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Protein

Solute carrier family 25 member 34

Gene

Slc25a34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 34
Gene namesi
Name:Slc25a34
Synonyms:Gm1369
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2686215 Slc25a34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei112 – 134Helical; Name=3Sequence analysisAdd BLAST23
Transmembranei184 – 205Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei292 – 315Helical; Name=6Sequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917901 – 318Solute carrier family 25 member 34Add BLAST318

Proteomic databases

PaxDbiA2ADF7
PRIDEiA2ADF7

Expressioni

Gene expression databases

BgeeiENSMUSG00000040740
CleanExiMM_SLC25A34
GenevisibleiA2ADF7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039188

Structurei

3D structure databases

ProteinModelPortaliA2ADF7
SMRiA2ADF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 111Solcar 1Add BLAST94
Repeati115 – 208Solcar 2Add BLAST94
Repeati218 – 309Solcar 3Add BLAST92

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0755 Eukaryota
ENOG410XS37 LUCA
GeneTreeiENSGT00550000074760
HOGENOMiHOG000165141
HOVERGENiHBG108440
InParanoidiA2ADF7
KOiK15117
OMAiDGLWGLQ
OrthoDBiEOG091G0MCY
PhylomeDBiA2ADF7
TreeFamiTF324506

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2ADF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPTQAQMAP AMDSREMVSP AVDLVLGASA CCLACVFTNP LEVVKTRLQL
60 70 80 90 100
QGELQAPGTY PRPYRGFVSS VAAVARADGL WGLQKGLAAG LLYQGLMNGV
110 120 130 140 150
RFYCYSLACQ AGLTQQPGGT VVAGAAAGAL GAFVGSPAYL VKTQLQAQTV
160 170 180 190 200
ATMAVGHQHQ HQGVLSALET IWRQQGMLGL WRGVGGAVPR VTVGSAAQLA
210 220 230 240 250
TFTSAKAWVQ DRQWFLEDSW LVTLAGGMIS SIAVVAVMTP LDVVSTRLYN
260 270 280 290 300
QPVDRAGRGQ LYGGLADCLV KTCQQEGPLA LYKGLGPAYL RLGPHTILSM
310
FFWDELRKLV ARAQHQGT
Length:318
Mass (Da):33,778
Last modified:February 20, 2007 - v1
Checksum:i0FC61CE7065CE4D6
GO
Isoform 2 (identifier: A2ADF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-219: WFLEDS → VRSWEH
     220-318: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):23,042
Checksum:i9C3594C1CB9B63F0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026235214 – 219WFLEDS → VRSWEH in isoform 2. 1 Publication6
Alternative sequenceiVSP_026236220 – 318Missing in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670446 Genomic DNA No translation available.
BC089627 mRNA Translation: AAH89627.2
CCDSiCCDS18878.1 [A2ADF7-1]
RefSeqiNP_001013802.1, NM_001013780.1 [A2ADF7-1]
UniGeneiMm.295682

Genome annotation databases

EnsembliENSMUST00000038661; ENSMUSP00000039188; ENSMUSG00000040740 [A2ADF7-1]
GeneIDi384071
KEGGimmu:384071
UCSCiuc008vox.1 mouse [A2ADF7-1]
uc008voy.1 mouse [A2ADF7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS2534_MOUSE
AccessioniPrimary (citable) accession number: A2ADF7
Secondary accession number(s): Q5FW51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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