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Protein

FERM domain-containing protein 7

Gene

Frmd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability.By similarity1 Publication

GO - Biological processi

  • negative regulation of protein binding Source: MGI
  • negative regulation of stress fiber assembly Source: MGI
  • positive regulation of lamellipodium assembly Source: MGI
  • positive regulation of small GTPase mediated signal transduction Source: MGI
  • regulation of neuron projection development Source: UniProtKB

Keywordsi

Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 7
Gene namesi
Name:Frmd7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2686379 Frmd7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003914621 – 703FERM domain-containing protein 7Add BLAST703

Proteomic databases

PaxDbiA2AD83
PRIDEiA2AD83

PTM databases

iPTMnetiA2AD83
PhosphoSitePlusiA2AD83

Expressioni

Tissue specificityi

In the developing cerebral cortex, strong expression is observed in the ventricular and intermediate zones at E13 and E17. At E17 and P0, expression appears to be restricted to the cortical plate. In neonates, highly expressed in cortex, hippocampus, cerebellum, olfactory bulb and eye with little or no expression in liver, kidney, skeletal muscle or heart muscle (at protein level).1 Publication

Inductioni

Up-regulated during retinoic acid-induced differentiation of neuroblastoma cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000036131 Expressed in 14 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiA2AD83 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057103

Structurei

3D structure databases

ProteinModelPortaliA2AD83
SMRiA2AD83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 282FERMPROSITE-ProRule annotationAdd BLAST281

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili525 – 552Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3531 Eukaryota
ENOG410XP7Q LUCA
GeneTreeiENSGT00920000148976
HOGENOMiHOG000231290
HOVERGENiHBG080212
InParanoidiA2AD83
OMAiKPCNYFL
OrthoDBiEOG091G015W
TreeFamiTF317513

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PRINTSiPR00935 BAND41
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AD83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHLKVQFLD DSQKIFVVDQ KSSGKALFNL SCGHLNLAEK EYFGLEFCSH
60 70 80 90 100
SGNNVWLELL KPITKQVKNP KEVVFKFMVK FFPVDPGHLR EELTRYLFTL
110 120 130 140 150
QIKKDLALGR LPCSDNCTAL MVSHILQSEL GDFHEETVRK HLVQTQYLPS
160 170 180 190 200
QASLESKIMQ FHQQHIGRSP AESDILLLDI ARKLDMYGIR PQPASDGEGM
210 220 230 240 250
QIHLAVAHMG VLVLRGNTKI NTFNWAKIRK LSFKRKHFLI KLHANILVLC
260 270 280 290 300
KDTLEFTMAS RDACKAFWKT CVEYHAFFRL SEEPKSKPKT LLCSKGSSFR
310 320 330 340 350
YSGRTQRQLL EYGKKGRLKS LPFERKQYPS QYHERQCRSS PDILSDVSKQ
360 370 380 390 400
VEDLRLTYGS SYYRNVNGVH ASESMLDSRR RNSAVEVTFA AELEHSKPEA
410 420 430 440 450
EATSLHPSQS SSSFTFIYAD PVFNTDPEPI EFFEERSPLS SFQTTSKFAD
460 470 480 490 500
SHTSKASPAR QLTYTDVPYI PCTSQKVDIM PPQVFFYVDK PPQVPRRSLI
510 520 530 540 550
MAEENMRPDS YVDHSAIKPA KRSPRNMRIK SLQQDLQELQ EAMARTSGRS
560 570 580 590 600
NINVEPEEED PHLDDAFAYN LQEQTPKRSQ SQSDMKTIRF PFGSEFRPLG
610 620 630 640 650
PCPALTRKTD LFACTFAEQE FPTVLIDQSS AERYVASESS DSESEIIKPD
660 670 680 690 700
YYFLYGKGTK SPRARIRLSS GSLQLEEEDE TISFATPGAE DRTLLKPCNY

FLA
Length:703
Mass (Da):80,330
Last modified:February 20, 2007 - v1
Checksum:i4D964A61B041F0C0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PXK8E9PXK8_MOUSE
FERM domain-containing protein 7
Frmd7
85Annotation score:

Sequence cautioni

The sequence AAI47258 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI47259 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC27826 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670230 Genomic DNA Translation: CAM15767.1
AK032347 mRNA Translation: BAC27826.1 Different initiation.
BC147257 mRNA Translation: AAI47258.1 Different initiation.
BC147258 mRNA Translation: AAI47259.1 Different initiation.
CCDSiCCDS53067.1
RefSeqiNP_001177261.1, NM_001190332.1
XP_006541568.1, XM_006541505.3
XP_006541569.1, XM_006541506.3
UniGeneiMm.393050

Genome annotation databases

EnsembliENSMUST00000060650; ENSMUSP00000057103; ENSMUSG00000036131
GeneIDi385354
KEGGimmu:385354
UCSCiuc012hgz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670230 Genomic DNA Translation: CAM15767.1
AK032347 mRNA Translation: BAC27826.1 Different initiation.
BC147257 mRNA Translation: AAI47258.1 Different initiation.
BC147258 mRNA Translation: AAI47259.1 Different initiation.
CCDSiCCDS53067.1
RefSeqiNP_001177261.1, NM_001190332.1
XP_006541568.1, XM_006541505.3
XP_006541569.1, XM_006541506.3
UniGeneiMm.393050

3D structure databases

ProteinModelPortaliA2AD83
SMRiA2AD83
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057103

PTM databases

iPTMnetiA2AD83
PhosphoSitePlusiA2AD83

Proteomic databases

PaxDbiA2AD83
PRIDEiA2AD83

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060650; ENSMUSP00000057103; ENSMUSG00000036131
GeneIDi385354
KEGGimmu:385354
UCSCiuc012hgz.1 mouse

Organism-specific databases

CTDi90167
MGIiMGI:2686379 Frmd7

Phylogenomic databases

eggNOGiKOG3531 Eukaryota
ENOG410XP7Q LUCA
GeneTreeiENSGT00920000148976
HOGENOMiHOG000231290
HOVERGENiHBG080212
InParanoidiA2AD83
OMAiKPCNYFL
OrthoDBiEOG091G015W
TreeFamiTF317513

Miscellaneous databases

PROiPR:A2AD83
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036131 Expressed in 14 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiA2AD83 baseline and differential

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PRINTSiPR00935 BAND41
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRMD7_MOUSE
AccessioniPrimary (citable) accession number: A2AD83
Secondary accession number(s): Q8CCP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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