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Protein

Tetratricopeptide repeat protein 39A

Gene

Ttc39a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 39A
Short name:
TPR repeat protein 39A
Gene namesi
Name:Ttc39a
Synonyms:Kiaa0452
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2444350 Ttc39a

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919971 – 578Tetratricopeptide repeat protein 39AAdd BLAST578

Proteomic databases

MaxQBiA2ACP1
PaxDbiA2ACP1
PeptideAtlasiA2ACP1
PRIDEiA2ACP1

PTM databases

PhosphoSitePlusiA2ACP1

Expressioni

Gene expression databases

BgeeiENSMUSG00000028555 Expressed in 134 organ(s), highest expression level in testis
ExpressionAtlasiA2ACP1 baseline and differential
GenevisibleiA2ACP1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102229

Structurei

3D structure databases

ProteinModelPortaliA2ACP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati280 – 313TPR 1Add BLAST34
Repeati470 – 503TPR 2Add BLAST34
Repeati511 – 544TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the TTC39 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3783 Eukaryota
ENOG410XS7D LUCA
GeneTreeiENSGT00390000009763
HOVERGENiHBG057941
InParanoidiA2ACP1
OMAiTKDSMYH
OrthoDBiEOG091G0NXI
PhylomeDBiA2ACP1
TreeFamiTF313761

Family and domain databases

InterProiView protein in InterPro
IPR019412 Iml2/TPR_39
IPR019734 TPR_repeat
IPR030416 TTC39A
PANTHERiPTHR31859 PTHR31859, 1 hit
PTHR31859:SF3 PTHR31859:SF3, 1 hit
PfamiView protein in Pfam
PF10300 DUF3808, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2ACP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQKGHKDSL YDCKGSPVSS LHEALDQCMT ALDLFLTNQF SEALSYLKPR
60 70 80 90 100
TKESMYHSLT YATILEMQAM MTFDPQDILL AGNMMKEAQS LCQRHRRKSS
110 120 130 140 150
MTDSFSNLVH RPTIDQFTEE EIHAEVCYAE CLLQRAALTF LQDENMVSFI
160 170 180 190 200
KGGIKVRNSY QTYKELDSLV QSSQYSKGES HRHFEGGVKL GVGAFNLTLS
210 220 230 240 250
MLPTRILRLL EFVGFSGNKD YGLLQLEEGA TGHSFRAVLC VMLLLCYHTF
260 270 280 290 300
LTFVLGTGNV NIEEAEKLLK PYLNRYPKGA IFLFFAGRIE AIKGNIDAAV
310 320 330 340 350
RRFEECCEAQ QHWKQFHHMC YWELMWCFTY KGQWKMAYFY ADLLSKENSW
360 370 380 390 400
SKATYIYMKA AYLSMFGKED YKPFGDNEVE LFRAVPGLKL KIAGKSLPTE
410 420 430 440 450
KFAIRKSRRY LSPNPISLPI PALEMMYIWN GYAVIGKQPT LTDGMLEVIT
460 470 480 490 500
KAEEMLAMGP ENEYSADDDC LVKLLKGLCL KYLGRIQEAE ENFRSISANE
510 520 530 540 550
KKIKYDHYLI PNALLELALL FMEQGRNEEA IKLLESAKQN YKNYSMESRT
560 570
HFRIQAATLQ ARSSLEDGNR SLVSSVSL
Length:578
Mass (Da):66,126
Last modified:February 20, 2007 - v1
Checksum:i32F06E2C07910FC8
GO
Isoform 2 (identifier: A2ACP1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGQKGHKDSLYDCK → MTTASGPGDLPA

Show »
Length:576
Mass (Da):65,634
Checksum:i39024F7753DACDA2
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X1WI14X1WI14_MOUSE
Tetratricopeptide repeat protein 39...
Ttc39a
159Annotation score:
A0A0A0MQC5A0A0A0MQC5_MOUSE
Tetratricopeptide repeat protein 39...
Ttc39a
189Annotation score:
A0A0A0MQI5A0A0A0MQI5_MOUSE
Tetratricopeptide repeat protein 39...
Ttc39a
137Annotation score:
A0A0A0MQL1A0A0A0MQL1_MOUSE
Tetratricopeptide repeat protein 39...
Ttc39a
109Annotation score:

