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Entry version 114 (07 Oct 2020)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Msx2-interacting protein

Gene

Spen

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Msx2-interacting proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SpenImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891706, Spen

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2ADB1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2ADB1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2ADB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040761, Expressed in testis and 256 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2ADB1, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2ADB1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 81RRMInterPro annotationAdd BLAST76
Domaini337 – 410RRMInterPro annotationAdd BLAST74
Domaini440 – 515RRMInterPro annotationAdd BLAST76
Domaini519 – 591RRMInterPro annotationAdd BLAST73
Domaini3454 – 3620SPOCInterPro annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni103 – 124DisorderedSequence analysisAdd BLAST22
Regioni170 – 209DisorderedSequence analysisAdd BLAST40
Regioni225 – 332DisorderedSequence analysisAdd BLAST108
Regioni694 – 1391DisorderedSequence analysisAdd BLAST698
Regioni1472 – 1516DisorderedSequence analysisAdd BLAST45
Regioni1530 – 2422DisorderedSequence analysisAdd BLAST893
Regioni2429 – 2448DisorderedSequence analysisAdd BLAST20
Regioni2457 – 2504DisorderedSequence analysisAdd BLAST48
Regioni2720 – 2757DisorderedSequence analysisAdd BLAST38
Regioni2805 – 2825DisorderedSequence analysisAdd BLAST21
Regioni2950 – 2999DisorderedSequence analysisAdd BLAST50
Regioni3286 – 3449DisorderedSequence analysisAdd BLAST164

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi191 – 205PolyampholyteSequence analysisAdd BLAST15
Compositional biasi225 – 241PolyampholyteSequence analysisAdd BLAST17
Compositional biasi242 – 327PolarSequence analysisAdd BLAST86
Compositional biasi694 – 727PolyampholyteSequence analysisAdd BLAST34
Compositional biasi746 – 760PolyampholyteSequence analysisAdd BLAST15
Compositional biasi774 – 827PolyampholyteSequence analysisAdd BLAST54
Compositional biasi838 – 870PolyampholyteSequence analysisAdd BLAST33
Compositional biasi880 – 909PolyampholyteSequence analysisAdd BLAST30
Compositional biasi929 – 1051PolyampholyteSequence analysisAdd BLAST123
Compositional biasi1087 – 1112PolarSequence analysisAdd BLAST26
Compositional biasi1114 – 1246PolyampholyteSequence analysisAdd BLAST133
Compositional biasi1354 – 1384PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1489 – 1516PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1530 – 1547PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1558 – 1572PolarSequence analysisAdd BLAST15
Compositional biasi1583 – 1621PolyampholyteSequence analysisAdd BLAST39
Compositional biasi1732 – 1759PolarSequence analysisAdd BLAST28
Compositional biasi1760 – 1776PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1777 – 1792PolarSequence analysisAdd BLAST16
Compositional biasi1835 – 1872PolyampholyteSequence analysisAdd BLAST38
Compositional biasi1895 – 1909PolarSequence analysisAdd BLAST15
Compositional biasi1911 – 1935PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1951 – 1972PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2018 – 2084PolyampholyteSequence analysisAdd BLAST67
Compositional biasi2107 – 2126PolarSequence analysisAdd BLAST20
Compositional biasi2255 – 2269PolarSequence analysisAdd BLAST15
Compositional biasi2331 – 2346PolarSequence analysisAdd BLAST16
Compositional biasi2379 – 2393PolarSequence analysisAdd BLAST15
Compositional biasi2479 – 2504PolarSequence analysisAdd BLAST26
Compositional biasi2724 – 2738PolarSequence analysisAdd BLAST15
Compositional biasi2975 – 2989Pro-richSequence analysisAdd BLAST15
Compositional biasi3286 – 3312PolarSequence analysisAdd BLAST27
Compositional biasi3313 – 3330Pro-richSequence analysisAdd BLAST18
Compositional biasi3331 – 3372PolarSequence analysisAdd BLAST42
Compositional biasi3398 – 3412PolarSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM Spen family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157087

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_224781_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
TVESDYC

Database of Orthologous Groups

More...
OrthoDBi
367857at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12348, RRM1_SHARP, 1 hit
cd12349, RRM2_SHARP, 1 hit
cd12350, RRM3_SHARP, 1 hit
cd12351, RRM4_SHARP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.290.10, 1 hit
3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034172, SHARP_RRM1
IPR034173, SHARP_RRM2
IPR034174, SHARP_RRM3
IPR034175, SHARP_RRM4
IPR016194, SPOC-like_C_dom_sf
IPR012921, SPOC_C
IPR010912, SPOC_met

