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Entry version 101 (02 Jun 2021)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

SCL-interrupting locus protein homolog

Gene

Stil

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SCL-interrupting locus protein homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:StilImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107477, Stil

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AD39

PRoteomics IDEntifications database

More...
PRIDEi
A2AD39

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
324548

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028718, Expressed in undifferentiated genital tubercle and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AD39, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AD39, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AD39

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni369 – 409DisorderedSequence analysisAdd BLAST41
Regioni454 – 551DisorderedSequence analysisAdd BLAST98
Regioni650 – 670DisorderedSequence analysisAdd BLAST21
Regioni782 – 804DisorderedSequence analysisAdd BLAST23
Regioni883 – 904DisorderedSequence analysisAdd BLAST22
Regioni925 – 959DisorderedSequence analysisAdd BLAST35
Regioni1106 – 1129DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili706 – 726Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi380 – 396Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi467 – 511Polar residuesSequence analysisAdd BLAST45
Compositional biasi790 – 804Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi883 – 897Polar residuesSequence analysisAdd BLAST15
Compositional biasi925 – 946Polar residuesSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007310

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007178_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QHHGHIQ

Database of Orthologous Groups

More...
OrthoDBi
342602at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331178

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026123, Sil

The PANTHER Classification System

More...
PANTHERi
PTHR15128, PTHR15128, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15253, STIL_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A2AD39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTRFPSSKM VPFHFPPSKL ALWNPMPIGE CIYLHLSYYR KPKLMVTEKA
60 70 80 90 100
IRLAYRHAKQ NKKNVPCFLL GSLTVDEDEE GVTLTIDRFD PGREIPECLE
110 120 130 140 150
RTPTASLPGD FLIPCRVHIQ GLGSRDVIVH NADDFSSALK ALQYHVCSKD
160 170 180 190 200
FLDCGKLLCL RAQITPRESL DGVDFNLQWT AVTLANSFKC VPVKPIPIIP
210 220 230 240 250
TALARNLSSN LNISQVQGTY KHGYITMDET RKLLLLLQSD PKVSSLPLVG
260 270 280 290 300
IWLAGIIHVY SPQVWACCLR YMFSSSIQER VFSESGNFII VLYSLTHKEP
310 320 330 340 350
EFYECLPCES RTPDLQFQLL TNKETLHLFN NVEPSGKNPI HFELSAESQD
360 370 380 390 400
AEAEAEVLSK ISKTLPVKRS SQKLSPGKIP INKHDTDLED EDFSPRPIPS
410 420 430 440 450
PHPVSQKISK VQPSVPELSL VLDNNFTESS NQSNPLEMMT VENPLLIKPS
460 470 480 490 500
QPELCDAKHS SEATTGEPFR RGPTNQLSQD TALRQSRGKQ SSTCKKESLQ
510 520 530 540 550
FRNTNAKPSL SVPSPDVAEK LQAVSAGSMQ KEDYPVRPST LDSRQPSLAP
560 570 580 590 600
QAQPHNLVFS THNSTRPMEL QVPTPSLPSY YPTNVCSCCQ HHGHIQYSTI
610 620 630 640 650
NSWQGNTVGS IQDLRSESLP KHAFFHSSGC PSLCPNAIYS SSSPVSMKQG
660 670 680 690 700
GMGAYSPHSN GEPSPVAGPS HVDSCVPHPC AMCMHMPNTA PDNGMMGLSP
710 720 730 740 750
DAYRFVTEQD RQLRLLQAQI QRLLEAQSLD PGSHKTVATV EDTVKAAKQM
760 770 780 790 800
ELVSMEAQSS PGLHMRKSVS IAVSTGASLF WNAAGDDQEP DSQPKQDDTK
810 820 830 840 850
ISSEDMNFSV DINNEATSLP GSASSLKAVD IPSFEESNLA VEEVNQPLPE
860 870 880 890 900
SNSSSEQSKE PGVPVFFPNA LLAESVSMCL QTAPTEGASN STELPQGTKD
910 920 930 940 950
EPYRPSDNQK IYQDLLGQVN HLLSNASQET EEPPTKAVVT NRECAKTQNT
960 970 980 990 1000
HHARKKRHNS GLVDKDCVLS ATIKQLRSLG VKIDSPTKVK KNEQKVDHAS
1010 1020 1030 1040 1050
VLACISPEAV ISGLNYMSFG NVGMSSLSPT GVDLSMEANA IALKYLSENQ
1060 1070 1080 1090 1100
LSQLSLARSK QNNGDSSVGL LHINSDRSTV GLSLVSPSNM SFATKKYMKR
1110 1120 1130 1140 1150
YGLLQSSDNS EDEEEPPSHA DSESDHVLNR NPACRPVQCG HEKEPSWNAC
1160 1170 1180 1190 1200
EIAQCSDCGS ADTRTDVPVL RNITNQAVQP RATEHLNEDS AISLRNLKPN
1210 1220 1230 1240 1250
PAMNLRTGKA EFTHHPEKEN ERDIAVFPGT LPSPETLKQM NSMDSVGTFL
1260
DVKRLRQLPK LF
Length:1,262
Mass (Da):138,761
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2B811E5CA5A39EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q60988STIL_MOUSE
SCL-interrupting locus protein homo...
Stil Sil
1,262Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GXH2A0A1B0GXH2_MOUSE
SCL-interrupting locus protein homo...
Stil
640Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RH61D6RH61_MOUSE
SCL-interrupting locus protein homo...
Stil
399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VXM5F6VXM5_MOUSE
SCL-interrupting locus protein homo...
Stil
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_033211.2, NM_009185.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000030490; ENSMUSP00000030490; ENSMUSG00000028718

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20460

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20460

UCSC genome browser

More...
UCSCi
uc008ueh.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_033211.2, NM_009185.3

3D structure databases

SMRiA2AD39
ModBaseiSearch...

Proteomic databases

MaxQBiA2AD39
PRIDEiA2AD39
ProteomicsDBi324548

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53510, 96 antibodies

The DNASU plasmid repository

More...
DNASUi
20460

Genome annotation databases

EnsembliENSMUST00000030490; ENSMUSP00000030490; ENSMUSG00000028718
GeneIDi20460
KEGGimmu:20460
UCSCiuc008ueh.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6491
MGIiMGI:107477, Stil

Phylogenomic databases

GeneTreeiENSGT00390000007310
HOGENOMiCLU_007178_0_0_1
OMAiQHHGHIQ
OrthoDBi342602at2759
TreeFamiTF331178

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
20460, 17 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Stil, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028718, Expressed in undifferentiated genital tubercle and 204 other tissues
ExpressionAtlasiA2AD39, baseline and differential
GenevisibleiA2AD39, MM

Family and domain databases

InterProiView protein in InterPro
IPR026123, Sil
PANTHERiPTHR15128, PTHR15128, 1 hit
PfamiView protein in Pfam
PF15253, STIL_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AD39_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AD39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 2, 2021
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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