Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 116 (31 Jul 2019)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Msx2-interacting protein

Gene

Spen

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Msx2-interacting proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SpenImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891706 Spen

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2ADB0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2ADB0

PeptideAtlas

More...
PeptideAtlasi
A2ADB0

PRoteomics IDEntifications database

More...
PRIDEi
A2ADB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040761 Expressed in 239 organ(s), highest expression level in thymus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2ADB0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2ADB0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2ADB0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 81RRMInterPro annotationAdd BLAST76
Domaini337 – 410RRMInterPro annotationAdd BLAST74
Domaini440 – 515RRMInterPro annotationAdd BLAST76
Domaini519 – 591RRMInterPro annotationAdd BLAST73
Domaini3477 – 3643SPOCInterPro annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni103 – 124DisorderedSequence analysisAdd BLAST22
Regioni170 – 209DisorderedSequence analysisAdd BLAST40
Regioni225 – 332DisorderedSequence analysisAdd BLAST108
Regioni626 – 674DisorderedSequence analysisAdd BLAST49
Regioni717 – 1414DisorderedSequence analysisAdd BLAST698
Regioni1495 – 1539DisorderedSequence analysisAdd BLAST45
Regioni1553 – 2445DisorderedSequence analysisAdd BLAST893
Regioni2452 – 2471DisorderedSequence analysisAdd BLAST20
Regioni2480 – 2527DisorderedSequence analysisAdd BLAST48
Regioni2743 – 2780DisorderedSequence analysisAdd BLAST38
Regioni2828 – 2848DisorderedSequence analysisAdd BLAST21
Regioni2973 – 3022DisorderedSequence analysisAdd BLAST50
Regioni3309 – 3472DisorderedSequence analysisAdd BLAST164

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi191 – 205PolyampholyteSequence analysisAdd BLAST15
Compositional biasi225 – 241PolyampholyteSequence analysisAdd BLAST17
Compositional biasi242 – 327PolarSequence analysisAdd BLAST86
Compositional biasi632 – 652PolyampholyteSequence analysisAdd BLAST21
Compositional biasi717 – 750PolyampholyteSequence analysisAdd BLAST34
Compositional biasi769 – 783PolyampholyteSequence analysisAdd BLAST15
Compositional biasi797 – 850PolyampholyteSequence analysisAdd BLAST54
Compositional biasi861 – 893PolyampholyteSequence analysisAdd BLAST33
Compositional biasi903 – 932PolyampholyteSequence analysisAdd BLAST30
Compositional biasi952 – 1074PolyampholyteSequence analysisAdd BLAST123
Compositional biasi1110 – 1135PolarSequence analysisAdd BLAST26
Compositional biasi1137 – 1269PolyampholyteSequence analysisAdd BLAST133
Compositional biasi1377 – 1407PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1512 – 1539PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1553 – 1570PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1581 – 1595PolarSequence analysisAdd BLAST15
Compositional biasi1606 – 1644PolyampholyteSequence analysisAdd BLAST39
Compositional biasi1755 – 1782PolarSequence analysisAdd BLAST28
Compositional biasi1783 – 1799PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1800 – 1815PolarSequence analysisAdd BLAST16
Compositional biasi1858 – 1895PolyampholyteSequence analysisAdd BLAST38
Compositional biasi1918 – 1932PolarSequence analysisAdd BLAST15
Compositional biasi1934 – 1958PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1974 – 1995PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2041 – 2107PolyampholyteSequence analysisAdd BLAST67
Compositional biasi2130 – 2149PolarSequence analysisAdd BLAST20
Compositional biasi2278 – 2292PolarSequence analysisAdd BLAST15
Compositional biasi2354 – 2369PolarSequence analysisAdd BLAST16
Compositional biasi2402 – 2416PolarSequence analysisAdd BLAST15
Compositional biasi2502 – 2527PolarSequence analysisAdd BLAST26
Compositional biasi2747 – 2761PolarSequence analysisAdd BLAST15
Compositional biasi2998 – 3012Pro-richSequence analysisAdd BLAST15
Compositional biasi3309 – 3335PolarSequence analysisAdd BLAST27
Compositional biasi3336 – 3353Pro-richSequence analysisAdd BLAST18
Compositional biasi3354 – 3395PolarSequence analysisAdd BLAST42
Compositional biasi3421 – 3435PolarSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0112 Eukaryota
ENOG410ZT33 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157087