Sequence cautioni

The sequence BAC36475 differs from that shown. Reason: Frameshift at positions 384 and 474.Curated
The sequence CAM13655 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM13658 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM13659 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM13660 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti552F → L in AAH23883 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0263541 – 14MGQKG…LYDCK → MTTASGPGDLPA in isoform 2. 3 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048659 mRNA Translation: BAC33414.1
AK076772 mRNA Translation: BAC36475.1 Frameshift.
AL669905 Genomic DNA Translation: CAM13655.1 Sequence problems.
AL669905 Genomic DNA Translation: CAM13656.1
AL669905 Genomic DNA Translation: CAM13657.1
AL669905 Genomic DNA Translation: CAM13658.1 Sequence problems.
AL669905 Genomic DNA Translation: CAM13659.1 Sequence problems.
AL669905 Genomic DNA Translation: CAM13660.1 Sequence problems.
BC023883 mRNA Translation: AAH23883.1
BC026660 mRNA Translation: AAH26660.1
AK172951 mRNA Translation: BAD32229.1
CCDSiCCDS18463.1 [A2ACP1-2]
CCDS51260.1 [A2ACP1-1]
RefSeqiNP_001139420.1, NM_001145948.1 [A2ACP1-1]
NP_700441.2, NM_153392.2 [A2ACP1-2]
UniGeneiMm.33091

Genome annotation databases

EnsembliENSMUST00000064129; ENSMUSP00000066334; ENSMUSG00000028555 [A2ACP1-2]
ENSMUST00000106618; ENSMUSP00000102229; ENSMUSG00000028555 [A2ACP1-1]
GeneIDi230603
KEGGimmu:230603
UCSCiuc008ucj.2 mouse [A2ACP1-2]
uc008uck.2 mouse [A2ACP1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048659 mRNA Translation: BAC33414.1
AK076772 mRNA Translation: BAC36475.1 Frameshift.
AL669905 Genomic DNA Translation: CAM13655.1 Sequence problems.
AL669905 Genomic DNA Translation: CAM13656.1
AL669905 Genomic DNA Translation: CAM13657.1
AL669905 Genomic DNA Translation: CAM13658.1 Sequence problems.
AL669905 Genomic DNA Translation: CAM13659.1 Sequence problems.
AL669905 Genomic DNA Translation: CAM13660.1 Sequence problems.
BC023883 mRNA Translation: AAH23883.1
BC026660 mRNA Translation: AAH26660.1
AK172951 mRNA Translation: BAD32229.1
CCDSiCCDS18463.1 [A2ACP1-2]
CCDS51260.1 [A2ACP1-1]
RefSeqiNP_001139420.1, NM_001145948.1 [A2ACP1-1]
NP_700441.2, NM_153392.2 [A2ACP1-2]
UniGeneiMm.33091

3D structure databases

ProteinModelPortaliA2ACP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102229

PTM databases

PhosphoSitePlusiA2ACP1

Proteomic databases

MaxQBiA2ACP1
PaxDbiA2ACP1
PeptideAtlasiA2ACP1
PRIDEiA2ACP1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064129; ENSMUSP00000066334; ENSMUSG00000028555 [A2ACP1-2]
ENSMUST00000106618; ENSMUSP00000102229; ENSMUSG00000028555 [A2ACP1-1]
GeneIDi230603
KEGGimmu:230603
UCSCiuc008ucj.2 mouse [A2ACP1-2]
uc008uck.2 mouse [A2ACP1-1]

Organism-specific databases

CTDi22996
MGIiMGI:2444350 Ttc39a
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3783 Eukaryota
ENOG410XS7D LUCA
GeneTreeiENSGT00390000009763
HOVERGENiHBG057941
InParanoidiA2ACP1
OMAiTKDSMYH
OrthoDBiEOG091G0NXI
PhylomeDBiA2ACP1
TreeFamiTF313761

Miscellaneous databases

ChiTaRSiTtc39a mouse
PROiPR:A2ACP1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028555 Expressed in 134 organ(s), highest expression level in testis
ExpressionAtlasiA2ACP1 baseline and differential
GenevisibleiA2ACP1 MM

Family and domain databases

InterProiView protein in InterPro
IPR019412 Iml2/TPR_39
IPR019734 TPR_repeat
IPR030416 TTC39A
PANTHERiPTHR31859 PTHR31859, 1 hit
PTHR31859:SF3 PTHR31859:SF3, 1 hit
PfamiView protein in Pfam
PF10300 DUF3808, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTT39A_MOUSE
AccessioniPrimary (citable) accession number: A2ACP1
Secondary accession number(s): A2ACN9
, A2ACP2, A2ACP3, A2ACP4, Q6A067, Q8C612, Q8CFL5, Q8K1A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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