAAAGG AGSPPAPLAP PAAGPPVCKS SEVLYERPQP
410 420 430 440 450
VPSFSSRTTG PPDPPRAARP SSAAPASRGA PRLPTVCGDF LLDYPLDRGL
460 470 480 490 500
PRGSGGAGWG ELLPAPEVPG PLSRRDGLLA MLPGPPPIYA ADGSSPLLRS
510 520 530 540 550
KDPNTRAIRS KPSGLPPEAV EGLEVHPNPL LWMPPPTRIP PAGERGGHKN
560 570 580 590 600
LALEGLRDWY IRNSGLAVGP QRRPMLPHVG PTHTPFLHAR CYEVGQSLYG
610 620
PPSQAPLPHS RSFTAPPVSG RYGGAFTDG
Length:629
Mass (Da):67,407
Last modified:February 20, 2007 - v1
Checksum:i277CF22B3D090564
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDD1A0A286YDD1_MOUSE
Coiled-coil domain-containing prote...
Ccdc120
278Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671995 Genomic DNA No translation available.
BC139064 mRNA Translation: AAI39065.1
CCDSiCCDS29972.1
RefSeqiNP_997085.2, NM_207202.2
UniGeneiMm.63342

Genome annotation databases

EnsembliENSMUST00000033490; ENSMUSP00000033490; ENSMUSG00000031150
GeneIDi54648
KEGGimmu:54648
UCSCiuc009smf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671995 Genomic DNA No translation available.
BC139064 mRNA Translation: AAI39065.1
CCDSiCCDS29972.1
RefSeqiNP_997085.2, NM_207202.2
UniGeneiMm.63342

3D structure databases

ProteinModelPortaliA2AEV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033490

PTM databases

iPTMnetiA2AEV7
PhosphoSitePlusiA2AEV7

Proteomic databases

MaxQBiA2AEV7
PaxDbiA2AEV7
PeptideAtlasiA2AEV7
PRIDEiA2AEV7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033490; ENSMUSP00000033490; ENSMUSG00000031150
GeneIDi54648
KEGGimmu:54648
UCSCiuc009smf.1 mouse

Organism-specific databases

CTDi90060
MGIiMGI:1859619 Ccdc120

Phylogenomic databases

eggNOGiKOG3529 Eukaryota
ENOG410XQFP LUCA
GeneTreeiENSGT00920000149019
HOGENOMiHOG000231367
HOVERGENiHBG080242
InParanoidiA2AEV7
OMAiPHPNPAH
OrthoDBiEOG091G05R8
PhylomeDBiA2AEV7
TreeFamiTF328984

Miscellaneous databases

PROiPR:A2AEV7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031150 Expressed in 181 organ(s), highest expression level in zone of skin
ExpressionAtlasiA2AEV7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR039108 CC120
IPR021774 DUF3338
PANTHERiPTHR16093:SF5 PTHR16093:SF5, 1 hit
PfamiView protein in Pfam
PF11819 DUF3338, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC120_MOUSE
AccessioniPrimary (citable) accession number: A2AEV7
Secondary accession number(s): A2AEV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2017
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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