Database of Orthologous Groups

More...
OrthoDBi
367857at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315637

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.290.10, 1 hit
3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 4 hits
PF07744 SPOC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2ADB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRETRHLWV GNLPENVREE KIIEHFKRYG RVESVKILPK RGSEGGVAAF
60 70 80 90 100
VDFVDIKSAQ KAHNSVNKMG DRDLRTDYNE PGTIPSAARG LDETVSIASR
110 120 130 140 150
SREVSGFRGS AGGPAYGPPP SLHAREGRYE RRLDGASDNR ERAYEHSAYG
160 170 180 190 200
HHERGTGAFD RTRHYDQDYY RDPRERTLQH GLYYTSRSRS PNRFDAHDPR
210 220 230 240 250
YEPRAREQFT LPSVVHRDIY RDDITREVRG RRPERSYQHS RSRSPHSSQS
260 270 280 290 300
RNQSPQRLAS QASRPTRSPS GSGSRSRSSS SDSISSSSSS SSNTDSSDSS
310 320 330 340 350
STASDDSPAR SVQSAAVPAP TSQLLSSLEK DEPRKSFGIK VQNLPVRSTD
360 370 380 390 400
TSLKDGLFHE FKKFGKVTSV QIHGASEERY GLVFFRQQED QEKALTASKG
410 420 430 440 450
KLFFGMQIEV TAWVGPETES ENEFRPLDER IDEFHPKATR TLFIGNLEKT
460 470 480 490 500
TTYHDLRNIF QRFGEIVDID IKKVNGVPQY AFLQYCDIAS VCKAIKKMDG
510 520 530 540 550
EYLGNNRLKL GFGKSMPTNC VWLDGLSSNV SDQYLTRHFC RYGPVVKVVF
560 570 580 590 600
DRLKGMALVL YSEIEDAQAA VKETKGRKIG GNKIKVDFAN RESQLAFYHC
610 620 630 640 650
MEKSGQDMRD FYEMLTERRA GQMAQSKHED WSADAQSPHK CREERRGSYE
660 670 680 690 700
YSQERTYYEN VRTPGTYPED SRRDYPARGR EFYSEWETYQ GEYYDSRYYD
710 720 730 740 750
EPREYREYRS DPYEQDIREY SYRQRERERE RERFESDRDH ERRPIERSQS
760 770 780 790 800
PVHLRRPQSP GVSPAHSERL PSDSERRLYR RSSERSGSCS SVSPPRYDKL
810 820 830 840 850
EKARLERYTK NEKADKERTF DPERVERERR IVRKEKGEKD KAERQKRKGK
860 870 880 890 900
AHSPSSQPSE TEQENDREQS PEKPRGSTKL SRDRADKEGP AKNRLELVPC
910 920 930 940 950
VVLTRVKEKE GKVIEHPPPE KLKARLGRDT TKASALDQKP QAAQGEPAKS
960 970 980 990 1000
DPARGKALRE KVLPSHAEVG EKEGRTKLRK HLKAEQTPEL SALDLEKLEA
1010 1020 1030 1040 1050
RKRRFADSGL KIEKQKPEIK KTSPETEDTR ILLKKQPDTS RDGVLLREGE
1060 1070 1080 1090 1100
SERKPVRKEI LKRESKKTKL ERLNSALSPK DCQDPAAVSA GSGSRPSSDV
1110 1120 1130 1140 1150
HAGLGELTHG SVETQETQPK KAIPSKPQPK QLQLLENQGP EKEEVRKNYC
1160 1170 1180 1190 1200
RPREEPAEHR AGQEKPHGGN AEEKLGIDID HTQSYRKQME QSRRKQRMEM
1210 1220 1230 1240 1250
EIAKAEKFGS PKKDVDDYER RSLVHEVGKP PQDVTDDSPP SKKRRTDHVD
1260 1270 1280 1290 1300
FDICTKRERN YRSSRQISED SERTSCSPSV RHGSFHDDDD PRGSPRLVSV
1310 1320 1330 1340 1350
KGSPKGDEKG LPYPNAAVRD DPLKCNPYDS GKREQTADTA KIKLSVLNSE
1360 1370 1380 1390 1400
GEPSRWDPPM KQDPSRFDVS FPNSVIKRDS LRKRSVRDLE PGEVPSDSDE
1410 1420 1430 1440 1450
DAEHRSQSPR ASSFYDSPRL SFLLRDRDQK LRERDERLAS SLERNKFYSF
1460 1470 1480 1490 1500
ALDKTITPDT KALLERAKSL SSSREENWSF LDWDSRFANF RNNKDKEKVD
1510 1520 1530 1540 1550
SAPRPIPSWY MKKKKIRTDS EGKLADKKDE RREEEQERQE LFASRFLHSS
