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Protein

Rab proteins geranylgeranyltransferase component A

Gene

Chm

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Rab proteins geranylgeranyltransferase component AUniRule annotation
Gene namesi
Name:ChmImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:892979 Chm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiA2AD03
PeptideAtlasiA2AD03
PRIDEiA2AD03

Expressioni

Gene expression databases

BgeeiENSMUSG00000025531 Expressed in 266 organ(s), highest expression level in cochlea
ExpressionAtlasiA2AD03 baseline and differential
GenevisibleiA2AD03 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA2AD03
SMRiA2AD03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4405 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOVERGENiHBG004961
OrthoDBiEOG091G01LC
TreeFamiTF320813

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR001738 Rab_escort
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 2 hits
PIRSFiPIRSF016550 Rab_ger_ger_transf_A_euk, 1 hit
PRINTSiPR00893 RABESCORT
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2AD03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADNLPSDFD VIVIGTGLPE SIIAAACSRS GQRVLHVDSR SYYGGNWASF
60 70 80 90 100
SFSGLLSWLK EYQENSDVVT ENSMWQEQIL ENEEAILLSS KDKTIQHVEV
110 120 130 140 150
FCYASQDLHK DVEEAGALQK NPASVMSAQA TEAAEAAEAA EAAEATEAAE
160 170 180 190 200
AACLPTAEES LSTRSCELPA EQSQCTGPES SPQVNDAEVG EKETQSDAKS
210 220 230 240 250
STEQSSEILP KVQDNTETPK RNVITYSQII KEGRRFNIDL VSKLLYSRGL
260 270 280 290 300
LIDLLIKSNV SRYAEFKNIT RILAFREGTV EQVPCSRADV FNSKQLTMVE
310 320 330 340 350
KRMLMKFLTF CVEYEDHPDE YKAYEETTFS EYLKTQKLTP NLQYFVLHSI
360 370 380 390 400
AMTSETTSST VDGLKATKKF LQCLGRYGNT PFLFPLYGQG ELPQCFCRMC
410 420 430 440 450
AVFGGIYCLR HSVQCLVVDK ESRKCKAIVD QFGQRIISKH FVIEDSYLSE
460 470 480 490 500
NTCSGVQYRQ ISRAVLITDG SVLKPDSDQQ VSILTVPAEE SGSFAVRVIE
510 520 530 540 550
LCSSTMTCMK GTYLVHLTCM SSKTAREDLE RVVQKLFTPY TEIEAENEQV
560 570 580 590 600
EKPRILWALY FNMRDSSDIS RDCYNDLPSN VYVCSGPDCN LGNDNAVQQA
610 620 630 640 650
ETVFQKICPN EDFCPAPPNP EDIILDGDSS QQEVSESSVI PETNSETPKE
660
STVLGDSEEP SE
Length:662
Mass (Da):73,664
Last modified:February 20, 2007 - v1
Checksum:iA5DFB31AEA6502C5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QXG2RAE1_MOUSE
Rab proteins geranylgeranyltransfer...
Chm Rep1
665Annotation score:
Q3UR39Q3UR39_MOUSE
Rab proteins geranylgeranyltransfer...
Chm
623Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669958 Genomic DNA No translation available.
RefSeqiNP_061288.2, NM_018818.2
UniGeneiMm.257316

Genome annotation databases

EnsembliENSMUST00000026607; ENSMUSP00000026607; ENSMUSG00000025531
GeneIDi12662
KEGGimmu:12662
UCSCiuc009udn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669958 Genomic DNA No translation available.
RefSeqiNP_061288.2, NM_018818.2
UniGeneiMm.257316

3D structure databases

ProteinModelPortaliA2AD03
SMRiA2AD03
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA2AD03
PeptideAtlasiA2AD03
PRIDEiA2AD03

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026607; ENSMUSP00000026607; ENSMUSG00000025531
GeneIDi12662
KEGGimmu:12662
UCSCiuc009udn.1 mouse

Organism-specific databases

CTDi1121
MGIiMGI:892979 Chm

Phylogenomic databases

eggNOGiKOG4405 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOVERGENiHBG004961
OrthoDBiEOG091G01LC
TreeFamiTF320813

Enzyme and pathway databases

ReactomeiR-MMU-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiChm mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025531 Expressed in 266 organ(s), highest expression level in cochlea
ExpressionAtlasiA2AD03 baseline and differential
GenevisibleiA2AD03 MM

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR001738 Rab_escort
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 2 hits
PIRSFiPIRSF016550 Rab_ger_ger_transf_A_euk, 1 hit
PRINTSiPR00893 RABESCORT
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AD03_MOUSE
AccessioniPrimary (citable) accession number: A2AD03
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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