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 4 hits
PF07744, SPOC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100939, SSF100939, 1 hit
SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 4 hits
PS50917, SPOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2ADB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRETRHLWV GNLPENVREE KIIEHFKRYG RVESVKILPK RGSEGGVAAF
60 70 80 90 100
VDFVDIKSAQ KAHNSVNKMG DRDLRTDYNE PGTIPSAARG LDETVSIASR
110 120 130 140 150
SREVSGFRGS AGGPAYGPPP SLHAREGRYE RRLDGASDNR ERAYEHSAYG
160 170 180 190 200
HHERGTGAFD RTRHYDQDYY RDPRERTLQH GLYYTSRSRS PNRFDAHDPR
210 220 230 240 250
YEPRAREQFT LPSVVHRDIY RDDITREVRG RRPERSYQHS RSRSPHSSQS
260 270 280 290 300
RNQSPQRLAS QASRPTRSPS GSGSRSRSSS SDSISSSSSS SSNTDSSDSS
310 320 330 340 350
STASDDSPAR SVQSAAVPAP TSQLLSSLEK DEPRKSFGIK VQNLPVRSTD
360 370 380 390 400
TSLKDGLFHE FKKFGKVTSV QIHGASEERY GLVFFRQQED QEKALTASKG
410 420 430 440 450
KLFFGMQIEV TAWVGPETES ENEFRPLDER IDEFHPKATR TLFIGNLEKT
460 470 480 490 500
TTYHDLRNIF QRFGEIVDID IKKVNGVPQY AFLQYCDIAS VCKAIKKMDG
510 520 530 540 550
EYLGNNRLKL GFGKSMPTNC VWLDGLSSNV SDQYLTRHFC RYGPVVKVVF
560 570 580 590 600
DRLKGMALVL YSEIEDAQAA VKETKGRKIG GNKIKVDFAN RESQLAFYHC
610 620 630 640 650
MEKSGQDMRD FYEMLTERRE ERRGSYEYSQ ERTYYENVRT PGTYPEDSRR
660 670 680 690 700
DYPARGREFY SEWETYQGEY YDSRYYDEPR EYREYRSDPY EQDIREYSYR
710 720 730 740 750
QRERERERER FESDRDHERR PIERSQSPVH LRRPQSPGVS PAHSERLPSD
760 770 780 790 800
SERRLYRRSS ERSGSCSSVS PPRYDKLEKA RLERYTKNEK ADKERTFDPE
810 820 830 840 850
RVERERRIVR KEKGEKDKAE RQKRKGKAHS PSSQPSETEQ ENDREQSPEK
860 870 880 890 900
PRGSTKLSRD RADKEGPAKN RLELVPCVVL TRVKEKEGKV IEHPPPEKLK
910 920 930 940 950
ARLGRDTTKA SALDQKPQAA QGEPAKSDPA RGKALREKVL PSHAEVGEKE
960 970 980 990 1000
GRTKLRKHLK AEQTPELSAL DLEKLEARKR RFADSGLKIE KQKPEIKKTS
1010 1020 1030 1040 1050
PETEDTRILL KKQPDTSRDG VLLREGESER KPVRKEILKR ESKKTKLERL
1060 1070 1080 1090 1100
NSALSPKDCQ DPAAVSAGSG SRPSSDVHAG LGELTHGSVE TQETQPKKAI
1110 1120 1130 1140 1150
PSKPQPKQLQ LLENQGPEKE EVRKNYCRPR EEPAEHRAGQ EKPHGGNAEE
1160 1170 1180 1190 1200
KLGIDIDHTQ SYRKQMEQSR RKQRMEMEIA KAEKFGSPKK DVDDYERRSL
1210 1220 1230 1240 1250
VHEVGKPPQD VTDDSPPSKK RRTDHVDFDI CTKRERNYRS SRQISEDSER
1260 1270 1280 1290 1300
TSCSPSVRHG SFHDDDDPRG SPRLVSVKGS PKGDEKGLPY PNAAVRDDPL
1310 1320 1330 1340 1350
KCNPYDSGKR EQTADTAKIK LSVLNSEGEP SRWDPPMKQD PSRFDVSFPN
1360 1370 1380 1390 1400
SVIKRDSLRK RSVRDLEPGE VPSDSDEDAE HRSQSPRASS FYDSPRLSFL
1410 1420 1430 1440 1450
LRDRDQKLRE RDERLASSLE RNKFYSFALD KTITPDTKAL LERAKSLSSS
1460 1470 1480 1490 1500
REENWSFLDW DSRFANFRNN KDKEKVDSAP RPIPSWYMKK KKIRTDSEGK
1510 1520 1530 1540 1550
LADKKDERRE EEQERQELFA SRFLHSSIFE QDSKRLQHLE RKSEEPDLPP
1560 1570 1580 1590 1600
GGLYGRQASE GANSTSDSVQ EPVVLFHSRF MELTRMQQKE KEKDQKPKEA
1610 1620 1630 1640 1650
EKQEEPETHP KTPEPAAETK EPEPKAPVSA GLPAVTVTVV TPEPASSAPE
1660 1670 1680 1690 1700
KAEEAAEAPS PAGEKPAEPA PVSEETKLVS EPASVPVEQP RQSDVPPGED
1710 1720 1730 1740 1750
SRDSQDSAAL APSAPQESAA TDAVPCVNAE PLTPGTTVSQ VESSVDPKPS
1760 1770 1780 1790 1800
SPQPLSKLTQ RSEEAEEGKV EKPDTTPSTE PDATQNAGVA SEAQPPASED
1810 1820 1830 1840 1850
VEANPPVAAK DRKTNKSKRS KTSVQAAAAS VVEKPVTRKS ERIDREKLKR
1860 1870 1880 1890 1900
SSSPRGEAQK LLELKMEAEK ITRTASKSSG GDTEHPEPSL PLSRSRRRNV
1910 1920 1930 1940 1950
RSVYATMTDH ESRSPAKEPV EQPRVTRKRL ERELQEAVVP PTTPRRGRPP