1560 1570 1580 1590 1600
IFEQDSKRLQ HLERKSEEPD LPPGGLYGRQ ASEGANSTSD SVQEPVVLFH
1610 1620 1630 1640 1650
SRFMELTRMQ QKEKEKDQKP KEAEKQEEPE THPKTPEPAA ETKEPEPKAP
1660 1670 1680 1690 1700
VSAGLPAVTV TVVTPEPASS APEKAEEAAE APSPAGEKPA EPAPVSEETK
1710 1720 1730 1740 1750
LVSEPASVPV EQPRQSDVPP GEDSRDSQDS AALAPSAPQE SAATDAVPCV
1760 1770 1780 1790 1800
NAEPLTPGTT VSQVESSVDP KPSSPQPLSK LTQRSEEAEE GKVEKPDTTP
1810 1820 1830 1840 1850
STEPDATQNA GVASEAQPPA SEDVEANPPV AAKDRKTNKS KRSKTSVQAA
1860 1870 1880 1890 1900
AASVVEKPVT RKSERIDREK LKRSSSPRGE AQKLLELKME AEKITRTASK
1910 1920 1930 1940 1950
SSGGDTEHPE PSLPLSRSRR RNVRSVYATM TDHESRSPAK EPVEQPRVTR
1960 1970 1980 1990 2000
KRLERELQEA VVPPTTPRRG RPPKTRRRAE EDGEHERKEP AETPRPAEGW
2010 2020 2030 2040 2050
RSPRSQKSAA AAGPQGKRGR NEQKVEAAAE AGAQASTREG NPKSRGEREA
2060 2070 2080 2090 2100
ASEPKRDRRD PSTDKNGPDT FPVEVLERKP PEKTYKSKRG RARSTRSAMD
2110 2120 2130 2140 2150
RAAHQRSLEM AARAAGQAAD KEAGPAAASP QESESPQKGS GSSPQLANNP
2160 2170 2180 2190 2200
ADPDREAEEE SASASTAPPE GTQLARQIEL EQAVQNIAKL PEPSAAAASK
2210 2220 2230 2240 2250
GTATATAASE EPAPEHGHKP AHQASETELA AAIGSIISDA SGEPENFSAP
2260 2270 2280 2290 2300
PSVPPGSQTH PREGMEPGLH EAESGILETG TATESSAPQV SALDPPEGSA
2310 2320 2330 2340 2350
DTKETRGNSG DSVQEAKGSK VEVTPPRKDK GRQKTTRRRK RNANKKVVAI
2360 2370 2380 2390 2400
TETRASEAEQ TQSESPAAEE ATAATPEAPQ EEKQSEKPPS PPAECTFDPS
2410 2420 2430 2440 2450
KTPPAESLSQ ENSAAEKTPC KAPVLPALPP LSQPALMDDG PQARFKVHSI
2460 2470 2480 2490 2500
IESDPVTPPS DSGIPPPTIP LVTIAKLPPP VIPGGVPHQS PPPKVTEWIT
2510 2520 2530 2540 2550
RQEEPRAQST PSPALPPDTK ASDMDTSSST LRKILMDPKY VSATGVTSTS
2560 2570 2580 2590 2600
VTSAIAEPVS APCLQEAPAP PCDPKHPPLE GVSAAAVPNA DTQASEVPVA
2610 2620 2630 2640 2650
ADKEKVAPVI APKITSVISR MPVSIDLENS QKITLAKPAP QTLTGLVSAL
2660 2670 2680 2690 2700
TGLVNVSLVP VNALKGPVKG SVATLKGLVS TPAGPVNLLK GPVNVLTGPV
2710 2720 2730 2740 2750
NVLTTPVSAT VGTVNAAPGP VTAACGVTAT TGTAAVTGAV TAPAAKGKQR
2760 2770 2780 2790 2800
ASSNENSRFH PGSMSVIDDR PADTGSGAGL RVNTSEGVVL LSYSGQKTEG
2810 2820 2830 2840 2850
PQRISAKISQ IPPASAMDIE FQQSVSKSQV KADSITPTQS APKGPQTPSA
2860 2870 2880 2890 2900
FANVAAHSTL VLTAQTYNAS PVISSVKTDR PSLEKPEPIH LSVSTPVTQG
2910 2920 2930 2940 2950
GTVKVLTQGI NTPPVLVHNQ LVLTPSIVTT NKKLADPVTL KIETKVLQPA
2960 2970 2980 2990 3000
NLGPTLTPHH PPALPSKLPA EVNHVPSGPS TPADRTIAHL ATPKPDTHSP
3010 3020 3030 3040 3050
RPTGPTPGLF PRPCHPSSTT STALSTNATV MLAAGIPVPQ FISSIHPEQS
3060 3070 3080 3090 3100
VIMPPHSITQ TVSLGHLSQG EVRMSTPTLP SITYSIRPET LHSPRAPLQP
3110 3120 3130 3140 3150
QQIEARAPQR VGTPQPATTG VPALATQHPP EEEVHYHLPV ARAAAPVQSE
3160 3170 3180 3190 3200
VLVMQSEYRL HPYTVPRDVR IMVHPHVTAV SEQPRATEGV VKVPPANKAP
3210 3220 3230 3240 3250
QQLVKEAVKT SDAKAVPAPA PVPVPVPVPT PAPPPHGEAR ILTVTPSSQL
