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Protein
Submitted name:

Mcf.2-transforming sequence

Gene

Mcf2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI
  • dendrite development Source: MGI
  • intracellular signal transduction Source: InterPro
  • regulation of Rho protein signal transduction Source: InterPro

Enzyme and pathway databases

ReactomeiR-MMU-193634 Axonal growth inhibition (RHOA activation)
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Mcf.2-transforming sequenceImported
Gene namesi
Name:Mcf2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:96932 Mcf2

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiA2AET8
PRIDEiA2AET8

Expressioni

Gene expression databases

BgeeiENSMUSG00000031139 Expressed in 84 organ(s), highest expression level in lumbar subsegment of spinal cord
ExpressionAtlasiA2AET8 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA2AET8
SMRiA2AET8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 88CRAL-TRIOInterPro annotationAdd BLAST64
Domaini510 – 690DHInterPro annotationAdd BLAST181
Domaini702 – 824PHInterPro annotationAdd BLAST123

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00930000150837
HOGENOMiHOG000231361
HOVERGENiHBG062385
KOiK20685

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A2AET8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEANPPRGK MRFRRNAASF PGSLHLVLVL RPTSFLQRTF TDIGFRFSQE
60 70 80 90 100
DFMLKLPVVM LSSVSDLLTY IDDKQLTPEL GGTLQYCHSE WIIFRNAIEK
110 120 130 140 150
FAVTVKEMAQ MLQSFGTELA ETELPQDILS IEEILAGRAE RYHLLKNDLT
160 170 180 190 200
AVTKEGKVLL MNLQVPATEE TVSSSLECTQ HINGDWQTIK KLLAQVHDME
210 220 230 240 250
TAFDGFWEKH QLKMEQYLQL WKFEQDFQEA VTQVEFLLSQ QRELGDITGN
260 270 280 290 300
LAQVKQRLKK LEILDDKSQE LLTKARIVIL RGHKLASNHH YALDLICQRC
310 320 330 340 350
NELRYLSDIL VNEIRTKRVQ LSRTFKVHRL LQQARQCCDQ GECLLASQGM
360 370 380 390 400
DKFQTKEDAQ KALQDVDNFL QMAMPFINYD IESLQYEFDV LLSPELKAQM
410 420 430 440 450
QNIQLKLENI RSAFQNQQAG CKSLKEVPEG AFQNLVPASE NVMRSRMIFF
460 470 480 490 500
SPKHVGIGYS FFQACRIFLK VKKSWRQIHA QSNVKVEAVE DSQEKNSDQS
510 520 530 540 550
PKLDNSLDIL KNHVLNELIQ TERAYVRELF TVLLGYRSEM DNPQMFDLMP
560 570 580 590 600
PLLRNKKDVL FGNMAEIYEF HNNIFMSRLE DCSDAPERVG PCFLERKDDF
610 620 630 640 650
QMYAKYCQNK PRSELIWRKY SECAFFQECQ RKLKHRLGLD SYLLKPVQRI
660 670 680 690 700
TKYQLLLKEL LKYSKEGEGT TKLKEALDSM LELLKSVNDS MHQTAINGYV
710 720 730 740 750
GNINELGKMV LQGSFNVWLG HRKGATKMKD FARFKPMQRH LFLYEKAVMF
760 770 780 790 800
CKRRFESGEG ADRYPSYSFK HCLKMEDVGI TEHVKGDNRK FEIRYSEKEE
810 820 830 840 850
IYIVQAPNVD VKMLWLKEIR KILVQQKELM TAKTQQDQAL DQDQLFPQQQ
860 870 880 890 900
NAELCKSSPF CVCEETLFNA TEAGAEVEQA GALIKVREAA VLAQAEASSA
910 920 930 940
AWNGMLPSAE GAAAIAEHSY NYFSSNNDHG EDRTQMRHMS EVTF
Length:944
Mass (Da):109,101
Last modified:February 5, 2008 - v1
Checksum:iF7965DD6F5A73FBF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BLE2Q8BLE2_MOUSE
Mcf.2-transforming sequence
Mcf2
1,031Annotation score:
Q8C067Q8C067_MOUSE
Mcf.2-transforming sequence
Mcf2
928Annotation score:
A0A2I3BR92A0A2I3BR92_MOUSE
Mcf.2-transforming sequence
Mcf2
1,111Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670778 Genomic DNA No translation available.
AL671984 Genomic DNA No translation available.
AL929279 Genomic DNA No translation available.
RefSeqiNP_001276659.1, NM_001289730.1
UniGeneiMm.93796

Genome annotation databases

EnsembliENSMUST00000033478; ENSMUSP00000033478; ENSMUSG00000031139
GeneIDi109904
KEGGimmu:109904
UCSCiuc009thy.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670778 Genomic DNA No translation available.
AL671984 Genomic DNA No translation available.
AL929279 Genomic DNA No translation available.
RefSeqiNP_001276659.1, NM_001289730.1
UniGeneiMm.93796

3D structure databases

ProteinModelPortaliA2AET8
SMRiA2AET8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA2AET8
PRIDEiA2AET8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033478; ENSMUSP00000033478; ENSMUSG00000031139
GeneIDi109904
KEGGimmu:109904
UCSCiuc009thy.3 mouse

Organism-specific databases

CTDi4168
MGIiMGI:96932 Mcf2

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00930000150837
HOGENOMiHOG000231361
HOVERGENiHBG062385
KOiK20685

Enzyme and pathway databases

ReactomeiR-MMU-193634 Axonal growth inhibition (RHOA activation)
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031139 Expressed in 84 organ(s), highest expression level in lumbar subsegment of spinal cord
ExpressionAtlasiA2AET8 baseline and differential

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AET8_MOUSE
AccessioniPrimary (citable) accession number: A2AET8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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