1960 1970 1980 1990 2000
KTRRRAEEDG EHERKEPAET PRPAEGWRSP RSQKSAAAAG PQGKRGRNEQ
2010 2020 2030 2040 2050
KVEAAAEAGA QASTREGNPK SRGEREAASE PKRDRRDPST DKNGPDTFPV
2060 2070 2080 2090 2100
EVLERKPPEK TYKSKRGRAR STRSAMDRAA HQRSLEMAAR AAGQAADKEA
2110 2120 2130 2140 2150
GPAAASPQES ESPQKGSGSS PQLANNPADP DREAEEESAS ASTAPPEGTQ
2160 2170 2180 2190 2200
LARQIELEQA VQNIAKLPEP SAAAASKGTA TATAASEEPA PEHGHKPAHQ
2210 2220 2230 2240 2250
ASETELAAAI GSIISDASGE PENFSAPPSV PPGSQTHPRE GMEPGLHEAE
2260 2270 2280 2290 2300
SGILETGTAT ESSAPQVSAL DPPEGSADTK ETRGNSGDSV QEAKGSKVEV
2310 2320 2330 2340 2350
TPPRKDKGRQ KTTRRRKRNA NKKVVAITET RASEAEQTQS ESPAAEEATA
2360 2370 2380 2390 2400
ATPEAPQEEK QSEKPPSPPA ECTFDPSKTP PAESLSQENS AAEKTPCKAP
2410 2420 2430 2440 2450
VLPALPPLSQ PALMDDGPQA RFKVHSIIES DPVTPPSDSG IPPPTIPLVT
2460 2470 2480 2490 2500
IAKLPPPVIP GGVPHQSPPP KVTEWITRQE EPRAQSTPSP ALPPDTKASD
2510 2520 2530 2540 2550
MDTSSSTLRK ILMDPKYVSA TGVTSTSVTS AIAEPVSAPC LQEAPAPPCD
2560 2570 2580 2590 2600
PKHPPLEGVS AAAVPNADTQ ASEVPVAADK EKVAPVIAPK ITSVISRMPV
2610 2620 2630 2640 2650
SIDLENSQKI TLAKPAPQTL TGLVSALTGL VNVSLVPVNA LKGPVKGSVA
2660 2670 2680 2690 2700
TLKGLVSTPA GPVNLLKGPV NVLTGPVNVL TTPVSATVGT VNAAPGPVTA
2710 2720 2730 2740 2750
ACGVTATTGT AAVTGAVTAP AAKGKQRASS NENSRFHPGS MSVIDDRPAD
2760 2770 2780 2790 2800
TGSGAGLRVN TSEGVVLLSY SGQKTEGPQR ISAKISQIPP ASAMDIEFQQ
2810 2820 2830 2840 2850
SVSKSQVKAD SITPTQSAPK GPQTPSAFAN VAAHSTLVLT AQTYNASPVI
2860 2870 2880 2890 2900
SSVKTDRPSL EKPEPIHLSV STPVTQGGTV KVLTQGINTP PVLVHNQLVL
2910 2920 2930 2940 2950
TPSIVTTNKK LADPVTLKIE TKVLQPANLG PTLTPHHPPA LPSKLPAEVN
2960 2970 2980 2990 3000
HVPSGPSTPA DRTIAHLATP KPDTHSPRPT GPTPGLFPRP CHPSSTTSTA
3010 3020 3030 3040 3050
LSTNATVMLA AGIPVPQFIS SIHPEQSVIM PPHSITQTVS LGHLSQGEVR
3060 3070 3080 3090 3100
MSTPTLPSIT YSIRPETLHS PRAPLQPQQI EARAPQRVGT PQPATTGVPA
3110 3120 3130 3140 3150
LATQHPPEEE VHYHLPVARA AAPVQSEVLV MQSEYRLHPY TVPRDVRIMV
3160 3170 3180 3190 3200
HPHVTAVSEQ PRATEGVVKV PPANKAPQQL VKEAVKTSDA KAVPAPAPVP
3210 3220 3230 3240 3250
VPVPVPTPAP PPHGEARILT VTPSSQLQGL PLTPPVVVTH GVQIVHSSGE
3260 3270 3280 3290 3300
LFQEYRYGDV RTYHAPAQQL THTQFPVASS ISLASRTKTS AQVPPEGEPL
3310 3320 3330 3340 3350
QSTQSAQPAP STQATQPIPP APPCQPSQLS QPAQPPSGKI PQVSQEAKGT
3360 3370 3380 3390 3400
QTGGVEQTRL PAIPTNRPSE PHAQLQRAPV ETAQPAHPSP VSVSMKPDLP
3410 3420 3430 3440 3450
SPLSSQAAPK QPLFVPANSG PSTPPGLALP HAEVQPAPKQ ESSPHGTPQR
3460 3470 3480 3490 3500
PVDMVQLLKK YPIVWQGLLA LKNDTAAVQL HFVSGNNVLA HRSLPLSEGG
3510 3520 3530 3540 3550
PPLRIAQRMR LEASQLEGVA RRMTVETDYC LLLALPCGRD QEDVVSQTES
3560 3570 3580 3590 3600
LKAAFITYLQ AKQAAGIINV PNPGSNQPAY VLQIFPPCEF SESHLSRLAP
3610 3620
DLLASISNIS PHLMIVIASV
Length:3,620
Mass (Da):395,983
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E8F9FDFE34DEF15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q62504MINT_MOUSE
Msx2-interacting protein
Spen Kiaa0929, Mint, Sharp
3,644Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ADB0A2ADB0_MOUSE
Msx2-interacting protein
Spen
3,643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL670285 Genomic DNA No translation available.
AL670446 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001334164.1, NM_001347235.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000078886; ENSMUSP00000077925; ENSMUSG00000040761