3260 3270 3280 3290 3300
QGLPLTPPVV VTHGVQIVHS SGELFQEYRY GDVRTYHAPA QQLTHTQFPV
3310 3320 3330 3340 3350
ASSISLASRT KTSAQVPPEG EPLQSTQSAQ PAPSTQATQP IPPAPPCQPS
3360 3370 3380 3390 3400
QLSQPAQPPS GKIPQVSQEA KGTQTGGVEQ TRLPAIPTNR PSEPHAQLQR
3410 3420 3430 3440 3450
APVETAQPAH PSPVSVSMKP DLPSPLSSQA APKQPLFVPA NSGPSTPPGL
3460 3470 3480 3490 3500
ALPHAEVQPA PKQESSPHGT PQRPVDMVQL LKKYPIVWQG LLALKNDTAA
3510 3520 3530 3540 3550
VQLHFVSGNN VLAHRSLPLS EGGPPLRIAQ RMRLEASQLE GVARRMTVET
3560 3570 3580 3590 3600
DYCLLLALPC GRDQEDVVSQ TESLKAAFIT YLQAKQAAGI INVPNPGSNQ
3610 3620 3630 3640
PAYVLQIFPP CEFSESHLSR LAPDLLASIS NISPHLMIVI ASV
Length:3,643
Mass (Da):398,534
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F48370A5044ADC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q62504MINT_MOUSE
Msx2-interacting protein
Spen Kiaa0929, Mint, Sharp
3,644Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ADB1A2ADB1_MOUSE
Msx2-interacting protein
Spen
3,620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL670285 Genomic DNA No translation available.
AL670446 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_062737.2, NM_019763.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000105786; ENSMUSP00000101412; ENSMUSG00000040761

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56381

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:56381

UCSC genome browser

More...
UCSCi
uc008von.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670285 Genomic DNA No translation available.
AL670446 Genomic DNA No translation available.
RefSeqiNP_062737.2, NM_019763.2

3D structure databases

SMRiA2ADB0
ModBaseiSearch...

Proteomic databases

jPOSTiA2ADB0
MaxQBiA2ADB0
PeptideAtlasiA2ADB0
PRIDEiA2ADB0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105786; ENSMUSP00000101412; ENSMUSG00000040761
GeneIDi56381
KEGGimmu:56381
UCSCiuc008von.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23013
MGIiMGI:1891706 Spen

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410ZT33 LUCA
GeneTreeiENSGT00940000157087
OrthoDBi367857at2759
TreeFamiTF315637

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Spen mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040761 Expressed in 239 organ(s), highest expression level in thymus
ExpressionAtlasiA2ADB0 baseline and differential
GenevisibleiA2ADB0 MM

Family and domain databases

CDDicd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met
PfamiView protein in Pfam
PF00076 RRM_1, 4 hits
PF07744 SPOC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2ADB0_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ADB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 31, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again