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Protein

Acyl-CoA wax alcohol acyltransferase 1

Gene

Awat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20) (By similarity).By similarity

Catalytic activityi

Acyl-CoA + a long-chain alcohol = CoA + a long-chain ester.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.75 3474
ReactomeiR-MMU-2142753 Arachidonic acid metabolism
R-MMU-8848584 Wax biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA wax alcohol acyltransferase 1 (EC:2.3.1.75)
Alternative name(s):
Diacylglycerol O-acyltransferase 2-like protein 3
Long-chain-alcohol O-fatty-acyltransferase 1
Gene namesi
Name:Awat1
Synonyms:Dgat2l3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3588200 Awat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei34 – 53HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202961 – 328Acyl-CoA wax alcohol acyltransferase 1Add BLAST328

Proteomic databases

PaxDbiA2ADU9
PRIDEiA2ADU9

Expressioni

Gene expression databases

BgeeiENSMUSG00000015665
CleanExiMM_DGAT2L3

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094088

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0831 Eukaryota
ENOG410XTG3 LUCA
GeneTreeiENSGT00750000117391
HOGENOMiHOG000179738
HOVERGENiHBG065791
InParanoidiA2ADU9
KOiK11171
OMAiMAKGVCS
OrthoDBiEOG091G0BGQ
TreeFamiTF314707

Family and domain databases

InterProiView protein in InterPro
IPR007130 DAGAT
PfamiView protein in Pfam
PF03982 DAGAT, 1 hit

Sequencei

Sequence statusi: Complete.

A2ADU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCSMKTEHL QSLSLLQWPL SYVAMFWIVQ PLLICLLFTP LWPLPTVYFV
60 70 80 90 100
WLLLDWKTPD KGGRRSDWVR NWNVWNHIRD YFPITILKTK DLSPSENYIM
110 120 130 140 150
GVHPHGLLTF GAFCNFCTEA TGFSKTFPGI TPHLATLSWF FKIPIIRDYI
160 170 180 190 200
MAKGLCSVSQ ASIDYLLSHG TGNLVGIVVG GVGEALQSVP NTTTLLLKKR
210 220 230 240 250
KGFVRTALQH GAHLVPTFTF GETEVYDQVL FHEDSRMFKF QSLFRRIFGF
260 270 280 290 300
YCCVFYGQGF HQDCKGLLPY HKPIITVVGE ALPLPQVKNP SPEIVDKYHA
310 320
LYMDALYKLF EQHKVQYGCS NTQKLIFL
Length:328
Mass (Da):37,573
Last modified:February 20, 2007 - v1
Checksum:i6CCFBAA4B4579FE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671299 Genomic DNA No translation available.
BC147680 mRNA Translation: AAI47681.1
BC147683 mRNA Translation: AAI47684.1
BC147829 mRNA Translation: AAI47830.1
BC147832 mRNA Translation: AAI47833.1
CCDSiCCDS41074.1
RefSeqiNP_001074605.1, NM_001081136.1
UniGeneiMm.77759

Genome annotation databases

EnsembliENSMUST00000096361; ENSMUSP00000094088; ENSMUSG00000015665
GeneIDi245533
KEGGimmu:245533
UCSCiuc009twb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAWAT1_MOUSE
AccessioniPrimary (citable) accession number: A2ADU9
Secondary accession number(s): B2RW94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: January 31, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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