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Protein
Submitted name:

HLA class II histocompatibility antigen, DQ beta 2 chain

Gene

HLA-DQB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class II histocompatibility antigen, DQ beta 2 chainImported
Submitted name:
cDNA FLJ40688 fis, clone THYMU2024185, highly similar to HLA class II histocompatibility antigen, DX beta chainImported
Gene namesi
Name:HLA-DQB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000232629.8
HGNCiHGNC:4945 HLA-DQB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000232629

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501456523629 – 275Sequence analysisAdd BLAST247

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiA2ADX3

Expressioni

Gene expression databases

BgeeiENSG00000232629

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 212Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140849
HOGENOMiHOG000100909
HOVERGENiHBG012730
OMAiDWNNYKD
OrthoDBiEOG091G0SXL

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

A2ADX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQIPGGFW AAAVTVMLVM LSTPVAEARD FPKDFLVQFK GMCYFTNGTE
60 70 80 90 100
RVRGVARYIY NREEYGRFDS DVGEFQAVTE LGRSIEDWNN YKDFLEQERA
110 120 130 140 150
AVDKVCRHNY EAELRTTLQR QVEPTVTISP SRTEALNHHN LLVCSVTDFY
160 170 180 190 200
PAQIKVRWFR NDQEETAGVV STSLIRNGDW TFQILVMLEI TPQRGDIYTC
210 220 230 240 250
QVEHPSLQSP ITVEWRAQSE SAQSKMLSGI GGFVLGLIFL GLGLIIRHRG
260 270
QKGPRGPPPA GNISAMIQSG ERAQA
Length:275
Mass (Da):30,948
Last modified:February 20, 2007 - v1
Checksum:i6E1A385D96839EE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671681 Genomic DNA No translation available.
AL672104 Genomic DNA No translation available.
AL713890 Genomic DNA No translation available.
BX296564 Genomic DNA No translation available.
CR936921 Genomic DNA No translation available.
AK098007 mRNA Translation: BAG53563.1
RefSeqiXP_005249108.1, XM_005249051.4
UniGeneiHs.731563

Genome annotation databases

EnsembliENST00000415137; ENSP00000387578; ENSG00000224305
ENST00000435145; ENSP00000410512; ENSG00000232629
ENST00000442806; ENSP00000394759; ENSG00000226165
ENST00000455520; ENSP00000409159; ENSG00000230675
GeneIDi3120
UCSCiuc003obz.3 human

Similar proteinsi

Entry informationi

Entry nameiA2ADX3_HUMAN
AccessioniPrimary (citable) accession number: A2ADX3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 18, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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