Database of genes from NCBI RefSeq genomes

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GeneIDi
56381

UCSC genome browser

More...
UCSCi
uc008vom.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670285 Genomic DNA No translation available.
AL670446 Genomic DNA No translation available.
RefSeqiNP_001334164.1, NM_001347235.1

3D structure databases

SMRiA2ADB1
ModBaseiSearch...

Proteomic databases

EPDiA2ADB1
jPOSTiA2ADB1
MaxQBiA2ADB1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
14431, 50 antibodies

Genome annotation databases

EnsembliENSMUST00000078886; ENSMUSP00000077925; ENSMUSG00000040761
GeneIDi56381
UCSCiuc008vom.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23013
MGIiMGI:1891706, Spen

Phylogenomic databases

GeneTreeiENSGT00940000157087
HOGENOMiCLU_224781_0_0_1
OMAiTVESDYC
OrthoDBi367857at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
56381, 3 hits in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Spen, mouse

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040761, Expressed in testis and 256 other tissues
ExpressionAtlasiA2ADB1, baseline and differential

Family and domain databases

CDDicd12348, RRM1_SHARP, 1 hit
cd12349, RRM2_SHARP, 1 hit
cd12350, RRM3_SHARP, 1 hit
cd12351, RRM4_SHARP, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034172, SHARP_RRM1
IPR034173, SHARP_RRM2
IPR034174, SHARP_RRM3
IPR034175, SHARP_RRM4
IPR016194, SPOC-like_C_dom_sf
IPR012921, SPOC_C
IPR010912, SPOC_met
PfamiView protein in Pfam
PF00076, RRM_1, 4 hits
PF07744, SPOC, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 4 hits
SUPFAMiSSF100939, SSF100939, 1 hit
SSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 4 hits
PS50917, SPOC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2ADB1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ADB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 7, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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